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1. 发明申请

WO2009125339A3 A CARRIER FOR OPTICAL DETECTION IN SMALL SAMPLE VOLUMES 审中-公开
公开(公告)号：WO2009125339A3
公开(公告)日：2009-10-15
申请号：PCT/IB2009/051454
申请日：2009-04-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
发明人： SCHLEIPEN, Johannes, J., H., B. , EVERS, Toon, H. , NIEUWENHUIS, Jeroen, H. , DITTMER, Wendy, U. , BRULS, Dominique, M. , PRINS, Menno, W., J. , NEIJZEN, Jacobus, H., M. , BOURQUIN, Yannyk, P., J.
IPC分类号： G01N21/25 , G01N21/41
摘要： The invention relates to a carrier (11) and an apparatus (100) for optical detection in a sample (1) in a sample chamber (2). The carrier (11) comprises an optical structure (50) for refracting an input light beam (Ll) into the adjacent sample chamber (2) and for collecting an output light beam (L2) from light that originates in the sample chamber (2) from the input light beam. Preferably, the optical structure (50) comprises grooves in the surface (12) of the carrier (11) in which the input light beam is transmitted over a short distance through a sample. The optical structure (50) can also be used for a wetting detection.

2. 发明申请

WO2010095071A1 SENSING DEVICE FOR DETECTING A TARGET SUBSTANCE 审中-公开
标题翻译：用于检测目标物质的感应装置
公开(公告)号：WO2010095071A1
公开(公告)日：2010-08-26
申请号：PCT/IB2010/050553
申请日：2010-02-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BRULS, Dominique, M. , EVERS, Toon, H. , SCHLEIPEN, Johannes, J., H., B.
发明人： BRULS, Dominique, M. , EVERS, Toon, H. , SCHLEIPEN, Johannes, J., H., B.
IPC分类号： G01N21/27 , G01N21/55 , G01N21/77 , G01N33/543
CPC分类号： G01N21/552 , G01N21/274 , G01N33/54373
摘要： The present invention relates to a sensing device (100) for detecting a target substance (2) in an investigation region (113). The sensing device (100) comprises a sensing surface (112) with an investigation region (113) and a reference region (120) thereon. The sensing device (100) further comprises a reference element (121) located at the reference region (120). The reference element (121) is adapted to shield the reference region (120) from the target substance (2) such that light reflected at the reference region (120) under total internal reflection conditions remains unaffected by the presence or absence of the target substance (2). This allows measuring a property, typically the intensity, of light reflected at the reference region (120) independent of the presence or absence of the target substance (2). This measured property of the reflected light can be used for performing an improved correction of light reflected at the investigation region (113).
摘要翻译：本发明涉及一种用于在调查区域（113）中检测目标物质（2）的感测装置（100）。感测装置（100）包括其上具有调查区域（113）和参考区域（120）的感测表面（112）。感测装置（100）还包括位于参考区域（120）处的参考元件（121）。参考元件（121）适于屏蔽参考区域（120）与目标物质（2），使得在全内反射条件下在参考区域（120）处反射的光线不会受到目标物质的存在或不存在的影响（2）。这允许独立于目标物质（2）的存在或不存在来测量在参考区域（120）处反射的光的特性（通常为强度）。反射光的测量特性可用于对在调查区域（113）反射的光进行改进的校正。

3. 发明申请

WO2011158174A1 MULTI EPITOPE ASSAY 审中-公开
标题翻译：多重抗生素测定
公开(公告)号：WO2011158174A1
公开(公告)日：2011-12-22
申请号：PCT/IB2011/052570
申请日：2011-06-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SABATTE, Gwenola , PRINS, Menno, W., J. , EVERS, Toon, H. , HARDEMAN, Wilhelmina, M. , ORSEL, Joukje, G.
发明人： SABATTE, Gwenola , PRINS, Menno, W., J. , EVERS, Toon, H. , HARDEMAN, Wilhelmina, M. , ORSEL, Joukje, G.
IPC分类号： G01N33/543
CPC分类号： G01N33/5306 , G01N33/54306 , G01N33/54333
摘要： The present invention is related to a method for detection of a biological target in an affinity assay, the method comprising the steps of providing a biological sample volume containing the biological target, adding a first capturing moiety to the biological sample volume comprising the biological target, wherein the first capturing moiety is adhered to a particle, concentration of the captured biological target into an elution volume that is smaller than the biological sample volume in step a), cleavage of the first capturing moiety or the biological target from the particle and direct or indirect detection and/or quantification of the biological target in a sandwich or competitive affinity assay format, wherein the biological target is associated with at least one capturing moiety, preferably at least two capturing moieties.
摘要翻译：本发明涉及亲和测定中生物靶标检测方法，该方法包括以下步骤：提供含生物靶的生物样品体积，向包含生物靶标的生物样品体积添加第一捕获部分，其中所述第一捕获部分被粘附到颗粒上，所捕获的生物靶的浓度在步骤a）中小于生物样品体积的洗脱体积，从所述颗粒切割所述第一捕获部分或所述生物靶，并直接或间接检测和/或以三明治或竞争亲和测定格式定量生物学靶标，其中生物靶标与至少一个捕获部分，优选至少两个捕获部分相关联。

4. 发明申请

WO2011030286A1 HIGHLY SENSITIVE IMMUNOASSAY WITH LARGE PARTICLE LABELS 审中-公开
标题翻译：具有大颗粒标签的高敏感免疫
公开(公告)号：WO2011030286A1
公开(公告)日：2011-03-17
申请号：PCT/IB2010/054020
申请日：2010-09-07
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , EVERS, Toon, H. , HEFTI, Marco, H. , DEKKERS, David, W. C. , MARTENS, Michael, F. W. C.
发明人： DITTMER, Wendy, U. , EVERS, Toon, H. , HEFTI, Marco, H. , DEKKERS, David, W. C. , MARTENS, Michael, F. W. C.
IPC分类号： G01N33/543
CPC分类号： G01N33/54346 , G01N33/54333 , G01N2333/58
摘要： The present invention is related to an immunoassay for the detection of an analyte in a sample, said assay comprising a plurality of moieties capable of binding to said analyte, wherein capture moieties which are not specific for the same epitope are bound to a solid substrate, and at least one epitope-specific detection moiety is bound to a detectable marker, and wherein the detectable marker to which the epitope-specific detection moiety is bound is a large particle marker having a particle size of ≥ 50 nm and ≤ 5000 nm.
摘要翻译：本发明涉及用于检测样品中分析物的免疫测定法，所述测定法包括能够结合所述分析物的多个部分，其中对相同表位不特异的捕获部分结合到固体基质上，并且至少一个表位特异性检测部分与可检测标记结合，并且其中所述表位特异性检测部分所结合的可检测标记是具有= 50nm和5000nm的粒度的大颗粒标记物。

5. 发明申请

WO2010073182A1 ASSAY FOR TROPONIN I USING MAGNETIC LABELS 审中-公开
标题翻译：使用磁性标签测定TROPONIN I
公开(公告)号：WO2010073182A1
公开(公告)日：2010-07-01
申请号：PCT/IB2009/055757
申请日：2009-12-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DITTMER, Wendy, U. , EVERS, Toon, H. , DE KIEVIT, Peggy , KAMPS, Ricky , VISSERS, Joost, L., M. , MARTENS, Michael, F., W., C. , DEKKERS, David, W., C.
发明人： DITTMER, Wendy, U. , EVERS, Toon, H. , DE KIEVIT, Peggy , KAMPS, Ricky , VISSERS, Joost, L., M. , MARTENS, Michael, F., W., C. , DEKKERS, David, W., C.
IPC分类号： G01N33/68 , G01N33/543
CPC分类号： G01N33/6887 , G01N33/54373 , G01N2800/324
摘要： The present invention relates to a method for measuring Troponin I in a sample comprising the steps of providing a sample, contacting the sample with a monoclonal anti-Troponin I antibody coupled to a magnetic label, contacting the sample with a polyclonal anti-Troponin I antibody coupled to a sensor surface and detecting the magnetic label on the sensor surface. The invention further relates to a device and a cartridge for measuring Troponin I in a sample.
摘要翻译：本发明涉及一种测量样品中肌钙蛋白I的方法，包括以下步骤：提供样品，使样品与偶联至磁性标签的单克隆抗肌钙蛋白I抗体接触，使样品与多克隆抗肌钙蛋白I抗体耦合到传感器表面并检测传感器表面上的磁性标签。本发明还涉及用于测量样品中的肌钙蛋白I的装置和盒。

6. 发明申请

WO2010044005A2 METHOD AND DEVICE FOR DETERMINING THE AMOUNT OF MAGNETICALLY LABELED TARGET COMPONENTS 审中-公开
标题翻译：用于确定磁性标签目标组件数量的方法和装置
公开(公告)号：WO2010044005A2
公开(公告)日：2010-04-22
申请号：PCT/IB2009/054372
申请日：2009-10-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , EVERS, Toon, H. , DITTMER, Wendy, U.
发明人： EVERS, Toon, H. , DITTMER, Wendy, U.
IPC分类号： G01N33/543 , G01N35/00 , G01R33/00 , G06F19/00
CPC分类号： G01N33/54326 , B82Y25/00 , G01N27/745 , G01N35/0098 , G01R33/093 , G01R33/1269
摘要： The invention relates to a method and a device (100) for determining the amount of a target component (2) in a sample, wherein magnetic particles (2) can bind to a contact surface (4) with kinetics that depend on the sample-amount of the target component. The method comprises at least two washing steps during which magnetic particles (2) are magnetically moved away from the contact surface (4) and corresponding measurements of the remaining amount of magnetic particles (2) at the contact surface (4). The amount of target component in the sample is estimated from at least one of such measurement results. The measurement allows to determine also high concentrations of target component for which the sensor surface (4) is saturated in a steady-state.
摘要翻译：本发明涉及一种用于确定样品中目标组分（2）的量的方法和装置（100），其中磁性颗粒（2）可以结合取决于样品的动力学的接触表面（4）目标成分的数量。该方法包括至少两个洗涤步骤，在该步骤中磁性颗粒（2）被磁性地远离接触表面（4）移动，并且在接触表面（4）处磁性颗粒（2）的剩余量的相应测量值。从这些测量结果中的至少一个估计样品中的目标成分的量。该测量允许确定传感器表面（4）在稳定状态下饱和的目标部件的高浓度。

7. 发明申请

WO2009093160A1 DETECTION OF TARGET COMPONENTS WITH THE HELP OF INDICATOR PARTICLES 审中-公开
标题翻译：用指示剂颗粒帮助检测目标组分
公开(公告)号：WO2009093160A1
公开(公告)日：2009-07-30
申请号：PCT/IB2009/050170
申请日：2009-01-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS N. V. , EVERS, Toon, H.
发明人： EVERS, Toon, H.
IPC分类号： G01N33/542 , G01N33/543
CPC分类号： G01N33/54373 , B82Y25/00 , B82Y30/00 , G01N21/552 , G01N27/745 , G01N33/542 , G01N33/54326
摘要： The invention relates to a system and a method for the detection of target components (102) in a sample with the help of indicator particles (101) distributed in said sample. The distance (d) between indicator particles (101) and a contact surface (112) is determined after the target components could bind to the contact surface and/or the indicator particles. Thus it is possible to detect how many target components (102) are bound without a need for a binding between indicator particles (101) and contact surface (112). Optionally the indicator particles (101) can be affected by a modulated force, e.g. via an electromagnet (141). The determination of the distance (d) between indicator particles (101) and contact surface (112) may for example be achieved by frustrated total internal reflection, measurement of magnetic fields, or FRET.
摘要翻译：本发明涉及借助于分布在所述样品中的指示剂颗粒（101）来检测样品中的目标组分（102）的系统和方法。在目标组分可以结合到接触表面和/或指示剂颗粒之后，确定指示剂颗粒（101）和接触表面（112）之间的距离（d）。因此，可以检测多少目标部件（102）被绑定，而不需要指示剂颗粒（101）和接触表面（112）之间的结合。任选地，指示剂颗粒（101）可以受到调制的力，例如，经由电磁体（141）。指示剂颗粒（101）和接触表面（112）之间的距离（d）的确定可以例如通过沮丧的全内反射，磁场测量或FRET来实现。

8. 发明申请

WO2010044007A2 PULSED MAGNETIC ACTUATION FOR SENSITIVE ASSAYS 审中-公开
标题翻译：用于敏感测定的脉冲磁致动
公开(公告)号：WO2010044007A2
公开(公告)日：2010-04-22
申请号：PCT/IB2009/054374
申请日：2009-10-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , EVERS, Toon, H. , OVSYANKO, Mikhail, M.
发明人： EVERS, Toon, H. , OVSYANKO, Mikhail, M.
IPC分类号： G01N33/53
CPC分类号： G01N33/54333 , B01L3/502761 , B01L2200/0668 , B01L2400/043 , B03C1/288 , B03C5/028 , B03C2201/18 , G01N27/745 , G01R33/1269
摘要： A method for controlling the movement of magnetic or magnetizable objects (10) in a biosensor cartridge. The method comprises the step of providing a biosensor cartridge with a laterally extending sensor surface (A) and at least a magnetic field generating means (20, 30, 30') for generating a magnetic field with a field gradient substantially perpendicular to the sensor surface(A). The magnetic field generating means (20, 30, 30') are alternatingly actuated such that the generated magnetic field directs alternatingly the magnetic or magnetizable objects (10) substantially perpendicular to the sensor surface (A) away and toward the sensor surface, wherein pulse lengths of the alternating actuation are adjusted such that a lateral movement of magnetizable objects along the laterally extending sensor surface is substantially avoided.
摘要翻译：用于控制生物传感器盒中的磁性或可磁化物体（10）的运动的方法。该方法包括提供具有横向延伸的传感器表面（A）和至少一个磁场生成装置（20,30,30'）的生物传感器盒的步骤，该磁场生成装置用于生成具有基本垂直于传感器表面的场梯度的磁场（一个）。磁场产生装置（20,30,30'）被交替地致动，使得所产生的磁场交替地将基本垂直于传感器表面（A）的磁性或可磁化物体（10）引导离开并朝向传感器表面，其中脉冲交替致动的长度被调整，以便基本上避免可磁化物体沿横向延伸的传感器表面的横向移动。

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