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    • 6. 发明申请
    • REAL-TIME MONITORING AND CONTROL OF HIFU THERAPY IN MULTIPLE DIMENSIONS
    • HIFU治疗多维度实时监测与控制
    • WO2011161559A1
    • 2011-12-29
    • PCT/IB2011/051855
    • 2011-04-27
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.ANAND, AjayPETRUZZELLO, JohnZHOU, ShiweiSETHURAMAN, Shriram
    • ANAND, AjayPETRUZZELLO, JohnZHOU, ShiweiSETHURAMAN, Shriram
    • A61N7/02A61B8/00
    • A61N7/00A61B8/4488A61B8/485A61B2090/378A61N7/02A61N2007/0052A61N2007/0082A61N2007/0095
    • Energy is transferred (336) to cause a mechanical property of biological tissue to change, as in ablation. An effect of the transferring is examined in more than one spatial dimension to, for example, make an ablation halting decision for a treatment region, i.e., line (312)or layer (314), or for a location (316) within the region. Halting decisions can be based on lesion-central and/or lesion-peripheral longitudinal displacement of treated tissue evaluated in real time against a characteristic curve. Steering in the azimuthal and/or elevation direction is afforded by, for example, linear, or 2D, multi-channel ultrasound arrays for therapy and imaging. Protocols includable are region-wide scanning (SI 010) and location-by-location completion for both (HIFU) therapy and tracking (acoustic-radiation-forced-based) displacement of treated tissue. Fine, location- to-location monitoring can be used for relatively inhomogeneous tissue; whereas, quicker, sparser and more generalized monitoring (1 100, 1200) can be employed for relatively homogeneous tissue.
    • 转移能量(336)以使生物组织的机械性能发生变化,如消融。 在多于一个空间维度中检查转移的效果,以便例如对处理区域(即,线路(312)或层(314))或区域(316)进行消融停止决定 。 暂停决定可以基于对特征曲线实时评估的处理组织的病变中心和/或病变周边纵向位移。 方位角和/或仰角方向的转向由例如用于治疗和成像的线性或2D多通道超声阵列提供。 可包括的协议是针对处理组织的(HIFU)治疗和跟踪(基于声辐射的强制)位移的区域扫描(SI 010)和位置逐个完成。 精细的位置到位置监测可用于相对不均匀的组织; 而对于相对均匀的组织,可以采用更快,更稀疏和更广泛的监测(1100,1200)。
    • 8. 发明申请
    • COLLAPSED MODE OPERABLE CMUT INCLUDING CONTOURED SUBSTRATE
    • 收缩模式可操作,包括嵌入式基板
    • WO2009077961A2
    • 2009-06-25
    • PCT/IB2008/055279
    • 2008-12-12
    • KONINKLIJKE PHILIPS ELECTRONICS, N.V.PETRUZZELLO, JohnFRASER, John DouglasZHOU, ShiweiDUFORT, BenoitLETAVIC, Theodore James
    • PETRUZZELLO, JohnFRASER, John DouglasZHOU, ShiweiDUFORT, BenoitLETAVIC, Theodore James
    • B06B1/0292
    • A capacitive ultrasound transducer capable of operation in collapsed mode either with a reduced bias voltage, or with no bias voltage, is provided. The transducer includes a substrate that is contoured so that a middle region of the flexible membrane is collapsed against the substrate in the absence of a bias voltage. A non-collapsible gap may exists between the substrate and peripheral regions of the flexible membrane. The contour of the substrate may be such as to strain the flexible membrane past the point of collapse, or to mechanically interfere with the flexible membrane. The substrate may include a further membrane disposed beneath the flexible membrane, the further membrane being contoured so that the flexible membrane is collapsed against it. The substrate may a support disposed beneath the further membrane to deflect a corresponding portion of the further membrane upward toward the flexible membrane. The support may be a post. The transducer may be operated in collapse mode with an improved efficiency (k 2 eff ) as compared to otherwise similar conventional transducers exhibiting comparably uncontoured substrates. A related medical imaging system is provided, which may include an array of such transducers disposed on a common substrate. A method of operating such a transducer is provided that includes operating the transducer in the collapse mode in the absence of a bias voltage.
    • 提供能够以折叠模式操作或者具有降低的偏置电压或没有偏置电压的电容式超声换能器。 换能器包括基底,该基底的轮廓使得柔性膜的中间区域在没有偏置电压的情况下相对于基底折叠。 在柔性膜的基底和周边区域之间可能存在不可收缩的间隙。 衬底的轮廓可以是使柔性膜经过塌陷点,或机械地干涉柔性膜。 衬底可以包括设置在柔性膜下方的另一膜,另外的膜被成形为使得柔性膜相对于其折叠。 衬底可以是设置在另外的膜下方的支撑件,以将另外的膜的相应部分向上朝向柔性膜偏转。 支持可能是一个帖子。 传感器可以在崩溃模式下操作,与具有相当的未构图基底的其它相似的传统换能器相比,效率(k 2 eff)提高。 提供了一种相关的医学成像系统,其可以包括设置在公共基底上的这种换能器的阵列。 提供了一种操作这种换能器的方法,其包括在没有偏置电压的情况下以折叠模式操作换能器。
    • 10. 发明申请
    • ULTRASOUND PROBE, METHOD AND DEVICE FOR ACQUIRING A BLOOD FLOW SIGNAL OF AN ARTERY AND SYSTEM FOR MEASURING SYSTOLIC BLOOD PRESSURE
    • 用于获取动脉血流信号的超声波探头,方法和装置以及用于测量同步血压的系统
    • WO2013014647A1
    • 2013-01-31
    • PCT/IB2012/053852
    • 2012-07-27
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.ZHONG, JianyiANAND, AjayPETRUZZELLO, JohnCHEN, YinanLU, Weijia
    • ZHONG, JianyiANAND, AjayPETRUZZELLO, JohnCHEN, YinanLU, Weijia
    • A61B8/04A61B8/06
    • A61B8/04A61B5/489A61B8/06A61B8/4236A61B8/4477A61B8/4483A61B8/488A61B8/5223
    • This invention provides an ultrasound probe, a device and method for acquiring a blood flow signal of an artery and a system for measuring systolic blood pressure. The ultrasound probe comprises a plurality of ultrasound transducers, wherein each of the plurality of ultrasound transducers is configured to obtain an echo signal by transmitting an ultrasonic wave, receiving an ultrasonic wave and transforming the received ultrasonic wave into the echo signal. The device for acquiring a blood flow signal of an artery comprises the ultrasound probe, wherein the ultrasound probe is intended to be attached to the exterior of the body. The device further comprises: a first deriving unit configured to derive, from each obtained echo signal, at least one Doppler signal, the at least one Doppler signal being associated with the ultrasound transducer obtaining the echo signal and being indicative of information about Doppler shift of the echo signal; a selecting unit configured to select a Doppler signal from the derived Doppler signals according to a predefined condition, the selected Doppler signal being indicative of the at least one characteristic of the blood flow in the artery of the body. In this way, the need for accurate localization of the artery by means of manual adjustment is eliminated on the proviso that the ultrasound probe is attached in such a way that the artery lies within the footprint of the ultrasound probe.
    • 本发明提供了一种用于获取动脉的血流信号的超声波探头,装置和方法以及用于测量收缩血压的系统。 所述超声波探头包括多个超声换能器,其中,所述多个超声波换能器中的每一个被配置为通过发送超声波,接收超声波并将所接收的超声波变换为回波信号来获得回波信号。 用于获取动脉的血流信号的装置包括超声波探头,其中超声波探头旨在附接到身体的外部。 所述设备还包括:第一导出单元,被配置为从每个获得的回波信号中导出至少一个多普勒信号,所述至少一个多普勒信号与超声换能器相关联,获得回波信号并且指示有关多普勒频移的信息 回波信号; 选择单元,被配置为根据预定义的条件从所述导出的多普勒信号中选择多普勒信号,所选择的多普勒信号指示所述身体的动脉中的血流的至少一个特征。 以这种方式,消除了通过手动调节对动脉进行精确定位的需要,条件是超声波探头以使得动脉位于超声探头的占地面积内的方式附接。