专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明专利

JPH10139718A PRODUCTION OF EICOSAPENTAENOIC ACID 失效
公开(公告)号：JPH10139718A
公开(公告)日：1998-05-26
申请号：JP29504896
申请日：1996-11-07
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , SHIZURI YOSHIICHI , KUSUMI TAKENORI
IPC分类号： C07C51/09 , C07C57/03 , C11C1/04
摘要： PROBLEM TO BE SOLVED: To obtain the subject compound useful for treatment of arteriosclerosis, etc., by producing eicosapentaenoic acid phloroglucinol from a brown alga of the family Dictyotaceae and hydrolyzing the compound in an alkali. SOLUTION: Eicosapentaenoic acid is produced by extracting a brown alga such as Distromium decumbens and Zonaria diesingiana with an organic solvent such as hexane or acetone, purifying the extract by chromatography to obtain eicosapentaenoic acid phloroglucinol and hydrolyzing the product in an alkali such as sodium hydroxide or potassium hydroxide while keeping the pH of the reaction liquid preferably to 12-14. The compound is useful as an agent for the treatment of hyperlipidemia, a nutritional supplementary food, a nutritional additive for the culture of fish and shell fish, etc.

2. 发明专利

JPH06108048A ANTIOXIDANT 失效
公开(公告)号：JPH06108048A
公开(公告)日：1994-04-19
申请号：JP26393092
申请日：1992-10-01
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , IZUMIDA HITOSHI , MIKI WATARU
IPC分类号： C09K15/06
摘要： PURPOSE:To obtain an antioxidant being useful as an antioxidant component for use in foods, cosmetics, perfumes, pharmaceuticals, etc., and having an antioxidant power stronger than that of the conventional natural antioxidants by using a specified compound as an effective component. CONSTITUTION:This antioxidant contains 4-ketozeaxanthin, for example, one chemically synthesized or extracted from living organisms such as a goldfish, a colored carp or a Cirroastropecten (a kind of a starfish) as an effective component.

3. 发明专利

JPH0549497A METHOD FOR PRODUCING ZEAXANTHIN 失效
公开(公告)号：JPH0549497A
公开(公告)日：1993-03-02
申请号：JP21245491
申请日：1991-08-23
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , OTAKI NOBUKO , MIKI WATARU
IPC分类号： C12P23/00 , C12R1/01
摘要： PURPOSE:To obtain the title compound useful for coloring cultured fishes, being readily purified, in high yield without admixture of chlorophyll by culturing a bacterium belonging to the genus Alteromonas, capable of producing zeaxanthin in a medium and collecting a product from the culture mixture. CONSTITUTION:A bacterium [e.g. Alteromonas sp. KK10,203C (FERM P-12,434)] belonging to the genus Alteromonas, capable of producing zeaxanthin is inoculated into a seed medium, subjected to shaking culture at 25 deg.C for 48 hours, the prepared seed culture solution is transferred to a culture tank in a ratio of 2%V/V, subjected to aerated spinner culture at 25 deg.C for 120 hours, the culture solution is filtered off to collect cells, which are ground, extracted with acetone, the extracted solution is concentrated, passed through a polystyrene-based adsorbent column, an adsorbed substance is eluted with methanol, concentrated, extracted with benzene and purified by silica gel chromatography and high- performance liquid chromatography to give zeaxanthin in high yield.

4. 发明专利

JPH07107993A PRODUCTION OF MYXOL AND ITS USE 失效
公开(公告)号：JPH07107993A
公开(公告)日：1995-04-25
申请号：JP25838393
申请日：1993-10-15
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , MIKI WATARU
IPC分类号： C12P23/00 , C07C35/18 , C09K15/06 , C12R1/20
摘要： PURPOSE:To obtain myxol useful as an antioxidant having strong oxidation- resistant force and free from mutagenicity by culturing a microorganism having ability producing myxol in a medium and then collecting myxol from the cultured mixture. CONSTITUTION:A microorganism which belongs to the genus Flavobacterium and having ability producing myxol, e.g. A99-3 strain (FERMP-13903) is cultured in a medium and the resultant bacterial cell and cultured medium are purified to provide the objective myxol expressed by the formula. Myxol is preferably contained in an amount of 0.05-5wt.% in an antioxidant.

5. 发明专利

JPH08337592A NEW CAROTENOID 失效
公开(公告)号：JPH08337592A
公开(公告)日：1996-12-24
申请号：JP14646295
申请日：1995-06-13
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , SHIZURI YOSHIICHI , HOSHINO TAKAYUKI
IPC分类号： C12P19/46 , C07H15/203 , C12R1/01
摘要： PURPOSE: To obtain a new carotenoid having high polarity and useful for a color tone improver or a color refreshing agent of fishes and shellfishes, etc., by comprising thermozeaxanthin, thermobiszeaxanthin and thermocryptoxanthin that are produced by a thermophile. CONSTITUTION: This new carotenoid is composed of a thermozeaxanthin of formula I (R1 is an acyl), a thermobiszeaxanthin of formula II (R2 and R3 are each an acyl) and a thermocryptoxanthin of formula III and useful for a color tone improver or a color refreshing agent of culture fishes and shellfishes or an additive to foods. This new carotenoid is obtained by planting Thermus thermophilus ATCC 27634 as a thermophile into a medium, shake-culturing at 70 deg.C for 24hr, collecting fungus bodies by centrifuging the cultured solution, extracting by adding acetone to the resultant solution, concentrating the resultant extracted solution, separating ethyl acetate fraction by adding water and ethyl acetate to the concentrated solution, concentrating.exsiccating and fractionating the exsiccated substance by a column chromatography.

6. 发明专利

JPH06165684A PRODUCTION OF 4-KETOZEAXANTHIN AND ITS USE 失效
公开(公告)号：JPH06165684A
公开(公告)日：1994-06-14
申请号：JP7033593
申请日：1993-03-29
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , IZUMIDA HITOSHI , MIKI WATARU
IPC分类号： C12P7/26 , C12R1/01 , C12R1/05 , C12R1/20 , C12R1/38 , A23K1/16
摘要： PURPOSE:To obtain 4-ketozeaxanthin useful as an agent for improving the color tone of cultured fish, etc., on an industrial scale at a low cost by culturing a 4-ketozeaxanthin-producing bacterial strain belonging to the genus Flavobacterium in a medium and separating the compound from the cultured product. CONSTITUTION:4-ketozeaxanthin useful as a color-tone improving agent such as a coloring component for cultured fish and shellfish (e.g. shrimp and red sea bream) and a color-tone improving agent for goldfish and fancy carp can be produced in high yield by culturing a bacterial strain belonging to the genus Flavobacterium, Alcaligenes, Pseudomonas, Alteromonas, Hyphomonas or Caryophanon and capable of producing 4-ketozeaxanthin [e.g. Flavobacterium sp. N-81106 (FERM P-12782)] in a medium and separating the compound from the cultured product.

7. 发明专利

JPH05199858A ANTIOXIDANT WITH FLEXIXANTHIN AS ACTIVE INGREDIENT AND PRODUCTION OF FLEXIXANTHIN 失效
公开(公告)号：JPH05199858A
公开(公告)日：1993-08-10
申请号：JP8252392
申请日：1992-04-03
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , OTAKI NOBUKO , SHIMIZU NOBUHISA , MIKI WATARU
IPC分类号： A23L3/3499 , C09K15/08 , C12P23/00 , C12R1/20
摘要： PURPOSE:To provide a powerful antioxidant preventing foods, cosmetics, medicines, or fatty oil from oxidation, containing, as active ingredient, flexixanthin. CONSTITUTION:For example, in the case of using a crude extract or purified flexixanthin as active ingredient, this agent is conditioned by emulsification and added, in the form of cream, to a food or cosmetic at a level of 0.1g/kg or 0.05g/kg, respectively. The flexixanthin can be obtained by culture of flexixanthin-producing microorganisms belonging to Flavobacterium [KK 10202C strain (FERM P-12433)] and by separating microbial cells from the resulting cultured product followed by extraction with an organic solvent.

8. 发明专利

JPH0597608A ANTIFOULING AGENT 失效
公开(公告)号：JPH0597608A
公开(公告)日：1993-04-20
申请号：JP25730791
申请日：1991-10-04
申请人： KAIYO BIO TECH LAB
发明人： OTAKI NOBUKO , YOKOYAMA AKIHIRO , SHIMIZU NOBUHISA , KONYA KAZUMI , MIKI WATARU
IPC分类号： A01N35/06 , A01N63/00
摘要： PURPOSE:To provide an antifouling agent having high safety and excellent antifouling effect and effective for preventing the adhesion and proliferation of harmful aquatic life such as shell and alga to the bottom of a ship, a facility in seawater, a construction in water, an inlet channel for cooling water, etc. CONSTITUTION:The objective antifouling agent contains a ubiquinone compound of formula I (R is H, 1-20C straight-chain alkyl or group of formula II; (n) is integer of 1-12) as an active component. Since the active component of the antifouling agent is a highly biodegradable compound originated from natural source, it has high safety to human body as well as environment. It does not kill the periphyton but inhibits the adhesion of the life and has excellent repelling effect on harmful aquatic adhesive life and high safety to fish and shellfish. The active component may be used singly or in combination with other antifouling agent. For example, the antifouling agent is a chemically synthesized compound, an extract of animal, bacteria, etc., containing the above compound or pure substance separated from the extract. The amount of the active component is preferably 5-20wt.% for paint based on the film-forming agent, 5-20wt.% for solution and 1-20wt.% for emulsion, respectively.

9. 发明专利

JPH04295460A NEW SUBSTANCE OKADAXANTHINE, ITS PRODUCTION AND USE THEREOF 失效
公开(公告)号：JPH04295460A
公开(公告)日：1992-10-20
申请号：JP6058691
申请日：1991-03-25
申请人： KAIYO BIO TECH LAB
发明人： MIKI WATARU , OTAKI NOBUKO , YOKOYAMA AKIHIRO , IZUMIDA HITOSHI , SHIMIZU NOBUHISA
IPC分类号： C07C403/08 , C12P7/02 , C12R1/38
摘要： PURPOSE:To obtain a new compound useful as an oxidation preventing component in foods, perfumes, dyestuffs, cosmetics and medicines, having strong antioxidation power. CONSTITUTION:A compound shown by the formula. The compound is obtained by subjecting a bacterium (e.g. KK10,2060 strain) belonging to the genus Pseudomonas to submerged spinner culture in a medium (e.g. yeast essence- glucose-peptone) at 16-37 deg.C for 1-7 days and purifying the prepared cells and the culture solution. The compound has the following physical and chemical properties. Color: yellow powder. Molecular weight: 704. Molecular formula; C50H72O2. TLC: Rf=0.49 (hexane-acetone (7:3'v/v), developed on silica gel 60F254 manufactured by Merck Company). Solubility: soluble in an alcohol such as methanol, an ether, ethyl acetate, etc., and insoluble in water. Use of both the compound shown by the formula and an antioxidant (e.g. tocopherol) in a ratio of 0.1/1 to 10/1 by weight shows an excellent synergistic oxidation- preventing effect.

10. 发明专利

JPH0984591A CAROTENOID SULFATE AND ITS PRODUCTION 失效
公开(公告)号：JPH0984591A
公开(公告)日：1997-03-31
申请号：JP27202695
申请日：1995-09-26
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , SHIZURI YOSHIICHI
IPC分类号： C12P11/00 , C12R1/20
摘要： PROBLEM TO BE SOLVED: To produce a new carotenoid sulfate, soluble in a water-soluble solvent and useful as a color tone improving agent and a redyeing agent for cultured fishes and shellfishes, a food additive, etc., by culturing a microorganism of the genus Flavobacterium having the productivity of a new carotenoid sulfate. SOLUTION: This new carotenoid sulfate is represented by formula I (M is H or a monovalent metal) and formula II (M is H or a monovalent metal) and is useful as a color tone improving agent and a redyeing agent for fishes and shellfishes, a food additive, etc., soluble in a water-soluble solvent. The new highly polar carotenoid is obtained by inoculating a microorganism, belonging to the genus Flavobacterium and having the ability to produce the new carotenoid sulfate [e.g. Flavobacterium PC-6 strain (FERM P-15183)] into a culture medium, separating the microbial cell from the cultured solution, extracting and purifying the resultant product as nostoxanthin-3-sulfate represented by formula I and 4-ketonostoxanthin-3'-sulfate represented by formula II.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式