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1. 发明专利

JPH1149794A DIAMINOALKYGLYCOSIDE AND ITS METAL CHELATE COMPOUND 失效
公开(公告)号：JPH1149794A
公开(公告)日：1999-02-23
申请号：JP21320397
申请日：1997-08-07
申请人： KAIYO BIO TECH LAB
发明人： YANO SHIGENOBU , MIKATA YUJI , SAKAKIBARA TORU , NISHIDA FUMIKO , MOCHIDA KENICHI
IPC分类号： C07H15/04 , A61K31/70 , A61K31/7028 , A61P31/04
摘要： PROBLEM TO BE SOLVED: To obtain a new diaminoalkylglycoside capable of being utilized as a raw material for optically active functional polymers, etc., and capable of being used as a ligand to form a chelate compound useful as a medicine having an antibacterial activity. SOLUTION: A new diaminoalkylglycoside of formula I [X is H, (CH2 )NCH2 NH2 (n) is an integer of 0-6; Y is H, (CH2 )NCH2 NH2 , (CH2 )NCH(NH2 )CH2 NH2 ; R is H, OH, NH2 COCH3 ], and a new chelate compound containing the alkylglycoside as a ligand and represented by formula II [(p), (q) are each a integer of 1-8; M is a metal ion]. The diaminoalkylglycoside of formula I can be utilized as a raw material for optically active functional polymers, and the chelate compound of formula II can be utilized as a medicine having an antibacterial activity. The compound of formula I is obtained by reacting a compound of formula III [R1 is H, OCOCH3 , NHCOCH3 ; Ac is acetyl; X1 , X2 are each H, (CH2 )n CHBr, etc.], with NaN3 in a polar solvent and subsequently removing the protecting group from the reaction product.

2. 发明专利

JPH10279404A ANTIFOULING AGENT 失效
公开(公告)号：JPH10279404A
公开(公告)日：1998-10-20
申请号：JP8044497
申请日：1997-03-31
申请人： KAIYO BIO TECH LAB
发明人： KAWAHARA HIROYUKI , AJIOKA KIYOKO , SHIZURI YOSHIICHI
IPC分类号： A01N33/10
摘要： PROBLEM TO BE SOLVED: To obtain an antifouling agent which has an excellent repelling effect on fouling organisms in water without killing them by formulating 7-hydroxy-N, N-di-n-propyl-2-aminotetralin as an active ingredient. SOLUTION: This antifouling agent contains 7-hydroxy-N,N-di-n-propyl-2- aminotetralin of the formula or its salt (hydrobromic acid salt and the like) as an active ingredient. This antifouling agent is prepared in forms of coating material, solution and emulsion to use. For example, when used as the coating material, an antifouling coating material is prepared by formulating the above active ingredient with a coating regulator and it is applied to ship-bottom, construction in water and waterway for cooling water. Further, the above active ingredient is preferably formulated in a proportion of 1 ppm-1 wt.% based on the each weights of coating material, solution and emulsion.

3. 发明专利

JPH10259101A ANTIFOULING AGENT 失效
公开(公告)号：JPH10259101A
公开(公告)日：1998-09-29
申请号：JP6496397
申请日：1997-03-18
申请人： TAISEI CORP , SEKISUI CHEMICAL CO LTD , KAIYO BIO TECH LAB
发明人： KAWAMATA MUTSUMI , KANEKO FUMIO , SUZUKI TARO , NOSE TAISUKE , SHIZURI YOSHIICHI , KAWAHARA HIROYUKI
IPC分类号： A01N25/10 , A01N43/38 , C09D5/16
摘要： PROBLEM TO BE SOLVED: To obtain a safe antifouling agent for a long period of time by allowing the agent to flow out from the resin composition containing indol repellent compounds at more than fixed rate. SOLUTION: The objective antifouling agent is a resin composition consisting of an indol repellent substance (e.g. 2,5,6-tribromo-1-metylgramine) and a resin part, and when the above resin composition is immersed in water, the repellent effect is displayed by regulating the effluence of the above indol repellent substance in the rate of 5μg/cm /day. The above expellent is usable is usable in forms of resin, coating material and solution. When using as the resin, for example, a thermosetting resin and an indol repellent substance are preferably formulated in amounts of 50-90wt.% and 10-50wt.%, respectively. and when using as the coating material and the solution, the contents of the thermosetting resin and the indol repellent substance are preferably 5-50wt.% and 5-70wt.%, respectively, based on the total weight.

4. 发明专利

JPH10150974A APPARATUS FOR CULTURING PHOTOSYNTHETIC MICROORGANISM AND CULTURING METHOD 失效
公开(公告)号：JPH10150974A
公开(公告)日：1998-06-09
申请号：JP31240096
申请日：1996-11-22
申请人： KAIYO BIO TECH LAB
发明人： KO KYO , KURANO NORIHIDE , AMOS RICHMOND
IPC分类号： C12M1/00 , C12N1/12 , C12R1/89
摘要： PROBLEM TO BE SOLVED: To provide an apparatus for culturing photosynthetic microorganism and a culturing method enabling the industrial utilization of photosynthetic microorganisms by the improvement of photo-utilization efficiency and the attainment of a high-density culture. SOLUTION: Both side faces of this photosynthetic microorganism culturing apparatus are made of a light-transmitting transparent material such as transparent plastic or transparent glass and the apparatus is lighted with lighting means 30 placed at both sides 11 of the apparatus. The thickness of the culture tank 1 is set to about

5. 发明专利

JPH1091A FKBP TYPE PPIASE DERIVED FROM THERMOPHILIC ARCHAEBACTERIUM, AND GENE CODING THE SAME 失效
公开(公告)号：JPH1091A
公开(公告)日：1998-01-06
申请号：JP15254696
申请日：1996-06-13
申请人： KAIYO BIO TECH LAB
发明人： FURUYA MASAHIRO , SUZUKI KIYOKO , MARUYAMA TADASHI
IPC分类号： C12N15/09 , C12N9/90 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To obtain a new gene coding thermophilic archaebacterium-derived FKBP type PPIase, having a specific base sequence, high in heat resistance, and useful for regenerating denatured proteins, stabilizing protein reagents, producing recombinant proteins, developing new immunosuppressive agents, etc. SOLUTION: This new gene, which codes a new PPIase (Peptidyl prolyl cistrans isomerase) having a DNA base sequence virtually identical with a DNA base sequence of the formula and has high heat resistance, is useful for regenerating denatured proteins, stabilizing protein reagents, produceing recombinant proteins, and developing new immunosuppressive agents and physiologically active substances, etc. This new gene is obtained by separating a genome DNA from thermophilic archaebacterium Methanococcus thermolithotrophicus DSM 2095 strain by conventional means followed by amplifying the genome DNA through PCR using a pair of primers composed of a partial sequence of the PPIase gene.

6. 发明专利

JPH09299089A THIRD ADHESIVE PROTEIN GENE OF BARNACLE 失效
公开(公告)号：JPH09299089A
公开(公告)日：1997-11-25
申请号：JP12341796
申请日：1996-05-17
申请人： KAIYO BIO TECH LAB
发明人： KAMINO KEI , SHIZURI YOSHIICHI
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C07K14/435 , C09J189/00 , C12N15/00 , C12P21/02 , C12R1/19 , C12R1/91
摘要： PROBLEM TO BE SOLVED: To obtain the subject new gene, capable of coding the third adhesive protein gene of a barnacle having a specific amino acid sequence and useful as a raw material for adhesives capable of maintaining the strength even when bonded in a wet environment or in water or a substrate, etc., for cell culture. SOLUTION: This new third adhesive protein gene of a barnacle, e.g. Megabalanus rosa is capable of coding the third adhesive protein having an amino acid sequence represented by the formula or the substantially same amino acid sequence that represented by the formula and is used for producing a protein useful in wide applications to a raw material for adhesives capable of providing an effective adhesive strength even when starting the bonding under wet conditions or in water, a substrate, etc., for cell culture by using a gene engineering technique. The gene is obtained by separating an mRNA from the Megabalanus rosa according to a conventional method, synthesizing a cDNA by using a reverse transcriptase with the resultant mRNA as a template, preparing a cDNA library using the synthesized cDNA and then screening the prepared library with a probe capable of coding a partial amino acid sequence of the third adhesive protein.

7. 发明专利

JPH09255677A NEW MACROLACTINS AND THEIR PRODUCTION 失效
公开(公告)号：JPH09255677A
公开(公告)日：1997-09-30
申请号：JP6453596
申请日：1996-03-21
申请人： KAIYO BIO TECH LAB
发明人： NAGAO TOMOKAZU , ADACHI KYOKO , ARAKI YOSHIO , NISHIJIMA MIYUKI , CHIN YOSHITAKA , SANO HIROSHI
IPC分类号： C12P17/08 , A61K31/335 , A61P31/04 , C07D313/00
摘要： PROBLEM TO BE SOLVED: To obtain new macrolactins having excellent antimicrobial activity, and useful as an antimicrobial agent also effective to resistant bacteria, by culturing microorganisms belonging to the genus Bacillus and having ability to produce the macrolactins in a medium. SOLUTION: The new macrolactins include macrolactin-G, macrolactin-H, macrolactin-I, macrolactin-J, macrolactin-K and macrolactin-L expressed by formula I, formula II, formula III, formula IV, formula V and formula VI, respectively, having excellent antimicrobial activity, and being useful as an antimicrobial agent also effective to resistant bacteria. These new macrolactins are obtained by culturing microorganisms belonging to the genus Bacillus and having ability to produce the macrolactins G to L [e.g. Bacillus sp. PP19-H3 (FERM P-15407)] in a medium to produce an accumulate these compounds in the cultured product followed by collecting these compounds.

8. 发明专利

JPH09238684A HEAT RESISTANT ATPASE ALPHA AND BETA SUBUNIT GENE 失效
公开(公告)号：JPH09238684A
公开(公告)日：1997-09-16
申请号：JP4926196
申请日：1996-03-06
申请人： KAIYO BIO TECH LAB
发明人： IIDA TOSHIMOCHI , SUZUKI KIYOKO , MARUYAMA TADASHI
IPC分类号： C12N15/09 , C07H21/04 , C12N9/14 , C12N15/00 , C12R1/01
摘要： PROBLEM TO BE SOLVED: To obtain new subject genes each having a specific base arrangement, coding for a heat resistant ATPase subunit and useful as an ATP supplying enzyme in a heat resistant reagent and a bioreactor. SOLUTION: The new genes possess DNA base sequences expressed by formulas I and II, or DNA base sequences essentially equal to those expressed by formulas I and II and code for a heat resistant ATPase α-subunit and β-subunit respectively and useful for producing ATPase useful as an ATP supplying enzyme in a heat resistant reagent and a bioreactor. The genes are obtained by extracting genome DNA from Thermococcus KI strain, a super thermophilic sulfur dependent bacteria, in a usual method and cloning by PCR by using a primer comprising a part of heat resistant ATPase α-subunit and β-subunit and the genome DNA as a template.

9. 发明专利

JPH0984591A CAROTENOID SULFATE AND ITS PRODUCTION 失效
公开(公告)号：JPH0984591A
公开(公告)日：1997-03-31
申请号：JP27202695
申请日：1995-09-26
申请人： KAIYO BIO TECH LAB
发明人： YOKOYAMA AKIHIRO , SHIZURI YOSHIICHI
IPC分类号： C12P11/00 , C12R1/20
摘要： PROBLEM TO BE SOLVED: To produce a new carotenoid sulfate, soluble in a water-soluble solvent and useful as a color tone improving agent and a redyeing agent for cultured fishes and shellfishes, a food additive, etc., by culturing a microorganism of the genus Flavobacterium having the productivity of a new carotenoid sulfate. SOLUTION: This new carotenoid sulfate is represented by formula I (M is H or a monovalent metal) and formula II (M is H or a monovalent metal) and is useful as a color tone improving agent and a redyeing agent for fishes and shellfishes, a food additive, etc., soluble in a water-soluble solvent. The new highly polar carotenoid is obtained by inoculating a microorganism, belonging to the genus Flavobacterium and having the ability to produce the new carotenoid sulfate [e.g. Flavobacterium PC-6 strain (FERM P-15183)] into a culture medium, separating the microbial cell from the cultured solution, extracting and purifying the resultant product as nostoxanthin-3-sulfate represented by formula I and 4-ketonostoxanthin-3'-sulfate represented by formula II.

10. 发明专利

JPH08275777A NEW N-ACETYLCHITOOLIGOSACCHARIDE DEACETYLASE AND ITS PRODUCTION 失效
公开(公告)号：JPH08275777A
公开(公告)日：1996-10-22
申请号：JP8107995
申请日：1995-04-06
申请人： KAIYO BIO TECH LAB , SHIZUOKA PREFECTURE , K I KASEI KK
发明人： IZUMIDA HITOSHI , SANO HIROSHI , ADACHI KYOKO , OISHI KAZUO , YAMAGISHI MASAAKI , OTA TOSHIYA , MOTOSUGI MASAYOSHI , MIWA TADASHI
IPC分类号： C12N9/80 , C12R1/63
摘要： PURPOSE: To obtain a new deacetylase important for producing a deacetylated substance of an N-acetylchitobiose and an N-acetylchitotriose useful as a synthetic intermediate for medicines, etc. CONSTITUTION: This deacetylase DA1 or DA2 is obtained by culturing a Vibrio sp. H-8 strain (FERM P-14737), etc., and having the following properties: (l) each capable of acting on an N-acetylchitobiose or an N-acetylchitotriose and carrying out the deacetylation thereof; (2) optimal pH8.5-9.0 (37 deg.C), 45 deg.C optimal temperature (pH8.5), stable by treatment at pH8.5 and 50 deg.C for 1hr, 20000-60000 molecular weight [measured according to a sodium dodecyl sulfate- polyacrylamide gel electrophoretic method (SDS-PAGE)] and 3.3 isoelectric point for the deacetylase DA1; (3) optimal pH8.0-8.5 (37 deg.C), 40 deg.C optimal temperature (pH8.5), stable by treatment at pH8.5 and 50 deg.C for 1hr, 20,000-60,000 molecular weight (measured according to the SDS-PAGE method] and 3.5 isoelectric point for the deacetylase DA2 and (4) each having high activities.

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