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1. 发明专利

JP2010105924A Skin keratinization-promoting agent 有权
标题翻译：皮肤促进促进剂
公开(公告)号：JP2010105924A
公开(公告)日：2010-05-13
申请号：JP2008276989
申请日：2008-10-28
申请人： Juntendo , Mikimoto Pharmaceut Co Ltd , 学校法人順天堂 , 御木本製薬株式会社
发明人： NIYONSABA FRANCOIS , OGAWA HIDEOKI , OKAMOTO KIKUHIKO , HATTORI FUMIHIRO , SAKAIDA KAZUNORI
IPC分类号： A61K8/19 , A61K8/98 , A61K33/00 , A61K35/56 , A61Q19/00 , A61Q19/08
摘要： PROBLEM TO BE SOLVED: To provide a new skin keratinization-promoting agent useful for improvement of barrier functions of the skin and prevention of skin ageing. SOLUTION: The skin keratinization-promoting agent comprises mineral components derived from a pearl layer. The mineral components derived from a pearl layer is obtained by calcining a pearl layer, obtained by denucleation of a pearl, or a pearl layer of a shell, then dissolving the mineral components in an acid or purified water followed by filtration and neutralization. The mineral components derived from the pearl layer contain calcium, sodium, magnesium, iron, zinc and a trace amount of other minerals. The compositional ratio of the main mineral components based on the dried matter is 50-99 mass%, preferably 70-95 mass%, of calcium, 0-40 mass%, preferably 1-15 mass%, of sodium, 0-5 mass%, preferably 0.01-1 mass%, of magnesium, 0-10 mass%, preferably 0.5-5 mass%, of iron and 0-5 mass%, preferably 0.01-1 mass%, of zinc. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供可用于改善皮肤屏障功能并防止皮肤老化的新型皮肤角质化促进剂。皮肤角质化促进剂包含衍生自珍珠层的矿物成分。来自珍珠层的矿物组分是通过煅烧通过脱壳珍珠获得的珍珠层或壳的珍珠层获得的，然后将矿物组分溶解在酸或纯净水中，然后过滤和中和。来自珍珠层的矿物成分含有钙，钠，镁，铁，锌和其他矿物质。基于干物质的主要矿物成分的组成比为50〜99质量％，优选为70〜95质量％的钙，0〜40质量％，优选为1-15质量％的钠，0〜5质量％％，优选0.01〜1质量％的镁，0〜10质量％，优选0.5〜5质量％的铁和0〜5质量％，优选0.01〜1质量％的锌。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2012148984A Gommage cosmetic material 审中-公开
标题翻译： GOMMAGE化妆品
公开(公告)号：JP2012148984A
公开(公告)日：2012-08-09
申请号：JP2011006537
申请日：2011-01-17
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： TATE YUKO , SAKAIDA KAZUNORI , TSUJI NOBUHIDE
IPC分类号： A61K8/81 , A61K8/24 , A61K8/34 , A61K8/73 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To obtain a gommage cosmetic material which is proper in a skin forming time, proper in the flexibility of skin, adsorbs and removes unnecessary sebum, and has a massage effect.SOLUTION: The oil-in-water type gommage cosmetic material contains the following components. (A) crystallitic cellose, (B) 0.1 to 3% of hydroxyapatite, (C) 30 to 60% of a multivalent alcohol, (D) alkaline-denaturation carboxy vinyl polymer (E) a water-soluble polymer molecule, (F) a liquid oil component, and (G) water. Furthermore, an effect is increased by using hydroxyapatite with a shell as an origin.
摘要翻译：要解决的问题：为了获得在皮肤形成时间中适当的化妆品，适合于皮肤的柔韧性，吸附和去除不需要的皮脂，并且具有按摩效果。
解决方案：水包油型化妆品包含以下成分。（A）结晶纤维素，（B）0.1〜3％的羟磷灰石，（C）30〜60％的多价醇，（D）碱变性羧乙烯基聚合物（E）水溶性聚合物分子，（F）液体油组分和（G）水。此外，通过使用以壳为起源的羟基磷灰石，可以提高效果。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2014051440A Metallothionein production accelerator and antioxidant 有权
标题翻译：金属催化剂生产加速器和抗氧化剂
公开(公告)号：JP2014051440A
公开(公告)日：2014-03-20
申请号：JP2012195315
申请日：2012-09-05
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： HAMAGUCHI MASANORI , HATTORI FUMIHIRO , SAKAIDA KAZUNORI
IPC分类号： A61K8/98 , A61K35/56 , A61P17/00 , A61P17/18 , A61P39/06 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To obtain a formulation effective in antioxidation by accelerating the production of metallothionein.SOLUTION: A formulation effective in antioxidation can be obtained by including the solubilized matter of a shell having a pearl and/or a pearl layer at low concentration for accelerating the production of metallothionein.
摘要翻译：要解决的问题：通过加速金属硫蛋白的生成获得有效的抗氧化配方。解决方案：通过将具有珍珠和/或珍珠层的壳的溶解物质包含在低浓度下，可以获得抗氧化作用。加速金属硫蛋白的生产。

4. 发明专利

JP2012211111A Powder for cosmetics and cosmetics compounded with the same 审中-公开
标题翻译：化妆品和化妆品粉末与其组合
公开(公告)号：JP2012211111A
公开(公告)日：2012-11-01
申请号：JP2011078110
申请日：2011-03-31
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： HATTORI FUMIHIRO , SAKAIDA KAZUNORI
IPC分类号： A61K8/19 , A61K8/98 , A61Q1/12
摘要： PROBLEM TO BE SOLVED: To obtain powder for cosmetics by easily taking out a pearl layer of a pearl oyster by utilizing the state of the calcium carbonate of a pearl oyster shell.SOLUTION: The powder for the cosmetics with the thin-sliced calcium carbonate as a main component is characterized in that the pearl oyster shell is crashed after being immersed in an alkaline solution, and sorted at 200 to 500 meshes. Furthermore, an effect is increased by heat-treating spherical powder whose average particle diameter is 0.05 to 0.5μ on the surface of the powder, and effectiveness such as the light scattering property and transparency is enhanced.
摘要翻译：待解决的问题：通过利用珍珠牡蛎壳的碳酸钙的状态容易地取出珍珠牡蛎的珍珠层，获得化妆品粉末。解决方案：以薄片碳酸钙为主要成分的化妆品用粉末的特征在于，将珍珠牡蛎壳浸入碱性溶液中后坠毁，并以200〜500目筛选。此外，通过在粉末的表面上热处理平均粒径为0.05〜0.5μm的球形粉末来提高效果，并且提高了光散射性和透明性等有效性。版权所有（C）2013，JPO＆INPIT

5. 发明专利

JP2006298812A Antioxidant, skin lotion for anti-oxidization, elastase activity inhibitor and maillard reaction inhibitor 审中-公开
标题翻译：抗氧化剂，用于抗氧化的皮肤润肤剂，弹性酶活性抑制剂和药物反应抑制剂
公开(公告)号：JP2006298812A
公开(公告)日：2006-11-02
申请号：JP2005121891
申请日：2005-04-20
申请人： Mikimoto Pharmaceut Co Ltd , Sakamoto Yakusoen:Kk , 御木本製薬株式会社 , 有限会社坂本薬草園
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , MATSUO YUKIMI , SAKAIDA KAZUNORI
IPC分类号： A61K36/18 , A23L1/30 , A61K8/00 , A61K8/96 , A61P3/10 , A61P9/10 , A61P17/00 , A61P39/06 , A61P43/00 , A61Q19/00 , C12N9/99
摘要： PROBLEM TO BE SOLVED: To utilize an extract of papaya (Carica papaya L.), on which only an effect as a health food is found out until now, effectively. SOLUTION: This papaya extract is found to exhibit a potent esterase activity inhibitory effect, Maillard reaction inhibitory effect and also SOD (superoxide dismutase) like activity, prevent various diseases such as senile phenomena accompanying with aging, diabetes, arteriosclelosis, etc., and also improve various skin troubles such as skin roughness, sensitive skin, dermatitis diseases, etc. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：利用番木瓜（Carica papaya L.）的提取物，其中仅有作为健康食品的作用才被发现到现在为止。解决方案：发现这种番木瓜提取物具有强效的酯酶活性抑制作用，美拉德反应抑制作用和SOD（超氧化物歧化酶）活性，预防伴随老化，糖尿病，动脉硬化等的各种疾病如老年现象。，还可以改善皮肤粗糙，皮肤敏感，皮炎等各种皮肤问题。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2013166710A Skin keratinization promoter and skin preparation for external use blended with the same 审中-公开
标题翻译：用于外部使用的皮肤护理促进剂和皮肤制剂
公开(公告)号：JP2013166710A
公开(公告)日：2013-08-29
申请号：JP2012029422
申请日：2012-02-14
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社 , Mie Univ , 国立大学法人三重大学
发明人： MAEYAMA KAORU , KANO SATORU , FUNAHARA DAISUKE , NAGAI KIYOHITO , HATTORI FUMIHIRO , SAKAIDA KAZUNORI , OKAMOTO KIKUHIKO
IPC分类号： A61K8/98 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a skin keratinization promoter useful for improving the barrier function of the skin and preventing the aging of the skin.SOLUTION: It has been found that N16 produced from shells of Akoya pearl oyster, pearl fragments or powder thereof and proteins related to the same increase expression of transglutaminase 1, sorayashin (S100A7) and loricrin gene, and especially the amount of sorayashin (S100A7) gene increases greatly. It has been found that they are very effective as a skin keratinization promoter. Sorayashin (S100A7) has the function of maintaining homeostasis of the skin such as anti-inflammation and microbial stasis, and therefore a skin preparation blended with the same is very effective.
摘要翻译：要解决的问题：提供可用于改善皮肤屏障功能并防止皮肤老化的皮肤角质化促进剂。解决方案：已经发现，由Akoya珍珠牡蛎贝壳，珍珠碎片或其粉末制成的N16和与转谷氨酰胺酶1，sorayashin（S100A7）和loricrin基因相同增加表达的蛋白质，特别是sorayashin（S100A7）基因的数量大大增加。已经发现它们作为皮肤角质化促进剂是非常有效的。 Sorayashin（S100A7）具有保持皮肤的体内平衡的功能，如抗炎和微生物淤滞，因此与其混合的皮肤制剂非常有效。

7. 发明专利

JP2011162469A Skin keratinization promoter 有权
标题翻译：皮肤护理促进剂
公开(公告)号：JP2011162469A
公开(公告)日：2011-08-25
申请号：JP2010025326
申请日：2010-02-08
申请人： Mie Univ , Mikimoto Pharmaceut Co Ltd , 国立大学法人三重大学 , 御木本製薬株式会社
发明人： MAEYAMA KAORU , HATTORI FUMIHIRO , SAKAIDA KAZUNORI , OKAMOTO KIKUHIKO , NAGAI KIYOHITO , KANO SATORU , FUNAHARA DAISUKE
IPC分类号： A61K8/64 , A61K8/98 , A61K35/56 , A61K38/00 , A61P17/16 , A61P43/00 , A61Q19/00 , A61Q19/08 , C07K14/435 , C12P21/02
摘要： PROBLEM TO BE SOLVED: To provide a skin keratinization promoter useful for improving the barrier function of the skin and preventing the aging of the skin.
SOLUTION: The skin keratinization promoter includes a nacrein protein which a shell or a pearl fragment of Pictada martensil or a powder thereof produces and this nacrein protein is (I) a protein obtained by extracting a substance obtained by decalcifying Pictada martensil or the like with a chelating agent or (II) a protein produced by genetic engineering utilizing this extracted substance and at least one host cell selected from Escherichia coli, yeast, and a cocoon.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供可用于改善皮肤屏障功能并防止皮肤老化的皮肤角质化促进剂。皮肤角质化促进剂包括珍珠质蛋白，其是皮癣马赛特的壳或珍珠片或其粉末产生的，并且该胶质细胞蛋白是（I）通过提取通过对Pictada马氏体脱钙获得的物质或类似于螯合剂或（II）通过使用该提取物质的遗传工程产生的蛋白质和至少一种选自大肠杆菌，酵母和茧的宿主细胞。版权所有（C）2011，JPO＆INPIT

8. 发明专利

JP2010059072A Sheet substance, method for producing the same and skin care preparation 有权
标题翻译：表面物质，其制备方法和皮肤保养制剂
公开(公告)号：JP2010059072A
公开(公告)日：2010-03-18
申请号：JP2008224785
申请日：2008-09-02
申请人： Mie Univ , Mikimoto Pharmaceut Co Ltd , 国立大学法人三重大学 , 御木本製薬株式会社
发明人： OKAMOTO KIKUHIKO , MAEYAMA KAORU , HATTORI FUMIHIRO , SAKAIDA KAZUNORI , NAGAI KIYOHITO , KANO SATORU , HORIUCHI SHIZUKA
IPC分类号： A61K8/98 , A61K8/02 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a sheet substance that is produced with almost no degeneration of a protein contained in seashell having a pearl and a pearl layer, a method for producing the same and a skin care preparation using the sheet substance.
SOLUTION: The sheet substance is produced by deashing a pearl layer-containing seashell, pearl fragment or a pearl layer-containing seashell fragment by using an ethylenediaminetetraacetate. The method for producing the sheet substance comprises (1) a process of dispersing a pearl layer-containing seashell, a pearl fragment or a pearl layer-containing seashell fragment into water, (2) a process of adding an ethylenediaminetetraacetate in an equimolar or more amount based on a calcium ion contained in the dispersed seashell or fragment and (3) a process of stirring under a condition wherein a formed sheet substance is not mutually strongly brought into contact with the fragment.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供几乎不含有珍珠和珍珠层的贝壳中所含蛋白质变性的片状物质，其制备方法和使用该片状物质的皮肤护理制剂。解决方案：通过使用乙二胺四乙酸酯将含珍珠层的贝壳，珍珠碎片或含珍珠层的贝壳片段除冰制成片状物质。片状物的制造方法包括（1）将含珍珠层的贝壳，珍珠碎片或珍珠层贝壳片段分散在水中的工序，（2）将乙二胺四乙酸酯加入到等摩尔以上的方法基于分散的贝壳或片段中包含的钙离子的量，和（3）在形成的片状物质不与片段相互强烈接触的条件下进行搅拌的过程。版权所有（C）2010，JPO＆INPIT

9. 发明专利

JP2006219448A External preparation for skin for acne 审中-公开
标题翻译： ACNE皮肤外用制剂
公开(公告)号：JP2006219448A
公开(公告)日：2006-08-24
申请号：JP2005035926
申请日：2005-02-14
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , MATSUO YUKIMI , SAKAIDA KAZUNORI
IPC分类号： A61K8/96 , A61K8/00 , A61K36/28 , A61P17/10 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a safer and effective preparation for acne by effectively utilizing an extract of Conyza filaginoides having high effectiveness. SOLUTION: The present inventors found that the extract of Conyza filaginoides significantly inhibits production of lipase. As a result, effective various external preparations inhibiting formation of acne are provided by using the extract of Conyza filaginoides. Further, present inventors found that various troubles of skin such as dullness of skin and chapped skin are further improved by combining and formulating the extract of Conyza filaginoides with specific agents selected from a humectant, a cell-activating agent, an antiinflammatory agent, an antioxidant, a beautifying and whitening agent, an antiplasmin agent, an active oxygen inhibitor and an antihistamic agent. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过有效利用具有高效益的Conyza filaginoides提取物，为痤疮提供更安全有效的制剂。解决方案：本发明人发现Conyza filaginoides的提取物显着抑制脂肪酶的产生。结果，通过使用Conyza filaginoides的提取物来提供抑制痤疮形成的有效的各种外用制剂。此外，本发明人发现通过将Conyza filaginoides的提取物与选自湿润剂，细胞活化剂，抗炎剂，抗氧化剂的特定试剂结合并配制而进一步改善皮肤的各种麻烦，例如皮肤和皮肤发红，，美白增白剂，抗血小板剂，活性氧抑制剂和抗组胺剂。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2014009212A Collagen production promoter 有权
标题翻译：胶原生产促销
公开(公告)号：JP2014009212A
公开(公告)日：2014-01-20
申请号：JP2012148366
申请日：2012-07-02
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： HAMAGUCHI MASANORI , HATTORI FUMIHIRO , SAKAIDA KAZUNORI
IPC分类号： A61K8/64 , A61K38/00 , A61P17/00 , A61P17/16 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide an external preparation for skin, suitable for preventing wrinkle formation and rough skin by promoting collagen production, specifically by promoting collagen production in human skin fibroblasts.SOLUTION: The inventors have found that a conchiolin hydrolysate is effective to promote collagen production and have expanded its use. They also have found that, when used as an origin of conchiolin, black-lip pearl oysters are effective to promote collagen production.
摘要翻译：要解决的问题：通过促进胶原蛋白产生，特别是通过促进人皮肤成纤维细胞中的胶原蛋白生成，提供适合于防止皱纹形成和粗糙皮肤的皮肤外用剂。解决方案：本发明人发现，conchiolin水解产物有效促进胶原蛋白生产，并扩大使用。他们还发现，当用作conchiolin的起源时，黑唇珍珠牡蛎有效促进胶原蛋白的生成。

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