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1. 发明专利

JP2006298814A Skin lotion for acne 审中-公开
标题翻译：皮肤润肤油
公开(公告)号：JP2006298814A
公开(公告)日：2006-11-02
申请号：JP2005121893
申请日：2005-04-20
申请人： Mikimoto Pharmaceut Co Ltd , Sakamoto Yakusoen:Kk , 御木本製薬株式会社 , 有限会社坂本薬草園
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , ARAMAKI KANAME , SAKAIDA KAZUNORI , MATSUO YUKIMI
IPC分类号： A61K8/96 , A61K8/00 , A61K36/18 , A61P17/10 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To utilize the extract of mango (Mangifera indica L.) effectively, of which effectiveness only as a health food is found until now. SOLUTION: This mango extract has a lipase inhibitory effect and it is found out to improve acne, etc. Further by blending 1 kind or ≥2 kinds of any of specific medicines such as a humectant, a cell-activator, an anti-inflammatory agent, an antioxidant, a beautifully whitening agent, a hyaluronidase inhibitor, an anti-plasmin agent, an active oxygen inhibitor, a collagenase activity inhibitor, an antihistamine agent and an elastase inhibitor with the extract, a more effective skin lotion is obtained. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：有效地利用芒果（Mangifera indica L.）的提取物，到目前为止，只有作为保健食品才有效果。解决方案：这种芒果提取物具有脂肪酶抑制作用，并且发现改善痤疮等。通过混合1种或2种任何特定药物如湿润剂，细胞活化剂，抗体抗炎剂，美白增白剂，透明质酸酶抑制剂，抗纤维蛋白溶酶剂，活性氧抑制剂，胶原酶活性抑制剂，抗组胺药和弹性蛋白酶抑制剂，得到更有效的皮肤洗剂。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2006298812A Antioxidant, skin lotion for anti-oxidization, elastase activity inhibitor and maillard reaction inhibitor 审中-公开
标题翻译：抗氧化剂，用于抗氧化的皮肤润肤剂，弹性酶活性抑制剂和药物反应抑制剂
公开(公告)号：JP2006298812A
公开(公告)日：2006-11-02
申请号：JP2005121891
申请日：2005-04-20
申请人： Mikimoto Pharmaceut Co Ltd , Sakamoto Yakusoen:Kk , 御木本製薬株式会社 , 有限会社坂本薬草園
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , MATSUO YUKIMI , SAKAIDA KAZUNORI
IPC分类号： A61K36/18 , A23L1/30 , A61K8/00 , A61K8/96 , A61P3/10 , A61P9/10 , A61P17/00 , A61P39/06 , A61P43/00 , A61Q19/00 , C12N9/99
摘要： PROBLEM TO BE SOLVED: To utilize an extract of papaya (Carica papaya L.), on which only an effect as a health food is found out until now, effectively. SOLUTION: This papaya extract is found to exhibit a potent esterase activity inhibitory effect, Maillard reaction inhibitory effect and also SOD (superoxide dismutase) like activity, prevent various diseases such as senile phenomena accompanying with aging, diabetes, arteriosclelosis, etc., and also improve various skin troubles such as skin roughness, sensitive skin, dermatitis diseases, etc. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：利用番木瓜（Carica papaya L.）的提取物，其中仅有作为健康食品的作用才被发现到现在为止。解决方案：发现这种番木瓜提取物具有强效的酯酶活性抑制作用，美拉德反应抑制作用和SOD（超氧化物歧化酶）活性，预防伴随老化，糖尿病，动脉硬化等的各种疾病如老年现象。，还可以改善皮肤粗糙，皮肤敏感，皮炎等各种皮肤问题。版权所有（C）2007，JPO＆INPIT

3. 发明专利

JP2006298813A Wrinkle and sag inhibitor and hyaluronidase activity inhibitor 审中-公开
标题翻译： WRINKLE和SAG抑制剂和HYALURONIDASE活性抑制剂
公开(公告)号：JP2006298813A
公开(公告)日：2006-11-02
申请号：JP2005121892
申请日：2005-04-20
申请人： Mikimoto Pharmaceut Co Ltd , Sakamoto Yakusoen:Kk , 御木本製薬株式会社 , 有限会社坂本薬草園
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , ARAMAKI KANAME , SAKAIDA KAZUNORI , MATSUO YUKIMI
IPC分类号： A61K36/18 , A23L1/30 , A61K8/00 , A61K8/96 , A61P17/16 , A61P43/00 , A61Q19/00 , C12N9/99
摘要： PROBLEM TO BE SOLVED: To provide a preparation of inhibiting hyaluronidase activity by utilizing the extract of mango (Mangifera indica L.) of which activity as a hyaluronidase inhibitor has not been confirmed yet. SOLUTION: This extract of mango inhibits the hyaluronidase activity significantly, and by blending the same in a preparation, it is found out that the preparation improves the wrinkles and sag of the skin. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：待解决的问题：为了通过利用尚未确认其作为透明质酸酶抑制剂的活性的芒果（Mangifera indica L.）提取物来提供抑制透明质酸酶活性的制剂。解决方案：芒果提取物显着抑制透明质酸酶活性，并通过将其混合在制剂中，发现该制剂改善皮肤的皱纹和松弛。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2008133249A Hair tonic 审中-公开
标题翻译：头发TONIC
公开(公告)号：JP2008133249A
公开(公告)日：2008-06-12
申请号：JP2006345025
申请日：2006-11-27
申请人： Koei Kogyo Kk , Sakamoto Yakusoen:Kk , 有限会社坂本薬草園 , 香栄興業株式会社
发明人： TADA TAKAHIRO , MATSUO YUKIMI
IPC分类号： A61K36/18 , A61K8/97 , A61P17/14 , A61P43/00 , A61Q7/00
摘要： PROBLEM TO BE SOLVED: To find out a method for effectively utilizing the extracts of plants belonging to the genus Salacia (Salacia oblanga, Salacia reticulata and Salacia prinoides) having a high effectiveness, and also on one hand to provide an effective hair tonic for preventing or improving the troubles of hairs such as the thinning of the hairs, hair loss, etc. SOLUTION: The extracts of the plants belonging to the genus Salacia (Salacia oblanga, Salacia reticulata and Salacia prinoides) are found out to have a function not recognized until now, i.e., 5α-reductase activity inhibitory effect, and to be effective for the troubles such as the thinning of the hairs, hair loss, etc. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：为了找到有效利用具有高效率的属于Salacia属（Salacia oblanga，Salacia reticulata和Salacia prinoides）属植物的提取物的方法，并且一方面提供有效的头发用于预防或改善毛发的烦恼的滋补品，例如毛发变薄，脱发等。解决方案：发现属于Salacia属（Salacia oblanga，Salacia reticulata和Salacia prinoides）的植物的提取物，具有迄今未确认的功能，即5α-还原酶活性抑制作用，对毛发变薄，脱发等困难有效。（C）2008，JPO＆INPIT

5. 发明专利

JP2009001540A Heart disease inhibitor 审中-公开
标题翻译：心脏病抑制剂
公开(公告)号：JP2009001540A
公开(公告)日：2009-01-08
申请号：JP2007214061
申请日：2007-08-20
申请人： Koei Kogyo Kk , Sakamoto Yakusoen:Kk , 有限会社坂本薬草園 , 香栄興業株式会社
发明人： FURUSE SHINJI , MATSUO YUKIMI , MITANI SHIGEKI , TADA TAKAHIRO
IPC分类号： A61K31/7048 , A61K36/18 , A61P9/00
摘要： PROBLEM TO BE SOLVED: To provide a medicine not only safe and daily administrable but also exhibiting excellent heart disease-inhibiting effects and a method for producing the medicine in high concentration in a good yield. SOLUTION: The heart disease inhibitor comprises mangiferin as an effective ingredient. The manufacturing method comprises extracting mangiferin contained in a plant belonging to the genus Salacia with alcoholic water at a temperature of 15-30°C. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：待解决的问题：提供不仅安全和日常施药，而且表现出优异的心脏病抑制作用的药物和以高产率高浓度生产药物的方法。
解决方案：心脏疾病抑制剂包括芒果苷作为有效成分。制造方法包括在15-30℃的温度下用含酒精水提取属于Salacia属植物的芒果苷。版权所有（C）2009，JPO＆INPIT

6. 发明专利

JP2007161646A Hyaluronidase activity inhibitor 审中-公开
标题翻译： HYALURONIDASE活性抑制剂
公开(公告)号：JP2007161646A
公开(公告)日：2007-06-28
申请号：JP2005360377
申请日：2005-12-14
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , HAMAGUCHI MASANORI , MATSUO YUKIMI
IPC分类号： A61K8/97 , A61K36/18 , A61P17/16 , A61P29/00 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To find out an ingredient having a hyaluronidase inhibitory activity and to provide an external preparation for skin effective against dermatopathy caused by a hyaluronidase using the ingredient. SOLUTION: It is found that the problems can be solved by providing an external preparation for skin effective against the dermatopathy e.g. inflammations caused by the hyaluronidase, and comprising an extract from a plant belonging to the plants of the genus Hippophae of the family Elaeagnaceae as an active ingredient. In addition to the extract from the plant belonging to the plants of the genus Hippophae of the family Elaeagnaceae, one or two or more kinds selected from a humectant, a softener, a cell activator, an anti-inflammatory agent, an antioxidant, a blood circulation promoter and a bleaching agent are further formulated to thereby afford an effective preparation. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：找出具有透明质酸酶抑制活性的成分，并提供使用该成分由透明质酸酶引起的对皮肤病有效的皮肤外用制剂。解决方案：发现问题可以通过提供皮肤有效的外用制剂来解决，例如皮肤病。由透明质酸酶引起的炎症，并且包含来自属于耳科科的沙棘属植物的植物的提取物作为活性成分。除了属于禾本科耳鼻喉科植物属植物的提取物之外，还有一种或两种以上选自湿润剂，软化剂，细胞活化剂，抗炎剂，抗氧化剂，血液循环促进剂和漂白剂进一步配制，从而提供有效的制剂。版权所有（C）2007，JPO＆INPIT

7. 发明专利

JP2006219447A Wrinkle formation inhibitor 审中-公开
标题翻译：皱纹形成抑制剂
公开(公告)号：JP2006219447A
公开(公告)日：2006-08-24
申请号：JP2005035925
申请日：2005-02-14
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , MATSUO YUKIMI , SAKAIDA KAZUNORI
IPC分类号： A61K36/28 , A61K8/00 , A61K8/96 , A61P17/16 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide external preparation having high effectiveness and obtained by utilizing an extract of Conyza filaginoides, in an external preparation for skin in which wrinkle formation of the skin is inhibited by significantly inhibiting elastase activity and Maillard reaction in skin dermal tissue by an extract extracted from a plant of the specific genus. SOLUTION: The present inventors found that an extract of Conyza filaginoides significantly inhibits elastase activity and Maillard reaction. As a result, the invention provides external preparation for skin which is effective for inhibiting wrinkle formation of the skin by utilizing the extract. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供高效的外用制剂，通过利用Conyza filaginoides的提取物，在皮肤外用剂中，通过显着抑制弹性蛋白酶活性和皮肤中的美拉德反应来抑制皮肤的皱纹形成通过从特定属植物提取的提取物的真皮组织。解决方案：本发明人发现Conyza filaginoides的提取物显着抑制弹性蛋白酶活性和美拉德反应。结果，本发明提供了通过利用提取物有效抑制皮肤皱纹形成的皮肤外用剂。版权所有（C）2006，JPO＆NCIPI

8. 发明专利

JP2006062991A Skin whitening agent for external use 审中-公开
标题翻译：皮肤白化剂外用
公开(公告)号：JP2006062991A
公开(公告)日：2006-03-09
申请号：JP2004244906
申请日：2004-08-25
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , MATSUO YUKIMI
IPC分类号： A61K8/00 , A61K8/96 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a skin care preparation for external use, suppressing melanization of B16 melanoma cells by suppressing autoxidation of dopaquinone as one factor of the melanization by using extracts of papaya whose effect as a whitening agent is conventionally unknown.
SOLUTION: The extracts of papaya suppress melanization in melanocytes of cutaneous epidermal tissue by dominantly inhibiting autoxidation of dopaquinone as one factor of melanization. Several skin troubles such as skin blotch, skin somberness and skin roughening are found to be improved by compounding the extracts, with one or more of specific agents of humectants, cell activators, antiphlogistics, antioxidants, skin whitening agents, antiplasmin agents, active oxygen-suppressing agents and antihistaminic agents.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供外用护肤品，通过使用作为增白剂作用的木瓜提取物，通过抑制多巴醌的自氧化作为黑化的一个因素来抑制B16黑素瘤细胞的黑化，其作为美白剂的作用通常是未知的。解决方案：番木瓜的提取物通过主要抑制多巴醌的自氧化作为黑化的一个因素，抑制皮肤表皮组织的黑素细胞的黑色素化。发现皮肤斑点，皮肤色素沉着和皮肤粗糙等几种皮肤问题可以通过将提取物与一种或多种保湿剂，细胞活化剂，消炎剂，抗氧化剂，皮肤增白剂，抗血小药剂，活性氧 - 抑制剂和抗组胺剂。版权所有（C）2006，JPO＆NCIPI

9. 发明专利

JP2006062988A Elastase activity inhibitor 审中-公开
标题翻译：弹性酶活性抑制剂
公开(公告)号：JP2006062988A
公开(公告)日：2006-03-09
申请号：JP2004244903
申请日：2004-08-25
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , SAKAIDA KAZUNORI , MATSUO YUKIMI , TSUJI NOBUHIDE
IPC分类号： A61K8/00 , A61K8/02 , A61K8/06 , A61K8/30 , A61K8/49 , A61K8/60 , A61K8/96 , A61K36/02 , A61K36/18 , A61K36/28 , A61K36/48 , A61K36/75 , A61K38/00 , A61K45/00 , A61P17/00 , A61P17/16 , A61P43/00 , A61Q19/00 , C07K7/06 , C12N9/99
摘要： PROBLEM TO BE SOLVED: To provide new uses using extracts of a plant belonging to the Genus Ageratum, whose effect other than that on hair growth, or the like, is not found conventionally. SOLUTION: The extracts of the plant belonging to the Genus Ageratum inhibit elastase derived from dermal fibroblast. Several cutaneous aging symptoms such as wrinkles, skin roughening and skin somberness are found to be improved and prevented by compounding the extracts, with one or more of specific agents of humectants, cell activators, antiphlogistics, antioxidants, skin-whitening agents, hyaluronidase inhibitors, antiplasmin agents, active oxygen-suppressing agents, collagenase activity inhibitors, antihistamic agents and elastase activity inhibitors. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：待解决的问题：为了提供使用属于Ageratum属的植物提取物的新用途，其除毛发生长之外的效果等通常不被发现。解决方案：属于the属属的植物提取物抑制来自真皮成纤维细胞的弹性蛋白酶。发现皮肤老化症状如皱纹，皮肤粗糙度和皮肤色素沉着等，通过将一些或多种特定的保湿剂，细胞活化剂，消炎剂，抗氧化剂，皮肤增白剂，透明质酸酶抑制剂，抗血小板剂，活性氧抑制剂，胶原酶活性抑制剂，抗组胺剂和弹性蛋白酶活性抑制剂。版权所有（C）2006，JPO＆NCIPI

10. 发明专利

JP2006219448A External preparation for skin for acne 审中-公开
标题翻译： ACNE皮肤外用制剂
公开(公告)号：JP2006219448A
公开(公告)日：2006-08-24
申请号：JP2005035926
申请日：2005-02-14
申请人： Mikimoto Pharmaceut Co Ltd , 御木本製薬株式会社
发明人： ADACHI KATSUYOSHI , TADA TAKAHIRO , MATSUO YUKIMI , SAKAIDA KAZUNORI
IPC分类号： A61K8/96 , A61K8/00 , A61K36/28 , A61P17/10 , A61P43/00 , A61Q19/00
摘要： PROBLEM TO BE SOLVED: To provide a safer and effective preparation for acne by effectively utilizing an extract of Conyza filaginoides having high effectiveness. SOLUTION: The present inventors found that the extract of Conyza filaginoides significantly inhibits production of lipase. As a result, effective various external preparations inhibiting formation of acne are provided by using the extract of Conyza filaginoides. Further, present inventors found that various troubles of skin such as dullness of skin and chapped skin are further improved by combining and formulating the extract of Conyza filaginoides with specific agents selected from a humectant, a cell-activating agent, an antiinflammatory agent, an antioxidant, a beautifying and whitening agent, an antiplasmin agent, an active oxygen inhibitor and an antihistamic agent. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：通过有效利用具有高效益的Conyza filaginoides提取物，为痤疮提供更安全有效的制剂。解决方案：本发明人发现Conyza filaginoides的提取物显着抑制脂肪酶的产生。结果，通过使用Conyza filaginoides的提取物来提供抑制痤疮形成的有效的各种外用制剂。此外，本发明人发现通过将Conyza filaginoides的提取物与选自湿润剂，细胞活化剂，抗炎剂，抗氧化剂的特定试剂结合并配制而进一步改善皮肤的各种麻烦，例如皮肤和皮肤发红，，美白增白剂，抗血小板剂，活性氧抑制剂和抗组胺剂。版权所有（C）2006，JPO＆NCIPI

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