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1. 发明授权

US09254283B2 Therapeutic agent for migraine 有权
标题翻译：偏头痛治疗药
公开(公告)号：US09254283B2
公开(公告)日：2016-02-09
申请号：US13055005
申请日：2009-07-23
申请人： Junichi Ikeda , Shunji Ichikawa , Masako Kurokawa , Tomoyuki Kanda
发明人： Junichi Ikeda , Shunji Ichikawa , Masako Kurokawa , Tomoyuki Kanda
IPC分类号： A61K31/535 , A01N43/40 , A61K31/44 , A61K31/427 , A61K31/519 , A61K31/52 , A61K45/06
CPC分类号： A61K31/427 , A61K31/519 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： Provided are therapeutic and/or preventive agents for migraine which comprise, as an active ingredient, a compound having a selective adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof; therapeutic and/or preventive agents for migraine which comprise, as an active ingredient, a compound having a selective adenosine A2A receptor antagonistic activity, which has an affinity for the adenosine A2A receptor 10 times or higher than that for the adenosine A1 receptor, or a pharmaceutically acceptable salt thereof; and the like.
摘要翻译：本发明提供了作为活性成分的具有选择性腺苷A2A受体拮抗活性的化合物或其药学上可接受的盐的偏头痛治疗和/或预防剂，或作为活性成分的具有选择性腺苷A2A受体拮抗作用的化合物，其对腺苷A2A受体的亲和力比腺苷A1受体高10倍以上，或其药学上可接受的盐; 等等。

2. 发明申请

US20110183992A1 THERAPEUTIC AGENT FOR MIGRAINE 有权
标题翻译： MIGRAINE的治疗剂
公开(公告)号：US20110183992A1
公开(公告)日：2011-07-28
申请号：US13055005
申请日：2009-07-23
申请人： Junichi Ikeda , Shunji Ichikawa , Masako Kurokawa , Tomoyuki Kanda
发明人： Junichi Ikeda , Shunji Ichikawa , Masako Kurokawa , Tomoyuki Kanda
IPC分类号： A61K31/519 , C07D487/04 , C07D417/14 , C07D487/14 , C07D495/04 , C07D473/32 , C07D417/04 , A61K31/4439 , A61K31/506 , A61K31/52 , A61K31/427 , A61P25/06
CPC分类号： A61K31/427 , A61K31/519 , A61K31/52 , A61K45/06 , A61K2300/00
摘要： Provided are therapeutic and/or preventive agents for migraine which comprise, as an active ingredient, a compound having a selective adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof; therapeutic and/or preventive agents for migraine which comprise, as an active ingredient, a compound having a selective adenosine A2A receptor antagonistic activity, which has an affinity for the adenosine A2A receptor 10 times or higher than that for the adenosine A1 receptor, or a pharmaceutically acceptable salt thereof; and the like.
摘要翻译：本发明提供了作为活性成分的具有选择性腺苷A2A受体拮抗活性的化合物或其药学上可接受的盐的偏头痛治疗和/或预防剂，或作为活性成分的具有选择性腺苷A2A受体拮抗作用的化合物，其对腺苷A2A受体的亲和力比腺苷A1受体高10倍以上，或其药学上可接受的盐; 等等。

3. 发明授权

US06222035B1 [1,2,4] triazolo [1,5-C] pyrimidine derivatives 失效
标题翻译： [1,2,4]三唑并[1,5-C]嘧啶衍生物
公开(公告)号：US06222035B1
公开(公告)日：2001-04-24
申请号：US09401984
申请日：1999-09-23
申请人： Hiroshi Tsumuki , Junichi Shimada , Hironori Imma , Akiko Nakamura , Hiromi Nonaka , Shizuo Shiozaki , Shunji Ichikawa , Tomoyuki Kanda , Yoshihisa Kuwana , Michio Ichimura , Fumio Suzuki
发明人： Hiroshi Tsumuki , Junichi Shimada , Hironori Imma , Akiko Nakamura , Hiromi Nonaka , Shizuo Shiozaki , Shunji Ichikawa , Tomoyuki Kanda , Yoshihisa Kuwana , Michio Ichimura , Fumio Suzuki
IPC分类号： C07D48700
CPC分类号： C07D487/04
摘要： [1,2,4]Triazolo[1,5-c]pyrimidine derivatives represented by formula (I) or pharmaceutically acceptable salts thereof are provided, which have adenosine A2A receptor antagonism and are useful for the treatment or prevention of various diseases induced by hyperactivity of adenosine A2A receptors (for example, Parkinson's disease or senile dementia): wherein R1 represents substituted or unsubstituted aryl, or the like; R2 represents hydrogen, halogen, lower alkyl, substituted or unsubstituted aryl, or the like; R3 represents hydrogen, halogen, XR10 (wherein X represents O or S; and R10 represents substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic ring, substituted or unsubstituted aralkyl, lower alkyl, or hydroxy lower alkyl), or the like; and Q represents hydrogen or 3,4-dimethoxybenzyl.
摘要翻译： [1,2,4]具有式（I）表示的三唑并[1,5-c]嘧啶衍生物或其药学上可接受的盐，其具有腺苷A2A受体拮抗作用，可用于治疗或预防由腺苷A2A受体（例如帕金森病或老年性痴呆）的多动症：其中R1表示取代或未取代的芳基等; R 2表示氢，卤素，低级烷基，取代或未取代的芳基等; R3表示氢，卤素，XR10（其中X表示O或S; R10表示取代或未取代的芳基，取代或未取代的芳族杂环，取代或未取代的芳烷基，低级烷基或羟基低级烷基）等; Q表示氢或3,4-二甲氧基苄基。

4. 发明授权

US5565460A Therapeutic purine agents for parkinson's disease 失效
标题翻译：治疗帕金森病的嘌呤药物
公开(公告)号：US5565460A
公开(公告)日：1996-10-15
申请号：US367346
申请日：1995-03-03
申请人： Fumio Suzuki , Junichi Shimada , Nobuaki Koike , Shunji Ichikawa , Joji Nakamura , Tomoyuki Kanda , Shigeto Kitamura
发明人： Fumio Suzuki , Junichi Shimada , Nobuaki Koike , Shunji Ichikawa , Joji Nakamura , Tomoyuki Kanda , Shigeto Kitamura
IPC分类号： A61K31/505 , A61K31/53 , C07D487/04 , A61K31/535 , A61K31/54
CPC分类号： C07D487/04 , A61K31/505 , A61K31/53
摘要： The present invention relates to a therapeutic agent for Parkinson's disease containing as an active ingredient a polycyclic compound or a pharmaceutically acceptable salt thereof, the compound being represented by the following Formula (I): ##STR1## and A represents N or CR.sup.5 (in which R.sup.5 represents hydrogen, or substituted or unsubstituted lower alkyl), or represented by the following Formula (II): ##STR2## wherein Y, R.sup.6 and R.sup.8 are as defined herein and B and the adjacent two carbon atoms are combined to form a substituted or unsubstituted, partially saturated or unsaturated, monocyclic or bicyclic, carbocyclic or heterocyclic group.
摘要翻译： PCT No.PCT / JP94 / 01196 Sec。 371日期1995年3月3日 102（e）1995年3月3日PCT PCT 1994年7月20日PCT公布。公开号WO95 / 03806 日期：1995年2月9日本发明涉及含有作为活性成分的多环化合物或其药学上可接受的盐的帕金森病治疗剂，该化合物由下式（I）表示：＆lt; IMAGE＆gt;（I）和 A表示N或CR 5（其中R 5表示氢或取代或未取代的低级烷基），或由下式（II）表示：其中Y，R 6和R 8如本文所定义，B和相邻的两个碳原子结合形成取代或未取代的，部分饱和或不饱和的单环或双环，碳环或杂环基团。

5. 发明申请

US20120184554A1 THERAPEUTIC AGENT FOR MOOD DISORDERS 有权
标题翻译：治疗病症的治疗药物
公开(公告)号：US20120184554A1
公开(公告)日：2012-07-19
申请号：US13393035
申请日：2010-09-02
申请人： Koji Yamada , Tomoyuki Kanda
发明人： Koji Yamada , Tomoyuki Kanda
IPC分类号： A61K31/5377 , A61K31/506 , A61P25/24 , A61K31/4365 , A61K31/4355 , A61K31/4709 , A61K31/436 , A61K31/435 , A61K31/4439 , A61K31/427
CPC分类号： C07D417/14 , A61K31/34 , A61K31/35 , A61K31/426 , A61K31/435 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D491/048 , C07D491/052 , C07D495/04
摘要： Provided are an agent for the treatment and/or prophylaxis of a mood disorder comprising, as an active ingredient, a thiazole derivative represented by the formula (I) wherein R1 represents aryl or the like, and R2 represents pyridyl or the like, or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译：提供了用于治疗和/或预防情绪障碍的药剂，其包含作为活性成分的由式（I）表示的噻唑衍生物，其中R 1表示芳基等，R 2表示吡啶基等，或药学上可接受的盐等。

6. 发明申请

US20120172362A1 THERAPEUTIC AGENT FOR ANXIETY DISORDERS 审中-公开
标题翻译：治疗恶病质的治疗剂
公开(公告)号：US20120172362A1
公开(公告)日：2012-07-05
申请号：US13393068
申请日：2010-09-02
申请人： Junya Kase , Tomoyuki Kanda
发明人： Junya Kase , Tomoyuki Kanda
IPC分类号： A61K31/4439 , A61K31/427 , A61K31/5377 , A61P25/22 , A61K31/4709 , A61K31/436 , A61K31/435 , A61K31/506 , A61K31/4355
CPC分类号： C07D417/14 , A61K31/426 , A61K31/4439 , A61K31/506 , A61K31/5377 , C07D491/048 , C07D491/052 , C07D495/04
摘要： Provided are an agent for the treatment and/or prophylaxis of an anxiety disorder comprising, as an active ingredient, a thiazole derivative represented by the formula (I) wherein R1 represents aryl or the like, and R2 represents pyridyl or the like, or a pharmaceutically acceptable salt thereof, and the like.
摘要翻译：提供了用于治疗和/或预防焦虑症的药剂，其包含作为活性成分的由式（I）表示的噻唑衍生物，其中R 1表示芳基等，R 2表示吡啶基等，或药学上可接受的盐等。

7. 发明授权

US06545000B1 [1,2,4]triazolo[1,5-c]pyrimidine derivatives 失效
标题翻译： [1,2,4]三唑并[1,5-c]嘧啶衍生物
公开(公告)号：US06545000B1
公开(公告)日：2003-04-08
申请号：US09787779
申请日：2001-03-22
申请人： Junichi Shimada , Hironori Imma , Naoto Osakada , Shizuo Shiozaki , Tomoyuki Kanda , Yoshihisa Kuwana
发明人： Junichi Shimada , Hironori Imma , Naoto Osakada , Shizuo Shiozaki , Tomoyuki Kanda , Yoshihisa Kuwana
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： The present invention relates to [1,2,4]triazolo[1,5-c]pyrimidine compounds represented by formula (I): wherein na and nb independently represent an integer of 0 to 4 and Q represents a hydrogen atom or 3,4-dimethoxybenzyl, or salts thereof exhibit activity as adenosine A2A receptor antagonists.
摘要翻译：本发明涉及由式（I）表示的[1,2,4]三唑并[1,5-c]嘧啶化合物：其中na和nb独立地表示0-4的整数，Q表示氢原子或3， 4-二甲氧基苄基或其盐表现出作为腺苷A 2A受体拮抗剂的活性。

8. 发明授权

US06198554B1 Method for producing a hologram and a display device using the same 失效
标题翻译：制造全息图的方法和使用该全息图的显示装置
公开(公告)号：US06198554B1
公开(公告)日：2001-03-06
申请号：US08741175
申请日：1996-10-29
申请人： Tomoyuki Kanda , Kazutoshi Koie , Katsuyoshi Nishii , Masahiro Shiozawa , Katsumi Kamiya , Atsuo Ishizuka
发明人： Tomoyuki Kanda , Kazutoshi Koie , Katsuyoshi Nishii , Masahiro Shiozawa , Katsumi Kamiya , Atsuo Ishizuka
IPC分类号： G03H102
CPC分类号： G02B5/32 , G03H1/0256 , G03H1/04 , G03H1/0404 , G03H1/0486 , G03H1/22 , G03H1/265 , G03H1/28 , G03H2001/2239 , G03H2001/306 , G03H2223/14 , G03H2240/51 , G03H2240/53 , G03H2250/32 , G03H2260/10 , H04N7/144
摘要： A method for producing a hologram recording an interference fringe formed by an object light and a reference light on a photosensitive dry plate, and the object light either having diffusing and scattering characteristics or being passed through an optical diffusion body, mainly includes the following steps: In a first step, a ratio &eegr;RO/&eegr;OO of a first diffraction efficiency &eegr;OO and a second diffraction efficiency &eegr;RO, is calculated. The diffraction efficiency &eegr;OO is dependent on two object light beams. The efficiency &eegr;RO is dependent on the object light and the reference light. In a second step, the intensity EO of the object light and the intensity ER of the reference light is adjusted in such a way that the ratio &eegr;RO/&eegr;OO is set to at least 10 and the efficiency &eegr;OO does not exceed 5%. A display device using the above hologram is structured by a display unit for generating a signal light; a hologram screen formed by either reflection or transmission hologram, and a projecting unit for projecting the signal light to the hologram screen. According to the present invention, it is possible to easily produce a hologram, for example, a screen hologram, having no cloudiness or cloudy state when an observer observes an image displayed on the screen, and to a display device using the above hologram screen.
摘要翻译：一种用于产生记录由感光干板上的物体光和参考光形成的干涉条纹的全息图的方法以及具有漫射和散射特性或通过光漫射体的目标光主要包括以下步骤：在第一步骤中，计算第一衍射效率etaOO和第二衍射效率etaRO的比率ηηRO/ eta。衍射效率etaOO取决于两个物体光束。效率etaRO取决于物体光和参考光。在第二步骤中，调整对象光的强度EO和参考光的强度ER，使得etaRO / eta00的比率设定为至少10，效率etaOO不超过5％.A显示使用上述全息图的装置由用于产生信号光的显示单元构成; 通过反射或透射全息图形成的全息屏幕和用于将信号光投射到全息屏幕的投影单元。根据本发明，可以容易地生成全息图，例如没有浑浊的全息图或观察者观察屏幕上显示的图像时的混浊状态，以及使用上述全息图的显示装置。

9. 发明授权

US06997831B2 Vehicular transmission 失效
标题翻译：车辆传动
公开(公告)号：US06997831B2
公开(公告)日：2006-02-14
申请号：US10680003
申请日：2003-10-07
申请人： Tomoyuki Kanda , Takao Sato , Yoshimichi Tsubata
发明人： Tomoyuki Kanda , Takao Sato , Yoshimichi Tsubata
IPC分类号： F16H37/02 , B60K41/22
CPC分类号： F16H37/021 , F16H61/66259 , F16H2061/023 , F16H2061/0448 , F16H2061/0488 , F16H2312/02 , Y10T74/19019 , Y10T477/6217 , Y10T477/6237 , Y10T477/689
摘要： A transmission equipped with a continuously variable ratio-change mechanism CVT and a LOW rotational transmission mechanism GT, which are disposed parallel with each other, comprises a forward clutch 65 and a reverse brake 66, which are used to set a power transmission through the continuously variable ratio-change mechanism, a LOW clutch 46, which is used to set a power transmission through the LOW rotational transmission mechanism, and a control unit ECU and a hydraulic control valve HV, which control the engagement of the clutches and the brake. When the transmission is switched from its neutral mode to its in-gear mode, at first, the forward clutch 65 is brought gradually into engagement, and then it is released before the LOW clutch 46 is brought into engagement in a squat control.
摘要翻译：配备有彼此平行配置的无级变速机构CVT和LOW旋转传动机构GT的变速器包括前进离合器65和倒车制动器66，其用于设定通过连续的动力传递用于设定通过LOW旋转传动机构的动力传递的LOW离合器46以及控制离合器和制动器的接合的控制单元ECU和液压控制阀HV。当变速器从空档模式切换到变速档时，首先使前进离合器65逐渐接合，然后在LOW离合器46进入蹲下控制之前将其释放。

10. 发明授权

US06500090B2 Control apparatus for an automotive continuously variable transmission 失效
标题翻译：一种用于汽车无级变速器的控制装置
公开(公告)号：US06500090B2
公开(公告)日：2002-12-31
申请号：US09944591
申请日：2001-09-04
申请人： Tomoyuki Kanda , Tamotsu Kotegawa , Yoshimichi Tsubata
发明人： Tomoyuki Kanda , Tamotsu Kotegawa , Yoshimichi Tsubata
IPC分类号： B60R4112
CPC分类号： F16H61/66272 , F16H61/66259 , F16H2061/6611 , Y10T477/624 , Y10T477/6243
摘要： In a control apparatus for an automotive continuously variable transmission having a forward-reverse selector mechanism in which a gear ratio for reverse is set closer to a speed reducing side than a gear ratio for forward and a belt type continuously variable transmission mechanism, a PH pressure that is outputted from a first regulator valve and a PL pressure that is outputted from a second regulator valve are changeably supplied to one and the other of a hydraulic cylinder of a drive pulley and a hydraulic cylinder of a driven pulley via a shift control valve. A hydraulic pressure supplied to a reversing hydraulic pressure connecting element from a reversing manual valve is inputted into an oil chamber of a first regulator valve so that the PH pressure is increased with the hydraulic pressure so inputted.
摘要翻译：在一种用于汽车用无级变速器的控制装置中，具有前后倒档选择机构，其中反向齿轮比设定为比前方的齿轮比更靠近减速侧，带式无级变速机构设置，PH压力从第一调节阀输出的压力和从第二调节阀输出的PL压力通过变速控制阀可变地供给到驱动带轮的液压缸和从动带轮的液压缸中的另一个。从反转手动阀向反转液压连接元件供给的液压被输入到第一调节阀的油室中，使得在输入的液压下使PH压力增加。

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