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1. 发明授权

US07517690B2 Cell lysis method using free radical 有权
标题翻译：细胞裂解法使用自由基
公开(公告)号：US07517690B2
公开(公告)日：2009-04-14
申请号：US11291053
申请日：2005-11-30
申请人： Jung-im Han , Young-sun Lee , Kak Namkoong , Kwang-wook Oh
发明人： Jung-im Han , Young-sun Lee , Kak Namkoong , Kwang-wook Oh
IPC分类号： G01N33/48
CPC分类号： C12N1/06 , Y10T436/107497 , Y10T436/206664 , Y10T436/25 , Y10T436/2575
摘要： Provided is a method of lysing a cell or a virus using a free radical. The method includes: applying an electric field to a mixture of a metal ion, a peroxide, and a cell or virus solution to increase the free radical generation, thereby lysing a cell or a virus. In the present method, cell lysis may be efficiently performed using a low electrical energy (several mV to several V). When the present method is applied to a microsystem, cell lysis can occur at a desired time and in a desired space by controlling the electrical energy, thus being suitable to realize a lab-on-a-chip (LOC).
摘要翻译：提供了使用自由基裂解细胞或病毒的方法。该方法包括：向金属离子，过氧化物和细胞或病毒溶液的混合物施加电场以增加自由基产生，从而裂解细胞或病毒。在本方法中，可以使用低电能（几mV至几V）有效地进行细胞裂解。当本方法应用于微系统时，细胞裂解可以通过控制电能在期望的时间和期望的空间中发生，从而适于实现芯片上的实验室（LOC）。

2. 发明申请

US20060115902A1 Cell lysis method using free radical 有权
公开(公告)号：US20060115902A1
公开(公告)日：2006-06-01
申请号：US11291053
申请日：2005-11-30
申请人： Jung-im Han , Young-sun Lee , Kak Namkoong , Kwang-wook Oh
发明人： Jung-im Han , Young-sun Lee , Kak Namkoong , Kwang-wook Oh
IPC分类号： G01N1/10
CPC分类号： C12N1/06 , Y10T436/107497 , Y10T436/206664 , Y10T436/25 , Y10T436/2575
摘要： Provided is a method of lysing a cell or a virus using a free radical. The method includes: applying an electric field to a mixture of a metal ion, a peroxide, and a cell or virus solution to increase the free radical generation, thereby lysing a cell or a virus. In the present method, cell lysis may be efficiently performed using a low electrical energy (several mV to several V). When the present method is applied to a microsystem, cell lysis can occur at a desired time and in a desired space by controlling the electrical energy, thus being suitable to realize a lab-on-a-chip (LOC).

3. 发明申请

US20060160688A1 Handheld centrifuge 有权
标题翻译：手持离心机
公开(公告)号：US20060160688A1
公开(公告)日：2006-07-20
申请号：US11333857
申请日：2006-01-17
申请人： Kak Namkoong , Young-sun Lee , Kwang-wook Oh , Christopher Ko , Jung-Im Han
发明人： Kak Namkoong , Young-sun Lee , Kwang-wook Oh , Christopher Ko , Jung-Im Han
IPC分类号： B04B5/02
CPC分类号： B01L3/5021 , B01L2300/043 , B01L2300/0681 , B04B5/0414 , B04B9/00 , B04B9/12
摘要： A handheld centrifuge is provided. In the handheld centrifuge, an inertia body has an axle to which one end of a string is connected and a pair of inertia wheels coupled to the axle, and at least one closed vessel is installed at the inertia body to contain a substance to be centrifuged.
摘要翻译：提供手持离心机。在手持式离心机中，惯性体具有一个轴的一端连接到该轴上，一对惯性轮联接到轴上，并且至少一个密封容器安装在惯性体上以容纳要离心的物质。

4. 发明授权

US07645223B2 Handheld centrifuge 有权
标题翻译：手持离心机
公开(公告)号：US07645223B2
公开(公告)日：2010-01-12
申请号：US11333857
申请日：2006-01-17
申请人： Kak Namkoong , Young-sun Lee , Kwang-wook Oh , Christopher Hansung Ko , Jung-Im Han
发明人： Kak Namkoong , Young-sun Lee , Kwang-wook Oh , Christopher Hansung Ko , Jung-Im Han
IPC分类号： B04B5/02 , B04B9/00
CPC分类号： B01L3/5021 , B01L2300/043 , B01L2300/0681 , B04B5/0414 , B04B9/00 , B04B9/12
摘要： A handheld centrifuge includes an inertia body having an axle and a pair of inertia wheels coupled to the axle. The inertia wheels are coupled to the axle in substantially perpendicular direction to the axle, and spaced apart from each other. A string is connected to the axle. At least one closed vessel is detachably installed on an outer face of the inertia wheel to contain a substance to be centrifuged. The closed vessel is installed in substantially radial direction of the inertia wheel.
摘要翻译：手持式离心机包括惯性体，其具有轴和耦合到该轴的一对惯性轮。惯性轮以基本上垂直于轴的方向联接到车轴并且彼此间隔开。一根绳子连接到轴上。至少一个密封容器可拆卸地安装在惯性轮的外表面上以容纳待离心的物质。密闭容器沿惯性轮的大致径向安装。

5. 发明申请

US20060127887A1 Isolation and purification method of biomolecules using hydrogel 有权
公开(公告)号：US20060127887A1
公开(公告)日：2006-06-15
申请号：US11191221
申请日：2005-07-27
申请人： Young-sun Lee , Jung-im Han , Hyo-yeon Lee , Kak Namkoong , Kwang-wook Oh
发明人： Young-sun Lee , Jung-im Han , Hyo-yeon Lee , Kak Namkoong , Kwang-wook Oh
IPC分类号： C12Q1/70 , C12Q1/68 , C12N1/20 , C12N5/00 , C07K1/26
CPC分类号： C12N15/1006
摘要： Provided is a method of isolating and purifying biomolecules using a hydrogel, the method including: bring a sample containing charged biomolecules into contact with a hydrogel to bind the biomolecules to the hydrogel; washing the hydrogel bound with the biomolecules; and eluting the bound biomolecules using an elution solvent. According to the method, the use of a hydrogel with a large surface area reduces the isolation time of biomolecules to 5 min or less, an external device such as an electromagnet is not required, and small-sized systems or LOC can be easily implemented due to applicability to microsystems through a polymer patterning technique.

6. 发明授权

US07579151B2 Isolation and purification method of biomolecules using hydrogel 有权
标题翻译：使用水凝胶分离和纯化生物分子的方法
公开(公告)号：US07579151B2
公开(公告)日：2009-08-25
申请号：US11191221
申请日：2005-07-27
申请人： Young-sun Lee , Jung-im Han , Hyo-yeon Lee , Kak Namkoong , Kwang-wook Oh
发明人： Young-sun Lee , Jung-im Han , Hyo-yeon Lee , Kak Namkoong , Kwang-wook Oh
IPC分类号： C12Q1/68 , C07H21/00
CPC分类号： C12N15/1006
摘要： Provided is a method of isolating and purifying biomolecules using a hydrogel, the method including: bring a sample containing charged biomolecules into contact with a hydrogel to bind the biomolecules to the hydrogel; washing the hydrogel bound with the biomolecules; and eluting the bound biomolecules using an elution solvent. According to the method, the use of a hydrogel with a large surface area reduces the isolation time of biomolecules to 5 min or less, an external device such as an electromagnet is not required, and small-sized systems or LOC can be easily implemented due to applicability to microsystems through a polymer patterning technique.
摘要翻译：提供了使用水凝胶分离和纯化生物分子的方法，该方法包括：使含有带电生物分子的样品与水凝胶接触以将生物分子结合至水凝胶; 洗涤与生物分子结合的水凝胶; 并使用洗脱溶剂洗脱结合的生物分子。根据该方法，使用具有大表面积的水凝胶将生物分子的隔离时间减少到5分钟以下，不需要诸如电磁体的外部装置，并且可以容易地实现小尺寸系统或LOC 通过聚合物图案化技术适用于微系统。

7. 发明授权

US07799557B2 Polymerase chain reaction (PCR) module and multiple PCR system using the same 有权
标题翻译：聚合酶链反应（PCR）模块和多重PCR系统使用相同
公开(公告)号：US07799557B2
公开(公告)日：2010-09-21
申请号：US11080705
申请日：2005-03-15
申请人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
发明人： Kwang-wook Oh , Jin-tae Kim , Kak Namkoong , Chin-sung Park , Yoon-kyoung Cho
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： G01N21/6486 , B01L3/50851 , B01L7/52 , B01L2300/0627 , B01L2300/18 , G01N21/0332
摘要： Provided are a DNA PCR module and a multiple PCR system using the same. More particularly, provided are a DNA PCR module with a combined PCR thermal cycler and PCR product detector, and a multiple PCR system using the same.
摘要翻译：提供了DNA PCR模块和使用其的多重PCR系统。更具体地，提供了具有组合的PCR热循环仪和PCR产物检测器的DNA PCR模块，以及使用其的多重PCR系统。

8. 发明授权

US07736050B2 Fluid mixing device using cross channels 有权
标题翻译：流体混合装置使用交叉通道
公开(公告)号：US07736050B2
公开(公告)日：2010-06-15
申请号：US11433594
申请日：2006-05-12
申请人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
发明人： Chin-sung Park , Joon-ho Kim , Kak Namkoong , Kwang-wook Oh
IPC分类号： B01F5/00
CPC分类号： B01F13/1013 , B01F5/0475 , B01F5/0478 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F13/1019 , B01F15/0203 , B01F15/0404 , B01F2015/0221 , G01N1/38
摘要： Provided is a fluid mixing device which produces a series of solutions with a concentration gradient. The fluid mixing device includes: a plurality of first channels disposed parallel to each other on a layer, and into which an equal amount of diluent flows from its upstream; a plurality of second channels formed perpendicular to the first channels on an adjacent layer to the layer on which the first channels are formed, and into which an equal amount of sample solution flows from its upstream; and via holes formed at at least one intersection between each of the first channel and a plurality of second channels so that a predetermined amount of sample solution flows from the second channels into corresponding first channels, wherein a series of solutions with different concentrations is produced in the first channels depending on the amount of sample solution that flows into the first channels through the via holes. Thus, a series of solutions with different concentrations is output from the first channels.
摘要翻译：提供了一种流体混合装置，其产生具有浓度梯度的一系列溶液。流体混合装置包括：在层上彼此平行设置的多个第一通道，等量的稀释剂从其上游流入其中; 多个第二通道，其垂直于与形成有第一通道的层相邻的第一通道形成，并且等量的样品溶液从其上游流入其中; 以及形成在每个第一通道和多个第二通道之间的至少一个相交处的通孔，使得预定量的样品溶液从第二通道流入相应的第一通道，其中一系列具有不同浓度的溶液在第一通道取决于通过通孔流入第一通道的样品溶液的量。因此，从第一通道输出一系列具有不同浓度的溶液。

9. 发明申请

US20060151732A1 Valve 有权
标题翻译：阀
公开(公告)号：US20060151732A1
公开(公告)日：2006-07-13
申请号：US11327236
申请日：2006-01-05
申请人： Kwang-wook Oh , Kak Namkoong
发明人： Kwang-wook Oh , Kak Namkoong
IPC分类号： F16K31/02
CPC分类号： F16K31/0679 , Y10T137/87788
摘要： A valve is provided. The valve includes a plunger, a chamber having a first region and a second region where the plunger moves back and forth, a first electromagnet and a second electromagnet which are located around the first region and the second region to apply a magnetic field to the plunger, a fluid inlet through which a fluid enters into the chamber, located between the first region and the second region of the chamber, and a second fluid outlet located on a vertical end part of the second region away from the first region.
摘要翻译：提供阀门。阀包括柱塞，具有第一区域和柱塞前后移动的第二区域的腔室，位于第一区域和第二区域周围的第一电磁体和第二电磁体，以向柱塞施加磁场，流体入口，流体通过所述流体入口位于所述室的所述第一区域和所述第二区域之间，以及位于所述第二区域的远离所述第一区域的垂直端部的第二流体出口。

10. 发明申请

US20060078931A1 Microchip unit, and method of conducting biochemical reaction using the microchip unit 审中-公开
标题翻译： Microchip单元和使用微芯片单元进行生化反应的方法
公开(公告)号：US20060078931A1
公开(公告)日：2006-04-13
申请号：US11245348
申请日：2005-10-06
申请人： Kwang-wook Oh , Yu-jin Seo , Gyeong-sik Ok , Jin-tae Kim , Kak Namkoong , Chin-sung Park
发明人： Kwang-wook Oh , Yu-jin Seo , Gyeong-sik Ok , Jin-tae Kim , Kak Namkoong , Chin-sung Park
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/502715 , B01L9/527 , B01L2200/027 , B01L2300/0816 , B01L2400/065
摘要： Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.
摘要翻译：提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。

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