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1. 发明授权

US08623368B2 Human recombinant monoclonal antibody that specifically binds to VCAM-1 and inhibits adhesion and transmigration between leukocytes and endothelial cells 失效
标题翻译：与VCAM-1特异性结合并抑制白细胞和内皮细胞之间粘附和迁移的人重组单克隆抗体
公开(公告)号：US08623368B2
公开(公告)日：2014-01-07
申请号：US13503103
申请日：2010-10-22
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K14/70542 , A61K2039/505 , C07K16/2836 , C07K2317/24 , C07K2319/30 , G01N33/57484 , G01N33/577 , G01N33/6893 , G01N33/74 , G01N2333/525 , G01N2333/70542 , G01N2800/24 , G01N2800/32 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
摘要翻译：本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗包含其的炎性疾病或癌症的组合物。根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，从而用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。

2. 发明申请

US20120276091A1 Human Recombinant Monoclonal Antibody That Specifically Binds to VCAM-1 and Inhibits Adhesion and Transmigration Between Leukocytes and Endothelial Cells 失效
标题翻译：与VCAM-1特异性结合并抑制白细胞与内皮细胞之间粘附和转移的人重组单克隆抗体
公开(公告)号：US20120276091A1
公开(公告)日：2012-11-01
申请号：US13503103
申请日：2010-10-22
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Dong Eun Lee , Su Yeon Ryu , Hyun Bo Shim , Kyung Jae Kang
IPC分类号： C07K16/28 , C12N5/07 , A61P35/00 , A61P29/00 , A61P9/00 , G01N33/53 , A61K39/395
CPC分类号： C07K14/70542 , A61K2039/505 , C07K16/2836 , C07K2317/24 , C07K2319/30 , G01N33/57484 , G01N33/577 , G01N33/6893 , G01N33/74 , G01N2333/525 , G01N2333/70542 , G01N2800/24 , G01N2800/32 , Y02A50/412 , Y02A50/58
摘要： The present invention relates to a human recombinant monoclonal antibody that specifically binds to human Vascular Cell Adhesion Molecule-1 (VCAM-1) to inhibit adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, and a prophylactic and therapeutic composition for inflammatory disease or cancer comprising the same. The human recombinant monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human endothelial cell, and effectively inhibits VCAM-1-mediated adhesion between leukocytes and activated endothelial cells and transmigration of leukocytes through the activated endothelial cells, thereby being used for the prevention and treatment of inflammatory disease such as asthma and arthritis, transplant rejection, cardiovascular disease, and cancer.
摘要翻译：本发明涉及特异性结合人血管细胞粘附分子-1（VCAM-1）以抑制白细胞与激活的内皮细胞之间的粘附和通过活化的内皮细胞的白细胞迁移的人重组单克隆抗体，以及预防和治疗包含其的炎性疾病或癌症的组合物。根据本发明的人重组单克隆抗体显示出对人内皮细胞上表达的VCAM-1的强亲和力，并且有效抑制白细胞和激活的内皮细胞之间的VCAM-1介导的粘附和白细胞通过活化的内皮细胞的迁移，从而用于预防和治疗炎性疾病如哮喘和关节炎，移植排斥反应，心血管疾病和癌症。

3. 发明申请

US20120308574A1 HUMAN MONOCLONAL ANTIBODY THAT SPECIFICALLY BINDS TO VCAM-1 AND A COMPOSITION FOR TREATING AN INFLAMMATORY DISEASE OR A CANCER COMPRISING THE SAME 失效
标题翻译：对VCAM-1特异性结合的人类单克隆抗体和用于治疗炎症性疾病的组合物或包含其的癌症
公开(公告)号：US20120308574A1
公开(公告)日：2012-12-06
申请号：US13262212
申请日：2010-03-31
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
IPC分类号： A61K39/395 , G01N33/574 , C07K16/18 , A61P9/10 , A61P35/00 , A61P11/06 , A61P1/00 , G01N33/566 , A61P29/00
CPC分类号： C07K16/2836 , A61K2039/505 , C07K14/70542 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.
摘要翻译：本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。

4. 发明授权

US08715670B2 Human monoclonal antibody that specifically binds to VCAM-1 and a composition for treating an inflammatory disease or a cancer comprising the same 失效
标题翻译：特异性结合VCAM-1的人单克隆抗体和用于治疗炎性疾病的组合物或包含其的癌症
公开(公告)号：US08715670B2
公开(公告)日：2014-05-06
申请号：US13262212
申请日：2010-03-31
申请人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
发明人： Jung Tae Lee , Kyung Duk Moon , Ji Yong Yoon , Byung Je Sung , Dong Heon Lee , Il Sun Lee , Dong Eun Lee , Su Yeon Ryu , Young Woo Park , So Young Choi , Ji Hyun Park , Myeoung Hee Jang
IPC分类号： A61K39/395 , C07K16/28 , G01N33/53
CPC分类号： C07K16/2836 , A61K2039/505 , C07K14/70542 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention relates to a human monoclonal antibody that specifically binds to VCAM-1, and a therapeutic composition for the treatment of inflammatory disease or cancer comprising the same. The human monoclonal antibody according to the present invention shows a strong affinity to VCAM-1 expressed on human or mouse endothelial cell, effectively inhibits leukocyte adhesion to activated endothelial cells expressing VCAM-1, and shows a low immunogenicity, thereby being used for the treatment of cancer or inflammatory disease such as asthma, rhinitis, arthritis, multiple sclerosis, bowel disease, arteriosclerosis, myocardial infarction and transplant rejection.
摘要翻译：本发明涉及特异性结合VCAM-1的人单克隆抗体以及用于治疗炎症性疾病或癌症的治疗组合物。根据本发明的人单克隆抗体对在人或小鼠内皮细胞上表达的VCAM-1显示出强亲和力，有效抑制白细胞与表达VCAM-1的活化内皮细胞粘附，并且显示出低的免疫原性，从而用于治疗的癌症或炎性疾病如哮喘，鼻炎，关节炎，多发性硬化，肠病，动脉硬化，心肌梗死和移植排斥。

5. 发明授权

US5820946A Method for fabricating ferroelectric thin film 失效
标题翻译：铁电薄膜的制造方法
公开(公告)号：US5820946A
公开(公告)日：1998-10-13
申请号：US646654
申请日：1996-05-08
申请人： Tae Song Kim , Joon Han Kim , Dong Heon Lee , Jeon-Kook Lee , Hyung Jin Jung
发明人： Tae Song Kim , Joon Han Kim , Dong Heon Lee , Jeon-Kook Lee , Hyung Jin Jung
IPC分类号： H01L21/20 , C23C14/02 , C23C14/08 , C23C14/34
CPC分类号： C23C14/088 , C23C14/024
摘要： A PZT ferroelectric thin film is sputter deposited on an electrode without microcracks while avoiding oxygen and Pb ion deficiencies at the electrode interface by initially forming a buffer layer containing a sufficient amount of a volatile Pb component and a sufficient amount of oxygen to easily absorb the energy of sputter particles. The PZT ferroelectric thin film can also be deposited by laser ablation.
摘要翻译： PZT铁电薄膜溅射沉积在电极上，没有微裂纹，同时通过初始形成含有足够量的挥发性Pb成分和足够量的氧以便容易吸收能量的缓冲层，同时避免在电极界面处的氧和Pb离子缺陷的溅射颗粒。 PZT铁电薄膜也可以通过激光烧蚀沉积。

6. 发明授权

US07002125B2 Commercial microwave oven with arranged components for heat dissipation 失效
标题翻译：商业微波炉，配有散热元件
公开(公告)号：US07002125B2
公开(公告)日：2006-02-21
申请号：US10997907
申请日：2004-11-29
申请人： Dong Heon Lee
发明人： Dong Heon Lee
IPC分类号： H05B6/70
CPC分类号： H05B6/642 , H05B2206/044
摘要： A microwave oven is provided, which includes a main cabinet for enclosing and protecting various components, having air inlet holes, a base frame under the main cabinet having a box form with an opened top and a front part with a plurality of air outlet holes, a bottom plate on the base frame, an inner case in a space above one side part of the bottom plate, the inner case having a cooking chamber formed therein, at least one magnetron, a transformer for regulating a voltage provided to the magnetron, at least one waveguide, a fan in a rear of outside of the inner case, and a flow guide for guiding air passed through the magnetron toward air outlet holes, thereby cooling components effectively, reducing a volume, and cost of the product.
摘要翻译：提供了一种微波炉，其包括用于封闭和保护各种部件的主柜，具有进气孔，主柜下方的底架，具有敞开的顶部的箱形，以及具有多个出气孔的前部，在底架上的底板，在底板的一个侧面上方的空间中的内壳，内壳具有形成在其中的烹饪室，至少一个磁控管，用于调节提供给磁控管的电压的变压器，至少一个波导，在内壳的外部后部的风扇，以及用于引导通过磁控管的空气朝向空气出口孔引导的流动引导件，从而有效地冷却部件，减少产品的体积和成本。

7. 发明授权

US06909079B2 Microwave oven having an internal components cooling structure 失效
标题翻译：微波炉具有内部部件冷却结构
公开(公告)号：US06909079B2
公开(公告)日：2005-06-21
申请号：US10713271
申请日：2003-11-17
申请人： Dong Heon Lee , Sang Ryul Lee , Yang Kyeong Kim , Wan Soo Kim
发明人： Dong Heon Lee , Sang Ryul Lee , Yang Kyeong Kim , Wan Soo Kim
IPC分类号： F24C7/02 , H05B6/80 , H05B6/64
CPC分类号： H05B6/642
摘要： Microwave oven including an outer case forming a top and sides of a cabinet, a base plate forming a bottom of the cabinet, a front panel and a rear panel mounted in a front part and a rear part of the base plate for forming a front surface and a rear surface respectively, an inner case forming a cooking chamber on the base plate, first and second transformer mounted at corners of one side of the base plate, a fan above the second transformer for drawing external air, a fan motor connected to the fan for providing a driving power to the fan, a fan housing for protecting the fan, an air duct between the first and second transformers, having one end in communication with the fan housing and the other end branched to first and second branch ducts, and first and second magnetron on an outside surface of the inner case, the first and second magnetron connected to the first and second branch ducts respectively, thereby cooling various components of the microwave oven, smoothly.
摘要翻译：微波炉包括形成机壳的顶部和侧面的外壳，形成机壳底部的基板，安装在基板的前部和后部中的前面板和后面板，用于形成前表面和后表面，分别在基板上形成烹饪室的内壳，安装在基板一侧的角落的第一和第二变压器，用于抽出外部空气的第二变压器上方的风扇，连接到用于为风扇提供驱动力的风扇，用于保护风扇的风扇壳体，在第一和第二变压器之间的空气管道，其一端与风扇壳体连通，另一端分支到第一和第二分支管道，以及第一和第二磁控管在内壳的外表面上，第一和第二磁控管分别连接到第一和第二分支管，从而平滑地冷却微波炉的各种部件。

8. 发明授权

US07120194B2 System for moving image data using wireless communication and the method of the same 失效
公开(公告)号：US07120194B2
公开(公告)日：2006-10-10
申请号：US10168494
申请日：2000-12-22
申请人： Dong Heon Lee
发明人： Dong Heon Lee
IPC分类号： H04B1/66
CPC分类号： H04N21/6131 , H04M1/725 , H04N19/17 , H04N19/46 , H04N19/503 , H04N19/85 , H04N21/43637 , H04N21/4622 , H04N21/4782
摘要： A home multimedia storage system includes an analog storing part for storing analog signal from a displayer in a video tape and playing the stored analog signal, and an analog/digital converting part for converting an analog signal from the displayer into a digital signal. A digital storing part is provided to store the digital signal converted by the analog/digital converting part and playing the stored digital signal. A digital/analog converting part also provided to convert the digital data output from the digital storing part into an analog play signal. A controller selects and transmits one of the analog signal stored in the analog storing part and the digital signal stored in the digital storing part to the displayer during a sound/image playback operation.

9. 发明授权

US06838649B2 Commercial microwave oven 失效
标题翻译：商业微波炉
公开(公告)号：US06838649B2
公开(公告)日：2005-01-04
申请号：US10716528
申请日：2003-11-20
申请人： Dong Heon Lee
发明人： Dong Heon Lee
IPC分类号： F24C7/02 , H05B6/80 , H05B6/70
CPC分类号： H05B6/642 , H05B2206/044
摘要： Commercial microwave oven including a main cabinet for enclosing and protecting various components, having air inlet holes, a base frame under the main cabinet having a box form with an opened top and a front part with a plurality of air outlet holes, a bottom plate on the base frame, an inner case in a space above one side part of the bottom plate, the inner case having a cooking chamber formed therein, a magnetron on a lower part of an outside of the inner case, a transformer for regulating a voltage provided to the magnetron, a waveguide on an underside of the bottom plate, a fan in a rear of outside of the inner case, and a flow guide for guiding air passed through the magnetron toward air outlet holes, thereby cooling components effectively, reducing a volume, and cost of the product.

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