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1. 发明授权

US06437048B1 Molded resin articles 失效
标题翻译：模塑树脂制品
公开(公告)号：US06437048B1
公开(公告)日：2002-08-20
申请号：US09029484
申请日：1998-07-07
申请人： Jun Saito , Hideo Nobuhara , Shingo Kikukawa , Hitoshi Sato , Akira Yamauchi , Kazuhiro Kimura , Tadashi Tanaka , Yoichi Kugimiya , Yoshitaka Morimoto , Hiroaki Ito , Tooru Fukazawa , Hiroyuki Maehara , Yasuhiro Shiraishi , Yuichi Yamanaka , Masataka Sugimoto , Hirohisa Ishii , Masahiko Taniguchi , Toshiki Yamamoto , Yasuhiko Nakagawa , Junichiro Yokota , Shouji Kawano
发明人： Jun Saito , Hideo Nobuhara , Shingo Kikukawa , Hitoshi Sato , Akira Yamauchi , Kazuhiro Kimura , Tadashi Tanaka , Yoichi Kugimiya , Yoshitaka Morimoto , Hiroaki Ito , Tooru Fukazawa , Hiroyuki Maehara , Yasuhiro Shiraishi , Yuichi Yamanaka , Masataka Sugimoto , Hirohisa Ishii , Masahiko Taniguchi , Toshiki Yamamoto , Yasuhiko Nakagawa , Junichiro Yokota , Shouji Kawano
IPC分类号： B29D2200
CPC分类号： C08F10/00 , C08F110/02 , C08F110/06 , C08F210/06 , C08L23/04 , C08L23/06 , C08L23/10 , C08L2205/02 , C08L2205/18 , Y10T428/1352 , C08F4/6492 , C08L2666/04 , C08F2500/17 , C08F2500/12 , C08F2500/11 , C08F2500/26 , C08F210/16 , C08F210/08
摘要： A plastic molded product of olefin (co)polymer composition comprises 0.01-5.0 weight parts high molecular weight polyethylene with an intrinsic viscosity &eegr;E in the range of 15-100 dl/g measured in 135° C. tetralin and preferably 100 weight parts polypropylene. The high molecular weight polyethylene has an average particle size in the range of 1-5000 nm and is finely dispersed as fine granules in the polypropylene, so that high melt strength and high crystallization temperature are attained, enabling various molding methods to be performed with high speed productivity. Using the polymer composition, plastics such as a resin foam, a film, a sheet, a layered plastic article with a coated substrate surface, a hollow plastic article, an injection molded plastic article, a fiber, a nonwoven web or a continuous tube-shaped plastic are provided. The olefin (co)polymer composition is obtained by preparing high molecular weight polyethylene granules using e.g. a titanium transition metal compound catalyst, and adding these, e.g. as a polymerization catalyst of propylene, singly or together with a polyolefin preparing catalyst.
摘要翻译：烯烃（共）聚合物组合物的塑性模制产品包含0.01-5.0重量份的高分子量聚乙烯，其特性粘度η为15-100dl / g，在135℃四氢化萘中测量，优选100重量份聚丙烯。高分子量聚乙烯的平均粒度为1-5000nm，在聚丙烯中作为细颗粒精细分散，从而获得高熔体强度和高结晶温度，能够实现各种成型方法的高效高效率。使用聚合物组合物，诸如树脂泡沫，薄膜，片材，具有涂覆的基材表面的分层塑料制品，中空塑料制品，注射成型的塑料制品，纤维，非织造纤维网或连续的管状聚合物组合物，提供了塑料。烯烃（共）聚合物组合物是通过使用例如制备高分子量聚乙烯颗粒来获得的。钛过渡金属化合物催化剂，并加入其中。作为丙烯的聚合催化剂，单独或与聚烯烃制备催化剂一起。

2. 发明授权

US6156845A Polyolefin composition and method of making 失效
标题翻译：聚烯烃组合物及其制备方法
公开(公告)号：US6156845A
公开(公告)日：2000-12-05
申请号：US809863
申请日：1997-04-02
申请人： Jun Saito , Hideo Nobuhara , Shingo Kikukawa , Hitoshi Sato , Akira Yamauchi
发明人： Jun Saito , Hideo Nobuhara , Shingo Kikukawa , Hitoshi Sato , Akira Yamauchi
IPC分类号： C08F4/642 , C08F4/649 , C08F4/651 , C08F4/654 , C08F4/655 , C08F10/00 , C08F10/06 , C08F110/02 , C08F110/06 , C08F210/06 , C08L23/02 , C08L23/04 , C08L23/10 , C08L23/00 , C08F255/02 , C08F255/08 , C08L23/16
CPC分类号： C08L23/02 , C08F10/00 , C08L23/04 , C08L23/10 , C08F10/06 , C08F110/02 , C08F110/06 , C08F210/06 , C08L2314/02 , Y10S526/904
摘要： An olefin (co-)polymer composition including 0.01 to 5.0 weight parts of high molecular weight polyethylene which is an ethylene homopolymer or an ethylene-olefin copolymer containing 50 weight % or more of an ethylene polymerization unit; and 100 weight parts of an olefin (co-)polymer other than the high molecular weight polyethylene, wherein said high molecular weight polyethylene has an intrinsic viscosity [.eta..sub.E ] of 15 to 100 dl/g measured in tetralin at 135.degree. C. or more, and said high molecular weight polyethylene exists as dispersed fine particles having a numerical average particle size of 1 to 5000 nm.
摘要翻译： PCT No.PCT / JP96 / 03028 Sec。 371日期1997年4月2日 102（e）1997年4月2日PCT PCT 1996年10月17日PCT公布。第WO94 / 14725号公报日期1997年04月24日包含0.01〜5.0重量份作为乙烯均聚物的高分子量聚乙烯或含有50重量％以上的乙烯聚合单元的乙烯 - 烯烃共聚物的烯烃（共）聚合物组合物，和100重量份的除了高分子量聚乙烯之外的烯烃（共）聚合物，其中所述高分子量聚乙烯在135℃下在四氢化萘中测得的特性粘度[η]为15-100dl / g，或并且所述高分子量聚乙烯作为数均粒径为1〜5000nm的分散微粒存在。

3. 发明授权

US06231804B1 Modified olefin (co)polymer composition, process for preparing the same, and modified olefin (co)polymer composition molding 失效
标题翻译：改性烯烃（共）聚合物组合物，其制备方法和改性烯烃（共）聚合物组合物成型
公开(公告)号：US06231804B1
公开(公告)日：2001-05-15
申请号：US09402327
申请日：1999-10-01
申请人： Akira Yamauchi , Shingo Kikukawa , Jun Saito , Hitoshi Sato
发明人： Akira Yamauchi , Shingo Kikukawa , Jun Saito , Hitoshi Sato
IPC分类号： C08L2302
CPC分类号： C08L23/04 , C08F10/00 , C08F110/02 , C08F210/06 , C08F255/02 , C08L23/06 , C08L23/10 , C08L51/06 , C08L2205/02 , C08L2312/00 , C08L2314/02 , C08F4/6465 , C08F4/651 , C08F4/6565 , C08F2/44 , C08L2666/04 , C08L2666/06 , C08L2666/02 , C08F2500/01 , C08F210/16 , C08F2500/11 , C08F2500/17
摘要： A high molecular weight polyethylene prepared by preliminary polymerization is added at the time of main polymerization of an olefin, for example, propylene, to prepare an olefin (co)polymer composition comprising the above high molecular weight polyethylene finely dispersed as fine particles in the polyolefin, such as polypropylene, and a cross-linked structure is formed in the olefin (co)polymer composition. This process can provide a modified olefin (co)polymer composition improved in the strength in a molten state in terms of melt tension or the like and in crystallization temperature and excellent in moldability such as high-speed producibility, and a molded modified olefin (co)polymer composition excellent in properties such as heat resistance and rigidity.
摘要翻译：在烯烃（例如丙烯）的主聚合时，通过预聚合制备的高分子量聚乙烯，以制备包含在聚烯烃中作为细颗粒细分散的上述高分子量聚乙烯的烯烃（共）聚合物组合物，如聚丙烯，在烯烃（共）聚合物组合物中形成交联结构。该方法可以提供改进的熔融状态下的熔融强度强度的改性烯烃（共）聚合物组合物，以及结晶温度，成型性如高速可生产性优异的成型改性烯烃（共）聚合物组合物，其性能如耐热性和刚性优异。

4. 发明授权

US06303696B1 Propylene (co)polymer composition using metallocene catalyst 失效
标题翻译：使用金属茂催化剂的丙烯（共）聚合物组合物
公开(公告)号：US06303696B1
公开(公告)日：2001-10-16
申请号：US09044708
申请日：1998-03-19
申请人： Tsutomu Ushioda , Jun Saito , Mototake Tsutsui , Shingo Kikukawa , Akira Yamauchi
发明人： Tsutomu Ushioda , Jun Saito , Mototake Tsutsui , Shingo Kikukawa , Akira Yamauchi
IPC分类号： C08F4642
CPC分类号： C08L23/02 , C08K5/098 , C08K5/13 , C08L23/06 , C08L23/10 , C08L2205/02 , Y10S526/943 , C08L2666/24 , C08L2666/04
摘要： The present invention provides a polypropylene composition having a high melt tension and an excellent formability by blending polypropylene (I) produced with a metallocene catalyst type and an olefin (co)polymer (II) comprising 0.01 to 5 parts by weight of the following component (II-1) and 100 parts by weight of the following component (II-2); (II-1): an ethylene homopolymer or an ethylene-olefin copolymer comprising at least 50 wt % ethylene polymerization units, which is a high molecular weight polyethylene having an intrinsic viscosity [&eegr;E] measured in tetralin at 135° C. of 15 to 100 dl/g; and (II-2): polypropylene.
摘要翻译：本发明提供一种聚丙烯组合物，其具有高熔体张力和优异的成形性，通过共混由茂金属催化剂型产生的聚丙烯（I）和烯烃（共）聚合物（II），其包含0.01至5重量份的以下组分（ II-1）和100重量份的下列组分（II-2）; （II-1）：包含至少50重量％乙烯聚合单元的乙烯均聚物或乙烯 - 烯烃共聚物，其是在135℃下在四氢化萘中测得的特性粘度η为15〜 100 dl / g; 和（II-2）：聚丙烯。

5. 发明授权

US06235845B1 Olefin (co)polymer composition 失效
标题翻译：烯烃（共）聚合物组成
公开(公告)号：US06235845B1
公开(公告)日：2001-05-22
申请号：US09462249
申请日：2000-01-05
申请人： Akira Yamauchi , Jun Saito , Hiroyuki Maehara , Yuuichi Yamanaka
发明人： Akira Yamauchi , Jun Saito , Hiroyuki Maehara , Yuuichi Yamanaka
IPC分类号： C08L2302
CPC分类号： C08L23/02 , C08L23/06 , C08L23/0815 , C08L23/10 , C08L2205/02 , C08L2666/04
摘要： An olefin (co)polymer composition of the present invention comprises 99 to 70 wt. % of olefin (co)polymer (I) and 1 to 30 wt. % of polyethylene-based polymer (II). The olefin (co)polymer (I) comprises 0.01 to 5.0 parts by weight of high molecular weight polyethylene (a) having an intrinsic viscosity &eegr;A measured in tetralin at 135° C. of 15 to 100 dl/g, which is an ethylene homopolymer or an ethylene-olefin copolymer comprising at least 50 wt. % of ethylene polymerization units, and 100 parts by weight of olefin (co)polymer (b) other than the high molecular weight polyethylene. The polyethylene-based polymer (II) has an intrinsic viscosity &eegr;II measured in tetralin at 135° C. of 0.10 to 10 dl/g, which is an ethylene homopolymer or an ethylene copolymer comprising at least 50 wt. % of ethylene polymerization units. Thus, the present invention provides a polypropylene-based olefin (co)polymer composition having excellent formability that is suitable for thermoforming such as vacuum forming and pressure forming, blow molding and foam molding, especially suitable for thermoforming.
摘要翻译：本发明的烯烃（共）聚合物组合物包含99至70wt。％的烯烃（共）聚合物（I）和1至30wt。％的聚乙烯类聚合物（II）。烯烃（共）聚合物（I）包含0.01至5.0重量份在135℃下在四氢化萘中测量的特性粘度etaA为15至100dl / g的高分子量聚乙烯（a），其为乙烯均聚物或包含至少50重量％的乙烯 - 烯烃共聚物。％的乙烯聚合单元和100重量份的除了高分子量聚乙烯之外的烯烃（共）聚合物（b）。聚乙烯基聚合物（II）在135℃的四氢化萘中测得的特性粘度等于0.10-10dl / g，其为乙烯均聚物或乙烯共聚物，其包含至少50wt。％的乙烯聚合单元。因此，本发明提供了一种具有优异成形性的聚丙烯基烯烃（共）聚合物组合物，其适用于诸如真空成型和压力成形，吹塑和泡沫模塑之类的热成型，特别适用于热成型。

6. 发明授权

US06271310B1 Polypropylene composition and process for producing the same 有权
标题翻译：聚丙烯组合物及其制备方法
公开(公告)号：US06271310B1
公开(公告)日：2001-08-07
申请号：US09402998
申请日：1999-10-15
申请人： Chikashi Okayama , Takanori Nakashima , Akira Yamauchi , Jun Saito , Michitaka Sasaki
发明人： Chikashi Okayama , Takanori Nakashima , Akira Yamauchi , Jun Saito , Michitaka Sasaki
IPC分类号： C08F800
CPC分类号： C08L23/10 , C08L23/02 , C08L23/0815 , C08L23/12 , C08L23/16 , C08L2666/04
摘要： A polypropylene composition which contains 0.01 to 5 parts by weight of an olefin (co)polymer (a) having an intrinsic viscosity of 15 to 100 dl/g, 100 parts by weight of a propylene homopolymer (b) having an intrinsic viscosity of 0.2 to 10 dl/g, and 28 to 300 parts by weight of an ethylene/propylene copolymer (c) having an intrinsic viscosity of 0.2 to 10 dl/g, and in which the ratio of the melt flow rate of the homopolymer (b) to that of the copolymer (c), MFRPP/MFRRC, is 0.3 to 4 and the product of the ratio of the intrinsic viscosity of the copolymer (c) to that of the homopolymer (b), [&eegr;]RC/[&eegr;]PP, and the weight ratio of the amount of the homopolymer (b) to that of the copolymer (c), WPP/WRC, is in the range of from 0.2 to 3.0. The composition has high melt tension, high crystallization temperature, and excellent thermal stability, and yields a molded article having excellent transparency, reduced molding shrinkage, and excellent resistance to whitening by impact or bending.
摘要翻译：含有0.01〜5重量份特性粘度为15〜100dl / g的烯烃（共）聚合物（a），100重量份特性粘度为0.2的丙烯均聚物（b）的聚丙烯组合物至10dl / g，和28-300重量份特性粘度为0.2-10dl / g的乙烯/丙烯共聚物（c），其中均聚物（b）的熔体流动速率共聚物（c）的MFRPP / MFRRC为0.3〜4，共聚物（c）的特性粘度与均聚物（b）的特性粘度的比，ηRC /η PP，均聚物（b）与共聚物（c）的重量比WPP / WRC的重量比在0.2〜3.0的范围内。该组合物具有高熔体张力，高结晶温度和优异的热稳定性，并且得到具有优异的透明性，降低的成型收缩率和通过冲击或弯曲而具有优异的抗白化性能的模制品。

7. 发明申请

US20140048805A1 BONDING-SUBSTRATE FABRICATION METHOD, BONDING SUBSTRATE, SUBSTRATE BONDING METHOD, BONDING-SUBSTRATE FABRICATION APPARATUS, AND SUBSTRATE ASSEMBLY 有权
公开(公告)号：US20140048805A1
公开(公告)日：2014-02-20
申请号：US13982697
申请日：2012-01-30
申请人： Tadatomo Suga , Akira Yamauchi , Ryuichi Kondou
发明人： Tadatomo Suga , Akira Yamauchi , Ryuichi Kondou
IPC分类号： H01L21/322 , H01L29/04 , H01L29/36 , H01L21/263
CPC分类号： H01L21/3221 , B23K1/20 , B23K20/24 , B23K2101/36 , H01J37/317 , H01J2237/202 , H01J2237/3165 , H01L21/02046 , H01L21/2007 , H01L21/263 , H01L21/302 , H01L21/67092 , H01L21/67115 , H01L21/76251 , H01L29/04 , H01L29/36
摘要： [Problem] To provide a substrate bonding technique having a wide range of application. [Solution] A silicon thin film is formed on a bonding surface, and the interface with the substrate is surface-treated using energetic particles/metal particles.

8. 发明授权

US08580743B2 Modified galectin 9 proteins and methods of treatment using them 有权
标题翻译：修饰的半乳凝素9蛋白和使用它们的治疗方法
公开(公告)号：US08580743B2
公开(公告)日：2013-11-12
申请号：US13591366
申请日：2012-08-22
申请人： Nozomu Nishi , Mitsuomi Hirashima , Akira Yamauchi , Aiko Ito
发明人： Nozomu Nishi , Mitsuomi Hirashima , Akira Yamauchi , Aiko Ito
IPC分类号： A61K38/00 , A61K35/02 , A61K35/04 , C07K14/00 , C12P21/00
CPC分类号： C07K14/4726 , A61K38/00 , A61K48/00 , Y02A50/402 , Y02A50/406 , Y02A50/411 , Y02A50/463 , Y02A50/471 , Y02A50/475 , Y02A50/48
摘要： A recombinant galectin 9 (rGal 9) is provided which exhibits an immune system-mediated action and a direct action on tumor cells (i.e., activity of inducing the intercellular adhesion and apoptosis of the tumor cells), thereby potent in inducing the inhibition of cancer metastasis and reduction. Moreover, the rGal 9 exerts no efficacy on non-activated lymphocytes but can induce apoptosis in activated T cells, in particular, CD4-positive T cells causing an excessive immune response.
摘要翻译：提供了重组galectin 9（rGal 9），其表现出免疫系统介导的作用和对肿瘤细胞的直接作用（即，诱导肿瘤细胞的细胞间粘附和凋亡的活性），从而有效诱导癌症的抑制转移和还原。此外，rGal9对非活化淋巴细胞没有效力，但可以诱导活化的T细胞，特别是导致过度免疫应答的CD4阳性T细胞的细胞凋亡。

9. 发明申请

US20120127485A1 PRESSURE APPLICATION APPARATUS AND PRESSURE APPLICATION METHOD 有权
标题翻译：压力应用装置和压力应用方法
公开(公告)号：US20120127485A1
公开(公告)日：2012-05-24
申请号：US13386788
申请日：2010-03-09
申请人： Akira Yamauchi
发明人： Akira Yamauchi
IPC分类号： G01B11/14
CPC分类号： H01L24/75 , G01B11/14 , H01L23/544 , H01L24/81 , H01L24/83 , H01L2224/131 , H01L2224/13124 , H01L2224/13144 , H01L2224/13147 , H01L2224/16225 , H01L2224/75 , H01L2224/75301 , H01L2224/757 , H01L2224/81009 , H01L2224/81121 , H01L2224/8113 , H01L2224/81132 , H01L2224/81191 , H01L2224/81204 , H01L2224/81801 , H01L2224/83121 , H01L2924/0001 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01029 , H01L2924/01033 , H01L2924/0107 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12042 , H01L2924/1461 , H01L2924/15788 , H01L2924/181 , H05K1/0269 , H05K3/303 , H05K2201/09918 , H05K2203/166 , Y02P70/613 , H01L2924/00012 , H01L2924/00014 , H01L2224/13099 , H01L2924/00
摘要： A pressure application technique is provided that enables two objects to be pressurized (e.g., objects to be bonded) to be positioned with greater accuracy before having pressure applied thereto. The objects to be pressurized are moved relative to each other in a Z direction such that the objects are brought into contact with each other (step S13). Then, a horizontal positional shift ΔD between the objects to be pressurized is measured in the contact state of the objects to be pressurized (step S14). Thereafter, positioning of the objects to be pressurized is again performed by moving the objects to be pressurized relative to each other in the horizontal direction, as a result of which the positional shift ΔD is corrected (step S17).
摘要翻译：提供了一种压力施加技术，其能够在施加压力之前使两个物体被加压（例如，待粘合的物体）以更高的准确度定位。要加压的物体在Z方向上彼此相对移动，使得物体彼此接触（步骤S13）。然后，在待加压物体的接触状态下测量待加压物体之间的水平位置移动量Dgr; D（步骤S14）。此后，通过在水平方向上相对于彼此移动要加压的物体来再次执行要加压的物体的定位，结果校正位置偏移＆Dgr; D（步骤S17）。

10. 发明申请

US20100330092A1 MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13 失效
标题翻译：具有对MMP13的中和活性的单克隆抗体
公开(公告)号：US20100330092A1
公开(公告)日：2010-12-30
申请号：US12668201
申请日：2008-07-08
申请人： Shoichi Naito , Junji Onoda , Akira Yamauchi , Yoshito Numata , Junji Kishono
发明人： Shoichi Naito , Junji Onoda , Akira Yamauchi , Yoshito Numata , Junji Kishono
IPC分类号： A61K39/395 , C07K16/40 , C12N5/16 , G01N33/573 , C12N9/99
CPC分类号： G01N33/573 , C07K16/40 , C07K2317/76 , G01N2333/8146
摘要： A neutralizing monoclonal antibody specifically reacting with MMP13, a method of neutralizing enzyme activity of MMP13 and an immunological measuring method each using the antibody, as well as a diagnostic agent and a pharmaceutical composition containing the antibody, are provided. Various antibodies to MMP13 have been hitherto obtained, but an antibody having neutralizing activity against MMP13 has not been obtained. The present inventors intensively studied, as a result, found out a neutralizing antibody having specificity for MMP13, resulting in completion of the present invention.
摘要翻译：提供了与MMP13特异性反应的中和单克隆抗体，中和MMP13的酶活性的方法和各自使用该抗体的免疫学测定方法，以及含有该抗体的诊断剂和药物组合物。迄今为止已经获得了MMP13的各种抗体，但是尚未获得具有针对MMP13的中和活性的抗体。本发明人深入研究了结果，发现了对MMP13具有特异性的中和抗体，从而完成了本发明。

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