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1. 发明专利

JP2004121231A Method for detecting target nucleic acid 有权
公开(公告)号：JP2004121231A
公开(公告)日：2004-04-22
申请号：JP2003304175
申请日：2003-08-28
申请人： Juki Corp , Tadashi Matsunaga , ジューキ株式会社 , 松永是
发明人： MARUYAMA KOHEI , NEMOTO ETSUO , YODA SEI , MATSUNAGA TADASHI
IPC分类号： G01N33/53 , C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/58 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To simply and efficiently detect a target nucleic acid in a sample, by clearly distinguishing the nucleic acid from another nucleic acid which has variation in one or more bases.
SOLUTION: An apparatus is so structured as to detect the target nucleic acid in a solution of the sample by distinguishing the nucleic acid from a variant nucleic acid having the variation in one or more bases, wherein the apparatus is used in conducting a hybridization method in which beads are used as a solid phase and a fluorescent or luminescent labeled probe is used as a nucleic acid probe. Further, the apparatus is so structured that a labeled probe which is not hybridized is washed and removed after hybridization reaction is completed, a solution for releasing the probe is added thereto, the target nucleic acid which is hybridized and fastened to the beads is made to be settled on a bottom surface of a container, the labeled probe is released from the beads to a supernatant by gradually raising a temperature of a reaction solution up to a temperature higher than a denaturation temperature of the target nucleic acid, and a quantity of the fluorescent light or the luminescent light is successively measured.
COPYRIGHT: (C)2004,JPO

2. 发明专利

JP2004028682A Measuring method of object substance 审中-公开
公开(公告)号：JP2004028682A
公开(公告)日：2004-01-29
申请号：JP2002183063
申请日：2002-06-24
申请人： Juki Corp , Tadashi Matsunaga , ジューキ株式会社 , 松永是
发明人： MARUYAMA KOHEI , NEMOTO ETSUO , UDAGAWA YUJI , MATSUNAGA TADASHI
IPC分类号： G01N33/53 , C12M1/40 , G01N21/78 , G01N33/543 , G01N33/566
摘要： PROBLEM TO BE SOLVED: To measure an object substance in a sample with a high sensitivity by detecting a fluorescent or luminous labelled substance bonded with beads.
SOLUTION: In a method of measuring the object substance in the sample by detecting the fluorescent or luminous labelled substance combined with the beads after a specific bond reaction using the beads is caused, the beads suspending after the reaction is settled on a bottom face and excitation light is cast onto the beads held settled on the bottom face, and then fluorescence or luminance caused is measured. By this method, a passage of the excitation light is not obstructed by the beads, and light emitted from the fluorescent or luminous substance reaches a detector directly so that a high detection sensitivity can be attained.
COPYRIGHT: (C)2004,JPO

3. 发明专利

JP2004024981A Detaching device for disposable chip for dispensing device 审中-公开
公开(公告)号：JP2004024981A
公开(公告)日：2004-01-29
申请号：JP2002183061
申请日：2002-06-24
申请人： Juki Corp , Tadashi Matsunaga , ジューキ株式会社 , 松永是
发明人： UDAGAWA YUJI , NEMOTO ETSUO , MARUYAMA KOHEI , MATSUNAGA TADASHI
IPC分类号： G01N35/10 , B01J4/00 , B01L3/02
摘要： PROBLEM TO BE SOLVED: To provide a detaching device of disposable chip for dispensing device which can efficiently detach a disposable chip from a dispensing nozzle part using upward and downward movement of the nozzle part. SOLUTION: The disposable chip is inserted by descending it into a through-hole of a substrate having the through-hole of larger diameter than the outside diameter of the disposable chip in the course of descending of the nozzle part fitting and holding the disposable chip, while a chip insertion control mechanism preventing the disposable chip from ascending from the through-hole in the course of ascending of the nozzle part. COPYRIGHT: (C)2004,JPO

4. 发明专利

JP2004028683A Automatic dispensing apparatus and liquid dispense method 有权
公开(公告)号：JP2004028683A
公开(公告)日：2004-01-29
申请号：JP2002183064
申请日：2002-06-24
申请人： Juki Corp , Tadashi Matsunaga , ジューキ株式会社 , 松永是
发明人： NEMOTO ETSUO , MARUYAMA KOHEI , UDAGAWA YUJI , MATSUNAGA TADASHI
IPC分类号： G01N1/00 , G01N35/10
摘要： PROBLEM TO BE SOLVED: To smoothly deliver a liquid sample or specimen into a well without allowing inclusion of bubbles. SOLUTION: An automatic dispensing apparatus comprises a dispensing head having a nozzle for sucking/delivering a liquid in a sample container having a plurality of the wells, a shaft driving means for transferring the dispensing head in X, Y and Z axis directions, pistons for sucking/delivering the liquid through the nozzle, piston driving means for driving the pistons and a control data storage section storing control data including speed change profile of the driving means calculated on the basis of data on delivery amounts and well shapes. The apparatus is further provided with a drive control means for raising a distal end of a tip mounted on the nozzle when the liquid is delivered into the well according to rise of a liquid level in the well in response to the amount of delivery and moving the same along an internal profile line of the well by reading the control data from the storage section and driving the respective driving means. COPYRIGHT: (C)2004,JPO

5. 发明专利

JP2004028681A Head for liquid dispensing apparatus 审中-公开
公开(公告)号：JP2004028681A
公开(公告)日：2004-01-29
申请号：JP2002183062
申请日：2002-06-24
申请人： Juki Corp , Tadashi Matsunaga , ジューキ株式会社 , 松永是
发明人： UDAGAWA YUJI , NEMOTO ETSUO , MARUYAMA KOHEI , MATSUNAGA TADASHI
IPC分类号： G01N35/10
摘要： PROBLEM TO BE SOLVED: To provide a head for a liquid dispensing apparatus which overcomes a defect due to displacement of a plate. SOLUTION: The dispensing head is mounted to the liquid dispensing apparatus, equipped with a plurality of tip nozzles and has a mechanism of mounted tips for sucking or discharging a solution in the reagent plate, a movement mechanism for freely moving along a Z axis and an X or Y axis and a positioning guide for contacting a side face of the reagent plate and moving the plate to a predetermined position in a XY plane while the head vertically and downwardly moves. COPYRIGHT: (C)2004,JPO

6. 发明专利

JP2003274925A Apparatus for automatically preparing nucleic acid and method for detecting nucleic acid in sample using the same 审中-公开
标题翻译：用于自动制备核酸的装置和使用该样品检测样品中的核酸的方法
公开(公告)号：JP2003274925A
公开(公告)日：2003-09-30
申请号：JP2002086380
申请日：2002-03-26
申请人： Juki Corp , Tokyo Univ Of Agriculture & Technology , ジューキ株式会社 , 東京農工大学長
发明人： YODA SEI , UDAGAWA YUJI , NEMOTO ETSUO , MARUYAMA KOHEI , MATSUNAGA TADASHI
IPC分类号： C12N15/09 , C12M1/00 , C12M1/32 , C12M1/38 , C12M1/42 , C12Q1/68
摘要： PROBLEM TO BE SOLVED: To automate a hybridization process requiring much time for detecting nucleic acids and a large space for experiment by very simple operation, bring a small size to an apparatus at the same time and simply and quickly prepare a single chain nucleic acid.
SOLUTION: The apparatus for automatically preparing the nucleic acid is constituted by installing at least (A) a reaction part having a reaction vessel holder, a heating and cooling device and a magnetic force controller, (B) a chip rack/supernatant recovering part having a chip rack and a supernatant recovery vessel, (C) a reagent part having a reagent-holding vessel and (D) a plurality of chip nozzles, having a mechanism for attaching and detaching the chip to and from the nozzle and a mechanism for sucking and injecting a treatment solution by attached chip and installing a head part installed with an arm unit movable toward X-Z axis direction. The method for detecting the nucleic acid in a sample uses the apparatus.
COPYRIGHT: (C)2003,JPO
摘要翻译：要解决的问题：为了使通过非常简单的操作需要大量时间来检测核酸和大的实验空间的杂交方法自动化，同时将小尺寸的设备带到设备上，并且简单且快速地制备单链核酸。解决方案：用于自动制备核酸的装置通过至少安装（A）具有反应容器支架的反应部件，加热和冷却装置和磁力控制器，（B）芯片架/上清液具有芯片架和上清液回收容器的回收部分，（C）具有试剂保持容器的试剂部分和（D）多个芯片喷嘴，具有用于将芯片连接到喷嘴和从喷嘴分离的机构，以及通过安装芯片吸取和注入处理溶液的机构，并安装安装有能够朝向XZ轴方向移动的臂单元的头部。用于检测样品中核酸的方法使用该装置。版权所有（C）2003，JPO

7. 发明专利

JP2007205774A Fluorescence measuring instrument 审中-公开
标题翻译：荧光测量仪器
公开(公告)号：JP2007205774A
公开(公告)日：2007-08-16
申请号：JP2006023006
申请日：2006-01-31
申请人： Juki Corp , Juki株式会社 , Tokyo Univ Of Agriculture & Technology , 国立大学法人東京農工大学
发明人： MARUYAMA KOHEI , MATSUNAGA TADASHI , TAKEYAMA HARUKO
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , G01J3/02 , G01J3/0218 , G01J3/0235 , G01J3/12 , G01J3/4406 , G01N2021/6419 , G01N2021/6484 , G01N2201/0627
摘要： PROBLEM TO BE SOLVED: To provide an inexpensive small-sized fluorescence measuring instrument improved in mechanical reliability.
SOLUTION: The fluorescence measuring instrument is constituted so as to irradiate a sample with exciting light and to measure the fluorescence emitted from the fluorescent substance in the sample to measure the measuring target in the sample, and has: an exciting light source composed of a plurality of LEDs having different emission wavelengths; a wavelength selecting filter for exciting light which permits the transmission only of a specific wavelength component in the exciting light emitted from the exciting light source; a plurality of floodlight projecting fibers for transmitting exciting light to irradiate the leading end of the sample; a plurality of light detection fibers for detecting the fluorescence emitted from the sample; an optical fiber positioning holder for holding a light projecting and detecting part composed of the floodlight projecting fibers and the light detection fibers; a light detecting wavelength selecting filter for permitting the transmission of only the specific wavelength component in the detected fluorescence; and a light condensing fiber for bundling the transmitted light to one light quantity detector. The instrument is characterized by alternately lighting the exciting light source to measure the measuring target.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种改善机械可靠性的便宜的小型荧光测量仪器。解决方案：荧光测量仪器被构成为用激发光照射样品并测量样品中荧光物质发出的荧光，以测量样品中的测量目标，并具有：激发光源具有不同发射波长的多个LED; 用于激发光的波长选择滤光器，其允许仅从由激发光源发射的激发光中的特定波长分量的透射; 多个泛光投射光纤，用于透射激发光以照射样品的前端; 用于检测从样品发出的荧光的多个光检测光纤; 用于保持由泛光灯投射光纤和光检测光纤构成的光投射检测部的光纤定位保持架; 光检测用波长选择滤光器，用于仅检测所检测的荧光中的特定波长成分; 以及用于将透射光束捆绑到一个光量检测器的聚光光纤。仪器的特点是交替点亮激发光源来测量测量目标。版权所有（C）2007，JPO＆INPIT

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