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1. 发明申请

US20070077198A1 Method for preparing radiolabeled thymidine having low chromophoric byproducts 有权
公开(公告)号：US20070077198A1
公开(公告)日：2007-04-05
申请号：US11603703
申请日：2006-11-22
申请人： Joseph Walsh , Henry Padgett , Tanea Ysaguirre
发明人： Joseph Walsh , Henry Padgett , Tanea Ysaguirre
IPC分类号： A61K51/00 , C07H19/12
CPC分类号： A61K51/0491 , C07H19/048 , Y02P20/55
摘要： The invention is a method and related precursor for preparing 18F-FLT. The precursor has a butoxycarbonyl protecting group at the 5′-position that results in low amounts of chromophoric byproducts being formed during deprotection. The method for preparing 18F-FLT is efficient and makes the final purification step less complicated.

2. 发明申请

US20050131223A1 Method for preparing radiolabeled thymidine having low chromophoric byproducts 有权
标题翻译：制备具有低发色副产物的放射性标记的胸苷的方法
公开(公告)号：US20050131223A1
公开(公告)日：2005-06-16
申请号：US10736087
申请日：2003-12-15
申请人： Joseph Walsh , Henry Padgett , Tanea Ysaguirre
发明人： Joseph Walsh , Henry Padgett , Tanea Ysaguirre
IPC分类号： A61K20060101 , A61K51/00 , A61K51/04 , A61M36/14 , C07H19/048
CPC分类号： A61K51/0491 , C07H19/048 , Y02P20/55
摘要： The invention is a method and related precursor for preparing 18F-FLT. The precursor has a butoxycarbonyl protecting group at the 5′-position that results in low amounts of chromophoric byproducts being formed during deprotection. The method for preparing 18F-FLT is efficient and makes the final purification step less complicated.
摘要翻译：本发明是一种用于制备F-FL-FLT的方法和相关前体。该前体在5'-位具有丁氧羰基保护基，导致在脱保护期间形成少量的发色副产物。制备 F-FLT的方法是有效的，并且使得最终的纯化步骤不那么复杂。

3. 发明申请

US20050131224A1 Method for preparing radiolabeled thymidine 审中-公开
标题翻译：制备放射性标记的胸苷的方法
公开(公告)号：US20050131224A1
公开(公告)日：2005-06-16
申请号：US10736084
申请日：2003-12-15
申请人： Joseph Walsh , Henry Padgett
发明人： Joseph Walsh , Henry Padgett
IPC分类号： A61K20060101 , A61K31/70 , C07H19/06
CPC分类号： C07H19/06
摘要： The invention is a novel method and precursor for preparing radiolabeled nucleosides. In particular, the invention is useful for preparing 3′-[18F]fluorothymidine. The method uses an enol group that is attached to the 2-position on the pyrimidine ring. The enol group attenuates thymidines activity so that the thymidine is easily radiolabeled in short number of steps with good yield.
摘要翻译：本发明是制备放射性标记核苷的新方法和前体。特别地，本发明可用于制备3' - [[18 F]氟胸苷。该方法使用连接在嘧啶环上2位上的烯醇基团。烯醇基团减少胸腺嘧啶的活性，使得胸苷容易以短的步骤以良好的产率放射标记。

4. 发明申请

US20050137421A1 Method for making fluorine labled L-Dopa 有权
标题翻译：制造氟化合物的方法
公开(公告)号：US20050137421A1
公开(公告)日：2005-06-23
申请号：US10742023
申请日：2003-12-19
申请人： Joseph Walsh , Henry Padgett
发明人： Joseph Walsh , Henry Padgett
IPC分类号： C07C227/32 , C07C229/36 , C07C269/06 , C07C271/22
CPC分类号： C07C271/22 , C07B2200/05 , C07B2200/07 , C07C227/32 , C07C229/36 , C07C269/06
摘要： The invention relates to a method for preparing F-Dopa and 18F-Dopa and intermediates that are useful in the method. The invention is a method that synthesizes F-Dopa and 18F-Dopa in good yield with high enantiopurity without the need for further transformations. The method includes the step of reacting a benzaldehyde derivative with a phosphonic acid derivative to produces an olefin intermediate that can be asymmetrically hydrogenated to produce the desired enantiomer.
摘要翻译：本发明涉及一种制备在该方法中有用的F-多巴和十八氟多卡因和中间体的方法。本发明是以高的对映体纯度合成F-Dopa和16 F-多巴的方法，而不需要进一步的转化。该方法包括使苯甲醛衍生物与膦酸衍生物反应以产生不对称氢化以产生所需对映异构体的烯烃中间体的步骤。

5. 发明授权

US07748590B2 Ultrasonic welding apparatus 失效
标题翻译：超声波焊接设备
公开(公告)号：US07748590B2
公开(公告)日：2010-07-06
申请号：US11129775
申请日：2005-05-16
申请人： Larry Reatherford , Elizabeth T. Hetrick , Daniel E. Wilkosz , Jan Skogsmo , Joseph Walsh
发明人： Larry Reatherford , Elizabeth T. Hetrick , Daniel E. Wilkosz , Jan Skogsmo , Joseph Walsh
IPC分类号： B23K1/06 , B23K37/00
CPC分类号： B23K20/10
摘要： An ultrasonic welding apparatus having an extractable sonotrode. The sonotrode having a non-threaded outer peripheral surface and a tapered mating surface that meets with a correspondingly tapered aperture formed in the end of the reed of the ultrasonic welding apparatus. In the preferred embodiment the ultrasonic welding apparatus includes a sonotrode removal mechanism for extracting the sonotrode from the reed.
摘要翻译：一种具有可提取超声波发生器的超声波焊接装置。超声波发生器具有无螺纹的外周表面和锥形配合表面，该锥形配合表面与形成在超声波焊接设备的钢筘端部的相应的锥形孔相遇。在优选实施例中，超声波焊接装置包括用于从簧片中提取超声波发生器的超声波去除机构。

6. 发明申请

US20070294271A1 Systems and methods for monitoring and detecting fraudulent uses of business applications 有权
标题翻译：用于监控和检测业务应用程序的欺诈性使用的系统和方法
公开(公告)号：US20070294271A1
公开(公告)日：2007-12-20
申请号：US11803439
申请日：2007-05-15
申请人： Jwahar Bammi , Bagepalli Krishna , Robert Posniak , Joseph Walsh
发明人： Jwahar Bammi , Bagepalli Krishna , Robert Posniak , Joseph Walsh
IPC分类号： G06F7/00
CPC分类号： G06Q10/00 , G06F11/3476 , G06F21/552
摘要： A systems and methods are described detect fraud in existing logs of raw data. There can be several disparate logs, each including data of disparate data types and generated by different and possibly unrelated software enterprise applications. The fraud management system aggregates and organizes the raw log data, extends the raw data with reference data, archives the data in a manner that facilitates efficient access and processing of the data, allows for investigation of potentially fraudulent usage scenarios, and uses the results of the investigation to identify patterns of data that correspond to correspond to high risk usage scenarios and/or process steps. In subsequent processing, archived data can be compared against the identified patterns corresponding to high risk usage scenarios to detect matches, and the invention thereby automatically detects high risk usage scenarios and issues appropriate alerts and reports.
摘要翻译：描述了原始数据的现有日志中的检测欺诈的系统和方法。可以有几个不同的日志，每个日志包括不同数据类型的数据，并由不同的和可能不相关的软件企业应用程序生成。欺诈管理系统聚合和组织原始日志数据，使用参考数据扩展原始数据，以有助于数据有效访问和处理的方式存档数据，允许调查潜在的欺诈性使用场景，并使用用于识别对应于高风险使用场景和/或处理步骤的数据模式的调查。在后续处理中，归档数据可以与对应于高风险使用场景的识别模式进行比较，以检测匹配，因此本发明自动检测高风险使用场景并发出适当的警报和报告。

7. 发明申请

US20070290573A1 Method of controlling a piezoelectric actuator 有权
标题翻译：控制压电致动器的方法
公开(公告)号：US20070290573A1
公开(公告)日：2007-12-20
申请号：US11804923
申请日：2007-05-21
申请人： Martin Sykes , Joseph Walsh , Daniel Hopley , Peter Griffin
发明人： Martin Sykes , Joseph Walsh , Daniel Hopley , Peter Griffin
IPC分类号： H01L41/00
CPC分类号： F02D41/2096 , F02D2041/2003 , F02D2041/2006 , F02D2041/2037 , F02D2041/2051 , F02D2041/2058 , F02D2041/2065 , F02D2041/2072 , F02D2041/2082 , F02D2200/0602 , H02N2/067
摘要： A method for controlling the displacement of a stack of a piezoelectric actuator for use in a fuel injector comprises determining a desired amount of charge (ΔQ) to be added or removed from the stack. The method further comprises determining an operating parameter of the fuel system and selecting a drive current level (PO, SO) and a drive time (topen, tclose) in accordance with the desired amount of charge (ΔQ) and the operating parameter, and driving the drive current through the stack for the drive time (topen, tclose) in order to add or remove the desired amount of charge (ΔQ).
摘要翻译：用于控制用于燃料喷射器的压电致动器的堆叠的位移的方法包括确定要从堆叠中添加或移除的期望的电荷量（DeltaQ）。该方法进一步包括确定燃料系统的运行参数，并依照下述方式选择驱动电流电平（PO，SO）和驱动时间（t开启，闭合）具有期望的电荷量（DeltaQ）和操作参数，并且驱动驱动电流通过堆栈以驱动驱动时间（t开<！ - SIPO - >关闭），以便添加或删除所需的电荷量（DeltaQ）。

8. 发明申请

US20070034697A1 Low-power hand-held transaction device 失效
标题翻译：低功率手持交易设备
公开(公告)号：US20070034697A1
公开(公告)日：2007-02-15
申请号：US11499249
申请日：2006-08-03
申请人： Joseph Walsh
发明人： Joseph Walsh
IPC分类号： G06K7/10 , G06K7/00
CPC分类号： G06K7/084 , G06K7/10722 , H04M1/2755 , H04M2250/14
摘要： An electronic hand-held device and method for inputting and sending requests and for receiving and outputting responses to the requests. The electronic hand-held device is a coupled to a telecommunications link over which requests are sent and responses are received. The electronic hand-held device can input request data in any number of different information media, including audio tones and voice signals, mechanical input to a keypad, printed bar codes, magnetic data stored in credit cards, and electronic data stored in electronic smart cards. The electronic hand-held device can output responses through an audio speaker, a visual LCD display device, and, optionally, through other output devices including printers. The electronic hand-held device is especially well suited for order entry and acquisition of product information.
摘要翻译：一种用于输入和发送请求并用于接收和输出对请求的响应的电子手持设备和方法。电子手持设备耦合到电信链路，通过该电信链路发送请求并接收响应。电子手持设备可以输入任何数量的不同信息媒体的请求数据，包括音频音调和语音信号，对小键盘的机械输入，打印的条形码，存储在信用卡中的磁数据以及存储在电子智能卡中的电子数据。电子手持装置可以通过音频扬声器，可视LCD显示装置以及可选地通过包括打印机的其它输出装置输出响应。电子手持设备特别适用于订购输入和获取产品信息。

9. 发明申请

US20060263293A1 Click chemistry method for synthesizing molecular imaging probes 审中-公开
标题翻译：点击合成分子成像探针的化学方法
公开(公告)号：US20060263293A1
公开(公告)日：2006-11-23
申请号：US11413596
申请日：2006-04-27
申请人： Hartmuth Kolb , Joseph Walsh , Kai Chen
发明人： Hartmuth Kolb , Joseph Walsh , Kai Chen
IPC分类号： A61K51/00 , C07F5/00
CPC分类号： G01N33/534 , A61K51/0491 , C07D249/04 , C07H7/06 , C07H19/048 , C07H19/056 , C07H19/06
摘要： The present disclosure provides a method for preparing a radioactive ligand or radioactive substrate having affinity for a target biomacromolecule, the method comprising: (a) reacting a first compound comprising a first functional group capable of participating in a click chemistry reaction, with a radioactive reagent under conditions sufficient to displace the leaving group with a radioactive component of the radioactive reagent to form a first radioactive compound; (b) providing a second compound comprising a second complementary functional group capable of participating in a click chemistry reaction with the first functional group; (c) reacting the first functional group of the first radioactive compound with the complementary functional group of the second compound via a click chemistry reaction to form the radioactive ligand or substrate; and (d) isolating the radioactive ligand or substrate.
摘要翻译：本公开提供了制备对目标生物大分子具有亲和力的放射性配体或放射性底物的方法，所述方法包括：（a）使包含能够参与点击化学反应的第一官能团的第一化合物与放射性试剂在足以用放射性试剂的放射性成分置换离去基团以形成第一种放射性化合物的条件下，（b）提供包含能够与第一官能团参与点击化学反应的第二互补官能团的第二化合物; （c）通过点击化学反应使第一放射性化合物的第一官能团与第二化合物的互补官能团反应以形成放射性配体或底物; 和（d）分离放射性配体或底物。

10. 发明申请

US20060161227A1 Apparatus and methods for optical stimulation of the auditory nerve 有权
标题翻译：用于光学刺激听觉神经的装置和方法
公开(公告)号：US20060161227A1
公开(公告)日：2006-07-20
申请号：US11274061
申请日：2005-11-14
申请人： Joseph Walsh , E. Jansen , Agnella Izzo , Claus-Peter Richter
发明人： Joseph Walsh , E. Jansen , Agnella Izzo , Claus-Peter Richter
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N1/36036 , A61N5/0622 , A61N2005/0605 , A61N2005/063 , A61N2005/067
摘要： A cochlear implant placed in a cochlea of a living subject for stimulating the auditory system of the living subject, where the auditory system comprises auditory neurons. In one embodiment, the cochlear implant includes a plurality of light sources, {Li}, placeable distal to the cochlea, each light source, L1, being operable independently and adapted for generating an optical energy, Ei, wherein i=1, . . . , N, and N is the number of the light sources, and delivering means placeable in the cochlea and optically coupled to the plurality of light sources, {Li}, such that in operation, the optical energies {Ei} generated by the plurality of light sources {Li} are delivered to target sites, {Gi}, of auditory neurons, respectively, wherein the target sites G1 and GN of auditory neurons are substantially proximate to the apical end and the basal end of the cochlea, respectively.
摘要翻译：耳蜗植入物放置在活体的耳蜗中，用于刺激活体的听觉系统，其中听觉系统包括听觉神经元。在一个实施例中，耳蜗植入物包括可放置在耳蜗远端的多个光源，每个光源L 1可独立操作，并且适于产生光能，其中i = 1，...。。。，N和N是光源的数量，以及放置在耳蜗中的光学耦合到多个光源的输送装置，使得在操作中光学能量由多个光源（L i i i i）生成的{E i i i i}被传送到目标部位，即听觉神经元，其中听觉神经元的靶位点G 1和N N N分别基本上接近耳蜗的顶端和基端。

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