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1. 发明申请

US20060161227A1 Apparatus and methods for optical stimulation of the auditory nerve 有权
标题翻译：用于光学刺激听觉神经的装置和方法
公开(公告)号：US20060161227A1
公开(公告)日：2006-07-20
申请号：US11274061
申请日：2005-11-14
申请人： Joseph Walsh , E. Jansen , Agnella Izzo , Claus-Peter Richter
发明人： Joseph Walsh , E. Jansen , Agnella Izzo , Claus-Peter Richter
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N1/36036 , A61N5/0622 , A61N2005/0605 , A61N2005/063 , A61N2005/067
摘要： A cochlear implant placed in a cochlea of a living subject for stimulating the auditory system of the living subject, where the auditory system comprises auditory neurons. In one embodiment, the cochlear implant includes a plurality of light sources, {Li}, placeable distal to the cochlea, each light source, L1, being operable independently and adapted for generating an optical energy, Ei, wherein i=1, . . . , N, and N is the number of the light sources, and delivering means placeable in the cochlea and optically coupled to the plurality of light sources, {Li}, such that in operation, the optical energies {Ei} generated by the plurality of light sources {Li} are delivered to target sites, {Gi}, of auditory neurons, respectively, wherein the target sites G1 and GN of auditory neurons are substantially proximate to the apical end and the basal end of the cochlea, respectively.
摘要翻译：耳蜗植入物放置在活体的耳蜗中，用于刺激活体的听觉系统，其中听觉系统包括听觉神经元。在一个实施例中，耳蜗植入物包括可放置在耳蜗远端的多个光源，每个光源L 1可独立操作，并且适于产生光能，其中i = 1，...。。。，N和N是光源的数量，以及放置在耳蜗中的光学耦合到多个光源的输送装置，使得在操作中光学能量由多个光源（L i i i i）生成的{E i i i i}被传送到目标部位，即听觉神经元，其中听觉神经元的靶位点G 1和N N N分别基本上接近耳蜗的顶端和基端。

2. 发明授权

US07833257B2 Apparatus and methods for optical stimulation of the auditory nerve 有权
标题翻译：用于光学刺激听觉神经的装置和方法
公开(公告)号：US07833257B2
公开(公告)日：2010-11-16
申请号：US11274061
申请日：2005-11-14
申请人： Joseph I. Walsh, Jr. , E. Duco Jansen , Agnella Izzo , Claus-Peter Richter
发明人： Joseph I. Walsh, Jr. , E. Duco Jansen , Agnella Izzo , Claus-Peter Richter
IPC分类号： A61N5/06
CPC分类号： A61N5/0603 , A61N1/36036 , A61N5/0622 , A61N2005/0605 , A61N2005/063 , A61N2005/067
摘要： A cochlear implant placed in a cochlea of a living subject for stimulating the auditory system of the living subject, where the auditory system comprises auditory neurons. In one embodiment, the cochlear implant includes a plurality of light sources, {Li}, placeable distal to the cochlea, each light source, L1, being operable independently and adapted for generating an optical energy, Ei, wherein i=1, . . . , N, and N is the number of the light sources, and delivering means placeable in the cochlea and optically coupled to the plurality of light sources, {Li}, such that in operation, the optical energies {Ei} generated by the plurality of light sources {Li} are delivered to target sites, {Gi}, of auditory neurons, respectively, wherein the target sites G1 and GN of auditory neurons are substantially proximate to the apical end and the basal end of the cochlea, respectively.
摘要翻译：耳蜗植入物放置在活体的耳蜗中，用于刺激活体的听觉系统，其中听觉系统包括听觉神经元。在一个实施例中，耳蜗植入物包括多个光源，其可放置在耳蜗远侧，每个光源L1独立地可操作并适于产生光学能量，其中i = 1。。。，N和N是光源的数量，以及可放置在耳蜗中并光耦合到多个光源的传送装置{Li}，使得在操作中由多个光源产生的光能{Ei} 光源{Li}分别传递到目标部位{Gi}，其中听觉神经元的目标部位G1和GN分别基本上接近耳蜗的顶端和基部末端。

3. 发明授权

US09150533B2 Local cochlear application of statins for stimulating neurite regrowth in the cochlea 有权
标题翻译：用于刺激耳蜗神经突再生的他汀类药物的局部耳蜗应用
公开(公告)号：US09150533B2
公开(公告)日：2015-10-06
申请号：US14105582
申请日：2013-12-13
申请人： Donna S. Whitlon , Claus-Peter Richter
发明人： Donna S. Whitlon , Claus-Peter Richter
IPC分类号： C07D309/30 , C07C69/28 , C07D307/34 , C07D209/24 , C07D213/55 , C07D207/34 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/4418
CPC分类号： C07D309/30 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/4418 , C07D207/34 , C07D209/24 , C07D213/55
摘要： Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and/or hair cells of the cochlea following acoustic or toxic insult.
摘要翻译：公开了用于刺激来自内耳螺旋神经节神经元的神经突生长的他汀类药物组合物，以及用于在听觉或毒性侮辱之后预防耳蜗听觉神经元和/或耳蜗细胞损伤的损伤或/或治疗方法。

4. 发明申请

US20140179723A1 LOCAL COCHLEAR APPLICATION OF STATINS FOR STIMULATING NEURITE REGROWTH IN THE COCHLEA 有权
标题翻译：本地COCHLEAR应用刺激神经再现在COCHLEA的统计
公开(公告)号：US20140179723A1
公开(公告)日：2014-06-26
申请号：US14105582
申请日：2013-12-13
申请人： Donna S. Whitlon , Claus-Peter Richter
发明人： Donna S. Whitlon , Claus-Peter Richter
IPC分类号： C07D309/30 , C07D207/34 , C07C69/28 , C07D213/55 , C07D209/24
CPC分类号： C07D309/30 , A61K31/366 , A61K31/40 , A61K31/405 , A61K31/4418 , C07D207/34 , C07D209/24 , C07D213/55
摘要： Statin compositions are disclosed for stimulating neurite growth from spiral ganglion neurons in the inner ear and methods for preventing damage to or treating damage of auditory neurons and/or hair cells of the cochlea following acoustic or toxic insult.
摘要翻译：公开了用于刺激来自内耳螺旋神经节神经元的神经突生长的他汀类药物组合物，以及用于在听觉或毒性侮辱之后预防耳蜗听觉神经元和/或耳蜗细胞损伤的损伤或/或治疗方法。

5. 发明授权

US07194314B1 Cochlear implant including a modiolar return electrode 有权
标题翻译：耳蜗植入物包括一个模板返回电极
公开(公告)号：US07194314B1
公开(公告)日：2007-03-20
申请号：US10641551
申请日：2003-08-15
申请人： Claus-Peter Richter , Steven Ho
发明人： Claus-Peter Richter , Steven Ho
IPC分类号： A61N1/04
CPC分类号： A61N1/0541 , A61N1/36036
摘要： A cochlear implant wherein the return path of the electrode array is located to increase current flow through the modiolus. The return electrode is placed at various locations outside the cochlea, and into the modiolus itself. In addition, the electrode array includes an inflatable membrane that is inflated to anchor the array in position in the cochlea with the electrode contacts pressed into contact with the modiolar wall and allowing the membrane to seal with the surrounding tissue of the cochlea, increasing the longitudinal resistance along the cochlear implant electrode, decreasing shunting of the injected current via scala tympani. In experiments that were conducted the current along the modiolus was determined to be, on average, 2.4 times larger with the return electrode in the modiolus than in an extracochlear location.
摘要翻译：耳蜗植入物，其中电极阵列的返回路径被定位成增加流经该组织的电流。返回电极放置在耳蜗外部的各个位置，并且进入曲柄本身。此外，电极阵列包括充气膜，其充气以将阵列锚定在耳蜗中的适当位置，其中电极接触件与模腔壁压接并允许膜与耳蜗的周围组织密封，增加纵向沿着耳蜗植入电极的电阻，通过鼓风鼓风降低注入电流的分流。在进行的实验中，沿着组织的电流被确定为与组织中的返回电极相比平均高2.4倍。

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