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1. 发明授权

UST101305I4 3[(3-Alkylamino-2-hydroxypropoxy)phenyl]-1,2-propanediols 失效
标题翻译： 3 [（3-烷基氨基-2-羟基丙氧基）苯基] -1,2-丙二醇
公开(公告)号：UST101305I4
公开(公告)日：1981-12-01
申请号：US182280
申请日：1980-08-28
申请人： Joseph W. Epstein , Leon Goldman , James D. Warren
发明人： Joseph W. Epstein , Leon Goldman , James D. Warren
IPC分类号： C07C43/23 , C07D303/22
CPC分类号： C07C43/23 , C07D303/22
摘要： This invention concerns novel 3-[(3-alkylamino-2-hydroxypropoxy)phenyl]-1,2-propanediols of the formula: ##STR1## wherein R is selected from the group consisting of straight or branched-chain lower alkyls (C.sub.1 -C.sub.6) and cycloalkyls (C.sub.1 -C.sub.6); R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen and 2,3-dihydroxypropyl, with the proviso that R.sub.1 and R.sub.2 may not be the same; and R.sub.3 is selected from the group consisting of lower alkyls (C.sub.1 -C.sub.4) and lower alkoxys (C.sub.1 -C.sub.4); and the acid addition salts thereof. These novel compounds are useful as antiarrhythmic agents and .beta.-andrenergic blockers in mammals.This invention also concerns novel compounds of the formula ##STR2## wherein R.sub.1 and R.sub.2 are selected from the group consisting of hydrogen and 2,3-dihydroxypropyl, with the proviso that R.sub.1 and R.sub.2 may not be the same; R.sub.3 is selected from the group consisting of lower alkyls (C.sub.1 -C.sub.4) and lower alkoxys (C.sub.1 -C.sub.4); and X is selected from the group consisting of ##STR3## and --CHOH--CH.sub.2 --Z (or a mixture of these compounds wherein X has both meanings stated above) where Z may be halogen, alkoxy sulfonyl and aryloxysulfonyl; and the acid-addition salts thereof. These compounds are useful as intermediates for the preparation of the active antiarrhythmic and .beta.-andrenergic blocking compounds described above.This invention also concerns a process for preparing said antiarrhythmic and .beta.-andrenergic blocking compounds from said intermediates.

2. 发明授权

US4564011A Laser optic device and method 失效
标题翻译：激光光学装置及方法
公开(公告)号：US4564011A
公开(公告)日：1986-01-14
申请号：US539160
申请日：1983-10-06
申请人： Leon Goldman
发明人： Leon Goldman
IPC分类号： A61B17/12 , A61B18/22 , A61B18/24 , A61B17/36
CPC分类号： A61B17/12 , A61B18/22 , A61B18/24 , A61B2018/2266
摘要： A laser optic device comprises at least one optic fiber disposed within a protective conduit which is mounted to a disposable probe assembly having a hollow needle insertable within the body. Laser energy is transmitted through the optic fiber to a lens at one end which is adapted to focus the laser energy through the hollow needle and into a blood vessel, for creating a blood clot, or into the tissue immediately adjacent a damaged blood vessel for creating white scar tissue thereby causing the vessel to shrink in size and at least partially disappear from view.
摘要翻译：激光光学装置包括设置在保护导管内的至少一个光纤，其被安装到具有可插入体内的中空针的一次性探针组件。激光能量通过光纤传输到一端的透镜，该透镜适于将激光能量聚焦穿过中空针头并进入血管，用于产生血块，或者紧邻受损血管的组织中，以产生白色瘢痕组织，从而导致血管的尺寸收缩并且至少部分地从视野消失。

3. 发明授权

US4928695A Laser diagnostic and treatment device 失效
标题翻译：激光诊断和治疗装置
公开(公告)号：US4928695A
公开(公告)日：1990-05-29
申请号：US312887
申请日：1989-02-17
申请人： Leon Goldman , Ellet H. Drake , Steven Goldman
发明人： Leon Goldman , Ellet H. Drake , Steven Goldman
IPC分类号： A61B1/04 , A61N5/06 , A61N5/067
CPC分类号： A61N5/0601 , A61B1/042 , A61N2005/067
摘要： An apparatus for detecting and treating abnormal electrical conducting tissue of an organ of the body which comprises a catheter insertable within a blood vessel or body cavity into proximity with the organ to be treated. An electrode or other electrical field-producing element is carried within the catheter and is effective to produce an electric field capable of inducing abnormal movement of the organ, e.g., a cardiac arrhythmia, when the electrode is placed at or near the focus of the abnormal electrical conducting tissue of the organ. A relatively undistorted image of such abnormal tissue is obtained using optical phase conjugation of a low energy laser beam which is directed to the focus of the damaged tissue and the along one or more optic fibers carried within the catheter to a viewing apparatus. A laser beam transmitted through another optic fiber carried within the catheter is then employed, if necessary, to destroy the damaged tissue.
摘要翻译：一种用于检测和处理身体器官的异常导电组织的装置，其包括可插入血管或体腔内的导管，以与被治疗器官接近。电极或其他电场产生元件被携带在导管内，并且有效地产生能够引起器官的异常运动的电场，例如心律不齐，当电极置于或接近异常的焦点时器官的导电组织。使用低能量激光束的光相位共轭获得这种异常组织的相对不失真的图像，该低能量激光束被引导到受损组织的焦点，并且沿导管内承载的一个或多个光纤被引导到观察装置。然后如果需要，则使用透射穿过导管内的另一光纤的激光束来破坏受损组织。

4. 发明授权

US4107326A Novel benzylideneaminoguanidines 失效
标题翻译：新亚苄基氨基胍
公开(公告)号：US4107326A
公开(公告)日：1978-08-15
申请号：US794600
申请日：1977-05-06
申请人： Leon Goldman , Yang-i Lin , Joseph William Marsico, Jr.
发明人： Leon Goldman , Yang-i Lin , Joseph William Marsico, Jr.
IPC分类号： C07C281/18 , C07C335/32 , A61K31/155 , C07C121/60 , C07C133/10
CPC分类号： C07C335/32 , C07C281/18 , C07C2101/02
摘要： This disclosure describes novel substituted benzylideneaminoguanidines useful as anti-hypertensive agents and as diuretics.
摘要翻译：本公开描述了用作抗高血压剂和用作利尿剂的新型取代的亚苄基氨基胍。

5. 发明授权

US4154947A Heterocyclic substituted benzylideneaminoguanidines 失效
标题翻译：杂环取代的亚苄基氨基胍
公开(公告)号：US4154947A
公开(公告)日：1979-05-15
申请号：US886211
申请日：1978-03-13
申请人： Leon Goldman , Joseph W. Marsico, Jr.
发明人： Leon Goldman , Joseph W. Marsico, Jr.
IPC分类号： C07D213/38 , C07D241/12 , C07D277/28 , C07D307/52 , C07D333/20 , C07D213/73 , C07D231/06 , C07D327/04 , C07D333/10
CPC分类号： C07D241/12 , C07D213/38 , C07D277/28 , C07D307/52 , C07D333/20
摘要： This disclosure describes novel substituted benzylideneaminoguanidines useful as anti-hypertensive agents and as diuretics.
摘要翻译：本公开描述了用作抗高血压剂和用作利尿剂的新型取代的亚苄基氨基胍。

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