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1. 发明公开

CN87102976A 4，5-二氢-1H-1，2，4-三唑-3-甲酰胺衍生物，制备该衍生物的中间体和含有该衍生物的除草剂组合失效
公开(公告)号：CN87102976A
公开(公告)日：1988-10-05
申请号：CN87102976
申请日：1987-04-24
申请人：吴羽化学工业株式会社
发明人：志田隆文 , 久保田芳和 , 一濑功 , 山崎词朗 , 新川博惠
IPC分类号： C07D249/10 , C07C133/02 , C07C133/10 , A01N43/707 , A01N33/26
CPC分类号： C07C251/72 , A01N43/653 , C07D249/10
摘要：本发明公开了以式(I)表示的4，5-二氢-1H-1，2，4-三唑-3-甲酰胺衍生物、制备该衍生物的中间体以及含有该衍生物作为有效成分的除草剂组合物。式中各项定义详见说明书。

2. 发明专利

JPS505175B1 失效
公开(公告)号：JPS505175B1
公开(公告)日：1975-02-28
申请号：JP1613570
申请日：1970-02-26
IPC分类号： C07C281/16 , C07C67/00 , C07C239/00 , C07C133/10

3. 发明专利

JPS501255B1 失效
公开(公告)号：JPS501255B1
公开(公告)日：1975-01-16
申请号：JP12155070
申请日：1970-12-29
IPC分类号： C09K3/00 , C07C67/00 , C07C239/00 , C07C281/16 , C09J11/00 , C07C133/10

4. 发明专利

JPS5123493B2 失效
公开(公告)号：JPS5123493B2
公开(公告)日：1976-07-17
申请号：JP8100173
申请日：1973-07-23
IPC分类号： C07D295/10 , A61K31/13 , A61K31/135 , A61K31/18 , C07C67/00 , C07C213/00 , C07C225/16 , C07C311/37 , C07D295/104 , C07D295/125 , C07D307/52 , C07D317/58 , C07D333/22 , A61K31/34 , A61K31/40 , C07C127/00 , C07C131/00 , C07C133/10 , C07D207/02 , C07D307/36 , C07D333/06

5. 发明公开

EP0325936A3 Aminoguanidine derivatives and inhibitory agents on maillard reaction containing them as active ingredients 失效
标题翻译：氨基胍衍生物和抑制剂对含有它们作为活性成分的反应物
公开(公告)号：EP0325936A3
公开(公告)日：1990-01-17
申请号：EP89100345.1
申请日：1989-01-10
申请人： ONO PHARMACEUTICAL CO., LTD.
发明人： Ohuchida, Shuichi Ono Pharmaceutical Co., Ltd. , Toda, Masaaki Ono Pharmaceutical Co., Ltd. , Miyamoto, Tsumoru Ono Pharmaceutical Co., Ltd.
IPC分类号： C07C133/10 , C07D213/76 , A61K31/155 , A61K31/44
CPC分类号： C07D213/77 , C07C281/16
摘要： An aminoguanidine derivative of the general formula:
(wherein, R 1b represents carbocyclic or heterocyclic ring substituted or unsubstituted by from 1 to 3 group(s) selected from halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), nitro group, phenoxy group, amino group, hydroxy group and acylamino group of from 2 to 4 carbon atom(s), X b represents single-bond, alkylene group of from 1 to 4 carbon atom(s) or alkenylene group of from 2 to 4 carbon atoms, or R 1b together with X b represents alkyl group of from 1 to 4 carbon atom(s), R 2b represents hydrogen atom, alkyl group of from 1 to 4 carbon atom(s) or phenyl group substituted or unsubstituted by from 1 to 3 group(s) selected from halogen atom, alkyl or alkoxy group of from 1 to 4 carbon atom(s), hydroxy and nitro group.), or an acid addition salt thereof possesses inhibitory activity on Maillard reaction, and these is useful for prevention and/or treatment of several diabetic complications and deseases induced by aging.

6. 发明公开

EP0027877A1 5,8-dihydroxy-1,4-bis(guanidinyl-amino)anthraquinones 失效
标题翻译： 5,8-二羟基-1,4-双（胍基 - 氨基）蒽醌类
公开(公告)号：EP0027877A1
公开(公告)日：1981-05-06
申请号：EP80105206.9
申请日：1980-09-02
申请人： AMERICAN CYANAMID COMPANY
发明人： Murdock, Keith Chadwick
IPC分类号： C07C133/10 , C07D233/52 , C07D243/04 , A61K31/175 , A61K31/395
CPC分类号： C07D233/52 , C07D243/04
摘要： This disclosure describes 1,4-bis(guanidinylamino)-5,8-dihydroxyanthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.
摘要翻译：本公开描述了用作螯合剂并用于抑制移植的小鼠肿瘤生长的1,4-双（胍基氨基）-5,8-二羟基蒽醌。

7. 发明授权

US4665085A Amidines, preparation process and therapeutical application thereof 失效
标题翻译：脒，其制备方法及其治疗应用
公开(公告)号：US4665085A
公开(公告)日：1987-05-12
申请号：US717185
申请日：1985-03-12
申请人： Claude Coquelet , Elisabeth Battais , Claude Bonne , Daniel Sincholle
发明人： Claude Coquelet , Elisabeth Battais , Claude Bonne , Daniel Sincholle
IPC分类号： C07C257/00 , A61K31/415 , C07C67/00 , C07C239/00 , C07C241/00 , C07C281/18 , C07C313/00 , C07D233/20 , C07D233/24 , C07D233/50 , C07D233/52 , A61K31/155 , C07C133/10
CPC分类号： C07C281/18 , A61K31/415 , C07D233/24 , C07D233/50 , C07D233/52
摘要： Compounds having the formula (I) wherein R.sub.1 and R.sub.2 are a hydrogen atom, an alkyl group or a hydroxy group, or else R.sub.1 and R.sub.2 form together a bivalent ethylene or trimethylene radical; R.sub.3 is a halogen atom, an alkyl group, an alkoxy group, a mono- or polyhydroxylated alkyl group, an amino group, a mono- or di-alkyl amino group, an acetamido or sulfonamido group; R.sub.1 is a hydroxy group, a mono- or polyhydroxylated alkyl group, an amino group, a mono- or dialkyl amino group, an acetamido or sulfonamido group; R.sub.4 being in the position 3, 4 or 5 and A is a bridge having from 1 to 3 links selected among the groups having the formula (II), --NH--,--N.dbd.--O-- and --S--. R.sub.5 represents an hydrogen atom, an alkyl group, a hydroxy group or an alkoxy group as well as the addition salts thereof with pharmaceutically acceptable acids. Said compound may be used in therapeutical treatment as antihypertensive agents, particularly in the ocular field. ##STR1##
摘要翻译： PCT No.PCT / FR84 / 00170 Sec。 371日期1985年3月12日 102（e）1985年3月12日PCT PCT。1984年7月6日PCT公布。公开号WO85 / 00366 1985年1月31日。具有式（I）的化合物，其中R 1和R 2是氢原子，烷基或羟基，或者R 1和R 2一起形成二价乙烯或三亚甲基; R3是卤素原子，烷基，烷氧基，单羟基或多羟基化烷基，氨基，一或二烷基氨基，乙酰氨基或亚磺酰氨基; R1是羟基，单羟基烷基或多羟基化烷基，氨基，一或二烷基氨基，乙酰氨基或亚磺酰氨基; R4为位置3,4或5，A为选自具有式（II）的基团，-NH - ， - N = -O-和-S-的1至3个连接的桥。 R5表示氢原子，烷基，羟基或烷氧基，以及其与药学上可接受的酸的加成盐。所述化合物可用作治疗性治疗作为抗高血压药，特别是在眼部。（I）（II）

8. 发明授权

US3852353A Oral hypoglycemic aminophenylsulfonyl-hydrocarbylbiguanides 失效
标题翻译：口服超高效氨基磺酰氟 - 乙酰胆碱
公开(公告)号：US3852353A
公开(公告)日：1974-12-03
申请号：US31454572
申请日：1972-12-12
申请人： HEAPHY C
发明人： HEAPHY C
IPC分类号： A61K31/27 , C07C317/36 , C07C133/10
CPC分类号： C07C317/36 , A61K31/27 , Y10S514/866
摘要： An oral hypoglycemic compound for use in the treatment of diabetes mellitus having the general formula

AND WHICH IS ONE OF THE GROUP CONSISTING OF: A. THE COMPOUND WHEREIN R1 is an aliphatic series containing 2 to 8 carbon atoms; B. THE COMPOUND WHEREIN R2 R3 and is a member of the group consisting of hydrogen, aliphatic, and aromatic radicals; and C. THE COMPOUND WHEREIN X represents an amino or a substituted amino radical. The compound is prepared by synthesizing p-amino benzenesulfonamide through the chlorsulfonation of acetanilide and placing a radical group in the para position of the benzene ring. The compound may be incorporated with therapeutically acceptable carriers to make compositions adapted to be administered orally in the treatment of diabetes mellitus. The compound is intended to aid in the regulation of metabolic disturbance in diabetes mellitus not only by stimulating the production and release of insulin but also by functioning as a substitute for insulin in this regulatory process.
摘要翻译：用于治疗具有通式的糖尿病的口服降血糖化合物，其为本组中的一个：

9. 发明授权

US3673253A Process for the production of aminoguanidine bicarbonate 失效
标题翻译：生产氨基胍二碳酸酯的方法
公开(公告)号：US3673253A
公开(公告)日：1972-06-27
申请号：US3673253D
申请日：1968-02-21
申请人： BAYER AG
发明人： SIMONS PETER
IPC分类号： C07C281/16 , C07C133/10
CPC分类号： C07C281/16
摘要： Production of aminoguanidine bicarbonate by reacting finely divided solid calcium cyanamide with hydrazine, in the form of mono or dihydrazine sulfate or hydrazine hydrate and sulfuric acid in admixture, in neutral to alkaline aqueous medium, e.g. at pH 7 to about 9.5 and about 15*-90* C, using sulfuric acid for pH adjustment to form aminoguanidine, cooling the reaction mixture, e.g. to about 60*-40* C, to precipitate the resultant calcium sulfate sludge, and treating the sludge-free resultant reaction mixture, e.g. at 25*-50* C, with a bicarbonate precipitating agent, e.g. alkali metal or ammonium bicarbonate or carbon dioxide and alkali metal or ammonium hydroxide, to precipitate the aminoguanidine bicarbonate therefrom; OPTIONALLY AVOIDING IRON CONTAMINATION OF THE DESIRED PRODUCT BY EITHER ADJUSTING TO ACID PH, e.g. pH 3-4, the reaction mixture prior to bicarbonate agent treatment to maintain such iron in soluble form, e.g. when Fe content low, or adjusting to about pH 7.5-8.5 the reaction mixture prior to bicarbonate agent treatment followed by air introduction, e.g. at 60*-45* C, to remove the iron content, e.g. when Fe content high-up to about 5 percent, as ferric hydroxide precipitate, the latter alternative being optionally carried out prior to calcium sulfate sludge precipitation (i.e. removal) to effect joint precipitation of such ferric hydroxide and sludge prior to bicarbonate treatment.
摘要翻译：在中性至碱性水性介质例如中性至碱性水性介质中，使细分散的固体氰氨腈与肼反应生成氨基胍碳酸氢盐，其形式为硫酸单或二肼硫酸盐或水合肼和硫酸。在pH7至约9.5和约15-90℃下，使用硫酸进行pH调节以形成氨基胍，冷却反应混合物，例如至约60°-40℃，以沉淀所得的硫酸钙污泥，并处理无污泥的所得反应混合物，例如在25℃-50℃下，用碳酸氢盐沉淀剂，碱金属或碳酸氢铵或二氧化碳和碱金属或氢氧化铵，以从其中沉淀氨基胍碳酸氢盐; 通过调节酸性pH可以避免所有产品的铁污染，例如 pH 3-4，在碳酸氢钠试剂处理之前的反应混合物保持这种可溶形式的铁，例如当Fe含量低时，或者在碳酸氢盐处理之前，随后空气引入，例如，将反应混合物调节至约pH 7.5-8.5。在60°-45℃下，除去铁含量，例如当Fe含量高达约5％时，随着氢氧化铁沉淀，后一种替代方案任选在硫酸钙污泥沉淀（即除去）之前进行，以在碳酸氢盐处理之前进行这种氢氧化铁和污泥的联合沉淀。

10. 发明授权

US3454640A Alkoxy- or alkylthio-alkyleneaminoalkylguanidines 失效
标题翻译：烷氧基或烷基-L-亚氨基亚氨基烷基
公开(公告)号：US3454640A
公开(公告)日：1969-07-08
申请号：US3454640D
申请日：1966-07-25
申请人： ABBOTT LAB
发明人： SHORT JAMES HAROLD
IPC分类号： C07C335/32 , C07C133/10
CPC分类号： C07C335/32

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