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1. 发明申请

US20090173348A1 Method And Apparatus For Inducing And Controlling Hypoxia 审中-公开
标题翻译：诱导和控制缺氧的方法和装置
公开(公告)号：US20090173348A1
公开(公告)日：2009-07-09
申请号：US11817062
申请日：2006-02-24
申请人： Joseph A. Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Ronald Somogyi , Eitan Prisman
发明人： Joseph A. Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Ronald Somogyi , Eitan Prisman
IPC分类号： A61M16/22
CPC分类号： A61B5/083 , A61M16/0045 , A61M16/0075 , A61M16/0084 , A61M16/22 , A61M2016/0039 , A61M2016/1025
摘要： An apparatus for inducing hypoxia in a subject is provided. The apparatus includes a breathing port, an inspiratory reservoir, means for introducing oxygen into the apparatus, means for controlling the flow rate of entry of oxygen into the apparatus at a rate below the subject's metabolic requirements, an expiratory reservoir having a vent, Sequential Gas Delivery means, and means for removing CO2 from the circuit. The Sequential Gas Delivery means are for directing the gases such that upon expiration, the subject expires into the expiratory reservoir, and, upon inspiration, subject inspires first from the inspiratory reservoir, and, on any breath, once said inspiratory reservoir is depleted, gas for the balance of that inspiration is delivered from the expiratory reservoir
摘要翻译：提供了一种在受试者中诱导缺氧的装置。该装置包括呼吸端口，吸气容器，用于将氧气引入装置的装置，用于以低于受试者代谢要求的速率控制氧进入装置的流速的装置，具有排气口的呼气储存器，连续气体输送装置，以及从电路中去除二氧化碳的装置。顺序气体输送装置用于引导气体，使得在呼气期间，受试者到达呼气储存器，并且在吸气时，受试者首先从吸气储器开始，并且在任何呼吸下，一旦吸气储存器耗尽，气体为了平衡这一灵感来自呼气水库

2. 发明授权

US07100606B2 Method of maintaining constant arterial PCO2 and measurement of anatomic and alveolar dead space 有权
标题翻译：维持恒定动脉PCO2和测量解剖和肺泡死亡空间的方法
公开(公告)号：US07100606B2
公开(公告)日：2006-09-05
申请号：US10838481
申请日：2004-05-04
申请人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Ronald Somogyi
发明人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Ronald Somogyi
IPC分类号： A61M16/00
CPC分类号： A61B5/4821 , A61B5/0836 , A61B5/087 , A61M16/12 , A61M16/208 , A61M2202/0225 , Y10S128/914 , A61M2202/0007
摘要： A method to maintain isocapnia for a subject. A fresh gas is provided to the subject when the subject breathes at a rate less than or equal to the fresh gas flowing to the subject. The fresh gas flow equal to a baseline minute ventilation minus a dead space gas ventilation of the subject contains a physiological insignificant amount of CO2. An additional reserve gas is provided to the subject when the subject breathes at a rate more than the fresh gas flowing to the subject. The reserve gas has a partial pressure of carbon dioxide equal to an arterial partial pressure of carbon dioxide of the subject. A breathing circuit is applied to the method to maintain isocapnia for a subject. The breathing circuit has an exit port, a non-rebreathing valve, a source of fresh gas, a fresh gas reservoir and a reserve gas supply.
摘要翻译：维持一个科目的伊萨卡尼亚的方法。当受试者以低于或等于流向对象的新鲜气体的速率呼吸时，向受试者提供新鲜的气体。等于基线分钟通气减去受试者的死空气通气量的新鲜气体流量包含生理上不显着的CO 2 2。当受试者以比流过对象的新鲜气体更多的速率呼吸时，向对象提供额外的储备气体。储备气体具有等于受试者的二氧化碳的动脉分压的二氧化碳分压。呼吸回路适用于维持受试者的异味病的方法。呼吸回路具有出口，非再呼吸阀，新鲜气体源，新鲜气体储存器和储备气体供应。

3. 发明授权

US06799570B2 Method of maintaining constant arterial PCO2 and measurement of anatomic and alveolar dead space 失效
公开(公告)号：US06799570B2
公开(公告)日：2004-10-05
申请号：US10135655
申请日：2002-04-30
申请人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Ronald Somogyi
发明人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Ronald Somogyi
IPC分类号： A61M1600
CPC分类号： A61B5/4821 , A61B5/0836 , A61B5/087 , A61M16/12 , A61M16/208 , A61M2202/0225 , Y10S128/914 , A61M2202/0007
摘要： A method to maintain isocapnia for a subject. A fresh gas is provided to the subject when the subject breathes at a rate less than or equal to the fresh gas flowing to the subject. The fresh gas flow equal to a baseline minute ventilation minus a dead space gas ventilation of the subject contains a physiological insignificant amount of CO2. An additional reserve gas is provided to the subject when the subject breathes at a rate more than the fresh gas flowing to the subject. The reserve gas has a partial pressure of carbon dioxide equal to an arterial partial pressure of carbon dioxide of the subject. A breathing circuit is applied to the method to maintain isocapnia for a subject. The breathing circuit has an exit port, a non-rebreathing valve, a source of fresh gas, a fresh gas reservoir and a reserve gas supply.

4. 发明授权

US08844528B2 Breathing circuits to facilitate the measurement of cardiac output during controlled and spontaneous ventilation 有权
标题翻译：呼吸电路，以便于在受控和自发通气期间测量心输出量
公开(公告)号：US08844528B2
公开(公告)日：2014-09-30
申请号：US10545519
申请日：2004-02-18
申请人： Joseph Fisher , David Preiss , Takafumi Azami , Alex Vesely , Eitan Prisman , Steve Iscoe , Ron Somogyi , Dan Nayot , Tehilla Adams
发明人： Joseph Fisher , David Preiss , Takafumi Azami , Alex Vesely , Eitan Prisman , Steve Iscoe , Ron Somogyi , Dan Nayot , Tehilla Adams
IPC分类号： A62B7/04 , F15C1/08
CPC分类号： A61B5/4821 , A61B5/029 , A61B5/083 , A61B5/0836 , A61M16/0078 , A61M16/08 , A61M16/0833 , A61M16/0858 , A61M16/202 , A61M16/205 , A61M16/206 , A61M16/208 , A61M16/22 , A61M2016/0027
摘要： A breathing circuit for sequential gas delivery of a first gas set (FGS) and a second gas set (SGS) employs an arrangement of conduits and active or passive valves to prevent mixing of the FGS and SGS including a valve triggered by depletion of FGS that makes the SGS available for inspiration after the FGS is depleted.
摘要翻译：用于第一气体组（FGS）和第二气体组（SGS）的连续气体输送的呼吸回路采用导管和主动阀或被动阀的布置，以防止FGS和SGS的混合，包括由FGS消耗触发的阀，使得SGS在FGS耗尽后可以获得灵感。

5. 发明申请

US20070062534A1 Breathing circuits to facilitate the measurement of cardiac output during controlled and spontaneous ventilation 有权
标题翻译：呼吸电路，以便于在受控和自发通气期间测量心输出量
公开(公告)号：US20070062534A1
公开(公告)日：2007-03-22
申请号：US10545519
申请日：2004-02-18
申请人： Joseph Fisher , David Preiss , Takafumi Azami , Alex Vesely , Eitan Prisman , Steve Iscoe , Ron Somogyi , Dan Nayot , Tehilla Adams
发明人： Joseph Fisher , David Preiss , Takafumi Azami , Alex Vesely , Eitan Prisman , Steve Iscoe , Ron Somogyi , Dan Nayot , Tehilla Adams
IPC分类号： A61M16/00
CPC分类号： A61B5/4821 , A61B5/029 , A61B5/083 , A61B5/0836 , A61M16/0078 , A61M16/08 , A61M16/0833 , A61M16/0858 , A61M16/202 , A61M16/205 , A61M16/206 , A61M16/208 , A61M16/22 , A61M2016/0027
摘要： A breathing circuit for use with a first gas set (FGS) and a second gas set (SGS), said circuit comprising means for keeping separate the FGS and SGS, and a means for sequentially delivering to a patient, first the FGS, and, on inspiration, when the patient inspires so as to deplete the supply of FGS into the circuit, subsequently delivers substantially SGS for the balance of inspiration.
摘要翻译：一种用于与第一气体组（FGS）和第二气体组（SGS）一起使用的呼吸回路，所述电路包括用于保持分离FGS和SGS的装置，以及用于依次递送给患者的装置，首先是FGS，灵感来自于患者的启发，以便将FGS的供应消耗到电路中，随后提供了基本的SGS以获得平衡的灵感。

6. 发明授权

US06612308B2 Portable isocapnia circuit and isocapnia method 有权
标题翻译：便携式isocapnia电路和isocapnia方法
公开(公告)号：US06612308B2
公开(公告)日：2003-09-02
申请号：US10093797
申请日：2002-03-08
申请人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Alex Stenzler
发明人： Joseph Fisher , Alex Vesely , Hiroshi Sasano , Steve Iscoe , Alex Stenzler
IPC分类号： A62B700
CPC分类号： A61M16/12 , A61M16/0045 , A61M16/08
摘要： A portable isocapnia circuit and an isocapnia method. A breathing port of the circuit allows a subject to inhale and exhale. Connected to the breathing port, a bifurcate conduit has a first conduit branch and a second conduit branch. The first conduit branch has an atmospheric air inlet, from which the atmospheric air is provided for inhalation, an inspiratory check valve to allow a one-way flow of the atmospheric air, and an atmospheric air aspirator. The second conduit branch has a one-way expiratory check valve and a expiratory gas reservoir. A one-way check valve is used to interconnect the first and second conduit branch, from which the expiratory gas stored in the expiratory gas reservoir flows to the first conduit branch to mix with the atmospheric air when the minute ventilation exceeds the atmospheric air.
摘要翻译：便携式异卡路里电路和异味法。电路的呼吸口允许受试者吸入并呼气。连接到呼吸端口，分叉导管具有第一导管支路和第二导管支路。第一管道分支具有大气空气入口，大气从该空气入口提供用于吸入，吸气止回阀允许大气空气的单向流动，以及大气抽气器。第二导管分支具有单向呼气止回阀和呼气气体储存器。单向止回阀用于互连第一和第二导管分支，当微小通气超过大气时，从呼吸气体储存器中吸入的呼吸气体流向第一导管支路与大气混合。

7. 发明授权

US08460202B2 Method of measuring cardiac related parameters non-invasively via the lung during spontaneous and controlled ventilation 失效
标题翻译：在自发和受控通气期间通过肺非侵入性测量心脏相关参数的方法
公开(公告)号：US08460202B2
公开(公告)日：2013-06-11
申请号：US10545562
申请日：2004-02-18
申请人： Joseph Fisher , David Preiss , Takafumi Asami , Alex Vesely , Eltan Prisman , Ron Somogyi , Steve Iscoe
发明人： Joseph Fisher , David Preiss , Takafumi Asami , Alex Vesely , Eltan Prisman , Ron Somogyi , Steve Iscoe
IPC分类号： A61B5/08
CPC分类号： A61B5/0205 , A61B5/083 , A61B5/14551 , A61B5/7225 , A61B5/7278 , A61M16/08 , A61M16/0833 , A61M16/085 , A61M16/0858 , A61M16/202 , A61M16/205 , A61M16/206 , A61M16/208 , A61M16/22
摘要： An apparatus to measure cardiac output (Q) and other parameters such as alveolar ventilation (VA), minute CO2 elimination from the lung (VCO2), minute oxygen consumption (VO2), oxygenated mixed venous partial pressure of CO2, (PvCO2-oxy), true mixed venous partial pressure of CO2(PvCO2), PaCO2, mixed venous oxygen saturation (SvO2), pulmonary shunt, and anatomical dead space, consisting of: a) a breathing circuit with characteristics that: i. on exhalation, exhaled gas is kept substantially separate from inhaled gas; ii. on inhalation, when VE is greater than FGS flow, the subject inhales FGS first and then inhales a gas that is substantially SGS, for the balance of inhalation; b) gas sensor means for monitoring gas concentrations at the patient-circuit interface c) a first gas set (FGS), and a second gas set (SGS), said second gas set which may comprise previously exhaled gases or exogenous gases or both d) a gas flow control means for controlling the rate of FGS flow into the breathing circuit e) means to identify phase of breathing, said means may consist of pressure sensors or analysis of signal generated by gas sensors or other means known to those skilled in the art; f) machine intelligence consisting of a computer or logic circuit capable of controlling the gas flow control means, receiving the output of the gas sensor means and means to identify phase of breathing, and performing the calculations for measuring cardiac output and other parameters as outlined in the disclosure.
摘要翻译：测量心输出量（Q）和其他参数如肺泡通气（VA），从肺中消除二氧化碳（VCO2），微量氧消耗（VO2），氧合混合静脉分压CO2（PvCO2-氧），真正的混合静脉分压二氧化碳（PvCO2），PaCO2，混合静脉血氧饱和度（SvO2），肺动脉分流和解剖死空间组成：a）具有以下特征的呼吸回路：在呼气时，呼出气体与吸入气体基本分离; ii。吸入时，当VE大于FGS流量时，受试者首先吸入FGS，然后吸入基本上为SGS的气体，用于吸入余量; b）用于监测患者 - 电路接口处的气体浓度的气体传感器装置c）第一气体组（FGS）和第二气体组（SGS），所述第二气体组可以包括先前呼出的气体或外来气体或二者）用于控制FGS流入呼吸回路的速率的气体流量控制装置e）识别呼吸相位的装置，所述装置可包括压力传感器或由气体传感器产生的信号分析或本领域技术人员已知的其它装置艺术; f）机器智能，包括能够控制气体流量控制装置的计算机或逻辑电路，接收气体传感器装置的输出和识别呼吸相位的装置，以及执行用于测量心输出量和其他参数的计算，如披露。

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