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    • 1. 发明授权
    • Bridged perinones/quinophthalones
    • 桥联perinones / quinophthalones
    • US06833455B2
    • 2004-12-21
    • US10302186
    • 2002-11-22
    • Christoph ThiebesJosef-Walter StawitzUlrich Feldhues
    • Christoph ThiebesJosef-Walter StawitzUlrich Feldhues
    • C07D40112
    • C09B25/00C07D215/20C09B57/12
    • Disclosed herein are bridged perinones/quinophthalones of the general formula (I) or tautomeric forms thereof where X1, X2, Ar1 Ar2 and B are as described herein and are particularly characterized in that the bridging B is a radical of the formula —T1—W—T2—, where T1 and T2 are independently O or S and W is alkylene, especially C1-C6-alkylene, C6-C10-arylene, especially phenylene or cycloalkylene, which are each optionally substituted or is the radical of the formula (a) where the phenyl rings are optionally substituted and A is a radical of the formula O, S, SO, SO2 or CO, optionally substituted alkylene, or optionally substituted cycloalkylene, said alkylene or cycloalkylene being attached to the adjacent phenyl rings itself or else via its substitutents, or W is a radical of the formulae where s and t are independently from 1 to 6, the ends of the radical B each being attached to an aromatic carbon atom of the two radicals Ar1 and Ar2. EINBETTENEINBETTEN
    • 本文公开了通式(I)的桥联环戊二烯酮/喹酞酮或其互变异构体,其中X1,X2,Ar1Ar2和B如本文所述,其特征在于桥连B是式-T1-W- T2-,其中T1和T2独立地是O或S,W是亚烷基,特别是C1-C6-亚烷基,C6-C10-亚芳基,特别是亚苯基或亚环烷基,它们各自任选被取代或者是式(a)的基团, 其中苯环任选被取代,并且A是式O,S,SO,SO 2或CO,任选取代的亚烷基或任选取代的亚环烷基的基团,所述亚烷基或亚环烷基本身连接至相邻的苯环,或通过其取代基 或者W是式的基团,其中s和t独立地为1至6,基团B的末端各自连接到两个基团Ar 1和Ar 2的芳族碳原子上。 EINBETTENEINBETTEN
    • 5. 发明申请
    • Colored buffer solution for automated clinical analyzer
    • 彩色缓冲溶液,用于自动临床分析仪
    • US20060172425A1
    • 2006-08-03
    • US11048601
    • 2005-02-01
    • Ralf NeiglMichael SommerBronislaw CzechHorst BernethAlan TothJosef-Walter Stawitz
    • Ralf NeiglMichael SommerBronislaw CzechHorst BernethAlan TothJosef-Walter Stawitz
    • G01N33/00
    • G01N35/08G01N21/05G01N21/80G01N2021/0346G01N2035/00277Y10T436/108331
    • A colored intercapsular buffer solution is used to reduce erroneous results from the absorption or carryover of small amounts of reagent R1 and/or R2 into the intercapsular buffer solution segment in the analytical line of a capsule chemistry liquid analysis system in an automated clinical analyzer. The absorption of small amounts of the regent R1 and/or R2 in the intercapsular buffer solution leads to erroneous results in the analysis of the test sample, S, because the R1 and/or R2 that is carried over and absorbed into the buffer does not react with test sample S. The R1/R2 carryover can be measured and determined by monitoring the absorbance of the colored buffer solution, wherein the change in absorbance can be measured and compared to a reference value. The sample is automatically retested if an unacceptable change in absorbance occurs. The colored buffer solution comprises a phthalocyanine dye, an aqueous solution of a base at a pH of about 9-12, a surfactant to reduce surface tension and improve flow characteristics of the intercapsular colored buffer reagent through the analytical line, and a chelating agent to reduce the adverse effects of metal contaminants.
    • 使用有色的胶囊缓冲溶液来减少在自动化临床分析仪中胶囊化学液体分析系统的分析线中的少量试剂R1和/或R2吸收或携带到胶囊缓冲溶液段中的错误结果。 在胶囊缓冲液溶液中少量摄取R1和/或R2的吸收导致对测试样品S的分析的错误结果,因为携带并吸收到缓冲液中的R1和/或R2不是 与测试样品S反应。可以通过监测着色缓冲溶液的吸光度来测量和确定R1 / R2携带量,其中可以测量吸光度的变化并与参考值进行比较。 如果吸光度发生不可接受的变化,样品将自动重新测试。 有色缓冲溶液包含酞菁染料,pH为约9-12的碱的水溶液,降低表面张力的表面活性剂,并通过分析线改善层间彩色缓冲剂的流动特性,以及螯合剂 减少金属污染物的不利影响。