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1. 发明申请

US20060172425A1 Colored buffer solution for automated clinical analyzer 审中-公开
标题翻译：彩色缓冲溶液，用于自动临床分析仪
公开(公告)号：US20060172425A1
公开(公告)日：2006-08-03
申请号：US11048601
申请日：2005-02-01
申请人： Ralf Neigl , Michael Sommer , Bronislaw Czech , Horst Berneth , Alan Toth , Josef-Walter Stawitz
发明人： Ralf Neigl , Michael Sommer , Bronislaw Czech , Horst Berneth , Alan Toth , Josef-Walter Stawitz
IPC分类号： G01N33/00
CPC分类号： G01N35/08 , G01N21/05 , G01N21/80 , G01N2021/0346 , G01N2035/00277 , Y10T436/108331
摘要： A colored intercapsular buffer solution is used to reduce erroneous results from the absorption or carryover of small amounts of reagent R1 and/or R2 into the intercapsular buffer solution segment in the analytical line of a capsule chemistry liquid analysis system in an automated clinical analyzer. The absorption of small amounts of the regent R1 and/or R2 in the intercapsular buffer solution leads to erroneous results in the analysis of the test sample, S, because the R1 and/or R2 that is carried over and absorbed into the buffer does not react with test sample S. The R1/R2 carryover can be measured and determined by monitoring the absorbance of the colored buffer solution, wherein the change in absorbance can be measured and compared to a reference value. The sample is automatically retested if an unacceptable change in absorbance occurs. The colored buffer solution comprises a phthalocyanine dye, an aqueous solution of a base at a pH of about 9-12, a surfactant to reduce surface tension and improve flow characteristics of the intercapsular colored buffer reagent through the analytical line, and a chelating agent to reduce the adverse effects of metal contaminants.
摘要翻译：使用有色的胶囊缓冲溶液来减少在自动化临床分析仪中胶囊化学液体分析系统的分析线中的少量试剂R1和/或R2吸收或携带到胶囊缓冲溶液段中的错误结果。在胶囊缓冲液溶液中少量摄取R1和/或R2的吸收导致对测试样品S的分析的错误结果，因为携带并吸收到缓冲液中的R1和/或R2不是与测试样品S反应。可以通过监测着色缓冲溶液的吸光度来测量和确定R1 / R2携带量，其中可以测量吸光度的变化并与参考值进行比较。如果吸光度发生不可接受的变化，样品将自动重新测试。有色缓冲溶液包含酞菁染料，pH为约9-12的碱的水溶液，降低表面张力的表面活性剂，并通过分析线改善层间彩色缓冲剂的流动特性，以及螯合剂减少金属污染物的不利影响。

2. 发明申请

US20050026240A1 Reagent composition for the analysis of residual white blood cells in leuko-reduced blood banking products 有权
标题翻译：用于分析白血病减少血库产品中残留白细胞的试剂组合物
公开(公告)号：US20050026240A1
公开(公告)日：2005-02-03
申请号：US10896338
申请日：2004-07-21
申请人： Michael Sommer , Pasquale Degiorgio , Bronislaw Czech , Gena Fischer , E. Chapman , David Zelmanovic , Jolanta Kunicka
发明人： Michael Sommer , Pasquale Degiorgio , Bronislaw Czech , Gena Fischer , E. Chapman , David Zelmanovic , Jolanta Kunicka
IPC分类号： G01N33/49 , G01N1/30 , G01N15/14 , G01N33/48 , G01N33/50
CPC分类号： G01N33/5002 , G01N2015/1486 , G01N2015/1488 , Y10T436/101666 , Y10T436/107497
摘要： The enumeration and analysis of residual white blood cells in a sample of leukocyte-reduced blood products is conducted by forming a suspension of the leukocyte-reduced blood products with a sufficient amount of a lysing reagent. The lysing reagent comprises a buffer with a low molar concentration, and a non-ionic surfactant. The suspension of leukocyte-reduced blood products and the lysing reagent is incubated for a sufficient time at a temperature sufficient to selectively lyse the platelets and red blood cells without damaging the white blood cells. The white blood cells of the lysed blood products are then contacted with a suitable dye to stain the white blood cells and the number of stained white blood cells is measured. The lysing reagent is free of harsh organic solvents which can damage the plastic components of automated clinical analyzers.
摘要翻译：通过用足够量的裂解试剂形成白细胞减少的血液制品的悬浮液来进行白细胞减少的血液制品样品中的残余白细胞的计数和分析。裂解试剂包含具有低摩尔浓度的缓冲液和非离子表面活性剂。将白细胞减少的血液制品和裂解试剂的悬浮液在足以在不损伤白细胞的情况下足以选择性地裂解血小板和红细胞的温度下孵育足够的时间。然后将裂解的血液制品的白细胞与合适的染料接触以染色白细胞，并测量染色的白细胞数。裂解试剂不含苛刻的有机溶剂，可能会损坏自动化临床分析仪的塑料部件。

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