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1. 发明申请

US20110124069A1 PRODUCTION METHOD 审中-公开
标题翻译：生产方法
公开(公告)号：US20110124069A1
公开(公告)日：2011-05-26
申请号：US13003930
申请日：2009-07-16
申请人： Jorg Mampel , Guido Meurer , Jurgen Eck
发明人： Jorg Mampel , Guido Meurer , Jurgen Eck
IPC分类号： C12P7/18 , C12N1/21
CPC分类号： C12P7/18
摘要： The invention relates to the development of microorganisms that produce 1,2-propanediol (1,2-PD) from glycerol, whereas glycerol is simultaneously the substrate carbon source for 1,2-PD- and biomass production. The invention demonstrates that any type of glycerol serves as carbon substrate for 1,2-PD biosynthesis. The microorganism is a recombinant organism, preferentially an E. coli K12 strain or a derivative thereof, particularly a strain, which is inactivated in competing pathways that lower 1,2-PD production.
摘要翻译：本发明涉及从甘油生产1,2-丙二醇（1,2-PD）的微生物的开发，而甘油同时是用于1,2-PD和生物质生产的底物碳源。本发明证明任何类型的甘油都用作用于1,2-PD生物合成的碳底物。微生物是重组生物，优选大肠杆菌K12菌株或其衍生物，特别是在降低1,2-PD产生的竞争途径中灭活的菌株。

2. 发明申请

US20100330384A1 METHOD OF TREATING CELLULOSIC MATERIALS WITH HYDROPHOBINS 有权
标题翻译：用疏水化合物处理纤维素材料的方法
公开(公告)号：US20100330384A1
公开(公告)日：2010-12-30
申请号：US12528366
申请日：2008-02-27
申请人： Esther Gabor , Andreas Buthe , Jurgen Eck , Franz Kaufmann , Hans-Jorg Koch , Guido Meurer
发明人： Esther Gabor , Andreas Buthe , Jurgen Eck , Franz Kaufmann , Hans-Jorg Koch , Guido Meurer
IPC分类号： B32B21/06 , B05D3/02 , B32B21/04 , B32B9/02
CPC分类号： D21H17/22 , B27K3/002 , B27K3/15 , B27K2240/70 , C08L89/00 , C08L97/02 , D06M15/15 , D21C5/005 , D21H17/005 , D21H19/50 , Y10T428/31971 , Y10T428/31978 , Y10T428/31986 , Y10T428/31989 , Y10T428/31993
摘要： By treatment with hydrophobins, cellulosic materials such as paper, cardboard, cotton or, especially, wood-based materials, such as solid wood, glued wood products or particle board, can be effectively protected against absorption of and attack by water and/or moisture.
摘要翻译：通过用疏水蛋白处理，可以有效地防止纤维素材料如纸，纸板，棉花，或特别是木质材料，例如实木，胶木制品或刨花板，以防止水和/或水分的吸收和侵袭。

3. 发明申请

US20080102496A1 Expression of Nitrile Hydratases in a Two-Vector Expression System 审中-公开
标题翻译：腈水合酶在双向表达系统中的表达
公开(公告)号：US20080102496A1
公开(公告)日：2008-05-01
申请号：US10593362
申请日：2005-02-18
申请人： Stefan Verseck , Steffen Osswald , Wai-Yee Phong , Klaus Liebeton , Jurgen Eck
发明人： Stefan Verseck , Steffen Osswald , Wai-Yee Phong , Klaus Liebeton , Jurgen Eck
IPC分类号： C12N1/20 , C12N15/00 , C12N15/64 , C12N9/88 , C12P7/40
CPC分类号： C12N15/70 , C12N9/88
摘要： The present invention relates to a novel system for expressing nitrile hydratase. In this system, the nitrile hydratases, which are composed of subunits, are formed such that the respective subunits are located on different plasmids and are expressed simultaneously in E. coli.
摘要翻译：本发明涉及一种表达腈水合酶的新型体系。在该系统中，形成由亚基组成的腈水合酶，使得各个亚基位于不同的质粒上并在大肠杆菌中同时表达。

4. 发明申请

US20110105442A2 MEANS AND METHODS FOR CONTROLLING COMMENSALES 审中-公开
标题翻译：用于控制通信的手段和方法
公开(公告)号：US20110105442A2
公开(公告)日：2011-05-05
申请号：US12867766
申请日：2009-02-18
申请人： Ute Dechert , Jurgen Eck , Michael Krohn
发明人： Ute Dechert , Jurgen Eck , Michael Krohn
IPC分类号： A61K31/122 , C07C49/647 , A61K31/60 , A61K31/17 , A61Q19/00 , A01P1/00 , A01N35/06
CPC分类号： A61K8/35 , A61L27/54 , A61L29/16 , A61L31/16 , A61L2300/404 , A61Q17/005
摘要： The present invention relates to a cosmetic composition for the cleaning of the skin, said composition comprising or consisting of one or more compounds of formula (I) wherein represents a single bond or double bond; R1 and R2 are independently selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, linear or branched C1 to C4 alkinyl, and linear or branched C1 to C4 alkanoyl; R4 is selected from H, linear or branched C1 to C4 alkyl, linear or branched C1 to C4 alkenyl, and linear or branched C1 to C4 alkinyl; and R3 and R5 are independently selected from H, OH and halogen, or R3 and R5 together are O to form an epoxid, wherein represents a single bond in case R3 and R5 together are O. Also provided are means and methods for the prevention or reduction of biofilm formation on an intracorporeal device and/or for the removal of biofilm from an intracorporeal device, wherein said biofilm comprises or consists of bacteria of the genus Propionibacterium. Furthermore provided is an intracorporeal device which is coated and/or loaded with one or more compounds as defined above.
摘要翻译：本发明涉及一种用于清洁皮肤的化妆品组合物，所述组合物包含一种或多种式（I）化合物或其组合，其中代表单键或双键; R 1和R 2独立地选自H，直链或支链C 1至C 4烷基，直链或支链C 1至C 4烯基，直链或支链C 1至C 4炔基，和直链或支链C 1至C 4烷酰基; R4选自H，直链或支链C1至C4烷基，直链或支链C1至C4烯基，直链或支链C1至C4炔基; 并且R 3和R 5独立地选自H，OH和卤素，或者R 3和R 5一起为O以形成环氧化物，其中在R 3和R 5一起为O的情况下表示单键。还提供了用于预防或在体内装置中减少生物膜形成和/或从体内装置去除生物膜，其中所述生物膜包含丙酸杆菌属的细菌或由其构成。此外，提供了一种体外装置，其被涂覆和/或加载一种或多种如上所定义的化合物。

5. 发明申请

US20060240423A1 Isolation and cloning of dna from uncultivated organisms 失效
标题翻译：从未培养的生物体中分离和克隆dna
公开(公告)号：US20060240423A1
公开(公告)日：2006-10-26
申请号：US10525708
申请日：2003-08-20
申请人： Achim Quaiser , Torsten Ochsenreiter , Alexander Treusch , Arnulf Kletzin , Christa Schleper , Patrick Lorenz , Jurgen Eck
发明人： Achim Quaiser , Torsten Ochsenreiter , Alexander Treusch , Arnulf Kletzin , Christa Schleper , Patrick Lorenz , Jurgen Eck
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12N15/1003
摘要： The present invention relates to a device for the isolation and/or purification of nucleic acid molecules suitable to bind and/or inactivate inhibitors of the activity of reagents or enzymes used for DNA manipulation and to separate a plurality of nucleic acid molecules with respect to their size. Moreover, the invention relates to a method for the isolation of a nucleic acid molecule comprising applying a sample to the device of the invention wherein said nucleic acid molecule preferably represents a fraction of the metagenome of a given habitat. Furthermore, the invention relates to a method for the generation of at least one gene library comprising nucleic acid molecules isolated by the method of the invention and to a nucleic acid molecule isolated by the method of the invention.
摘要翻译：本发明涉及用于分离和/或纯化适于结合和/或失活用于DNA操作的试剂或酶的活性抑制剂的核酸分子的装置，并且相对于它们分离多个核酸分子尺寸。此外，本发明涉及用于分离核酸分子的方法，包括将样品施用于本发明的装置，其中所述核酸分子优选代表给定栖息地的元素的一部分。此外，本发明涉及产生至少一种包含通过本发明方法分离的核酸分子的基因文库以及通过本发明的方法分离的核酸分子的方法。

6. 发明授权

US07872100B2 Nitrile hydratases from metagenome libraries 有权
标题翻译：来自宏基因组文库的腈水合酶
公开(公告)号：US07872100B2
公开(公告)日：2011-01-18
申请号：US10593357
申请日：2005-03-10
申请人： Stefan Verseck , Klaus Liebeton , Jurgen Eck
发明人： Stefan Verseck , Klaus Liebeton , Jurgen Eck
IPC分类号： C07K14/00 , C07K17/00 , C07H21/02 , C07H21/04
CPC分类号： C12N9/88 , C12Y402/01084
摘要： The present invention is concerned with the preparation of novel nitrile hydratases. These latter are preferably obtained from nonculturable organisms by means of a PCR-based screening, in metagenome DNA libraries, using special degenerate primers.
摘要翻译：本发明涉及新型腈水合酶的制备。这些后者优选通过基于PCR的筛选从使用特殊简并引物的宏基因组DNA文库中获得来自非可培养生物体。

7. 发明申请

US20050221380A1 Method for determination of the responsiveness of an individual to mistletoe lectin 失效
标题翻译：确定个体对槲寄生凝集素的反应性的方法
公开(公告)号：US20050221380A1
公开(公告)日：2005-10-06
申请号：US10499297
申请日：2002-12-20
申请人： Johannes Muthing , Jasna Peter-Katalinic , Martin Langer , Babette Mockel , Jurgen Eck
发明人： Johannes Muthing , Jasna Peter-Katalinic , Martin Langer , Babette Mockel , Jurgen Eck
IPC分类号： G01N33/53 , C07K16/18 , C07K16/28 , C12N15/09 , C12Q1/02 , C12Q1/48 , G01N33/566 , G01N33/573 , G01N33/574 , G01N33/577 , G01N33/66 , A61K38/16
CPC分类号： C12Q1/48 , C07K16/18 , G01N33/566 , G01N33/66 , G01N2333/42 , G01N2400/00 , G01N2800/52
摘要： A method for the determination of the responsiveness of an individual to mistletoe lectin or to (an) mistletoe lectin single chain(s), wherein the expression of a membrane-bound receptor for mistletoe lectin is characteristic of a corresponding responsiveness.
摘要翻译：用于测定个体对槲寄生凝集素或（一种）槲寄生凝集素单链的响应性的方法，其中槲寄生凝集素的膜结合受体的表达是相应的响应性的特征。

8. 发明申请

US20050003419A1 Glycosyl hydrolases 有权
标题翻译：糖基水解酶
公开(公告)号：US20050003419A1
公开(公告)日：2005-01-06
申请号：US10872874
申请日：2004-06-21
申请人： Roland Breves , Karl-Heinz Maurer , Jurgen Eck , Patrick Lorenz , Holger Zinke
发明人： Roland Breves , Karl-Heinz Maurer , Jurgen Eck , Patrick Lorenz , Holger Zinke
IPC分类号： D06L1/20 , C11D3/386 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/26 , C12N9/28 , C12N15/09 , C12N15/56 , C12P7/06 , C12P19/14 , C12Q1/68 , C12S11/00 , D06L4/40 , C07H21/04 , C12N9/20
CPC分类号： C12N9/2414 , C07K2319/00 , C11D3/386 , Y02E50/17
摘要： The invention relates to a new glycosyl hydrolases with an amyloltic activity and nucleic acids coding for said gylcosyl hydrolases, A PCR-based method for identifying and preparing new gylcosyl hydrolases from metagenome DNA and several possible technical uses for such glycosyl hydrolases with an amylolytic activity. Washing and cleaning products containing such enzymes, and methods and possible uses corresponding thereto are particularly interesting.
摘要翻译：本发明涉及具有淀粉分解活性的新糖基水解酶和编码所述格基糖基水解酶的核酸，基于PCR的从宏基因组DNA鉴定和制备新的糖基水解酶的方法以及具有淀粉分解活性的这种糖基水解酶的几种可能的技术用途。含有这些酶的洗涤和清洁产品，以及与其对应的方法和可能的用途是特别有趣的。

9. 发明申请

US20110217232A1 Method for Determination of the Responsiveness of an Individual to Misletoe Lectin 审中-公开
标题翻译：用于确定个体对误用凝集素的反应性的方法
公开(公告)号：US20110217232A1
公开(公告)日：2011-09-08
申请号：US12643857
申请日：2009-12-21
申请人： Johannes Muthing , Jasna Peter-Katalinic , Martin Langer , Babette Mockel , Jurgen Eck
发明人： Johannes Muthing , Jasna Peter-Katalinic , Martin Langer , Babette Mockel , Jurgen Eck
IPC分类号： A61K51/10 , C07K16/00 , C07K2/00 , A61K38/14 , A61K51/08 , A61K39/395 , A61K39/00 , A61P31/12 , A61P37/04 , A61P43/00 , G01N33/567
CPC分类号： C12Q1/48 , C07K16/18 , G01N33/566 , G01N33/66 , G01N2333/42 , G01N2400/00 , G01N2800/52
摘要： A method for the determination of the responsiveness of an individual to mistletoe lectin or to (an) mistletoe lectin single chain(s), wherein the expression of a membrane-bound receptor for mistletoe lectin is characteristic of a corresponding responsiveness.
摘要翻译：用于测定个体对槲寄生凝集素或（一种）槲寄生凝集素单链的响应性的方法，其中槲寄生凝集素的膜结合受体的表达是相应的响应性的特征。

10. 发明申请

US20080227157A1 Nucleic acids encoding fusion proteins based on ribosome-inactivating proteins of the mistletoe Viscum Album 审中-公开
标题翻译：基于槲寄生槲寄生的核糖体灭活蛋白编码融合蛋白的核酸
公开(公告)号：US20080227157A1
公开(公告)日：2008-09-18
申请号：US11803114
申请日：2007-05-11
申请人： Jurgen Eck , Arno Schmidt , Holger Zinke
发明人： Jurgen Eck , Arno Schmidt , Holger Zinke
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12N1/20
CPC分类号： C07K14/42 , A61K38/00 , C07K2319/02 , C07K2319/21 , C07K2319/50 , C07K2319/55 , C07K2319/75 , C12N15/62
摘要： The invention relates to nucleic acid molecules which encode fusion proteins which contain as components at least one effector module, a processing module and a targeting module. The nucleic acid molecules according to the invention preferably also encode a modulator module and/or an affinity module. The invention furthermore relates to vectors containing these nucleic acid molecules, hosts transformed with the vectors according to the invention, fusion proteins encoded by nucleic acids according to the invention or produced by the hosts according to the invention as well as to medicaments containing the polypeptides or vectors according to the invention. The invention thus also concerns corresponding processes, uses and kits.
摘要翻译：本发明涉及编码融合蛋白的核酸分子，所述融合蛋白含有至少一个效应子模块，处理模块和靶向模块作为组分。根据本发明的核酸分子优选还编码调节剂模块和/或亲和力模块。本发明还涉及含有这些核酸分子的载体，用本发明的载体转化的宿主，由根据本发明的核酸编码或由本发明的宿主产生的融合蛋白以及含有多肽的药物或根据本发明的载体。因此，本发明也涉及相应的过程，用途和试剂盒。

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