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1. 发明申请

US20050070965A1 Method and system for discriminating RA driven from LA driven atrial flutter 审中-公开
标题翻译：用于区分LA驱动的LA驱动的心房扑动的方法和系统
公开(公告)号：US20050070965A1
公开(公告)日：2005-03-31
申请号：US10674641
申请日：2003-09-29
申请人： Jong Kil , Xiaoyi Min , Peter Boileau
发明人： Jong Kil , Xiaoyi Min , Peter Boileau
IPC分类号： A61N1/362 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/3622
摘要： A method and system for evaluating observed atrial activity, such as via an implantable cardiac stimulation device, to discriminate between the left and right atria as sites of origin of observed atrial flutter. The left and right atrial rates are compared for equivalence, stability, and relative time shift with respect to each other to determine which, if either, can be identified as the chamber of origin of the tachycardia. If relative comparison of the observed left and right atrial events is inconclusive, an evaluation can be made to attempt to determine the first flutter beat and its location under the assumption that the chamber in which a flutter beat was first observed was the site of origin. Determination of a particular atrium as the site of origin of flutter facilitates targeted delivery of ATP therapy to the determined site of origin.
摘要翻译：用于评估观察到的心房活动的方法和系统，例如通过可植入心脏刺激装置，以将左心房和右心房区分为观察到的心房扑动的原点。将左心房率和右心房率相对于彼此进行相等，稳定和相对时移进行比较，以确定哪个（如果有的话）可以被确定为心动过速的起始室。如果观察到的左心房事件和右心房事件的相对比较是不确定的，则可以在假设首先观察到颤动搏动的腔室是起点位置的假设下进行评估以试图确定第一扑动搏动及其位置。作为颤动起源部位的特定心房的确定有助于将ATP治疗靶向递送到确定的原位点。

2. 发明授权

US07225015B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
公开(公告)号：US07225015B1
公开(公告)日：2007-05-29
申请号：US10603398
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0468
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.

3. 发明申请

US20070156056A1 SYSTEM AND METHOD FOR DETECTING CARDIAC ISCHEMIA BASED ON T-WAVES USING AN IMPLANTABLE MEDICAL DEVICE 有权
标题翻译：使用可植入医疗设备检测基于T波的心脏异常的系统和方法
公开(公告)号：US20070156056A1
公开(公告)日：2007-07-05
申请号：US11686784
申请日：2007-03-15
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery Snell , Gene Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery Snell , Gene Bornzin , Jong Kil
IPC分类号： A61B5/04
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

4. 发明授权

US07218960B1 System and method for detecting cardiac ischemia based on T-waves using an implantable medical device 有权
标题翻译：使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07218960B1
公开(公告)日：2007-05-15
申请号：US10606299
申请日：2003-06-24
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/7242 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发病的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

5. 发明授权

US07349732B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
公开(公告)号：US07349732B1
公开(公告)日：2008-03-25
申请号：US10735944
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/0402
CPC分类号： A61B5/042 , A61B5/04011
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.

6. 发明授权

US07643872B2 System and method for detecting cardiac ischemia based on T-Waves using an implantable medical device 有权
标题翻译：用于使用可植入医疗装置检测基于T波的心脏缺血的系统和方法
公开(公告)号：US07643872B2
公开(公告)日：2010-01-05
申请号：US11686784
申请日：2007-03-15
申请人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
发明人： Xiaoyi Min , Yougandh Chitre , Jeffery D. Snell , Gene A. Bornzin , Jong Kil
IPC分类号： A61B5/0452 , A61N1/36
CPC分类号： A61B5/0452 , A61B5/0456 , A61B5/046 , A61B5/0464 , A61B5/7242 , A61N1/3627 , A61N1/3702
摘要： A technique is provided for detecting episodes of cardiac ischemia based on an examination of the total energy of T-waves. Since cardiac ischemia is often a precursor to acute myocardial infarction (AMI) or ventricular fibrillation (VF), the technique thereby provides a method for predicting the possible onset of AMI or VF. Briefly, the technique integrates internal electrical cardiac signals occurring during T-waves and then compares the result against a running average. If the result exceeds the average by some predetermined amount, ischemia is thereby detected and a warning signal is provided to the patient. The maximum slope of the T-wave is also exploited. Techniques are also set forth herein for reliably detecting T-waves, which help prevent P-waves from being misinterpreted as T-waves on unipolar sensing channels. The T-wave detection technique may be used in conjunction with ischemia detection or for other purposes.
摘要翻译：提供了一种基于对T波总能量的检查来检测心脏缺血发作的技术。由于心脏缺血通常是急性心肌梗死（AMI）或心室颤动（VF）的前兆，因此该技术提供了一种预测AMI或VF可能发作的方法。简而言之，该技术集成了T波期间发生的内部电心脏信号，然后将结果与运行平均值进行比较。如果结果超过平均预定量，则由此检测到缺血，并向患者提供警告信号。 T波的最大斜率也被利用。本文还阐述了可靠地检测T波的技术，这有助于防止P波被单解为单极感测通道上的T波。 T波检测技术可以与缺血检测或其他目的结合使用。

7. 发明授权

US07546157B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
标题翻译：使用由可植入医疗装置感测到的内部心脏信号来模拟表面EKG的系统和方法
公开(公告)号：US07546157B1
公开(公告)日：2009-06-09
申请号：US10735948
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/04
CPC分类号： A61B5/0402 , A61N1/3702
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.
摘要翻译：使用由植入装置的内部引线检测的信号来模拟表面心电图（EKG）。在一个示例中，使用将使用不同电极感测的信号的部分连接的技术来执行仿真，例如通过将在心房中感测的远场心室信号与在心室中感测到的远场心房信号组合，或者通过组合近场在心房中感测到的信号在心室感测到近场信号。在另一示例中，使用选择性地放大或衰减使用单个电极对感测的单个信号的部分的技术来执行仿真，例如通过衰减相对于该场的远场部分的心房单极信号的近场部分相同的信号或通过将相对于心室部分的交叉室信号的心房部分衰减到相同的信号。表面EKG仿真可以由植入装置本身或外部编程器基于发送到其上的心脏信号执行。

8. 发明授权

US07383080B1 System and method for emulating a surface EKG using internal cardiac signals sensed by an implantable medical device 有权
标题翻译：使用由可植入医疗装置感测到的内部心脏信号来模拟表面EKG的系统和方法
公开(公告)号：US07383080B1
公开(公告)日：2008-06-03
申请号：US10736111
申请日：2003-12-12
申请人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
发明人： Jong Kil , Gene A. Bornzin , Peter Boileau , Euljoon Park
IPC分类号： A61B5/0402
CPC分类号： A61B5/04021
摘要： A surface electrocardiogram (EKG) is emulated using signals detected by the internal leads of an implanted device. In one example, the emulation is performed using a technique that concatenates portions of signals sensed using different electrodes, such as by combining far-field ventricular signals sensed in the atria with far-field atrial signals sensed in the ventricles or by combining near-field signals sensed in the atria with near-field signals sensed in the ventricles. In another example, the emulation is performed using a technique that selectively amplifies or attenuates portions of a single signal sensed using a single pair of electrodes, such as by attenuating near-field portions of an atrial unipolar signal relative to far-field portions of the same signal or by attenuating atrial portions of a cross-chamber signal relative to ventricular portions to the same signal. The surface EKG emulation may be performed by the implanted device itself or by an external programmer based on cardiac signals transmitted thereto.
摘要翻译：使用由植入装置的内部引线检测的信号来模拟表面心电图（EKG）。在一个示例中，使用将使用不同电极感测的信号的部分连接的技术来执行仿真，例如通过将在心房中感测的远场心室信号与在心室中感测到的远场心房信号组合，或者通过组合近场在心房中感测到的信号在心室感测到近场信号。在另一示例中，使用选择性地放大或衰减使用单个电极对感测的单个信号的部分的技术来执行仿真，例如通过衰减相对于该场的远场部分的心房单极信号的近场部分相同的信号或通过将相对于心室部分的交叉室信号的心房部分衰减到相同的信号。表面EKG仿真可以由植入装置本身或外部编程器基于发送到其上的心脏信号执行。

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