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1. 发明授权

US09283304B2 Absorbable stent having a coating for controlling degradation of the stent and maintaining pH neutrality 有权
标题翻译：可吸收支架具有用于控制支架降解并保持pH中性的涂层
公开(公告)号：US09283304B2
公开(公告)日：2016-03-15
申请号：US12277556
申请日：2008-11-25
申请人： Jonathon Z. Zhao
发明人： Jonathon Z. Zhao
IPC分类号： A61F2/06 , A61L31/02 , A61L31/10 , A61L31/14
CPC分类号： A61F2/89 , A61F2250/0067 , A61L31/022 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2420/00 , C08L67/04
摘要： A biocompatible metallic material may be configured into any number of implantable medical devices, including intraluminal stents. The biocompatible metallic material may comprise a magnesium alloy. The magnesium alloy implantable medical device may be designed to degrade over a given period of time. In order to control the degradation time, the device may be coated or otherwise have affixed thereto one or more coatings, one of which comprises a material for controlling the degradation time and maintain a pH neutral environment proximate the device. Additionally, therapeutic agents may be incorporated into one or more of the coatings on the implantable medical device.
摘要翻译：生物相容性金属材料可以被配置成任何数量的可植入医疗装置，包括腔内支架。生物相容性金属材料可以包括镁合金。镁合金可植入医疗装置可以设计成在给定的时间段内降解。为了控制降解时间，可以将该装置涂覆或以其它方式固定到其上一个或多个涂层，其中一个涂层包括用于控制降解时间的材料，并且在该装置附近保持pH中性环境。此外，治疗剂可以并入到可植入医疗装置上的一个或多个涂层中。

2. 发明授权

US08828416B2 Local vascular delivery of topotecan in combination with rapamycin to prevent restenosis following vascular injury 有权
标题翻译：拓扑替康与雷帕霉素组合的局部血管输送，以防止血管损伤后的再狭窄
公开(公告)号：US08828416B2
公开(公告)日：2014-09-09
申请号：US10796397
申请日：2004-03-09
申请人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
发明人： Robert Falotico , Tom Jay Parry , Jonathon Z. Zhao
IPC分类号： A61F2/00 , A61L31/10 , A61L31/16 , A61L33/00
CPC分类号： A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/416 , A61L2300/434 , A61L2420/08 , C08L27/12 , C08L33/02
摘要： Medical devices, in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，用于递送可植入医疗装置的装置可以被修改，以在展开期间减少对可植入医疗装置的损害。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

3. 发明授权

US08574550B2 Biocompatible polymeric contrast agents and radiopaque materials for medical services 有权
标题翻译：用于医疗服务的生物相容性聚合造影剂和不透射线材料
公开(公告)号：US08574550B2
公开(公告)日：2013-11-05
申请号：US13494455
申请日：2012-06-12
申请人： Jonathon Z. Zhao
发明人： Jonathon Z. Zhao
IPC分类号： A61K49/00
CPC分类号： C08G83/003 , A61K31/785 , A61K49/0442 , A61L31/06 , A61L31/18 , C08G63/08 , C08L101/005 , C08L101/04
摘要： In accordance with the present invention, a high intensity radiopaque contrast agent is disclosed. The agent may be coated on or incorporated within bulk materials, which may then be subsequently utilized to fabricate a radiopaque medical device. Primary effects through chemistry include higher radiopaque concentrations per unit weight of the radiopaque element or agent. Secondary effects include selective placement of the radiopaque elements which may further enhance the radiopacity of the device with reduced requirements of the radiopaque agent. Such a radiopaque contrast agent may be produced in various forms such as a dendrimer and/or incorporated as the end groups of polymeric chain. In addition one can incorporate biological and/or pharmaceutical agents in combination with the present invention.
摘要翻译：根据本发明，公开了一种高强度不透射线造影剂。药剂可以涂覆在散装材料上或并入其中，然后可随后用于制造不透射线的医疗装置。通过化学的主要作用包括每单位重量的不透射线元素或药剂的不透射线浓度更高。二次效应包括不透射线元件的选择性放置，这可以进一步增强装置的不透射线能力，同时对不透射线剂的要求降低。这种不透射线的造影剂可以以各种形式生产，例如树枝状聚合物和/或作为聚合物链的端基引入。此外，可以结合本发明并入生物和/或药剂。

4. 发明授权

US08506984B2 Therapeutic agent elution control process 有权
标题翻译：治疗剂洗脱控制过程
公开(公告)号：US08506984B2
公开(公告)日：2013-08-13
申请号：US11493324
申请日：2006-07-26
申请人： David Cook , Robert Falotico , Lily Kuo , Jonathon Z. Zhao
发明人： David Cook , Robert Falotico , Lily Kuo , Jonathon Z. Zhao
IPC分类号： A61F2/02 , A61K31/4745
CPC分类号： A61L31/10 , A61F2/07 , A61F2/91 , A61F2/95 , A61F2/954 , A61F2002/065 , A61F2002/075 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including vulnerable plaque. Implantable coated medical devices may be processed through annealing to better control the elution characteristics of the therapeutic agents. Furthermore, annealing leads to better therapeutic agent stability and a larger device shelf-life.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗特定疾病，包括易损斑块。可以通过退火处理可植入的涂覆的医疗装置，以更好地控制治疗剂的洗脱特性。此外，退火导致更好的治疗剂稳定性和更大的器件保质期。

5. 发明授权

US08409601B2 Rapamycin coated expandable devices 有权
标题翻译：雷帕霉素涂层可扩张装置
公开(公告)号：US08409601B2
公开(公告)日：2013-04-02
申请号：US12790046
申请日：2010-05-28
申请人： Ronald C. Dadino , Jonathon Z. Zhao
发明人： Ronald C. Dadino , Jonathon Z. Zhao
IPC分类号： A61F2/00
CPC分类号： A61K31/08 , A61K31/16 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/4745 , A61L29/08 , A61L29/16 , A61L31/16 , A61L2300/416 , A61L2300/606
摘要： Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
摘要翻译：医疗器械可用于局部和区域治疗剂递送。这些治疗剂或化合物可以减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗2型糖尿病患者中的特定疾病，包括再狭窄，易损斑块和动脉粥样硬化。

6. 发明授权

US07811555B2 Tri-branched biologically active copolymer 有权
标题翻译：三分支生物活性共聚物
公开(公告)号：US07811555B2
公开(公告)日：2010-10-12
申请号：US11323274
申请日：2005-12-30
申请人： Jonathon Z. Zhao
发明人： Jonathon Z. Zhao
IPC分类号： A61K31/74
CPC分类号： A61L31/10 , A61L27/34 , A61L29/085 , C08F220/38
摘要： The present invention discloses a tri-branched copolymer comprising a hydrophobic domain, a hydrophilic domain, a biologically active moiety, and an alkyl core of 2 to 10 carbon atoms. The hydrophobic domain, the hydrophilic domain, and the biologically active moiety are separately linked to the alkyl core of 2 to 10 carbon atoms through three functional groups, wherein said three functional groups are independently the same or different. Preferably, the tri-branched copolymer is prepared through reversible addition fragmentation transfer (RAFT) polymerization and conjugation reactions. The present invention also discloses a coating composition for applying on at least a portion of one surface of an article. The coating composition comprises the inventive tri-branched copolymer. In another aspect, the present invention discloses an article having the inventive coating composition thereon. Preferably, the article is a medical device or a component of a medical device.
摘要翻译：本发明公开了包含疏水结构域，亲水结构域，生物活性部分和2-10个碳原子的烷基核心的三支链共聚物。疏水结构域，亲水结构域和生物活性部分通过三个官能团分别连接至2至10个碳原子的烷基核心，其中所述三个官能团各自独立地相同或不同。优选地，通过可逆加成断裂转移（RAFT）聚合和共轭反应制备三支化共聚物。本发明还公开了一种用于在制品的一个表面的至少一部分上施加的涂料组合物。涂料组合物包含本发明的三支化共聚物。另一方面，本发明公开了一种在其上具有本发明的涂料组合物的制品。优选地，制品是医疗装置或医疗装置的部件。

7. 发明申请

US20100233236A1 DRUG COATED EXPANDABLE DEVICES 有权
标题翻译：药物涂层可扩展装置
公开(公告)号：US20100233236A1
公开(公告)日：2010-09-16
申请号：US12784572
申请日：2010-05-21
申请人： Jonathon Z. Zhao
发明人： Jonathon Z. Zhao
IPC分类号： A61K31/436 , B05D3/00 , A61F2/00 , A61P7/00
CPC分类号： A61L29/16 , A61K31/337 , A61K31/4355 , A61K31/436 , A61K31/4745 , A61L31/16 , A61L2300/416
摘要： Medical devices may be utilized for local and regional therapeutic agent delivery. These therapeutic agents or compounds may reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the prevention of thrombosis. The drugs, agents, and/or compounds may also be utilized to treat specific disorders, including restenosis, vulnerable plaque, and atherosclerosis in type 2 diabetic patients.
摘要翻译：医疗器械可用于局部和区域治疗剂递送。这些治疗剂或化合物可以减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括预防血栓形成。药物，药剂和/或化合物也可用于治疗2型糖尿病患者中的特定疾病，包括再狭窄，易损斑块和动脉粥样硬化。

8. 发明申请

US20100161039A1 ADHESION PROMOTING TEMPORARY MASK FOR COATED SURFACES 审中-公开
公开(公告)号：US20100161039A1
公开(公告)日：2010-06-24
申请号：US12342465
申请日：2008-12-23
申请人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
发明人： Vipul Dave , Robert Faiotico , Chengxue Li , Thai M. Nguyen , Theodore L. Parker , Jonathon Z. Zhao
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L33/0011 , A61L2300/00
摘要： An expandable medical device includes a plurality of elongated struts, forming a substantially cylindrical device which is expandable from a first diameter to a second diameter. A plurality of different beneficial agents may be loaded into different openings within the struts for delivery to the tissue. For treatment of conditions such as restenosis, different agents are loaded into different openings in the device to address different biological processes involved in restenosis and are delivered at different release kinetics matched to the biological process treated. The different agents may also be used to address different diseases from the same drug delivery device. In addition, anti-thrombotic agents may be affixed to at least a portion of the surfaces of the medical device for the prevention of sub-acute thrombosis. To ensure that the different agents remain affixed to the device as well as to each other, masking and de-masking processes may be utilized.

9. 发明申请

US20080171705A1 METHODS OF INDUCING AND TREATING VASCULAR DISEASE 审中-公开
标题翻译：诱导和治疗血管疾病的方法
公开(公告)号：US20080171705A1
公开(公告)日：2008-07-17
申请号：US11954381
申请日：2007-12-12
申请人： Robert Falotico , Jonathon Z. Zhao , Lei Zhao
发明人： Robert Falotico , Jonathon Z. Zhao , Lei Zhao
IPC分类号： A61K38/08 , A61P43/00
CPC分类号： A01K67/0276 , A01K2207/10 , A01K2217/05 , A01K2227/105 , A01K2267/0375
摘要： Animal testing, wherein the animals have disease state characteristics substantially equivalent to those found in humans, may be utilized to evaluate the efficacy of medical devices and/or therapeutic agents.
摘要翻译：动物测试，其中动物具有与人类基本相同的疾病状态特征，可用于评估医疗器械和/或治疗剂的功效。

10. 发明授权

US08871239B2 Polymeric materials for medical devices 有权
标题翻译：用于医疗器械的聚合材料
公开(公告)号：US08871239B2
公开(公告)日：2014-10-28
申请号：US13544043
申请日：2012-07-09
申请人： Jonathon Z. Zhao
发明人： Jonathon Z. Zhao
IPC分类号： A61K9/00 , A61P7/02 , A61P29/00 , A61L29/08 , A61L31/16 , A61L29/04 , A61L27/16 , A61L29/16 , A61L31/10 , A61L31/04 , A61L27/34 , A61L27/54
CPC分类号： A61L31/10 , A61L27/16 , A61L27/34 , A61L27/54 , A61L29/041 , A61L29/085 , A61L29/16 , A61L31/048 , A61L31/16 , A61L2300/216 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/606 , A61L2420/06 , C08L27/12
摘要： The present invention includes biocompatible polymeric coatings, membranes, matrices, and films to be used with implantable medical devices. Medical devices containing such materials applied to a surface thereof contain a film-forming fluorous homo-polymer or copolymer containing the polymerized residue of a fluorous moiety, wherein the relative amounts of the polymerized residues of one or more moieties are effective to provide the coating and films with properties effective for use in coating implantable med devices.
摘要翻译：本发明包括与可植入医疗装置一起使用的生物相容性聚合物涂层，膜，基质和膜。包含施用于其表面的这种材料的医疗装置包含含有氟部分的聚合残基的成膜氟聚合物或共聚物，其中一个或多个部分的聚合残基的相对量有效提供涂层和具有有效用于涂覆可植入医疗器械的性质的膜。

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