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1. 发明申请

US20120201800A1 Methods and Devices for Sustained In-Vivo Release Of an Active Agent 审中-公开
标题翻译：用于活性剂持续体内释放的方法和装置
公开(公告)号：US20120201800A1
公开(公告)日：2012-08-09
申请号：US13205497
申请日：2011-08-08
申请人： John W. Higuchi , S. Kevin Li , William I. Higuchi , Matthew S. Hastings
发明人： John W. Higuchi , S. Kevin Li , William I. Higuchi , Matthew S. Hastings
IPC分类号： A61K31/58 , A61K31/573 , A61K47/28 , A61P27/02 , A61P27/06 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61K38/43 , A61P9/10
CPC分类号： A61K9/0009 , A61F9/0017 , A61K9/0048 , A61K31/573 , A61K31/58 , A61K41/00 , A61K45/06 , A61N1/0412 , A61N1/044 , A61N1/303 , A61N1/327 , A61K2300/00
摘要： The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the subject. The depot can then release the active agent over a sustained period of time.
摘要翻译：本发明包括用于向受试者提供活性剂的持续体内释放的方法和装置。在一些方面，这样的释放可以通过活体活性剂与贮库形成剂反应来实现，以便在受试者内形成缓释活性剂贮库。然后，仓库可以在持续的时间段内释放活性剂。

2. 发明授权

US08755880B2 Intraocular iontophoretic device and associated methods 有权
公开(公告)号：US08755880B2
公开(公告)日：2014-06-17
申请号：US11414137
申请日：2006-04-27
申请人： John W. Higuchi , S. Kevin Li
发明人： John W. Higuchi , S. Kevin Li
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61N1/044 , A61N1/0448
摘要： The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.

3. 发明授权

US08634907B2 Intraocular iontophoretic device and associated methods 有权
标题翻译：眼内离子电渗疗法及相关方法
公开(公告)号：US08634907B2
公开(公告)日：2014-01-21
申请号：US11414134
申请日：2006-04-27
申请人： John W. Higuchi , S. Kevin Li
发明人： John W. Higuchi , S. Kevin Li
IPC分类号： A61N1/30
CPC分类号： A61N1/306 , A61N1/044 , A61N1/0448
摘要： The present invention includes methods and devices for delivering an active agent into the eye of a subject. One such device may include an anode assembly having an anode housing and an anode configured to electrically couple to a power source, the anode assembly being configured to contact and remain against a surface of the eye. The device may also include a cathode assembly having a cathode housing and a cathode configured to electrically couple to the power source, the cathode assembly being configured to contact and remain against the surface of the eye. Additionally, the device may include at least one active agent reservoir functionally associated with at least one of the anode assembly and the cathode assembly.
摘要翻译：本发明包括用于将活性剂递送到受试者的眼睛中的方法和装置。一个这样的装置可以包括阳极组件，阳极组件具有阳极壳体和被配置为电耦合到电源的阳极，阳极组件构造成接触并保持在眼睛的表面上。该装置还可以包括具有阴极壳体和阴极的阴极组件，该阴极壳体和阴极被配置为电耦合到电源，阴极组件构造成接触并保持抵靠眼睛的表面。另外，该装置可以包括与阳极组件和阴极组件中的至少一个功能性相关联的至少一个活性剂储存器。

4. 发明申请

US20090143752A1 Passive intraocular drug delivery devices and associated methods 审中-公开
标题翻译：被动眼内药物输送装置及相关方法
公开(公告)号：US20090143752A1
公开(公告)日：2009-06-04
申请号：US11999266
申请日：2007-12-03
申请人： John W. Higuchi , S. Kevin Li
发明人： John W. Higuchi , S. Kevin Li
IPC分类号： A61F9/00
CPC分类号： A61F9/0017
摘要： The present invention provides methods and devices for the passive delivery of active agents into the eye of a subject. In one aspect, for example, a device for passively delivering an active agent into an eye of a subject may include a housing configured to conform to at least a portion of an eye surface, and a first reservoir component located within the housing and configured to be fluidically coupled to a first ocular surface, where the first reservoir contains an ionized active agent. The device may further include a second reservoir component located within the housing and configured to be fluidically coupled to a second ocular surface located adjacent to the first ocular surface, where the second reservoir component contains a depot forming agent having a charge that is opposite in polarity as compared to the ionized active agent. The ionized active agent and the depot forming agent are configured to form a precipitate when contacted together at room to body temperature and at a pH of between about 4 to about 8 in an aqueous medium. Additionally, the device does not include an electrode.
摘要翻译：本发明提供了将活性剂被动递送到受试者的眼睛中的方法和装置。在一个方面，例如，用于将活性剂被动地递送到受试者的眼睛中的装置可以包括构造成符合眼表面的至少一部分的壳体和位于壳体内的第一储存器部件，并且被配置为流体耦合到第一眼表面，其中第一储存器包含电离活性剂。该装置还可以包括位于壳体内并被配置为流体耦合到位于邻近第一眼表面的第二眼表面的第二储存器部件，其中第二储存器部件包含具有与极性相反的电荷的贮库形成剂与电离活性剂相比。离子化活性剂和贮库形成剂被配置为当在水性介质中在室温和约4至约8的pH下接触在一起时形成沉淀物。另外，该装置不包括电极。

5. 发明申请

US20100040669A1 Non-Invasive Ocular Delivery of Rapamycin 审中-公开
标题翻译：雷帕霉素的非侵入性眼部递送
公开(公告)号：US20100040669A1
公开(公告)日：2010-02-18
申请号：US12540271
申请日：2009-08-12
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F2/00 , A61K31/436
CPC分类号： A61K31/7048 , A61K9/0009 , A61K9/0048 , A61K9/0051 , A61K31/4174 , A61K45/06 , A61N1/0428 , A61N1/0444 , A61K2300/00
摘要： Methods and systems for preventing or treating various ocular conditions are disclosed and described. In one aspect, for example, a method for noninvasively delivering a water insoluble macrolide into an eye of a subject for treatment of an ocular condition is provided. Such a method may include administering non-invasively a water soluble form of the macrolide directly into an eye of a subject having or at risk for having the ocular condition, wherein the water soluble form is converted into the water insoluble macrolide in the eye in order to treat the ocular condition.
摘要翻译：公开和描述了用于预防或治疗各种眼部病症的方法和系统。在一个方面，例如，提供了一种将水不溶性大环内酯非侵入性递送到受试者的眼睛中用于治疗眼睛病症的方法。这种方法可以包括非侵入性地将大环内酯类的水溶性形式直接施用到具有或具有眼睛病症风险的对象的眼睛中，其中水溶性形式按顺序转化为眼睛中的水不溶性大环内酯以治疗眼睛状况。

6. 发明申请

US20140031766A9 Intrascleral Drug Delivery Device and Associated Methods 审中-公开
标题翻译： Intrascleral药物输送装置及相关方法
公开(公告)号：US20140031766A9
公开(公告)日：2014-01-30
申请号：US13113672
申请日：2011-05-23
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F9/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61F2250/0068
摘要： The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的方法和装置。在一个方面，例如，本发明提供了一种眼药物递送装置，其包括构造成耦合到对象的眼睛的壳体和耦合到壳体的角膜密封件，并且定位在壳体中以在使用期间包围角膜以形成角膜区域，其中壳体从角膜密封件向外延伸以形成巩膜区域，并且其中巩膜区域在使用期间位于眼睛的巩膜上方。该装置还包括联接到壳体并被定位成将活性剂释放到巩膜区域中的活性剂储存器和耦合到壳体的压力调节器，其可操作以在壳体和眼睛之间引入负压。因此，角膜密封件可操作以响应于负压将角膜区域与巩膜区域隔离。

7. 发明申请

US20090093780A1 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 有权
标题翻译：室内静电装置及相关方法
公开(公告)号：US20090093780A1
公开(公告)日：2009-04-09
申请号：US11867503
申请日：2007-10-04
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61M35/00 , A61F2/00 , A61P27/02 , A61K47/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

8. 发明申请

US20130345615A1 Intracorneal Drug Delivery Device and Associated Methods 审中-公开
标题翻译：角膜内给药装置及相关方法
公开(公告)号：US20130345615A1
公开(公告)日：2013-12-26
申请号：US13529873
申请日：2012-06-21
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F9/00 , A61N1/30 , A61M35/00
CPC分类号： A61F9/0017 , A61N1/0428 , A61N1/303 , G02C7/04
摘要： Methods and devices for delivering an active agent into the eye of a subject are provided. In one aspect, an ocular device for delivering an active agent through a cornea of an eye of a subject can include a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region. The device can also include an active agent reservoir coupled to the housing and positioned to release active agent into the corneal region, and a pressure regulator coupled to the housing and operable to introduce negative pressure between the housing and the eye. The corneal seal is operable to fluidically isolate the corneal region from the sclera in response to the negative pressure, thus minimizing contact of the active agent with the sclera.
摘要翻译：提供了将活性剂递送到受试者的眼睛中的方法和装置。在一个方面，用于通过受试者眼睛的角膜递送活性剂的眼部装置可以包括被配置为耦合到对象的眼睛的壳体和耦合到壳体并且定位在壳体中的角膜密封件，以包围使用角膜形成角膜区域。该装置还可以包括联接到壳体并被定位成将活性剂释放到角膜区域中的活性剂储存器，以及耦合到壳体并可操作以在壳体和眼睛之间引入负压的压力调节器。角膜密封件可操作以响应于负压将角膜区域与巩膜流体隔离，从而最小化活性剂与巩膜的接触。

9. 发明申请

US20120302972A1 Intrascleral Drug Delivery Device and Associated Methods 审中-公开
标题翻译： Intrascleral药物输送装置及相关方法
公开(公告)号：US20120302972A1
公开(公告)日：2012-11-29
申请号：US13113672
申请日：2011-05-23
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F9/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61F2250/0068
摘要： The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的方法和装置。在一个方面，例如，本发明提供了一种眼药物递送装置，其包括构造成耦合到对象的眼睛的壳体和耦合到壳体的角膜密封件，并且定位在壳体中以在使用期间包围角膜以形成角膜区域，其中壳体从角膜密封件向外延伸以形成巩膜区域，并且其中巩膜区域在使用期间位于眼睛的巩膜上方。该装置还包括联接到壳体并被定位成将活性剂释放到巩膜区域中的活性剂储存器和耦合到壳体的压力调节器，其可操作以在壳体和眼睛之间引入负压。因此，角膜密封件可操作以响应于负压将角膜区域与巩膜区域隔离。

10. 发明授权

US08480638B2 Intraocular iontophoretic device and associated methods 有权
标题翻译：眼内离子电渗疗法及相关方法
公开(公告)号：US08480638B2
公开(公告)日：2013-07-09
申请号：US11867503
申请日：2007-10-04
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61M35/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

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