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1. 发明申请

US20090093780A1 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 有权
标题翻译：室内静电装置及相关方法
公开(公告)号：US20090093780A1
公开(公告)日：2009-04-09
申请号：US11867503
申请日：2007-10-04
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61M35/00 , A61F2/00 , A61P27/02 , A61K47/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

2. 发明申请

US20110077582A1 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：室内静电装置及相关方法
公开(公告)号：US20110077582A1
公开(公告)日：2011-03-31
申请号：US12903837
申请日：2010-10-13
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61N1/30 , A61F9/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

3. 发明授权

US08480638B2 Intraocular iontophoretic device and associated methods 有权
标题翻译：眼内离子电渗疗法及相关方法
公开(公告)号：US08480638B2
公开(公告)日：2013-07-09
申请号：US11867503
申请日：2007-10-04
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61M35/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

4. 发明申请

US20080027371A1 Method and device for minimally invasive site specific ocular drug delivery 审中-公开
标题翻译：用于微创部位特异性眼药物递送的方法和装置
公开(公告)号：US20080027371A1
公开(公告)日：2008-01-31
申请号：US11881729
申请日：2007-07-26
申请人： John W. Higuchi , Anthony L. Tuitupou
发明人： John W. Higuchi , Anthony L. Tuitupou
IPC分类号： A61N1/30 , A61F2/00 , A61K31/44 , A61K31/56
CPC分类号： A61F9/0017 , A61K31/44 , A61K31/56 , A61N1/30
摘要： The present invention includes techniques for delivering an active agent into the eye of a subject. Accordingly, in one aspect a method may include delivering invasively an active agent into a peripheral tissue of the eye to form a drug reservoir, and applying an electric current to the drug reservoir to thus drive at least a portion of the active agent at least partially through the choroid. Numerous configurations are contemplated for the positioning of the electric current relative to the drug reservoir. For example, in one aspect the electric current may be applied to the drug reservoir from a non-invasively positioned electrode. In another aspect, the electric current may be applied to the drug reservoir from an invasively positioned electrode. A variety of invasive positions are contemplated, including, for example, positioning the invasive electrode within the peripheral tissue. In yet another aspect, delivering the active agent may further include implanting an invasive electrode having an associated drug reservoir containing the active agent into the peripheral tissue.
摘要翻译：本发明包括将活性剂递送到受试者的眼睛中的技术。因此，一方面，一种方法可以包括将活性剂侵入性输送到眼睛的外周组织中以形成药物储存器，以及向药物储存器施加电流，从而至少部分地驱动至少一部分活性剂通过脉络膜。考虑到相对于药物储存器定位电流的许多构造。例如，在一个方面，电流可以从非侵入性定位的电极施加到药物储存器。另一方面，电流可以从入侵定位的电极施加到药物储存器。考虑了各种侵入位置，包括例如将侵入性电极定位在外周组织内。在另一方面，递送活性剂还可以包括将含有活性剂的相关药物储存器的侵入性电极植入外周组织中。

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