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1. 发明申请

US20090093780A1 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 有权
标题翻译：室内静电装置及相关方法
公开(公告)号：US20090093780A1
公开(公告)日：2009-04-09
申请号：US11867503
申请日：2007-10-04
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61M35/00 , A61F2/00 , A61P27/02 , A61K47/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

2. 发明申请

US20110077582A1 INTRAOCULAR IONTOPHORETIC DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：室内静电装置及相关方法
公开(公告)号：US20110077582A1
公开(公告)日：2011-03-31
申请号：US12903837
申请日：2010-10-13
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61N1/30 , A61F9/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

3. 发明授权

US08480638B2 Intraocular iontophoretic device and associated methods 有权
标题翻译：眼内离子电渗疗法及相关方法
公开(公告)号：US08480638B2
公开(公告)日：2013-07-09
申请号：US11867503
申请日：2007-10-04
申请人： Anthony L. Tuitupou , John W. Higuchi
发明人： Anthony L. Tuitupou , John W. Higuchi
IPC分类号： A61M35/00
CPC分类号： A61K9/0009 , A61F9/0017 , A61M35/003 , A61M2210/0612 , A61N1/30
摘要： The present invention includes methods and devices for non-invasively delivering an active agent to the eye of a subject. In one aspect, for example, a device for delivering an active agent to an eye of a subject may include an ocular lens-shaped housing configured to contact a surface of the eye, and a reservoir coupled to the housing and configured to deliver an active agent to the eye, wherein the reservoir is located entirely within a 180 degree section of the housing. In another aspect, the reservoir is located entirely within a 150 degree section of the housing.
摘要翻译：本发明包括用于非侵入性地将活性剂递送到受试者的眼睛的方法和装置。在一个方面，例如，用于将活性剂递送到受试者的眼睛的装置可以包括被配置为接触眼睛的表面的眼睛透镜形状的壳体，以及耦合到壳体并被配置为递送活动药剂到眼睛，其中储存器完全位于壳体的180度部分内。在另一方面，储存器完全位于壳体的150度部分内。

4. 发明申请

US20080027371A1 Method and device for minimally invasive site specific ocular drug delivery 审中-公开
标题翻译：用于微创部位特异性眼药物递送的方法和装置
公开(公告)号：US20080027371A1
公开(公告)日：2008-01-31
申请号：US11881729
申请日：2007-07-26
申请人： John W. Higuchi , Anthony L. Tuitupou
发明人： John W. Higuchi , Anthony L. Tuitupou
IPC分类号： A61N1/30 , A61F2/00 , A61K31/44 , A61K31/56
CPC分类号： A61F9/0017 , A61K31/44 , A61K31/56 , A61N1/30
摘要： The present invention includes techniques for delivering an active agent into the eye of a subject. Accordingly, in one aspect a method may include delivering invasively an active agent into a peripheral tissue of the eye to form a drug reservoir, and applying an electric current to the drug reservoir to thus drive at least a portion of the active agent at least partially through the choroid. Numerous configurations are contemplated for the positioning of the electric current relative to the drug reservoir. For example, in one aspect the electric current may be applied to the drug reservoir from a non-invasively positioned electrode. In another aspect, the electric current may be applied to the drug reservoir from an invasively positioned electrode. A variety of invasive positions are contemplated, including, for example, positioning the invasive electrode within the peripheral tissue. In yet another aspect, delivering the active agent may further include implanting an invasive electrode having an associated drug reservoir containing the active agent into the peripheral tissue.
摘要翻译：本发明包括将活性剂递送到受试者的眼睛中的技术。因此，一方面，一种方法可以包括将活性剂侵入性输送到眼睛的外周组织中以形成药物储存器，以及向药物储存器施加电流，从而至少部分地驱动至少一部分活性剂通过脉络膜。考虑到相对于药物储存器定位电流的许多构造。例如，在一个方面，电流可以从非侵入性定位的电极施加到药物储存器。另一方面，电流可以从入侵定位的电极施加到药物储存器。考虑了各种侵入位置，包括例如将侵入性电极定位在外周组织内。在另一方面，递送活性剂还可以包括将含有活性剂的相关药物储存器的侵入性电极植入外周组织中。

5. 发明申请

US20100040669A1 Non-Invasive Ocular Delivery of Rapamycin 审中-公开
标题翻译：雷帕霉素的非侵入性眼部递送
公开(公告)号：US20100040669A1
公开(公告)日：2010-02-18
申请号：US12540271
申请日：2009-08-12
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F2/00 , A61K31/436
CPC分类号： A61K31/7048 , A61K9/0009 , A61K9/0048 , A61K9/0051 , A61K31/4174 , A61K45/06 , A61N1/0428 , A61N1/0444 , A61K2300/00
摘要： Methods and systems for preventing or treating various ocular conditions are disclosed and described. In one aspect, for example, a method for noninvasively delivering a water insoluble macrolide into an eye of a subject for treatment of an ocular condition is provided. Such a method may include administering non-invasively a water soluble form of the macrolide directly into an eye of a subject having or at risk for having the ocular condition, wherein the water soluble form is converted into the water insoluble macrolide in the eye in order to treat the ocular condition.
摘要翻译：公开和描述了用于预防或治疗各种眼部病症的方法和系统。在一个方面，例如，提供了一种将水不溶性大环内酯非侵入性递送到受试者的眼睛中用于治疗眼睛病症的方法。这种方法可以包括非侵入性地将大环内酯类的水溶性形式直接施用到具有或具有眼睛病症风险的对象的眼睛中，其中水溶性形式按顺序转化为眼睛中的水不溶性大环内酯以治疗眼睛状况。

6. 发明申请

US20140031766A9 Intrascleral Drug Delivery Device and Associated Methods 审中-公开
标题翻译： Intrascleral药物输送装置及相关方法
公开(公告)号：US20140031766A9
公开(公告)日：2014-01-30
申请号：US13113672
申请日：2011-05-23
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F9/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61F2250/0068
摘要： The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的方法和装置。在一个方面，例如，本发明提供了一种眼药物递送装置，其包括构造成耦合到对象的眼睛的壳体和耦合到壳体的角膜密封件，并且定位在壳体中以在使用期间包围角膜以形成角膜区域，其中壳体从角膜密封件向外延伸以形成巩膜区域，并且其中巩膜区域在使用期间位于眼睛的巩膜上方。该装置还包括联接到壳体并被定位成将活性剂释放到巩膜区域中的活性剂储存器和耦合到壳体的压力调节器，其可操作以在壳体和眼睛之间引入负压。因此，角膜密封件可操作以响应于负压将角膜区域与巩膜区域隔离。

7. 发明申请

US20130345615A1 Intracorneal Drug Delivery Device and Associated Methods 审中-公开
标题翻译：角膜内给药装置及相关方法
公开(公告)号：US20130345615A1
公开(公告)日：2013-12-26
申请号：US13529873
申请日：2012-06-21
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F9/00 , A61N1/30 , A61M35/00
CPC分类号： A61F9/0017 , A61N1/0428 , A61N1/303 , G02C7/04
摘要： Methods and devices for delivering an active agent into the eye of a subject are provided. In one aspect, an ocular device for delivering an active agent through a cornea of an eye of a subject can include a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region. The device can also include an active agent reservoir coupled to the housing and positioned to release active agent into the corneal region, and a pressure regulator coupled to the housing and operable to introduce negative pressure between the housing and the eye. The corneal seal is operable to fluidically isolate the corneal region from the sclera in response to the negative pressure, thus minimizing contact of the active agent with the sclera.
摘要翻译：提供了将活性剂递送到受试者的眼睛中的方法和装置。在一个方面，用于通过受试者眼睛的角膜递送活性剂的眼部装置可以包括被配置为耦合到对象的眼睛的壳体和耦合到壳体并且定位在壳体中的角膜密封件，以包围使用角膜形成角膜区域。该装置还可以包括联接到壳体并被定位成将活性剂释放到角膜区域中的活性剂储存器，以及耦合到壳体并可操作以在壳体和眼睛之间引入负压的压力调节器。角膜密封件可操作以响应于负压将角膜区域与巩膜流体隔离，从而最小化活性剂与巩膜的接触。

8. 发明申请

US20120302972A1 Intrascleral Drug Delivery Device and Associated Methods 审中-公开
标题翻译： Intrascleral药物输送装置及相关方法
公开(公告)号：US20120302972A1
公开(公告)日：2012-11-29
申请号：US13113672
申请日：2011-05-23
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61F9/00
CPC分类号： A61F9/0026 , A61F9/0017 , A61F2250/0068
摘要： The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.
摘要翻译：本发明提供了将活性剂递送到受试者的眼睛中的方法和装置。在一个方面，例如，本发明提供了一种眼药物递送装置，其包括构造成耦合到对象的眼睛的壳体和耦合到壳体的角膜密封件，并且定位在壳体中以在使用期间包围角膜以形成角膜区域，其中壳体从角膜密封件向外延伸以形成巩膜区域，并且其中巩膜区域在使用期间位于眼睛的巩膜上方。该装置还包括联接到壳体并被定位成将活性剂释放到巩膜区域中的活性剂储存器和耦合到壳体的压力调节器，其可操作以在壳体和眼睛之间引入负压。因此，角膜密封件可操作以响应于负压将角膜区域与巩膜区域隔离。

9. 发明申请

US20120201800A1 Methods and Devices for Sustained In-Vivo Release Of an Active Agent 审中-公开
标题翻译：用于活性剂持续体内释放的方法和装置
公开(公告)号：US20120201800A1
公开(公告)日：2012-08-09
申请号：US13205497
申请日：2011-08-08
申请人： John W. Higuchi , S. Kevin Li , William I. Higuchi , Matthew S. Hastings
发明人： John W. Higuchi , S. Kevin Li , William I. Higuchi , Matthew S. Hastings
IPC分类号： A61K31/58 , A61K31/573 , A61K47/28 , A61P27/02 , A61P27/06 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61K38/43 , A61P9/10
CPC分类号： A61K9/0009 , A61F9/0017 , A61K9/0048 , A61K31/573 , A61K31/58 , A61K41/00 , A61K45/06 , A61N1/0412 , A61N1/044 , A61N1/303 , A61N1/327 , A61K2300/00
摘要： The present invention includes methods and devices for providing sustained in-vivo release of an active agent to a subject. In some aspects, such release may be achieved by reacting an active agent in-vivo with a depot forming agent in order to form a sustained release active agent depot inside the subject. The depot can then release the active agent over a sustained period of time.
摘要翻译：本发明包括用于向受试者提供活性剂的持续体内释放的方法和装置。在一些方面，这样的释放可以通过活体活性剂与贮库形成剂反应来实现，以便在受试者内形成缓释活性剂贮库。然后，仓库可以在持续的时间段内释放活性剂。

10. 发明授权

US10398594B2 Intrascleral drug delivery device and associated methods 有权
公开(公告)号：US10398594B2
公开(公告)日：2019-09-03
申请号：US13113672
申请日：2011-05-23
申请人： John W. Higuchi
发明人： John W. Higuchi
IPC分类号： A61M35/00 , A61F9/00 , A61M29/00
摘要： The present invention provides methods and devices for delivering an active agent into the eye of a subject. In one aspect, for example, the present invention provides an ocular drug delivery device including a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region, where the housing extends outward from the corneal seal to form a scleral region, and where the scleral region being positioned over the eye's sclera during use. The device further includes an active agent reservoir coupled to the housing and positioned to release active agent into the scleral region and a pressure regulator coupled to the housing that is operable to introduce negative pressure between the housing and the eye. Thus the corneal seal is operable to fluidically isolate the corneal region from the scleral region in response to the negative pressure.

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