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1. 发明申请

US20060089369A1 Inhibitors of glycogen synthase kinase 3 失效
公开(公告)号：US20060089369A1
公开(公告)日：2006-04-27
申请号：US11220400
申请日：2005-09-06
申请人： John Nuss , Stephen Harrison , David Ring , Rustum Boyce , Kirk Johnson , Keith Pfister , Savithri Ramurthy , Lynn Seely , Allan Wagman , Manoj Desai , Barry Levine
发明人： John Nuss , Stephen Harrison , David Ring , Rustum Boyce , Kirk Johnson , Keith Pfister , Savithri Ramurthy , Lynn Seely , Allan Wagman , Manoj Desai , Barry Levine
IPC分类号： A61K31/52 , A61K31/497 , A61K31/4439 , A61K31/506 , C07D473/12 , C07D401/02 , C07D403/02 , C07D405/02 , C07D409/02
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

2. 发明授权

US07045519B2 Inhibitors of glycogen synthase kinase 3 失效
公开(公告)号：US07045519B2
公开(公告)日：2006-05-16
申请号：US09949035
申请日：2001-09-06
申请人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Kirk Johnson , Keith B. Pfister , Savithri Ramurthy , Lynn Seely , Allan S. Wagman , Manoj C. Desai , Barry H. Levine
发明人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Kirk Johnson , Keith B. Pfister , Savithri Ramurthy , Lynn Seely , Allan S. Wagman , Manoj C. Desai , Barry H. Levine
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

3. 发明授权

US07425557B2 Inhibitors of glycogen synthase kinase 3 失效
标题翻译：糖原合酶激酶抑制剂3
公开(公告)号：US07425557B2
公开(公告)日：2008-09-16
申请号：US11220400
申请日：2005-09-06
申请人： John M Nuss , Stephen D Harrison , David B Ring , Rustum S Boyce , Kirk Johnson , Keith B Pfister , Savithri Ramurthy , Lynn Seely , Allan S Wagman , Manoj C Desai , Barry H Levine
发明人： John M Nuss , Stephen D Harrison , David B Ring , Rustum S Boyce , Kirk Johnson , Keith B Pfister , Savithri Ramurthy , Lynn Seely , Allan S Wagman , Manoj C Desai , Barry H Levine
IPC分类号： A61K31/497 , C07D241/36 , C07D471/00 , C07D487/00 , C07D403/00 , C07D401/00 , C07D405/00
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D213/85 , C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： New pyridine-based compounds of Formula I, compositions, and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3-mediated disorders in vivo are provided. The methods, compounds, and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要翻译：提供了新的吡啶类化合物，组合物和抑制糖原合成酶激酶（GSK3）活性的体外活性和在体内治疗GSK3介导的病症的方法。本发明的方法，化合物和组合物可以单独使用或与其它药理活性剂组合用于治疗由GSK3活性介导的病症，例如糖尿病，阿尔茨海默氏病和其它神经变性疾病，肥胖症，动脉粥样硬化性心血管疾病，原发性高血压，多囊卵巢综合征，X综合征，局部缺血，创伤性脑损伤，双相情感障碍，免疫缺陷或癌症。

4. 发明授权

US07037918B2 Inhibitors of glycogen synthase kinase 3 失效
公开(公告)号：US07037918B2
公开(公告)日：2006-05-02
申请号：US10309535
申请日：2002-12-03
申请人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Sean P. Brown , Dane A. Goff , Kirk W. Johnson , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Lynn Seely , Sharadha Subramanian , Allan S. Wagman , Xiaohui A. Zhou
发明人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Sean P. Brown , Dane A. Goff , Kirk W. Johnson , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Lynn Seely , Sharadha Subramanian , Allan S. Wagman , Xiaohui A. Zhou
IPC分类号： A61K31/505 , A61K31/535 , A61K31/47 , A61K31/475 , A61K31/52
CPC分类号： C07D213/74 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12
摘要： New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

5. 发明授权

US06489344B1 Inhibitors of glycogen synthase kinase 3 失效
标题翻译：糖原合酶激酶抑制剂3
公开(公告)号：US06489344B1
公开(公告)日：2002-12-03
申请号：US09336098
申请日：1999-06-18
申请人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Sean P. Brown , Dane A. Goff , Kirk W. Johnson , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Lynn Seely , Sharadha Subramanian , Allan S. Wagman , Xiaohui A. Zhou
发明人： John M. Nuss , Stephen D. Harrison , David B. Ring , Rustum S. Boyce , Sean P. Brown , Dane A. Goff , Kirk W. Johnson , Keith B. Pfister , Savithri Ramurthy , Paul A. Renhowe , Lynn Seely , Sharadha Subramanian , Allan S. Wagman , Xiaohui A. Zhou
IPC分类号： C07D40104
CPC分类号： C07D213/74 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D417/12
摘要： New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
摘要翻译：提供了新的嘧啶或吡啶类化合物，体外抑制糖原合成酶激酶（GSK3）活性和体内GSK3介导的病症治疗的组合物和方法。本发明的方法，化合物和组合物可以单独使用或与其它药理活性剂组合用于治疗由GSK3活性介导的病症，例如治疗糖尿病，阿尔茨海默病和其他神经变性疾病，肥胖症，动脉粥样硬化心血管疾病，原发性高血压，多囊卵巢综合征，X综合征，缺血，创伤性脑损伤，双相情感障碍，免疫缺陷或癌症。

6. 发明授权

US07921851B2 Nipple covering system 有权
标题翻译：乳头覆盖系统
公开(公告)号：US07921851B2
公开(公告)日：2011-04-12
申请号：US12368257
申请日：2009-02-09
申请人： Daniel R. Kurz , Lynn Seely
发明人： Daniel R. Kurz , Lynn Seely
IPC分类号： A61F13/00
CPC分类号： A61J13/00 , A61F13/141 , A61F15/008 , A61F2013/15016 , A61M19/00 , A61M2210/1007
摘要： One aspect of the present invention relates to a covering member for a protruding portion of a patient's body. This cover is flexible and collapsible so that it conforms to the shape of the encased portion of the body. This prevents the cover from being noticed while it is worn under clothing. The cover can contain a medicament or agent for pretreating a portion of the body before an examination or procedure. When the cover is used to apply a topical anesthetic to a portion of the body for a recommended period of time prior to the procedure or examination commencing, the amount of discomfort experienced by the patient can be significantly reduced compared to the amount experienced by the patient who has the anesthetic applied for just a few moments before the procedure begins. Alternatively, the cover can be used to hold a medicament or agent on the intended portion of the body in order to heal a wound or cure a condition such as a skin rash or the like.
摘要翻译：本发明的一个方面涉及一种用于患者身体的突出部分的覆盖部件。该盖子是柔性的并且可折叠的，使得其符合身体的包裹部分的形状。这样可以防止在衣服穿着时注意盖子。盖子可以包含用于在检查或程序之前预处理身体的一部分的药物或试剂。当在手术或检查开始之前使用盖子将局部麻醉剂施用于身体的一部分建议的时间段时，与患者经历的量相比，可以显着降低患者的不适量在手术开始之前麻醉药物只需要几分钟就可以使用。或者，盖可以用于将药物或药剂保持在身体的预期部分上，以便愈合伤口或治愈诸如皮疹等的状况。

7. 发明申请

US20090250074A1 NIPPLE COVERING SYSTEM 有权
标题翻译： NIPPLE覆盖系统
公开(公告)号：US20090250074A1
公开(公告)日：2009-10-08
申请号：US12368257
申请日：2009-02-09
申请人： Daniel R. Kurz , Lynn Seely
发明人： Daniel R. Kurz , Lynn Seely
IPC分类号： A61J13/00 , A61F13/00
CPC分类号： A61J13/00 , A61F13/141 , A61F15/008 , A61F2013/15016 , A61M19/00 , A61M2210/1007
摘要： One aspect of the present invention relates to a covering member for a protruding portion of a patient's body. This cover is flexible and collapsible so that it conforms to the shape of the encased portion of the body. This prevents the cover from being noticed while it is worn under clothing. The cover can contain a medicament or agent for pretreating a portion of the body before an examination or procedure. When the cover is used to apply a topical anesthetic to a portion of the body for a recommended period of time prior to the procedure or examination commencing, the amount of discomfort experienced by the patient can be significantly reduced compared to the amount experienced by the patient who has the anesthetic applied for just a few moments before the procedure begins. Alternatively, the cover can be used to hold a medicament or agent on the intended portion of the body in order to heal a wound or cure a condition such as a skin rash or the like.
摘要翻译：本发明的一个方面涉及一种用于患者身体的突出部分的覆盖部件。该盖子是柔性的并且可折叠的，使得其符合身体的包裹部分的形状。这样可以防止在衣服穿着时注意盖子。盖子可以包含用于在检查或程序之前预处理身体的一部分的药物或试剂。当在手术或检查开始之前使用盖子将局部麻醉剂施用于身体的一部分建议的时间段时，与患者经历的量相比，可以显着降低患者的不适量在手术开始之前麻醉药物只需要几分钟就可以使用。或者，盖可以用于将药物或药剂保持在身体的预期部分上，以便愈合伤口或治愈诸如皮疹等的状况。

8. 发明申请

US20060074363A1 Cover and applicator for a portion of a mammalian body 有权
公开(公告)号：US20060074363A1
公开(公告)日：2006-04-06
申请号：US11291738
申请日：2005-12-01
申请人： Daniel Kurz , Lynn Seely
发明人： Daniel Kurz , Lynn Seely
IPC分类号： A61F5/00
CPC分类号： A61J13/00 , A61F13/141 , A61F15/008 , A61F2013/15016 , A61M19/00 , A61M2210/1007
摘要： One aspect of the present invention relates to a covering member for a protruding portion of a patient's body. This cover is flexible and collapsible so that it conforms to the shape of the encased portion of the body. This prevents the cover from being noticed while it is worn under clothing. The cover can contain a medicament or agent for pretreating a portion of the body before an examination or procedure. When the cover is used to apply a topical anesthetic to a portion of the body for a recommended period of time prior to the procedure or examination commencing, the amount of discomfort experienced by the patient can be significantly reduced compared to the amount experienced by the patient who has the anesthetic applied for just a few moments before the procedure begins. Alternatively, the cover can be used to hold a medicament or agent on the intended portion of the body in order to heal a wound or cure a condition such as a skin rash or the like.

9. 发明申请

US20120302974A1 NIPPLE COVER 有权
公开(公告)号：US20120302974A1
公开(公告)日：2012-11-29
申请号：US13486999
申请日：2012-06-01
申请人： Daniel R. Kurz , Lynn Seely
发明人： Daniel R. Kurz , Lynn Seely
IPC分类号： A61M35/00
CPC分类号： A61J13/00 , A61F13/141 , A61F15/008 , A61F2013/15016 , A61M19/00 , A61M2210/1007
摘要： One aspect of the present application relates to a covering member for a protruding portion of a patient's body. This cover is flexible and collapsible so that it conforms to the shape of the encased portion of the body.
摘要翻译：本申请的一个方面涉及一种用于患者身体的突出部分的覆盖部件。该盖子是柔性的并且可折叠的，使得其符合身体的包裹部分的形状。

10. 发明申请

US20110184355A1 NIPPLE COVERING SYSTEM 有权
标题翻译： NIPPLE覆盖系统
公开(公告)号：US20110184355A1
公开(公告)日：2011-07-28
申请号：US13083442
申请日：2011-04-08
申请人： Daniel R. Kurz , Lynn Seely
发明人： Daniel R. Kurz , Lynn Seely
IPC分类号： A61M35/00
CPC分类号： A61J13/00 , A61F13/141 , A61F15/008 , A61F2013/15016 , A61M19/00 , A61M2210/1007
摘要： One aspect of the present invention relates to a covering member for a protruding portion of a patient's body. This cover is flexible and collapsible so that it conforms to the shape of the encased portion of the body. This prevents the cover from being noticed while it is worn under clothing. The cover can contain a medicament or agent for pretreating a portion of the body before an examination or procedure. When the cover is used to apply a topical anesthetic to a portion of the body for a recommended period of time prior to the procedure or examination commencing, the amount of discomfort experienced by the patient can be significantly reduced compared to the amount experienced by the patient who has the anesthetic applied for just a few moments before the procedure begins. Alternatively, the cover can be used to hold a medicament or agent on the intended portion of the body in order to heal a wound or cure a condition such as a skin rash or the like.
摘要翻译：本发明的一个方面涉及一种用于患者身体的突出部分的覆盖部件。该盖子是柔性的并且可折叠的，使得其符合身体的包裹部分的形状。这样可以防止在衣服穿着时注意盖子。盖子可以包含用于在检查或程序之前预处理身体的一部分的药物或试剂。当在手术或检查开始之前使用盖子将局部麻醉剂施用于身体的一部分建议的时间段时，与患者经历的量相比，可以显着降低患者的不适量在手术开始之前麻醉药物只需要几分钟就可以使用。或者，盖可以用于将药物或药剂保持在身体的预期部分上，以便愈合伤口或治愈诸如皮疹等的状况。

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