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1. 发明申请

US20070048503A1 Solvatochromic visual indicator and the use of the same 有权
标题翻译：溶色变色视觉指示剂和使用相同
公开(公告)号：US20070048503A1
公开(公告)日：2007-03-01
申请号：US11216731
申请日：2005-08-31
申请人： John MacDonald , Alison Bagwell , Yanbin Huang , Jaeho Kim , Stephanie Martin
发明人： John MacDonald , Alison Bagwell , Yanbin Huang , Jaeho Kim , Stephanie Martin
IPC分类号： B41M5/00
CPC分类号： A61F13/42 , Y10S428/913 , Y10T428/24802 , Y10T428/24868
摘要： A graphic and/or message display system is described. The graphic and/or message display system functions to develop over a period of time a hidden graphic or message on an indicator panel or display area. The hidden graphic or message is revealed when an obscuring graphic reacts with a solvent to change color become at least substantially transparent. The graphic and/or message display system may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as a positive reinforcement or a reminder to perform a task. Methods for using the graphic and/or message display system are also described.
摘要翻译：描述图形和/或消息显示系统。图形和/或消息显示系统用于在一段时间内在指示器面板或显示区域上开发隐藏的图形或消息。隐藏的图形或消息被揭示，当模糊的图形与溶剂反应以改变颜色变得至少基本上是透明的。图形和/或消息显示系统可以用作独立设备，或者可以作为各种物品或产品的一部分而被并入，例如作为正的强化或提醒来执行任务。还描述了使用图形和/或消息显示系统的方法。

2. 发明申请

US20070048247A1 Deodorizing tablets 审中-公开
标题翻译：除臭片
公开(公告)号：US20070048247A1
公开(公告)日：2007-03-01
申请号：US11217098
申请日：2005-08-31
申请人： Stephanie Martin , John MacDonald , Jaeho Kim
发明人： Stephanie Martin , John MacDonald , Jaeho Kim
IPC分类号： A61K31/12 , A61L9/00
CPC分类号： A61L9/01
摘要： A tablet that is capable of reducing odor when added to a liquid is provided. The deodorizing tablet may be used in a wide variety of applications in which odor control is desired, such as in toilets, water treatment/sewage systems, well water, bedpans, and so forth. In addition to providing odor control, the tablet is generally soluble in the liquid so that its components are better able to contact malodorous compounds contained within the liquid. In this regard, the present inventors have discovered that certain quinone compounds are both odor inhibiting and also soluble in liquids (e.g., urine), and thus particularly useful in forming the deodorizing tablet of the present invention.
摘要翻译：提供了当添加到液体中时能够减少气味的片剂。除臭片剂可用于需要气味控制的各种应用中，例如在厕所，水处理/污水系统，井水，卧床等中。除了提供气味控制之外，片剂通常可溶于液体，使得其组分更好地接触包含在液体中的恶臭化合物。在这方面，本发明人已经发现某些醌化合物既气味抑制又可溶于液体（例如尿液），因此特别可用于形成本发明的除臭片剂。

3. 发明申请

US20050131363A1 Odor-reducing quinone compounds 有权
标题翻译：气味降低醌化合物
公开(公告)号：US20050131363A1
公开(公告)日：2005-06-16
申请号：US10955316
申请日：2004-09-30
申请人： John MacDonald , Stephanie Martin , Jaeho Kim
发明人： John MacDonald , Stephanie Martin , Jaeho Kim
IPC分类号： A23L1/00 , A23L1/22 , A23L1/236 , A61K9/00 , A61K9/14 , A61K9/51 , A61K9/70 , A61K31/197 , A61K31/375 , A61K31/57 , A61K31/65 , A61K47/48 , A61Q5/10 , A61L9/01 , A61F13/15 , A61K31/12
CPC分类号： D06M13/005 , A23L27/32 , A23L27/77 , A23V2002/00 , A61K31/197 , A61K31/375 , A61K31/57 , A61K31/65 , A61L9/01 , A61L9/014 , A61L15/46 , A61L2300/216 , A61L2300/442 , A61L2300/624 , D21H17/06 , D21H21/14 , D21H21/28 , Y10T442/2525 , A23V2200/25
摘要： An odor control composition that comprises an odor-reducing quinone compound and optionally high surface area particles is provided. In one embodiment, the odor-reducing quinone compound is an anthraquinone having the following structure: wherein the numbers 1 through 8 refer to optional substitution positions for functional groups. For example, positions 5 through 8 of the anthraquinone may be unsubstituted with functional groups. Examples of such quinone compounds may include those obtained from a dye selected from the group consisting of Acid Blue 25, Acid Green 41, Acid Blue 45, Mordant Violet 5, Acid Blue 129, Acid Green 25, D&C Green No. 5, Acid Green 27, and combinations thereof.
摘要翻译：提供了包含气味降低醌化合物和任选的高表面积颗粒的气味控制组合物。在一个实施方案中，气味降低醌化合物是具有以下结构的蒽醌：其中数字1至8表示官能团的任选取代位置。例如，蒽醌的5至8位可以被官能团取代。这样的醌化合物的实例可以包括从由酸性蓝25，酸性绿41，酸性蓝45，媒染紫5，酸性蓝129，酸性绿25，D＆C绿5，酸性绿 27及其组合。

4. 发明申请

US20070026074A1 Vaginal treatment composition 有权
标题翻译：阴道治疗组合物
公开(公告)号：US20070026074A1
公开(公告)日：2007-02-01
申请号：US11194064
申请日：2005-07-29
申请人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
发明人： Stephanie Martin , Lei Huang , Shu-Ping Yang , Yanbin Huang , Julie Villanueva , Sharon Greene , Kelly Arehart , Curtis Sayre , Robert Johnson
IPC分类号： A61K9/14 , A61K31/70 , A61K31/045
CPC分类号： A61K9/0034 , A61K31/192 , A61K31/70 , A61K47/36
摘要： A vaginal treatment composition that rapidly forms a gel when placed into contact with monovalent or polyvalent cations, such as sodium (Na+) and calcium (Ca2+) cations naturally found in vaginal mucosa, is provided. The gel may form in less than about 1 hour, in some embodiments less than about 1 minute, and in some embodiments, less than about 30 seconds. Among other things, such rapid gelation reduces the likelihood of leakage during use. In addition, because the gel may form intravaginally, it is more likely to retain its structure and shape over an extended period of time. In this manner, the gel may provide the prolonged release of a therapeutic agent that inhibits and/or treats vaginal infection. For instance, the gel may remain within the vagina for about 2 to about 48 hours to provide the desired effect.
摘要翻译：当与一价或多价阳离子接触时迅速形成凝胶的阴道处理组合物，例如天然存在的钠（Na +）+和钙（Ca 2+）+阳离子提供阴道粘膜。凝胶可以在小于约1小时，在一些实施方案中小于约1分钟，并且在一些实施方案中小于约30秒形成。除此之外，这种快速凝胶化可降低使用过程中泄漏的可能性。另外，因为凝胶可以阴道内形成，所以更可能在延长的时间段内保持其结构和形状。以这种方式，凝胶可提供抑制和/或治疗阴道感染的治疗剂的延长释放。例如，凝胶可以保留在阴道内约2至约48小时以提供期望的效果。

5. 发明申请

US20060134728A1 Microbial detection and quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20060134728A1
公开(公告)日：2006-06-22
申请号：US11117651
申请日：2005-04-28
申请人： John MacDonald , Stephanie Martin , Jason Lye
发明人： John MacDonald , Stephanie Martin , Jason Lye
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/06 , C12Q1/04 , Y10T442/2566
摘要： A method for semi-quantitatively or quantitatively detecting the presence of a microbe in a sample is provided. The method utilizes a test dye that undergoes a detectable color change in the presence of one or more microbes. For example, in one embodiment, the test dye is a solvatochromic dye (e.g., Reichardt's dye) that responds to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth. Regardless, the color of the test dye may be compared to the color of a control dye, wherein the color of the control dye corresponds to a known microbe concentration.
摘要翻译：提供了一种半定量或定量检测样品中微生物存在的方法。该方法利用在一种或多种微生物存在下经历可检测的颜色变化的测试染料。例如，在一个实施方案中，测试染料是响应于微生物组分（例如细胞膜，细胞质等）与细胞外的环境的极性差异的溶剂化色素染料（例如，Reichardt's染料）。或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。无论如何，可以将测试染料的颜色与对照染料的颜色进行比较，其中对照染料的颜色对应于已知的微生物浓度。

6. 发明申请

US20070249958A1 Method for detecting the onset of ovulation 有权
标题翻译：检测排卵发作的方法
公开(公告)号：US20070249958A1
公开(公告)日：2007-10-25
申请号：US11408154
申请日：2006-04-20
申请人： Stephanie Martin , RameshBabu Boga , John MacDonald
发明人： Stephanie Martin , RameshBabu Boga , John MacDonald
IPC分类号： A61B10/00
CPC分类号： A61B10/0012 , A61B2010/0006 , A61B2010/0087 , A61D17/002 , G01N31/223 , Y10T436/18 , Y10T436/182 , Y10T436/25875
摘要： A method for detecting the onset of ovulation in a female mammal is provided. The method comprises contacting mouth air of the female mammal with an arylmethane test chromogen in an amount effective to undergo a rapid and detectable color change in the presence of one or more volatile sulfur compounds. The color of the test chromogen is compared to a control color that corresponds to a pre-ovulatory sulfur content. The difference in color between the test chromogen and the control color is correlated to the onset of ovulation.
摘要翻译：提供了一种用于检测雌性哺乳动物排卵发作的方法。该方法包括使一种或多种挥发性硫化合物存在下有效地经历快速和可检测的颜色变化的量使该雌性哺乳动物的口腔空气与芳基甲烷测试的色原体接触。将测试色原体的颜色与对应于排卵前的硫含量的对照颜色进行比较。测试色原体和对照色之间的颜色差异与排卵的发生相关。

7. 发明申请

US20070249012A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20070249012A1
公开(公告)日：2007-10-25
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. A lateral flow device incorporating solvatochromic dyes and a method of detecting bacteria are also included.
摘要翻译：溶剂化色素染料在本文中用于通过将它们并入各种底物如薄膜，机织和非织造织物，纸巾，共成型和气流成网材料和粘合梳理纤维网中来表示细菌的存在。这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。还包括含有溶剂化色素染料的侧流装置和检测细菌的方法。

8. 发明申请

US20070140971A1 Method for screening for bacterial conjunctivitis 有权
标题翻译：筛选细菌性结膜炎的方法
公开(公告)号：US20070140971A1
公开(公告)日：2007-06-21
申请号：US11303001
申请日：2005-12-15
申请人： John MacDonald , Stephanie Martin , Jason Lye
发明人： John MacDonald , Stephanie Martin , Jason Lye
IPC分类号： A61K49/00 , C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/14
摘要： A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may vary depending on whether the microbe is a bacteria or virus. Without intending to be limited by theory, the present inventors believe that the chromogen interacts with the peptidoglycan-based cell wall structure of bacteria to induce a color change that is even more apparent at infectious levels. It is believed that this interaction occurs to a much greater extent in bacteria than in viruses. Accordingly, although the chromogen may still undergo a color change in the presence of the viruses, it is typically to a much lesser extent. In this manner, the degree of color change of the chromogen may be used in the present invention as a mechanism for differentiating between viral and bacterial conjunctivitis.
摘要翻译：提供了一种快速检测宿主感染性结膜炎的方法。该方法包括使眼睛测试样品与在微生物存在下显示颜色变化的色原体（例如，Reichardt's染料）接触。本发明人已经发现，颜色变化的程度可以根据微生物是细菌还是病毒而变化。不期望受理论的限制，本发明人相信色原体与细菌的基于聚肽聚糖的细胞壁结构相互作用以诱导在感染水平上更加明显的颜色变化。相信这种相互作用在细菌中比在病毒中更大程度地发生。因此，虽然染色体在病毒存在的情况下仍可能发生颜色变化，但通常其程度要小得多。以这种方式，在本发明中可以使用色原体的颜色变化程度作为区分病毒和细菌性结膜炎的机制。

9. 发明申请

US20060134613A1 Detection of microbe contamination on elastomeric articles 有权
标题翻译：检测弹性制品上的微生物污染
公开(公告)号：US20060134613A1
公开(公告)日：2006-06-22
申请号：US11117635
申请日：2005-04-28
申请人： Stephanie Martin , John MacDonald , Allison Bagwell , Jason Lye , Robert Johnson
发明人： Stephanie Martin , John MacDonald , Allison Bagwell , Jason Lye , Robert Johnson
IPC分类号： C12Q1/70 , C12Q1/04 , C12M1/34
CPC分类号： C12Q1/04 , G01N33/528
摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.
摘要翻译：提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。

10. 发明申请

US20080145316A1 Skin coating with microbial indicator 审中-公开
标题翻译：皮肤涂层微生物指示剂
公开(公告)号：US20080145316A1
公开(公告)日：2008-06-19
申请号：US11639833
申请日：2006-12-14
申请人： John Gavin MacDonald , Stephanie Martin , Molly K. Smith , Jason Lye
发明人： John Gavin MacDonald , Stephanie Martin , Molly K. Smith , Jason Lye
IPC分类号： A61K49/00 , C12Q1/04 , C12Q1/70
CPC分类号： A61L26/0061 , A61L24/001
摘要： Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. A skin coating is provided that has an indicator that gives a visible color change upon contact with microbes or microbial by-products and so provides an early warning of infection. The coating is a curable coating composition that may also be used without skin preps and may be used to protect other disruptions in the skin like wounds, bruises, abrasions, burns, acne, blisters, bites, stings, punctures and cuts. It may also be used to close wounds or provide an additional barrier to other parts of the skin, such as the nails and mucosa.
摘要翻译：皮肤密封剂通常用于皮肤制服上以密封皮肤，并且在手术切口之前将任何残留的细菌保持在适当位置。这种密封剂通常在手术后留在皮肤上。提供皮肤涂层，其具有指示剂，其在与微生物或微生物副产物接触时产生可见的颜色变化，因此提供感染的早期预警。该涂层是可固化的涂料组合物，其也可以不使用皮肤制剂使用，并且可以用于保护皮肤中的其它中断，例如伤口，瘀伤，擦伤，烧伤，痤疮，水疱，叮咬，叮咬，刺穿和切口。它还可以用于闭合伤口或提供对皮肤其他部分（例如指甲和粘膜）的额外屏障。

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