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1. 发明申请

US20080145316A1 Skin coating with microbial indicator 审中-公开
标题翻译：皮肤涂层微生物指示剂
公开(公告)号：US20080145316A1
公开(公告)日：2008-06-19
申请号：US11639833
申请日：2006-12-14
申请人： John Gavin MacDonald , Stephanie Martin , Molly K. Smith , Jason Lye
发明人： John Gavin MacDonald , Stephanie Martin , Molly K. Smith , Jason Lye
IPC分类号： A61K49/00 , C12Q1/04 , C12Q1/70
CPC分类号： A61L26/0061 , A61L24/001
摘要： Skin sealants are usually applied over skin preps to seal the skin and hold any remaining bacteria in place prior to surgical incisions. This sealant is generally left on the skin after surgery. A skin coating is provided that has an indicator that gives a visible color change upon contact with microbes or microbial by-products and so provides an early warning of infection. The coating is a curable coating composition that may also be used without skin preps and may be used to protect other disruptions in the skin like wounds, bruises, abrasions, burns, acne, blisters, bites, stings, punctures and cuts. It may also be used to close wounds or provide an additional barrier to other parts of the skin, such as the nails and mucosa.
摘要翻译：皮肤密封剂通常用于皮肤制服上以密封皮肤，并且在手术切口之前将任何残留的细菌保持在适当位置。这种密封剂通常在手术后留在皮肤上。提供皮肤涂层，其具有指示剂，其在与微生物或微生物副产物接触时产生可见的颜色变化，因此提供感染的早期预警。该涂层是可固化的涂料组合物，其也可以不使用皮肤制剂使用，并且可以用于保护皮肤中的其它中断，例如伤口，瘀伤，擦伤，烧伤，痤疮，水疱，叮咬，叮咬，刺穿和切口。它还可以用于闭合伤口或提供对皮肤其他部分（例如指甲和粘膜）的额外屏障。

2. 发明申请

US20100248299A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20100248299A1
公开(公告)日：2010-09-30
申请号：US12749814
申请日：2010-03-30
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译：合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。染料溶液也可以干燥，从而产生水溶液的干燥残余物。据信这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

3. 发明授权

US07687245B2 Microbial detection and quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US07687245B2
公开(公告)日：2010-03-30
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John Gavin MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/22
CPC分类号： C12Q1/04
摘要： Suitable dyes are used herein to indicate the presence of microbial contamination by spraying them onto surfaces in the form of an aqueous solution. The dye solution may also be allowed to dry, thus producing the dried residue of an aqueous solution. It's believed that these dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye.
摘要翻译：合适的染料在本文中用于通过以水溶液的形式将它们喷雾到表面上来表示存在微生物污染。染料溶液也可以干燥，从而产生水溶液的干燥残余物。据信这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。

4. 发明申请

US20060134728A1 Microbial detection and quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20060134728A1
公开(公告)日：2006-06-22
申请号：US11117651
申请日：2005-04-28
申请人： John MacDonald , Stephanie Martin , Jason Lye
发明人： John MacDonald , Stephanie Martin , Jason Lye
IPC分类号： C12Q1/04 , C12M1/34
CPC分类号： C12Q1/06 , C12Q1/04 , Y10T442/2566
摘要： A method for semi-quantitatively or quantitatively detecting the presence of a microbe in a sample is provided. The method utilizes a test dye that undergoes a detectable color change in the presence of one or more microbes. For example, in one embodiment, the test dye is a solvatochromic dye (e.g., Reichardt's dye) that responds to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth. Regardless, the color of the test dye may be compared to the color of a control dye, wherein the color of the control dye corresponds to a known microbe concentration.
摘要翻译：提供了一种半定量或定量检测样品中微生物存在的方法。该方法利用在一种或多种微生物存在下经历可检测的颜色变化的测试染料。例如，在一个实施方案中，测试染料是响应于微生物组分（例如细胞膜，细胞质等）与细胞外的环境的极性差异的溶剂化色素染料（例如，Reichardt's染料）。或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。无论如何，可以将测试染料的颜色与对照染料的颜色进行比较，其中对照染料的颜色对应于已知的微生物浓度。

5. 发明申请

US20080057532A1 Method for detecting Candida on skin 有权
标题翻译：检测皮肤上假丝酵母的方法
公开(公告)号：US20080057532A1
公开(公告)日：2008-03-06
申请号：US11513500
申请日：2006-08-31
申请人： Stephanie Martin , Andrew M. Long , J. Gavin MacDonald , Jason Lye
发明人： Stephanie Martin , Andrew M. Long , J. Gavin MacDonald , Jason Lye
IPC分类号： C12Q1/04
CPC分类号： A61L15/56 , G01N2333/245 , G01N2333/31 , G01N2333/40
摘要： A method and system for rapidly detecting Candida on the skin of a host, such as an infant with diaper rash, is provided. The method includes contacting a dermal sample with a colorant that exhibits a certain spectral response (e.g., color change) in the presence of Candida. For example, the colorant may change from a first color to a second color, from colorless to a color, or from a color to colorless. The colorant is typically capable of differentiating between Candida (e.g., Candida albicans) and other microorganisms commonly associated with diaper rash, such as S. aureus and E. coli. Thus, when a dermal sample is placed into contact with the colorant, the color change may simply be observed to determine whether the infection is caused by Candida. If the color change occurs to a certain extent (e.g., from yellow to bright red), it may be determined that the test sample contains Candida. Likewise, if a color change occurs to a lesser extent (e.g., from yellow to faint orange) or not at all, it may be determined that the dermal sample contains other microorganisms (e.g., S. aureus or E. coli), no infection is present, or that the infection is simply due to other causes. Regardless, it will become readily apparent whether or not treatment for Candida is needed.
摘要翻译：提供了用于快速检测宿主皮肤上的假丝酵母的方法和系统，例如具有尿布疹的婴儿。该方法包括使真皮样品与在假丝酵母存在下显示特定光谱响应（例如颜色变化）的着色剂接触。例如，着色剂可以从第一颜色变为第二颜色，从无色到颜色，或从颜色变为无色。着色剂通常能够区分假丝酵母（例如白色念珠菌）和通常与尿布疹相关的其它微生物，例如金黄色葡萄球菌和大肠杆菌。因此，当真皮样品与着色剂接触时，可以简单地观察颜色变化以确定感染是否由念珠菌引起。如果颜色变化发生一定程度（例如，从黄色到鲜红色），则可以确定测试样品含有念珠菌。同样地，如果在较小程度上发生颜色变化（例如，从黄色到微弱橙色），或根本不发生变色，则可以确定真皮样品含有其他微生物（例如金黄色葡萄球菌或大肠杆菌），无感染存在，或感染仅仅是由于其他原因。无论是否需要对念珠菌的治疗，将变得显而易见。

6. 发明申请

US20070249012A1 Microbial Detection and Quantification 有权
标题翻译：微生物检测和定量
公开(公告)号：US20070249012A1
公开(公告)日：2007-10-25
申请号：US10581404
申请日：2004-12-16
申请人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
发明人： Jason Lye , John MacDonald , Ning Wei , Stephanie Martin
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04
摘要： Solvatochromic dyes are used herein to indicate the presence of bacteria by incorporating them into various substrates such as films, woven and nonwoven fabrics, paper towels, coform and airlaid materials and bonded carded webs. These dyes change color in response to a change in polarity of the environment. Since water is a polar solvent and most bacteria are made from non-polar substances, the presence of bacteria changes the polarity of the environment, triggering a change visible by the unaided eye. A lateral flow device incorporating solvatochromic dyes and a method of detecting bacteria are also included.
摘要翻译：溶剂化色素染料在本文中用于通过将它们并入各种底物如薄膜，机织和非织造织物，纸巾，共成型和气流成网材料和粘合梳理纤维网中来表示细菌的存在。这些染料响应于环境极性的变化而改变颜色。由于水是极性溶剂，大多数细菌都是由非极性物质制成的，所以细菌的存在会改变环境的极性，引发肉眼可见的变化。还包括含有溶剂化色素染料的侧流装置和检测细菌的方法。

7. 发明申请

US20070140971A1 Method for screening for bacterial conjunctivitis 有权
标题翻译：筛选细菌性结膜炎的方法
公开(公告)号：US20070140971A1
公开(公告)日：2007-06-21
申请号：US11303001
申请日：2005-12-15
申请人： John MacDonald , Stephanie Martin , Jason Lye
发明人： John MacDonald , Stephanie Martin , Jason Lye
IPC分类号： A61K49/00 , C12Q1/04
CPC分类号： C12Q1/04 , C12Q1/14
摘要： A method for rapidly detecting infectious conjunctivitis in a host is provided. The method includes contacting an ocular test sample with a chromogen (e.g., Reichardt's dye) that exhibits a color change in the presence of a microbe. The present inventors have discovered that the extent of the color change may vary depending on whether the microbe is a bacteria or virus. Without intending to be limited by theory, the present inventors believe that the chromogen interacts with the peptidoglycan-based cell wall structure of bacteria to induce a color change that is even more apparent at infectious levels. It is believed that this interaction occurs to a much greater extent in bacteria than in viruses. Accordingly, although the chromogen may still undergo a color change in the presence of the viruses, it is typically to a much lesser extent. In this manner, the degree of color change of the chromogen may be used in the present invention as a mechanism for differentiating between viral and bacterial conjunctivitis.
摘要翻译：提供了一种快速检测宿主感染性结膜炎的方法。该方法包括使眼睛测试样品与在微生物存在下显示颜色变化的色原体（例如，Reichardt's染料）接触。本发明人已经发现，颜色变化的程度可以根据微生物是细菌还是病毒而变化。不期望受理论的限制，本发明人相信色原体与细菌的基于聚肽聚糖的细胞壁结构相互作用以诱导在感染水平上更加明显的颜色变化。相信这种相互作用在细菌中比在病毒中更大程度地发生。因此，虽然染色体在病毒存在的情况下仍可能发生颜色变化，但通常其程度要小得多。以这种方式，在本发明中可以使用色原体的颜色变化程度作为区分病毒和细菌性结膜炎的机制。

8. 发明申请

US20060134613A1 Detection of microbe contamination on elastomeric articles 有权
标题翻译：检测弹性制品上的微生物污染
公开(公告)号：US20060134613A1
公开(公告)日：2006-06-22
申请号：US11117635
申请日：2005-04-28
申请人： Stephanie Martin , John MacDonald , Allison Bagwell , Jason Lye , Robert Johnson
发明人： Stephanie Martin , John MacDonald , Allison Bagwell , Jason Lye , Robert Johnson
IPC分类号： C12Q1/70 , C12Q1/04 , C12M1/34
CPC分类号： C12Q1/04 , G01N33/528
摘要： An elastomeric article that contains a chromogen that undergoes a detectable change in color in the presence of one or more microbes is provided. For example, in one embodiment, the chromogen is a solvatochromic dye (e.g., Reichardt's dye) that undergoes a color change in the presence of bacteria or other microbes. More specifically, such dyes may respond to differences in polarity between microbe components (e.g., cell membrane, cytoplasm, etc.) and the environment outside the cell. Alternatively, other mechanisms may be wholly or partially responsible for the interaction between the dye and the microbe, such as acid-base reactions, redox reactions, and so forth.
摘要翻译：提供了包含在一种或多种微生物存在下经历可检测的颜色变化的色原体的弹性制品。例如，在一个实施方案中，色原是在细菌或其它微生物存在下经历颜色变化的溶剂化色素染料（例如，Reichardt's染料）。更具体地，这样的染料可以响应微生物组分（例如细胞膜，细胞质等）与细胞外的环境之间的极性差异。或者，其它机理可以完全或部分地负责染料和微生物之间的相互作用，例如酸碱反应，氧化还原反应等。

9. 发明申请

US20070100304A1 Absorbent articles with improved odor control 有权
标题翻译：具有改善气味控制的吸收制品
公开(公告)号：US20070100304A1
公开(公告)日：2007-05-03
申请号：US11263598
申请日：2005-10-31
申请人： David Fell , Megan Lan , William Georger , Kelly Arehart , Bao Do , Stephanie Martin
发明人： David Fell , Megan Lan , William Georger , Kelly Arehart , Bao Do , Stephanie Martin
IPC分类号： A61F13/15
CPC分类号： A61L15/46 , A61F13/15658 , A61F13/53 , A61F13/8405 , A61F2013/15943 , A61F2013/530489 , A61F2013/530671 , A61F2013/8408 , A61F2013/8426 , A61F2013/8435 , A61F2013/8447 , A61F2013/8461 , A61L9/014 , A61L15/18 , A61L2300/10 , A61L2300/216 , A61L2300/606 , Y10T156/1084 , Y10T442/2525
摘要： A technique for incorporating odor control agent particles into an absorbent article is provided. More specifically, the odor control particles are “homogenously” distributed (e.g., in a substantially uniform manner) within an airformed fiber matrix of an absorbent core of an absorbent article. An absorbent core containing such a homogeneously distributed odor control particles may possess a greater surface area for contacting malodorous compounds, thereby increasing the likelihood of odor reduction.
摘要翻译：提供了将气味控制剂颗粒结合到吸收制品中的技术。更具体地，气味控制颗粒在吸收制品的吸收芯的气流形成的纤维基质内“均匀地”分布（例如基本均匀的方式）。含有这种均匀分布的气味控制颗粒的吸收芯可以具有更大的用于接触恶臭化合物的表面积，从而增加气味降低的可能性。

10. 发明申请

US20070048503A1 Solvatochromic visual indicator and the use of the same 有权
标题翻译：溶色变色视觉指示剂和使用相同
公开(公告)号：US20070048503A1
公开(公告)日：2007-03-01
申请号：US11216731
申请日：2005-08-31
申请人： John MacDonald , Alison Bagwell , Yanbin Huang , Jaeho Kim , Stephanie Martin
发明人： John MacDonald , Alison Bagwell , Yanbin Huang , Jaeho Kim , Stephanie Martin
IPC分类号： B41M5/00
CPC分类号： A61F13/42 , Y10S428/913 , Y10T428/24802 , Y10T428/24868
摘要： A graphic and/or message display system is described. The graphic and/or message display system functions to develop over a period of time a hidden graphic or message on an indicator panel or display area. The hidden graphic or message is revealed when an obscuring graphic reacts with a solvent to change color become at least substantially transparent. The graphic and/or message display system may be used as a stand-alone device or may be incorporated as part of various articles or products, for instance, as a positive reinforcement or a reminder to perform a task. Methods for using the graphic and/or message display system are also described.
摘要翻译：描述图形和/或消息显示系统。图形和/或消息显示系统用于在一段时间内在指示器面板或显示区域上开发隐藏的图形或消息。隐藏的图形或消息被揭示，当模糊的图形与溶剂反应以改变颜色变得至少基本上是透明的。图形和/或消息显示系统可以用作独立设备，或者可以作为各种物品或产品的一部分而被并入，例如作为正的强化或提醒来执行任务。还描述了使用图形和/或消息显示系统的方法。

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