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1. 发明授权

US07691858B2 Kinase inhibitors and methods of use thereof 有权
标题翻译：激酶抑制剂及其使用方法
公开(公告)号：US07691858B2
公开(公告)日：2010-04-06
申请号：US11789832
申请日：2007-04-25
申请人： John Doukas , Chi Ching Mak , Elena Dneprovskaia , Glenn Noronha
发明人： John Doukas , Chi Ching Mak , Elena Dneprovskaia , Glenn Noronha
IPC分类号： C07D475/08 , C07D241/20 , C07D241/12 , C07D241/24 , A61K31/4985 , A61P9/08 , A61P11/00 , A61P35/00 , A01N43/50
CPC分类号： C07D475/08
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗死，癌症，缺血/再灌注损伤，自身免疫疾病如类风湿性关节炎，眼睛疾病如葡萄膜炎，视网膜病变或黄斑变性，黄斑水肿或其他玻璃体视网膜疾病，诸如自身免疫性疾病，血管渗漏综合征，水肿或涉及白细胞激活的疾病，移植排斥，呼吸系统疾病如哮喘，成人或急性呼吸窘迫综合征（ARDS），慢性阻塞性肺疾病等的炎性疾病。

2. 发明申请

US20090275569A1 Benzotriazine Inhibitors of Kinases 审中-公开
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US20090275569A1
公开(公告)日：2009-11-05
申请号：US12207019
申请日：2008-09-09
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/541 , A61K31/53 , C07D417/12 , C07D413/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

3. 发明申请

US20080027070A1 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS 有权
标题翻译： 2-氨基-5-取代的吡咯咪嗪抑制剂
公开(公告)号：US20080027070A1
公开(公告)日：2008-01-31
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： A61K31/495 , A61K31/505 , A61P19/02 , A61P27/02 , A61P29/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D239/02
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译：提供具有一般结构（A）的化合物。本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。

4. 发明授权

US08481536B2 Benzotriazine inhibitors of kinases 有权
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US08481536B2
公开(公告)日：2013-07-09
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

5. 发明授权

US08030487B2 2-amino—5-substituted pyrimidine inhibitors 有权
标题翻译： 2-氨基-5-取代的嘧啶抑制剂
公开(公告)号：US08030487B2
公开(公告)日：2011-10-04
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved P. Pathak , Joel Renick , Richard M. Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved P. Pathak , Joel Renick , Richard M. Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： C07D239/42 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , A61K31/505 , A61K31/506 , A61P19/02 , A61P35/00
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译：提供具有一般结构（A）的化合物。本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。

6. 发明申请

US20110294796A1 BENZOTRIAZINE INHIBITORS OF KINASES 有权
标题翻译：苄基苯并噻嗪类抑制剂
公开(公告)号：US20110294796A1
公开(公告)日：2011-12-01
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/53 , C07D253/10 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/5377 , A61K31/541 , A61P9/10 , A61P35/00 , A61P11/00 , A61P17/02 , A61P19/02 , A61P7/00 , A61P9/00 , A61P37/00 , A61P29/00 , C07D403/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

7. 发明授权

US07456176B2 Benzotriazine inhibitors of kinases 有权
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US07456176B2
公开(公告)日：2008-11-25
申请号：US11102405
申请日：2005-04-07
申请人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Glenn Noronha , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Xianchang Gong , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/53 , A61P19/02 , A61P35/00
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

8. 发明申请

US20070208019A1 Vasculostatic agents and methods of use thereof 审中-公开
标题翻译：血管平滑剂及其使用方法
公开(公告)号：US20070208019A1
公开(公告)日：2007-09-06
申请号：US11653190
申请日：2007-01-11
申请人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
发明人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
IPC分类号： A61K31/5377 , A61K31/525 , A61K39/395 , A61K31/704 , A61K31/7048 , A61K31/337 , A61K31/404
CPC分类号： C07D209/14 , C07D209/48 , C07D239/88 , C07D239/90 , C07D239/95 , C07D241/42 , C07D253/10 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗塞，癌症，缺血/再灌注损伤，自身免疫性疾病如类风湿性关节炎，眼睛疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病，炎性疾病，血管渗漏综合征，水肿，移植排斥，成人/急性呼吸窘迫综合征（ARDS）等。

9. 发明申请

US20070259876A1 Kinase inhibitors and methods of use thereof 有权
标题翻译：激酶抑制剂及其使用方法
公开(公告)号：US20070259876A1
公开(公告)日：2007-11-08
申请号：US11789832
申请日：2007-04-25
申请人： John Doukas , Chi Mak , Elena Dneprovskaia , Glenn Noronha
发明人： John Doukas , Chi Mak , Elena Dneprovskaia , Glenn Noronha
IPC分类号： A61K31/525 , C07D475/04
CPC分类号： C07D475/08
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗死，癌症，缺血/再灌注损伤，自身免疫疾病如类风湿性关节炎，眼睛疾病如葡萄膜炎，视网膜病变或黄斑变性，黄斑水肿或其他玻璃体视网膜疾病，诸如自身免疫性疾病，血管渗漏综合征，水肿或涉及白细胞激活的疾病，移植排斥，呼吸系统疾病如哮喘，成人或急性呼吸窘迫综合征（ARDS），慢性阻塞性肺疾病等的炎性疾病。

10. 发明授权

US07208493B2 Vasculostatic agents and methods of use thereof 有权
标题翻译：血管平滑剂及其使用方法
公开(公告)号：US07208493B2
公开(公告)日：2007-04-24
申请号：US10679209
申请日：2003-10-02
申请人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John D. Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
发明人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John D. Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
IPC分类号： A61K31/4985 , C07D471/02
CPC分类号： C07D209/14 , C07D209/48 , C07D239/88 , C07D239/90 , C07D239/95 , C07D241/42 , C07D253/10 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases , inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗塞，癌症，缺血/再灌注损伤，自身免疫性疾病如类风湿性关节炎，眼睛疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病，炎性疾病，血管渗漏综合征，水肿，移植排斥，成人/急性呼吸窘迫综合征（ARDS）等。

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