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1. 发明申请

US20090275569A1 Benzotriazine Inhibitors of Kinases 审中-公开
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US20090275569A1
公开(公告)日：2009-11-05
申请号：US12207019
申请日：2008-09-09
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/541 , A61K31/53 , C07D417/12 , C07D413/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

2. 发明授权

US07691858B2 Kinase inhibitors and methods of use thereof 有权
标题翻译：激酶抑制剂及其使用方法
公开(公告)号：US07691858B2
公开(公告)日：2010-04-06
申请号：US11789832
申请日：2007-04-25
申请人： John Doukas , Chi Ching Mak , Elena Dneprovskaia , Glenn Noronha
发明人： John Doukas , Chi Ching Mak , Elena Dneprovskaia , Glenn Noronha
IPC分类号： C07D475/08 , C07D241/20 , C07D241/12 , C07D241/24 , A61K31/4985 , A61P9/08 , A61P11/00 , A61P35/00 , A01N43/50
CPC分类号： C07D475/08
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as uveitis, retinopathies or macular degeneration, macular edema or other vitreoretinal diseases, inflammatory diseases such as autoimmune diseases, vascular leakage syndrome, edema, or diseases involving leukocyte activation, transplant rejection, respiratory diseases such as asthma, adult or acute respiratory distress syndrome (ARDS), chronic obstructive pulmonary disease, and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗死，癌症，缺血/再灌注损伤，自身免疫疾病如类风湿性关节炎，眼睛疾病如葡萄膜炎，视网膜病变或黄斑变性，黄斑水肿或其他玻璃体视网膜疾病，诸如自身免疫性疾病，血管渗漏综合征，水肿或涉及白细胞激活的疾病，移植排斥，呼吸系统疾病如哮喘，成人或急性呼吸窘迫综合征（ARDS），慢性阻塞性肺疾病等的炎性疾病。

3. 发明申请

US20080027070A1 2-AMINO--5-SUBSTITUTED PYRIMIDINE INHIBITORS 有权
标题翻译： 2-氨基-5-取代的吡咯咪嗪抑制剂
公开(公告)号：US20080027070A1
公开(公告)日：2008-01-31
申请号：US11772572
申请日：2007-07-02
申请人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
发明人： Glenn Noronha , Jianguo Cao , Colleen Gritzen , Chi Ching Mak , Andrew McPherson , Ved Pathak , Joel Renick , Richard Soll , Binqi Zeng , Elena Dneprovskaia
IPC分类号： A61K31/495 , A61K31/505 , A61P19/02 , A61P27/02 , A61P29/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D239/02
CPC分类号： C07D239/48 , C07D401/12 , C07D401/14 , C07D409/12 , C07D413/12
摘要： Compounds having the general structure (A) are provided. The compounds of the invention are capable of inhibiting kinases, such as members of the Src kinase family, Vegfr and various other specific receptor and non-receptor kinases.
摘要翻译：提供具有一般结构（A）的化合物。本发明的化合物能够抑制激酶，例如Src激酶家族的成员，Vegfr和各种其它特异性受体和非受体激酶。

4. 发明申请

US20070191405A1 Bi-aryl meta-pyrimidine inhibitors of kinases 有权
公开(公告)号：US20070191405A1
公开(公告)日：2007-08-16
申请号：US11588638
申请日：2006-10-26
申请人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
发明人： Glenn Noronha , Chi Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved Pathak , Daniel Lohse , John Hood , Richard Soll
IPC分类号： A61K31/506 , C07D403/02 , C07D407/02
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

5. 发明申请

US20050191761A1 ANALYTE SENSING VIA ACRIDINE-BASED BORONATE BIOSENSORS 失效
标题翻译：通过基于ACRIDINE的BORONATE生物传感器进行分析
公开(公告)号：US20050191761A1
公开(公告)日：2005-09-01
申请号：US09952563
申请日：2001-09-12
申请人： Aaron Heiss , Joseph Walsh , David Vachon , Glenn Noronha , Jonathan Reilly , Bill Ponder , William Van Antwerp
发明人： Aaron Heiss , Joseph Walsh , David Vachon , Glenn Noronha , Jonathan Reilly , Bill Ponder , William Van Antwerp
IPC分类号： C12Q1/54 , G01N33/66 , G01N33/543
CPC分类号： G01N33/66 , C12Q1/54 , Y10T436/144444
摘要： Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. These biosensor molecules address the problem of obtaining fluorescence emission at wavelengths greater than about 500 nm. Biosensor molecules generally include an (1) an acridine-based fluorophore, (2) a linker moiety and (3) a boronate substrate recognition/binding moiety, which binds polyhydroxylate analytes, such as glucose. These biosensor molecules further include a “switch” element that is drawn from the electronic interactions among these submolecular components. This fluorescent switch is generally “off” in the absence of bound polyhydroxylate analyte and is generally “on” in the presence of bound polyhydroxylate analyte. Thus, the reversible binding of a polyhydroxylate analyte essentially turns the fluorescent switch “on” and “off”. This property of the biosensor molecules, as well as their ability to emit fluorescent light at greater than about 500 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
摘要翻译：描述荧光生物传感器分子，荧光生物传感器和系统，以及制造和使用这些生物传感器分子和系统的方法。这些生物传感器分子解决了在大于约500nm的波长处获得荧光发射的问题。生物传感器分子通常包括（1）基于吖啶的荧光团，（2）接头部分和（3）结合多羟基化合物分析物如葡萄糖的硼酸酯底物识别/结合部分。这些生物传感器分子还包括从这些亚分子组分之间的电子相互作用中抽出的“开关”元件。在不存在结合的多羟基甲酸盐分析物的情况下，该荧光开关通常是“关闭”的，并且在结合的多羟基化合物分析物的存在下通常是“开”的。因此，多羟基化合物分析物的可逆结合基本上使得荧光开关“开”和“关”。生物传感器分子的这种性质以及它们在大于约500nm处发射荧光的能力使得这些生物传感器分子特别适用于检测和测量体内葡萄糖浓度。

6. 发明授权

US08604042B2 Bi-aryl meta-pyrimidine inhibitors of kinases 有权
公开(公告)号：US08604042B2
公开(公告)日：2013-12-10
申请号：US12862517
申请日：2010-08-24
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , C07D239/42 , C07D401/04 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/5377 , C07D239/42 , C07D239/48 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

7. 发明授权

US07528143B2 Bi-aryl meta-pyrimidine inhibitors of kinases 有权
标题翻译：激酶的双芳基间 - 嘧啶抑制剂
公开(公告)号：US07528143B2
公开(公告)日：2009-05-05
申请号：US11588638
申请日：2006-10-26
申请人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
发明人： Glenn Noronha , Chi Ching Mak , Jianguo Cao , Joel Renick , Andrew McPherson , Binqi Zeng , Ved P. Pathak , Daniel L. Lohse , John D. Hood , Richard M. Soll
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02 , C07D401/00 , C07D403/00 , C07D407/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D239/48 , C07D239/42 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有一般结构（A）的联芳基间 - 嘧啶化合物。本发明的嘧啶化合物能够抑制激酶，例如Jak激酶家族的成员和各种其它特异性受体和非受体激酶。

8. 发明授权

US06927246B2 Polymers functionalized with fluorescent boronate motifs and methods for making them 有权
标题翻译：用荧光硼酸盐图案功能化的聚合物及其制备方法
公开(公告)号：US06927246B2
公开(公告)日：2005-08-09
申请号：US10075415
申请日：2002-02-14
申请人： Glenn Noronha , Jonathan Reilly , Joseph C. Walsh , Brooks Cochran , Aaron M. Heiss , Bill C. Ponder , David J. Vachon
发明人： Glenn Noronha , Jonathan Reilly , Joseph C. Walsh , Brooks Cochran , Aaron M. Heiss , Bill C. Ponder , David J. Vachon
IPC分类号： C07F5/02 , G01N33/66 , C08K5/55
CPC分类号： C07F5/025 , G01N33/66 , Y10T436/144444
摘要： Improved polymer matrices which incorporate fluorescent biosensor molecules as well as methods of making and using these polymer matrices are described. Such matrices can be used in fluorescent biosensors and biosensor systems, including those which are used in the detection of polyhydroxylated analytes such as glucose. The properties of the polymer matrices of the invention renders biosensors utilizing such matrices particularly well-suited for detecting and measuring in-vivo glucose concentrations.
摘要翻译：描述了掺入荧光生物传感器分子的改进的聚合物基质以及制备和使用这些聚合物基质的方法。这些基质可用于荧光生物传感器和生物传感器系统，包括用于检测多羟基化分析物如葡萄糖的那些。本发明的聚合物基质的性质使得利用这种基质的生物传感器特别适合于检测和测量体内葡萄糖浓度。

9. 发明授权

US06766183B2 Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers 有权
标题翻译：长波荧光团传感器化合物等聚合物中的荧光传感器化合物
公开(公告)号：US06766183B2
公开(公告)日：2004-07-20
申请号：US10033240
申请日：2001-12-28
申请人： Joseph C. Walsh , Aaron M. Heiss , Glenn Noronha , David J. Vachon , Stephen M. Lane , Joe H. Satcher, Jr. , Thomas A. Peyser , William Peter Van Antwerp , John Joseph Mastrototaro
发明人： Joseph C. Walsh , Aaron M. Heiss , Glenn Noronha , David J. Vachon , Stephen M. Lane , Joe H. Satcher, Jr. , Thomas A. Peyser , William Peter Van Antwerp , John Joseph Mastrototaro
IPC分类号： A61B500
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/14532 , C12Q1/005 , G01N33/66 , Y10T436/143333 , Y10T436/144444
摘要： Fluorescent biosensor molecules, fluorescent biosensors and systems, as well as methods of making and using these biosensor molecules and systems are described. Embodiments of these biosensor molecules exhibit fluorescence emission at wavelengths greater than about 650 nm. Typical biosensor molecules include a fluorophore that includes an iminium ion, a linker moiety that includes a group that is an anilinic type of relationship to the fluorophore and a boronate substrate recognition/binding moiety, which binds glucose. The fluorescence molecules modulated by the presence or absence of polyhydroxylated analytes such as glucose. This property of these molecules of the invention, as well as their ability to emit fluorescent light at greater than about 650 nm, renders these biosensor molecules particularly well-suited for detecting and measuring in-vivo glucose concentrations.
摘要翻译：描述荧光生物传感器分子，荧光生物传感器和系统，以及制造和使用这些生物传感器分子和系统的方法。这些生物传感器分子的实施例在大于约650nm的波长处表现出荧光发射。典型的生物传感器分子包括包含亚胺离子的荧光团，连接部分，其包含与荧光团相关的苯胺型的基团和结合葡萄糖的硼酸酯底物识别/结合部分。通过存在或不存在多羟基化分析物如葡萄糖来调节荧光分子。本发明的这些分子的这种性质以及它们在大于约650nm发射荧光的能力使得这些生物传感器分子特别适用于检测和测量体内葡萄糖浓度。

10. 发明授权

US08481536B2 Benzotriazine inhibitors of kinases 有权
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US08481536B2
公开(公告)日：2013-07-09
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

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