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1. 发明授权

US07476650B2 Enzyme inhibition 有权
标题翻译：酶抑制
公开(公告)号：US07476650B2
公开(公告)日：2009-01-13
申请号：US10871752
申请日：2004-06-17
申请人： Craig M. Crews , Mikael Elofsson , Ute Splittgerber , Kyung Bo Kim
发明人： Craig M. Crews , Mikael Elofsson , Ute Splittgerber , Kyung Bo Kim
IPC分类号： A01N43/02 , A61K38/00
CPC分类号： C07K5/1016 , C07K5/1008 , C07K5/101 , C07K7/06
摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include an electron withdrawing group adjacent to the ring functionality, and the peptide include at least three peptide units. Among other therapeutic utilities, the peptide-based compounds exhibit anti-inflammatory and inhibition of cell proliferation, involving therapeutic applications for these compounds.
摘要翻译：包括含杂原子的三元环的基于肽的化合物有效地选择性地抑制N末端亲核试剂（Ntn）水解酶的比活性。具有多种活性的那些Ntn的活性可被所描述的化合物差别地抑制。例如，本发明化合物可以选择性地抑制20S蛋白酶体的胰凝乳蛋白酶样和PGPH活性。基于肽的化合物包括与环官能团相邻的吸电子基团，并且肽包括至少三个肽单元。在其他治疗用途中，基于肽的化合物表现出抗炎和抑制细胞增殖，涉及这些化合物的治疗应用。

2. 发明申请

US20070204500A1 Front-loading display system 有权
标题翻译：前端显示系统
公开(公告)号：US20070204500A1
公开(公告)日：2007-09-06
申请号：US11713357
申请日：2007-03-01
申请人： Ute Splittgerber
发明人： Ute Splittgerber
IPC分类号： A47G1/06
CPC分类号： A47G1/06 , A47G2001/0666 , A47G2001/0672
摘要： The subject matter of the current invention is directed to a front-loading display system adapted for safe, frequent, and rapid change of displayed objects. The display system includes a base and an object-holding assembly. The object-holding assembly can be releasably attached to the base through the use of a fastener, which allows the base to remain mounted to a mounting surface when changing display objects. In a preferred embodiment, the fastener employs magnetic force to connect the base and the object-holding assembly. The display object is retained between a resting plate and a cover plate, the two plates being releasably attached to each other by the use of at least one holding device, which may be selected from clips, clasps, hinges and elastic bands.
摘要翻译：本发明的主题涉及适于安全，频繁和快速地更改显示对象的前装显示系统。显示系统包括基座和物体保持组件。物体保持组件可以通过使用紧固件可释放地附接到基座，这允许基座在改变显示对象时保持安装到安装表面。在优选实施例中，紧固件采用磁力来连接基座和物体保持组件。显示对象被保持在静止板和盖板之间，两个板通过使用至少一个保持装置可释放地彼此附接，该夹持装置可以选自夹子，钩扣，铰链和弹性带。

3. 发明授权

US08481536B2 Benzotriazine inhibitors of kinases 有权
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US08481536B2
公开(公告)日：2013-07-09
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Binqi Zeng , Ningning Zhao , Elena Dneprovskaia
IPC分类号： A61K31/53 , A61P35/00 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

4. 发明授权

US07208493B2 Vasculostatic agents and methods of use thereof 有权
标题翻译：血管平滑剂及其使用方法
公开(公告)号：US07208493B2
公开(公告)日：2007-04-24
申请号：US10679209
申请日：2003-10-02
申请人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John D. Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
发明人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John D. Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
IPC分类号： A61K31/4985 , C07D471/02
CPC分类号： C07D209/14 , C07D209/48 , C07D239/88 , C07D239/90 , C07D239/95 , C07D241/42 , C07D253/10 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases , inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗塞，癌症，缺血/再灌注损伤，自身免疫性疾病如类风湿性关节炎，眼睛疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病，炎性疾病，血管渗漏综合征，水肿，移植排斥，成人/急性呼吸窘迫综合征（ARDS）等。

5. 发明申请

US20050282814A1 Vasculostatic agents and methods of use thereof 审中-公开
标题翻译：血管平滑剂及其使用方法
公开(公告)号：US20050282814A1
公开(公告)日：2005-12-22
申请号：US11105845
申请日：2005-04-13
申请人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
发明人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
IPC分类号： C07D209/14 , A61K31/405 , A61K31/525 , A61K31/724 , C07D209/02 , C07D209/04 , C07D209/48 , C07D239/88 , C07D239/90 , C07D239/95 , C07D241/42 , C07D253/10 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , C07D519/00
CPC分类号： C07D209/14 , A61K31/337 , A61K31/519 , A61K31/704 , A61K31/724 , A61K45/06 , C07D209/48 , C07D239/88 , C07D239/90 , C07D239/95 , C07D241/42 , C07D253/10 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗塞，癌症，缺血/再灌注损伤，自身免疫性疾病如类风湿性关节炎，眼睛疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病，炎性疾病，血管渗漏综合征，水肿，移植排斥，成人/急性呼吸窘迫综合征（ARDS）等。

6. 发明授权

US06831099B1 Enzyme inhibition 有权
标题翻译：酶抑制
公开(公告)号：US06831099B1
公开(公告)日：2004-12-14
申请号：US09569748
申请日：2000-05-11
申请人： Craig M. Crews , Mikael Elofsson , Ute Splittgerber , Ny Sin , Kyung Bo Kim
发明人： Craig M. Crews , Mikael Elofsson , Ute Splittgerber , Ny Sin , Kyung Bo Kim
IPC分类号： A01N4320
CPC分类号： C07K5/1016 , C07K5/1008 , C07K5/101 , C07K7/06
摘要： Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited by the compounds described. For example, the chymotrypsin-like and PGPH activities of the 20S proteasome can be selectively inhibited with the inventive compounds. The peptide-based compounds include an electron withdrawing group adjacent to the ring functionality, and the peptide include at least three peptide units. Among other therapeutic utilities, the peptide-based compounds exhibit anti-inflammatory and inhibition of cell proliferation, involving therapeutic applications for these compounds.
摘要翻译：包括含杂原子的三元环的基于肽的化合物有效地选择性地抑制N末端亲核试剂（Ntn）水解酶的比活性。具有多种活性的那些Ntn的活性可被所描述的化合物差别地抑制。例如，本发明化合物可以选择性地抑制20S蛋白酶体的胰凝乳蛋白酶样和PGPH活性。基于肽的化合物包括与环官能团相邻的吸电子基团，并且肽包括至少三个肽单元。在其他治疗用途中，基于肽的化合物表现出抗炎和抑制细胞增殖，涉及这些化合物的治疗应用。

7. 发明授权

US08484873B2 Front-loading display system 有权
标题翻译：前端显示系统
公开(公告)号：US08484873B2
公开(公告)日：2013-07-16
申请号：US11713357
申请日：2007-03-01
申请人： Ute Splittgerber
发明人： Ute Splittgerber
IPC分类号： A47G1/06
CPC分类号： A47G1/06 , A47G2001/0666 , A47G2001/0672
摘要： The subject matter of the current invention is directed to a front-loading display system adapted for safe, frequent, and rapid change of displayed objects. The display system includes a base and an object-holding assembly. The object-holding assembly can be releasably attached to the base through the use of a fastener, which allows the base to remain mounted to a mounting surface when changing display objects. In a preferred embodiment, the fastener employs magnetic force to connect the base and the object-holding assembly. The display object is retained between a resting plate and a cover plate, the two plates being releasably attached to each other by the use of at least one holding device, which may be selected from clips, clasps, hinges and elastic bands.
摘要翻译：本发明的主题涉及适于安全，频繁和快速地更改显示对象的前装显示系统。显示系统包括基座和物体保持组件。物体保持组件可以通过使用紧固件可释放地附接到基座，这允许基座在改变显示对象时保持安装到安装表面。在优选实施例中，紧固件采用磁力来连接基座和物体保持组件。显示对象被保持在静止板和盖板之间，两个板通过使用至少一个保持装置可释放地彼此附接，该夹持装置可以选自夹子，钩扣，铰链和弹性带。

8. 发明申请

US20090275569A1 Benzotriazine Inhibitors of Kinases 审中-公开
标题翻译：苯并三嗪激酶抑制剂
公开(公告)号：US20090275569A1
公开(公告)日：2009-11-05
申请号：US12207019
申请日：2008-09-09
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , Glenn Noronha , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/5377 , C07D403/12 , A61K31/541 , A61K31/53 , C07D417/12 , C07D413/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

9. 发明申请

US20070208019A1 Vasculostatic agents and methods of use thereof 审中-公开
标题翻译：血管平滑剂及其使用方法
公开(公告)号：US20070208019A1
公开(公告)日：2007-09-06
申请号：US11653190
申请日：2007-01-11
申请人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
发明人： Wolfgang Wrasidlo , John Doukas , Ivor Royston , Glenn Noronha , John Hood , Elena Dneprovskaia , Xianchang Gong , Ute Splittgerber , Ningning Zhao
IPC分类号： A61K31/5377 , A61K31/525 , A61K39/395 , A61K31/704 , A61K31/7048 , A61K31/337 , A61K31/404
CPC分类号： C07D209/14 , C07D209/48 , C07D239/88 , C07D239/90 , C07D239/95 , C07D241/42 , C07D253/10 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D471/04 , C07D487/04
摘要： Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.
摘要翻译：组合物和方法，用于治疗与受损的血管淤滞相关的疾病。本发明的方法和组合物可用于治疗各种疾病，包括例如中风，心肌梗塞，癌症，缺血/再灌注损伤，自身免疫性疾病如类风湿性关节炎，眼睛疾病如视网膜病变或黄斑变性或其他玻璃体视网膜疾病，炎性疾病，血管渗漏综合征，水肿，移植排斥，成人/急性呼吸窘迫综合征（ARDS）等。

10. 发明申请

US20110294796A1 BENZOTRIAZINE INHIBITORS OF KINASES 有权
标题翻译：苄基苯并噻嗪类抑制剂
公开(公告)号：US20110294796A1
公开(公告)日：2011-12-01
申请号：US12980235
申请日：2010-12-28
申请人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
发明人： Xianchang Gong , Kathy Barrett , Jianguo Cao , Colleen Gritzen , John D. Hood , Chi Ching Mak , Andrew McPherson , Ved Prakash Pathak , Joel Renick , Richard M. Soll , Ute Splittgerber , Wolfgang Wrasidlo , Ningning Zhao , Elena Dneprovskaia , Binqi Zeng , Glenn Noronha
IPC分类号： A61K31/53 , C07D253/10 , C07D401/12 , C07D413/12 , C07D417/12 , A61K31/5377 , A61K31/541 , A61P9/10 , A61P35/00 , A61P11/00 , A61P17/02 , A61P19/02 , A61P7/00 , A61P9/00 , A61P37/00 , A61P29/00 , C07D403/12
CPC分类号： C07D253/08 , C07D403/04 , C07D403/12 , C07D413/04
摘要： The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.
摘要翻译：本发明提供具有式（I）的苯并三嗪化合物。本发明的苯并三嗪化合物能够抑制激酶，Src激酶家族的成员和各种其它特异性受体和非受体激酶。

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