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1. 发明申请

US20080300585A1 Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动
公开(公告)号：US20080300585A1
公开(公告)日：2008-12-04
申请号：US11978888
申请日：2007-10-30
申请人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
发明人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/22002 , A61B2017/22054 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
摘要翻译：本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

2. 发明授权

US08157794B2 Method and device for performing cooling-or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动
公开(公告)号：US08157794B2
公开(公告)日：2012-04-17
申请号：US11978888
申请日：2007-10-30
申请人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
发明人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/22002 , A61B2017/22054 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
摘要翻译：本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

3. 发明授权

US08043351B2 Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死，以抑制使用组织保护的心房颤动
公开(公告)号：US08043351B2
公开(公告)日：2011-10-25
申请号：US11978787
申请日：2007-10-30
申请人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Rebecca S. Inderbitzen
发明人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Rebecca S. Inderbitzen
IPC分类号： A61F7/12
CPC分类号： A61F7/12 , A61B18/02 , A61B18/08 , A61B2017/00243 , A61B2017/22002 , A61B2017/22051 , A61B2017/22054 , A61B2018/00023 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.
摘要翻译：提供增强的方法和装置以治疗房颤或抑制或减少血管成形术或支架置入后的再狭窄。血管成形术后立即将球囊导管放置在通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经在已经就位的导丝上传送。诸如全氟化碳的流体流入气球以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。类似的导管可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面接触邻近左心房的肺静脉部分的至少部分圆周。在另一个实施方案中，同时进行血液灌注。在另一个实施方案中，由冷冻消融导管接触的不希望消融的组织通过单独的加热步骤被保护而不被损坏。

4. 发明授权

US07001378B2 Method and device for performing cooling or cryo-therapies, for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection 失效
公开(公告)号：US07001378B2
公开(公告)日：2006-02-21
申请号：US10110360
申请日：2002-03-01
申请人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Stephen R. Cooper , Rebecca S. Inderbitzen
发明人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Stephen R. Cooper , Rebecca S. Inderbitzen
IPC分类号： A61B18/18
CPC分类号： A61F7/12 , A61B18/02 , A61B18/08 , A61B2017/22002 , A61B2017/22051 , A61B2017/22054 , A61B2018/00023 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.

5. 发明授权

US07288089B2 Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死，以抑制使用组织保护的心房颤动
公开(公告)号：US07288089B2
公开(公告)日：2007-10-30
申请号：US11151488
申请日：2005-06-13
申请人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Rebecca S. Inderbitzen
发明人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Rebecca S. Inderbitzen
IPC分类号： A61B18/18
CPC分类号： A61F7/12 , A61B18/02 , A61B18/08 , A61B2017/00243 , A61B2017/22002 , A61B2017/22051 , A61B2017/22054 , A61B2018/00023 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.
摘要翻译：提供增强的方法和装置以治疗房颤或抑制或减少血管成形术或支架置入后的再狭窄。血管成形术后立即将球囊导管放置在通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经在已经就位的导丝上传送。诸如全氟化碳的流体流入气球以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。类似的导管可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面接触邻近左心房的肺静脉部分的至少部分圆周。在另一个实施方案中，同时进行血液灌注。在另一个实施方案中，由冷冻消融导管接触的不希望消融的组织通过单独的加热步骤被保护而不被损坏。

6. 发明授权

US08043283B2 Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动
公开(公告)号：US08043283B2
公开(公告)日：2011-10-25
申请号：US11982988
申请日：2007-11-06
申请人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
发明人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/22002 , A61B2017/22054 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
摘要翻译：本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

7. 发明授权

US07291144B2 Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation 有权
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死以抑制心房颤动
公开(公告)号：US07291144B2
公开(公告)日：2007-11-06
申请号：US10039466
申请日：2002-01-03
申请人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
发明人： John D. Dobak, III , Hans W. Kramer , Steven A. Yon
IPC分类号： A61B18/02
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/22002 , A61B2017/22054 , A61B2018/00023 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： The present invention provides an enhanced method and device to inhibit or reduce the rate of restenosis following angioplasty or stent placement. The invention involves placing a balloon tipped catheter in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place from a balloon angioplasty. A fluid such as a perfluorocarbon may be flowed into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. The catheter may also be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon is in contact with at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium.
摘要翻译：本发明提供了抑制或降低血管成形术或支架放置后再狭窄发生率的增强方法和装置。本发明涉及将气囊顶端的导管放置在血管成形术后立即通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经从球囊血管成形术已经就位的导线传送。诸如全氟化碳的流体可以流入气囊中以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。导管还可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面与邻近左心房的肺静脉部分的至少部分圆周接触。

8. 发明授权

US06905494B2 Method and device for performing cooling- or cryo-therapies for, e.g., angioplasty with reduced restenosis or pulmonary vein cell necrosis to inhibit atrial fibrillation employing tissue protection 失效
标题翻译：用于进行冷冻或低温治疗的方法和装置，例如血管成形术，减少再狭窄或肺静脉细胞坏死，以抑制使用组织保护的心房颤动
公开(公告)号：US06905494B2
公开(公告)日：2005-06-14
申请号：US10086585
申请日：2002-02-28
申请人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Rebecca S. Inderbitzen
发明人： Steven A. Yon , John D. Dobak, III , Hans W. Kramer , Rebecca S. Inderbitzen
IPC分类号： A61B17/00 , A61B17/22 , A61B18/00 , A61B18/02 , A61B18/08 , A61F7/12 , A61B18/18
CPC分类号： A61F7/12 , A61B18/02 , A61B18/08 , A61B2017/00243 , A61B2017/22002 , A61B2017/22051 , A61B2017/22054 , A61B2018/00023 , A61B2018/00041 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262 , A61F2007/126
摘要： An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.
摘要翻译：提供增强的方法和装置以治疗房颤或抑制或减少血管成形术或支架置入后的再狭窄。血管成形术后立即将球囊导管放置在通过球囊血管成形术处理或打开的区域中。可以具有双气囊结构的气囊可以通过引导导管并且已经在已经就位的导丝上传送。诸如全氟化碳的流体流入气球以冷冻邻近球囊的组织，这种冷却与再狭窄的减少有关。类似的导管可用于通过插入和充气气囊来减少心房颤动，使得球囊的外表面接触邻近左心房的肺静脉部分的至少部分圆周。在另一个实施方案中，同时进行血液灌注。在另一个实施方案中，由冷冻消融导管接触的不希望消融的组织通过单独的加热步骤被保护而不被损坏。

9. 发明授权

US06585752B2 Fever regulation method and apparatus 有权
公开(公告)号：US06585752B2
公开(公告)日：2003-07-01
申请号：US10005416
申请日：2001-11-07
申请人： John D. Dobak, III , Steven A. Yon , Michael Magers
发明人： John D. Dobak, III , Steven A. Yon , Michael Magers
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B5/20 , A61B18/02 , A61B2017/00292 , A61B2017/22069 , A61B2018/0212 , A61B2018/0262 , A61B2090/064 , A61F2007/0056 , A61F2007/0059 , A61F2007/0069 , A61F2007/0095 , A61F2007/126 , A61M5/44 , A61M25/00 , A61M25/0029 , A61M25/003 , A61M25/0032 , A61M25/0068 , A61M2025/0002 , A61M2025/0034 , A61M2025/0073 , A61M2205/36 , A61M2205/366 , A61M2210/1085
摘要： A device and method for providing body cooling for treating fever. The cooling device applies cooling to blood flowing in a vein or artery, e.g., the vena cavae, that is then distributed throughout the body.

10. 发明授权

US06576001B2 Lumen design for catheter 有权
公开(公告)号：US06576001B2
公开(公告)日：2003-06-10
申请号：US10005056
申请日：2001-12-03
申请人： Randell L. Werneth , Kevin P. Gilmartin , Steven A. Yon , Juan C Lasheras , John D Dobak, III
发明人： Randell L. Werneth , Kevin P. Gilmartin , Steven A. Yon , Juan C Lasheras , John D Dobak, III
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/126
摘要： The invention provides a device for heating or cooling a surrounding fluid in a feeding vessel and a method of manufacturing the same. The device includes a catheter assembly capable of insertion to a selected blood vessel in the vascular system of a patient. The assembly includes an elongated catheter body, a heat transfer element located at a distal portion of the catheter body and including an interior, an elongated supply lumen adapted to deliver a working fluid to the interior of the heat transfer element and having a hydraulic diameter, an elongated return lumen adapted to return a working fluid from the interior of the heat transfer element and having a hydraulic diameter, and wherein the ratio of the hydraulic diameter of the return lumen to the hydraulic diameter of the supply lumen is substantially equal to 0.75. The method of manufacturing the catheter assembly involves extruding an elongated catheter body; locating a heat transfer element including an interior at a distal portion of the catheter body; extruding an integrated elongated bi-lumen member including a first lumen adapted to receive a guide wire and a second lumen having a hydraulic diameter, the second lumen comprising either a supply lumen to deliver a working fluid to an interior of the heat transfer element or a return lumen to return a working fluid from the interior of the heat transfer element; and providing the integrated bi-lumen member substantially within the elongated catheter body so that a third lumen having a hydraulic diameter is formed, the third lumen comprising either a supply lumen to deliver a working fluid to an interior of the heat transfer element or a return lumen to return a working fluid from the interior of the heat transfer element and the ratio of the second lumen hydraulic diameter to the third lumen hydraulic diameter is substantially equal to 0.75.

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