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1. 发明授权

US06737415B2 Anti-bacterial agents based upon oxoanion binding 失效
标题翻译：基于氧阴离子结合的抗菌剂
公开(公告)号：US06737415B2
公开(公告)日：2004-05-18
申请号：US10227327
申请日：2002-08-22
申请人： Stephen R. Cooper , Kraig M. Yager
发明人： Stephen R. Cooper , Kraig M. Yager
IPC分类号： A61K3169
CPC分类号： A61K31/381 , A01N43/26 , A01N43/82 , A01N43/90 , A01N55/00 , A01N57/36 , A61K31/38 , A61K31/425 , A61K31/66 , A61K31/69
摘要： Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1, and T2 are each independently selected from the group consisting of O, NR, and CH2, where R=H or C1-C8 alkyl, or C1-C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.
摘要翻译：结构I的化合物可用于治疗细菌生长，其中E选自B，P和S，T1和T2各自独立地选自O，NR和CH 2，其中 R = H或C 1 -C 8烷基或C 1 -C 8氧代烷基，L选自乙烯，丙烯和四至六元脂环和芳环，条件是结构I不包括AI-2- 硼酸盐该化合物可用于治疗人类的细菌感染并调节生物膜形成。包含一种或多种这样的化合物的药物组合物可用于治疗人类的细菌感染。

2. 发明授权

US5621144A Fluorinated compounds as oxygen transport agents 失效
标题翻译：氟化合物作为氧运输剂
公开(公告)号：US5621144A
公开(公告)日：1997-04-15
申请号：US370239
申请日：1995-01-09
申请人： Stephen R. Cooper
发明人： Stephen R. Cooper
IPC分类号： C07C43/10 , C07C43/164 , C07C69/63 , C07C69/708 , C07C205/40 , C07C233/36 , C07C235/08 , C07C309/65 , C07C309/66 , C07C309/73 , C07C233/12
CPC分类号： C07C235/08 , C07C205/40 , C07C233/36 , C07C309/65 , C07C309/66 , C07C309/73 , C07C43/10 , C07C43/164 , C07C69/63 , C07C69/708
摘要： New compounds are described typically having the formula CH.sub.3 C(CH.sub.2 R).sub.3 or ZCH.sub.2 C(CH.sub.2 R).sub.3 where R is a fluorohydrocarbon or perfluorocarbon group, preferably containing 4-16 carbon atoms and more F atoms that H atoms. Z is a hydrophilic group which may make the compound self-emulsifiable. The compounds are useful as oxygen transport agents in vivo, for which purpose aqueous emulsions are used, as a blood substitute.
摘要翻译：通常具有式CH 3 C（CH 2 R）3或ZCH 2 C（CH 2 R）3）的新化合物，其中R是氟代烃或全氟化碳基团，优选含有4-16个碳原子和更多个F原子的H原子。 Z是可以使化合物自乳化的亲水基团。这些化合物在体内可用作氧传递剂，为此，使用水性乳液作为血液代用品。

3. 发明授权

US6135456A Target apparatus and methods for playing new target games 失效
标题翻译：用于播放新的目标游戏的目标设备和方法
公开(公告)号：US6135456A
公开(公告)日：2000-10-24
申请号：US275607
申请日：1999-03-24
申请人： Stephen R. Cooper
发明人： Stephen R. Cooper
IPC分类号： A63B63/00 , A63B67/00 , A63B69/38 , F41J5/02 , A63B69/00
CPC分类号： A63B67/002 , A63B63/00 , A63B71/0622 , A63B2024/004 , A63B2024/0043 , A63B2207/02 , A63B2220/803 , A63B2220/805 , A63B2220/89 , A63B61/003 , A63B69/38 , A63B71/0669
摘要： A target apparatus for use in playing new target games comprises a frame within which one or more of a plurality of target zones may be visually designated, with the location of the visually designated target zone(s) changing over time in accordance with a predetermined pattern. Methods for utilizing the apparatus to play new target games are also described. Rules for three new target games (entitled SINGLES TARGET TENNIS, DOUBLES TARGET TENNIS and TEAM TARGET TENNIS) are disclosed in detail, although the apparatus may also be used to play additional target games. Electronic versions of the new target games are also disclosed.
摘要翻译：用于播放新的目标游戏的目标装置包括其中可视觉地指定多个目标区域中的一个或多个的帧，其中视觉指定的目标区域的位置根据预定模式随时间而改变。还描述了利用该装置来播放新的目标游戏的方法。详细披露了三个新的目标游戏（标题为“SINGLES TARGET TENNIS”，“DOUBLES TARGET TENNIS”和“TEAM TARGET TENNIS”）的规则，尽管该设备也可用于播放额外的目标游戏。新的目标游戏的电子版本也被披露。

4. 发明授权

US5641472A Tungsten clusters 失效
标题翻译：钨簇
公开(公告)号：US5641472A
公开(公告)日：1997-06-24
申请号：US504728
申请日：1995-07-20
申请人： Ella Y. Fung , Stephen R. Cooper
发明人： Ella Y. Fung , Stephen R. Cooper
IPC分类号： A61K49/04 , C07F11/00
CPC分类号： A61K49/04 , C07F11/005 , Y10T436/24
摘要： The present invention provides new tri-tungsten compounds of the general structure: ##STR1## wherein R.sup.1 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.2 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.3 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.4 is --(C.sub.k H.sub.1 Z.sub.m) or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.5 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.6 is --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; Z is a functional group attachable on aliphatic chains or aromatic rings; R.sup.7 is an anionic molecule, neutral molecule, --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.8 is an anionic molecule, neutral molecule, --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; R.sup.9 is an anionic molecule, neutral molecule, --C.sub.k H.sub.1 Z.sub.m or --(C.sub.k H.sub.1 Z.sub.n) (C.sub.6 H.sub.(5-q) Z.sub.q).sub.p ; k is about 0-20; l is about 0-50; m is about 1-50; n is about 0-50; p is about 1-10; q is about 1-5; M is a counter positive or negative ion; and a is about -6-+6. W in the structure is the generally accepted one letter symbol for tungsten. Methods of imaging using compounds of the invention and processes for producing compounds of the invention are also disclosed.
摘要翻译：本发明提供了一般结构的新的三钨化合物：其中R1是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R2是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R3是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R4是 - （CkH1Zm）或 - （CkH1Zn）（C6H（5-q）Zq）p; R5是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R6是-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; Z是可连接在脂族链或芳环上的官能团; R7是阴离子分子，中性分子-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R8是阴离子分子，中性分子-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; R9是阴离子分子，中性分子-CkH1Zm或 - （CkH1Zn）（C6H（5-q）Zq）p; k约为0-20; l约为0-50; m约为1-50; n约为0-50; p约为1-10; q约为1-5; M是反正离子或负离子; a约为-6 + 6。结构中的W是钨的普遍接受的一个字母符号。还公开了使用本发明化合物成像的方法和本发明化合物的制备方法。

5. 发明授权

US4315482A Three-dimensional phonetic alphabet 失效
标题翻译：三维拼音字母
公开(公告)号：US4315482A
公开(公告)日：1982-02-16
申请号：US152518
申请日：1980-05-22
申请人： Stephen R. Cooper , Charles H. Cooper
发明人： Stephen R. Cooper , Charles H. Cooper
IPC分类号： A01K15/02
CPC分类号： A01K15/025 , Y10S119/905
摘要： A phonetic alphabet for communicating with dolphins, porpoises and whales inlcludes three basic geometric shapes, various combinations of which are used to represent speech sounds. The alphabet consists of eighteen symbols which may be understood by animals trained to identify these symbols with words by using their innate echolocation sensory capabilities, and may also be understood visually by human trainers.
摘要翻译：用于与海豚，海豚和鲸鱼通信的语音字母包括三个基本的几何形状，其各种组合用于表示语音。字母表由十八个符号组成，训练有素的动物可以通过使用其先天的回声定位感觉能力来识别这些符号，并且还可以由人类教练视觉地理解。

6. 发明授权

US5592616A Method for performing efficient memory testing on large memory arrays using test code executed from cache memory 失效
标题翻译：使用从高速缓冲存储器执行的测试代码对大型存储器阵列执行高效存储器测试的方法
公开(公告)号：US5592616A
公开(公告)日：1997-01-07
申请号：US481634
申请日：1995-06-07
申请人： Richard W. Finch , Stephen R. Cooper
发明人： Richard W. Finch , Stephen R. Cooper
IPC分类号： G11C29/12 , G06F11/00
CPC分类号： G11C29/12
摘要： In connection with a computer system, a method for performing efficient memory testing of large memory arrays in a single contiguous block is disclosed. Memory test code normally residing in ROM or flash memory is copied to a processor's primary (L1) cache via the processor's test registers. Once contained in the processor's L1 cache, the memory test code is executed to test all of system memory in a single, contiguous block, allowing a more complete test for memory-related faults. The method results in greatly improved performance because the only accesses external to the processor are memory test accesses, and because cache memory is typically high-speed as compared to RAM, ROM or flash memory.
摘要翻译：结合计算机系统，公开了一种用于在单个连续块中执行大存储器阵列的有效存储器测试的方法。通常驻留在ROM或闪存中的内存测试代码将通过处理器的测试寄存器复制到处理器的主（L1）缓存。一旦包含在处理器的L1高速缓存中，则执行内存测试代码以测试单个连续块中的所有系统内存，从而允许对内存相关故障进行更完整的测试。该方法导致性能大大提高，因为处理器外部的唯一访问是存储器测试访问，并且因为与RAM，ROM或闪存相比，高速缓存的存储器通常是高速的。

7. 发明授权

US4074250A Alarm box with fingerprint recorder 失效
标题翻译：报警盒带指纹记录仪
公开(公告)号：US4074250A
公开(公告)日：1978-02-14
申请号：US680845
申请日：1976-04-27
申请人： Stephen R. Cooper
发明人： Stephen R. Cooper
IPC分类号： G08B25/12 , G08B29/00
CPC分类号： G08B25/12
摘要： An alarm box for summoning police and/or fire personnel to the scene of an emergency. The alarm box is provided with means for obtaining and recording the fingerprints of the operator, thus deterring the improper use of the alarm box by unauthorized persons. Simultaneously with the transmission of an alarm, at least one of the fingerprints of the operator is obtained and recorded. The alarm box is also provided with transmission means for transmitting a facsimile of the fingerprint or fingerprints obtained to the central station or dispatcher, thereby facilitating and insuring identification of an unauthorized user.

8. 发明授权

US07208612B2 Crystals of LuxP and complexes thereof 失效
公开(公告)号：US07208612B2
公开(公告)日：2007-04-24
申请号：US10227400
申请日：2002-08-22
申请人： Bonnie L. Bassler , Stephan Schauder , Xin Chen , Frederick M. Hughson , Stephen R. Cooper
发明人： Bonnie L. Bassler , Stephan Schauder , Xin Chen , Frederick M. Hughson , Stephen R. Cooper
IPC分类号： C07D307/94 , A01N43/30
CPC分类号： C07K14/28 , A61K38/164 , A61K47/62 , C07K2299/00 , Y02A90/26
摘要： A crystal comprising LuxP is obtained, and a binding site for autoinducer-2 (AI-2) identified. The X-ray crystallographic data for LuxP and a LuxP-AI-2 complex is determined and used in a drug discovery method. Pharmaceutical compositions comprising ligands identified by such drug discovery methods are used to treat bacterial infections.

9. 发明授权

US07074776B2 Anti-bacterial agents based upon oxoanion binding 失效
标题翻译：基于氧阴离子结合的抗菌剂
公开(公告)号：US07074776B2
公开(公告)日：2006-07-11
申请号：US10676770
申请日：2003-10-01
申请人： Stephen R. Cooper , Kraig M. Yager
发明人： Stephen R. Cooper , Kraig M. Yager
IPC分类号： A61K31/69 , A61K31/66 , A61K31/41 , A61K31/425 , A61K31/38
CPC分类号： A61K31/381 , A01N43/26 , A01N43/82 , A01N43/90 , A01N55/00 , A01N57/36 , A61K31/38 , A61K31/425 , A61K31/66 , A61K31/69
摘要： Compounds of the structure I: are useful for treating bacterial growth, wherein E is selected from the group consisting of B, P, and S, T1 and T2 are each independently selected from the group consisting of O, NR, and CH2, where R═H or C1–C8 alkyl, or C1–C8 oxoalkyl, and L is selected from the group consisting of ethylene, propylene, and four to six-membered alicyclic and aromatic rings, provided that structure I does not include AI-2-borate. The compounds may be used to treat bacterial infections in human beings and to regulate biofilm formation. Pharmaceutical compositions comprising one or more such compounds are useful for treating bacterial infections in human beings.
摘要翻译：结构I的化合物可用于治疗细菌生长，其中E选自B，P和S，T 1和T 2各自为独立地选自O，NR和CH 2，其中RH或C 1 -C 8烷基，或C _{1个C 8低级烷基，L选自乙烯，丙烯和四至六元脂环和芳环，条件是结构I不包括AI -2-硼酸盐。该化合物可用于治疗人类的细菌感染并调节生物膜形成。包含一种或多种这样的化合物的药物组合物可用于治疗人类的细菌感染。}

10. 发明授权

US5826880A Multi-level chess game with additional chess pieces 失效
标题翻译：多级棋牌游戏与附加棋子
公开(公告)号：US5826880A
公开(公告)日：1998-10-27
申请号：US685193
申请日：1996-07-18
申请人： Stephen R. Cooper
发明人： Stephen R. Cooper
IPC分类号： A63F3/02
CPC分类号： A63F3/00214 , A63F3/02 , A63F2003/00217 , A63F2003/0022 , A63F2003/00996
摘要： A multi-level chess game for three-dimensional play comprises an odd-numbered plurality of chessboards, means for arranging the chessboards in vertical spaced relation to one another, a pair of conventional sets of standard chess pieces, and at least one pair of supplemental sets of additional chess pieces. The most preferred embodiment of the invention includes only three chessboards and only one pair of supplemental sets of additional chess pieces, with the latter initially positioned on the uppermost chessboard, with the conventional sets of standard chess pieces initially positioned on the lowermost chessboard, and with the intermediate chessboard initially vacant. Rules for play of the game are also disclosed, including rules for movement of the chess pieces from one chessboard to another.
摘要翻译：用于三维游戏的多级象棋游戏包括奇数多个棋盘，用于将棋盘彼此垂直间隔布置的装置，一对传统的标准棋子集合，以及至少一对补充棋盘一套额外的棋子。本发明最优选的实施例仅包括三个棋盘和仅一对附加棋子的补充集合，后者最初位于最上面的棋盘上，传统的一组标准棋子最初位于最下面的棋盘上，并且与中间棋盘最初空置。还披露了游戏规则，包括将棋子从一个棋盘移动到另一棋盘的规则。

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