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1. 发明授权

US08647336B2 Cryogenic medical device with thermal guard and method 有权
标题翻译：具有保温和低温保护的低温医疗器械
公开(公告)号：US08647336B2
公开(公告)日：2014-02-11
申请号：US12816479
申请日：2010-06-16
申请人： Randell L. Werneth
发明人： Randell L. Werneth
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/14 , A61B18/18 , A61B2017/00243 , A61B2018/0022 , A61B2018/0212 , A61B2018/0262
摘要： A medical device, system and method are provided for thermal medical treatment. A medical device for cryogenic treatment may include a tip and a thermal guard or shield. The tip may be at a distal end of a catheter shaft, having a distal surface and lateral surfaces. The thermal guard may be coupled to the catheter proximal of the distal tip, surrounding the longitudinal axis and exposing the distal surface, to resist heat transfer from body fluids to the lateral surfaces of the tip. An efficiency of heat transfer from selected tissue to be treated to the distal surface of the cryogenic tip is thereby increased.
摘要翻译：提供用于热疗治疗的医疗装置，系统和方法。用于低温处理的医疗装置可以包括尖端和保护罩或护罩。尖端可以在导管轴的远端处，具有远侧表面和侧表面。热保护器可以耦合到远侧末端的近端的导管，围绕纵向轴线并暴露远侧表面，以抵抗从体液到尖端的侧表面的热传递。因此，从被处理的选定组织到低温尖端的远端表面的热传递效率提高。

2. 发明授权

US08486063B2 Ablation catheter 有权
标题翻译：消融导管
公开(公告)号：US08486063B2
公开(公告)日：2013-07-16
申请号：US12245625
申请日：2008-10-03
申请人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
发明人： Randell L. Werneth , Marshall L. Sherman , Thomas M. Castellano , J. Christopher Flaherty , Gary Edward Currie
IPC分类号： A61B18/18
CPC分类号： A61B18/16 , A61B18/1492 , A61B18/18 , A61B2017/00482 , A61B2018/0016 , A61B2018/00214 , A61B2018/00291 , A61B2018/00351 , A61B2018/1467
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter which has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。

3. 发明授权

US08337492B2 Ablation catheter 有权
标题翻译：消融导管
公开(公告)号：US08337492B2
公开(公告)日：2012-12-25
申请号：US12938791
申请日：2010-11-03
申请人： Christopher G. Kunis , Ricardo David Roman , Alexander J. Asconeguy , J. Christopher Flaherty , Randell L. Werneth
发明人： Christopher G. Kunis , Ricardo David Roman , Alexander J. Asconeguy , J. Christopher Flaherty , Randell L. Werneth
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/02 , A61B18/1815 , A61B2018/00029 , A61B2018/0016 , A61B2018/00214 , A61B2018/00267 , A61B2018/00351 , A61B2018/00375 , A61B2018/00577 , A61B2018/00791 , A61B2018/00821 , A61B2018/00839 , A61B2018/1435 , A61B2018/1467 , A61B2018/1475 , A61B2018/1861 , A61N7/022
摘要： Devices, systems and methods are disclosed for the mapping of electrical signals and the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be transformed from a compact, linear configuration to a helical configuration, such as to map and ablate pulmonary vein ostia.
摘要翻译：公开了用于映射电信号和组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以从紧凑的线性构型转变为螺旋构型，例如绘制和消融肺静脉口。

4. 发明授权

US07211106B2 Selective organ cooling apparatus and method 有权
公开(公告)号：US07211106B2
公开(公告)日：2007-05-01
申请号：US10763542
申请日：2004-01-23
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

5. 发明授权

US06679907B2 Method and device for applications of selective organ cooling 有权
标题翻译：选择性器官冷却应用的方法和装置
公开(公告)号：US06679907B2
公开(公告)日：2004-01-20
申请号：US10210819
申请日：2002-07-31
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： The invention provides a method and device for heating or cooling a surrounding fluid in a feeding vessel. The device includes a catheter assembly capable of insertion to a selected feeding vessel in the vascular system of a patient. The assembly includes a heat transfer element at a distal end of the catheter assembly, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid, the surface irregularities having a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The assembly also includes a supply catheter to deliver a working fluid to an interior of the heat transfer element, a return catheter to return a working fluid from the interior of the heat transfer element, and a drug delivery catheter running substantially parallel to the axis of the catheter assembly. The method includes selectively controlling the temperature of a selected volume of blood in a patient by introducing a catheter assembly into a blood vessel feeding a selected volume of blood in a patient and delivering a working fluid through a supply catheter in the catheter assembly and returning the working fluid through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. A liquid, such as a drug, is delivered through a drug delivery catheter to the volume of blood in the feeding vessel.
摘要翻译：本发明提供一种用于加热或冷却进料容器中的周围流体的方法和装置。该装置包括能够插入患者血管系统中的选定进料容器的导管组件。所述组件包括在所述导管组件的远端处的传热元件，所述传热元件具有多个外表面凹凸，其形状和布置成在周围流体中产生湍流，所述表面凹凸具有至少等于边界的深度进料容器中周围流体的流动层厚度。该组件还包括供应导管，用于将工作流体输送到传热元件的内部;返回导管，用于从工作流体从传热元件的内部返回;以及药物输送导管，其基本上平行于导管组件。该方法包括通过将导管组件引入供给患者中选定体积的血液的血管中并通过导管组件中的供应导管输送工作流体来选择性地控制患者中所选体积的血液的温度，工作流体通过导管组件中的返回导管。在形成导管组件的远端的传热元件和进料容器中的血液体积之间传递热量。诸如药物的液体通过药物输送导管递送到进料容器中的血液体积。

6. 发明授权

US08682410B2 Multi-array monophasic action potential medical device 有权
标题翻译：多阵列单相动作电位医疗器械
公开(公告)号：US08682410B2
公开(公告)日：2014-03-25
申请号：US13044698
申请日：2011-03-10
申请人： Randell L. Werneth , Meleze Hocini , Mark T. Stewart , Dan Wittenberger , Timothy J. Corvi , Michael Lau , Vinod Sharma
发明人： Randell L. Werneth , Meleze Hocini , Mark T. Stewart , Dan Wittenberger , Timothy J. Corvi , Michael Lau , Vinod Sharma
IPC分类号： A61B5/042 , A61B18/14
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.
摘要翻译：一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。

7. 发明授权

US08617156B2 Low power tissue ablation system 有权
标题翻译：低功率组织消融系统
公开(公告)号：US08617156B2
公开(公告)日：2013-12-31
申请号：US12340414
申请日：2008-12-19
申请人： Randell L. Werneth , Christopher G. Kunis , J. Christopher Flaherty , Marshall L. Sherman
发明人： Randell L. Werneth , Christopher G. Kunis , J. Christopher Flaherty , Marshall L. Sherman
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/00084 , A61B2017/00243 , A61B2018/00214 , A61B2018/00351 , A61B2018/00666 , A61B2018/00898 , A61B2018/1467 , A61B2018/1475
摘要： Devices, systems and methods are disclosed for the ablation of tissue. Embodiments include an ablation catheter that has an array of ablation elements attached to a deployable carrier assembly. The carrier assembly can be constrained within the lumen of a catheter, and deployed to take on an expanded condition. The carrier assembly includes multiple electrodes that are configured to ablate tissue at low power. Additional embodiments include a system that includes an interface unit for delivering one or more forms of energy to the ablation catheter.
摘要翻译：公开了用于组织消融的装置，系统和方法。实施例包括消融导管，其具有附接到可展开的载体组件的消融元件阵列。载体组件可以被限制在导管的内腔中，并且被部署以展开扩张状态。载体组件包括被配置成以低功率消融组织的多个电极。另外的实施例包括包括用于将一种或多种形式的能量递送到消融导管的接口单元的系统。

8. 发明授权

US08617152B2 Ablation system with feedback 有权
标题翻译：消融系统与反馈
公开(公告)号：US08617152B2
公开(公告)日：2013-12-31
申请号：US11179332
申请日：2005-07-12
申请人： Randell L. Werneth , Marshall L. Sherman , J. Christopher Flaherty
发明人： Randell L. Werneth , Marshall L. Sherman , J. Christopher Flaherty
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B8/0833 , A61B2017/00106 , A61B2017/00243 , A61B2018/00351 , A61B2018/00702 , A61B2018/00791
摘要： Devices, systems and methods are disclosed for the ablation of tissue and treatment of cardiac arrhythmia. An ablation system includes an ablation catheter that has an array of ablation elements and a location element, an esophageal probe also including a location element, and an interface unit that provides energy to the ablation catheter. The distance between the location elements, determined by calculating means of the system, can be used by the system to set or modify one or more system parameters.
摘要翻译：公开了用于消融组织和治疗心律失常的装置，系统和方法。消融系统包括具有消融元件阵列和位置元件的消融导管，还包括定位元件的食道探针以及向消融导管提供能量的界面单元。由系统的计算装置确定的位置元件之间的距离可由系统用于设置或修改一个或多个系统参数。

9. 发明申请

US20120283585A1 Atrial Appendage Occlusion and Arrhythmia Treatment 审中-公开
标题翻译：心房闭塞和心律失常治疗
公开(公告)号：US20120283585A1
公开(公告)日：2012-11-08
申请号：US13368685
申请日：2012-02-08
申请人： Randell L. Werneth , David Zarbatany
发明人： Randell L. Werneth , David Zarbatany
IPC分类号： A61B5/02 , A61F2/01
CPC分类号： A61N1/3756 , A61B17/0057 , A61B2017/00243 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615
摘要： Atrial appendage occlusion devices and arrhythmia treatment.
摘要翻译：心房闭塞装置和心律失常治疗。

10. 发明申请

US20120232374A1 MULTI-ARRAY MONOPHASIC ACTION POTENTIAL MEDICAL DEVICE 有权
标题翻译：多阵列单因素行动潜能医疗器械
公开(公告)号：US20120232374A1
公开(公告)日：2012-09-13
申请号：US13044698
申请日：2011-03-10
申请人： Randell L. WERNETH , Meleze HOCINI , Mark T. STEWART , Dan WITTENBERGER , Timothy J. CORVI , Michael LAU , Vinod SHARMA
发明人： Randell L. WERNETH , Meleze HOCINI , Mark T. STEWART , Dan WITTENBERGER , Timothy J. CORVI , Michael LAU , Vinod SHARMA
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/0422 , A61B18/1492 , A61B2018/1467 , A61B2018/1472 , A61B2218/002
摘要： A medical device including a catheter having a shaft with a distal portion; a first plurality of substantially hemispherical electrodes coupled to the distal portion; a second plurality of substantially hemispherical electrodes coupled to the shaft proximal of the first plurality, where the second plurality of electrodes are oriented substantially orthogonal to the first plurality of electrodes; and an additional electrode coupled to the shaft. A console may have a processor in electrical communication with the first and second plurality of electrodes and the reference electrode, the processor programmed to obtaining a monophasic action potential recording from at least one of the first and second plurality of electrodes.
摘要翻译：一种医疗装置，包括具有远端部的轴的导管; 耦合到所述远端部分的第一多个基本上半球形的电极; 耦合到所述第一多个的所述轴近端的第二多个基本上半球形的电极，其中所述第二多个电极定向成基本上垂直于所述第一多个电极; 以及连接到所述轴的附加电极。控制台可以具有与第一和第二多个电极和参考电极电连通的处理器，该处理器被编程为从第一和第二多个电极中的至少一个获得单相动作电位记录。

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