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1. 发明申请

US20120077708A1 BETA-2 MICROGLOBULIN AS A BIOMARKER FOR PERIPHERAL ARTERY DISEASE 失效
标题翻译： BETA-2 MICROGLOBULIN作为外周动脉疾病的生物标志物
公开(公告)号：US20120077708A1
公开(公告)日：2012-03-29
申请号：US13243593
申请日：2011-09-23
申请人： John Cooke , Eric T. Fung , Eiichiro Kimura
发明人： John Cooke , Eric T. Fung , Eiichiro Kimura
IPC分类号： C40B30/10 , G01N33/566 , G01N33/573
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
摘要翻译：本发明提供了一种2微球蛋白作为用于在受试者中鉴定或评估外周动脉疾病的生物标志物。

2. 发明申请

US20110151481A1 BETA-2 MICROGLOBULIN AS A BIOMARKER FOR PERIPHERAL ARTERY DISEASE 失效
标题翻译： BETA-2 MICROGLOBULIN作为外周动脉疾病的生物标志物
公开(公告)号：US20110151481A1
公开(公告)日：2011-06-23
申请号：US12972867
申请日：2010-12-20
申请人： John Cooke , Eric T. Fung , Eiichiro Kimura
发明人： John Cooke , Eric T. Fung , Eiichiro Kimura
IPC分类号： G01N33/573 , G01N33/543 , G01N33/68 , G01N33/92 , G06F19/00 , A61B5/00
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
摘要翻译：本发明提供了一种2微球蛋白作为用于在受试者中鉴定或评估外周动脉疾病的生物标志物。

3. 发明授权

US07867719B2 Beta-2 microglobulin as a biomarker for peripheral artery disease 有权
公开(公告)号：US07867719B2
公开(公告)日：2011-01-11
申请号：US11685146
申请日：2007-03-12
申请人： John Cooke , Eric T. Fung , Eiichiro Kimura
发明人： John Cooke , Eric T. Fung , Eiichiro Kimura
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.

4. 发明授权

US08053204B2 Beta-2 microglobulin as a biomarker for peripheral artery disease 失效
标题翻译： β-2微球蛋白作为外周动脉疾病的生物标志物
公开(公告)号：US08053204B2
公开(公告)日：2011-11-08
申请号：US12972867
申请日：2010-12-20
申请人： John Cooke , Eric T. Fung , Eiichiro Kimura
发明人： John Cooke , Eric T. Fung , Eiichiro Kimura
IPC分类号： G01N33/53 , G01N33/543
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
摘要翻译：本发明提供了一种2微球蛋白作为用于在受试者中鉴定或评估外周动脉疾病的生物标志物。

5. 发明授权

US08377646B2 Beta-2 microglobulin as a biomarker for peripheral artery disease 失效
标题翻译： β-2微球蛋白作为外周动脉疾病的生物标志物
公开(公告)号：US08377646B2
公开(公告)日：2013-02-19
申请号：US13243593
申请日：2011-09-23
申请人： John P. Cooke , Eric T. Fung , Eiichiro Kimura
发明人： John P. Cooke , Eric T. Fung , Eiichiro Kimura
IPC分类号： G01N33/53 , G01N31/00
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
摘要翻译：本发明提供了一种2微球蛋白作为用于在受试者中鉴定或评估外周动脉疾病的生物标志物。

6. 发明申请

US20080026412A1 BETA-2 MICROGLOBULIN AS A BIOMARKER FOR PERIPHERAL ARTERY DISEASE 有权
标题翻译： BETA-2 MICROGLOBULIN作为外周动脉疾病的生物标志物
公开(公告)号：US20080026412A1
公开(公告)日：2008-01-31
申请号：US11685146
申请日：2007-03-12
申请人： John Cooke , Eric Fung , Eiichiro Kimura
发明人： John Cooke , Eric Fung , Eiichiro Kimura
IPC分类号： G01N33/00 , G01N33/48
CPC分类号： G01N33/564 , G01N33/6893 , G01N2800/323 , G01N2800/52
摘要： The present invention provides β2 microglobulin as a biomarker for qualifying or assessing peripheral artery disease in a subject.
摘要翻译：本发明提供β2微球蛋白作为用于鉴定或评估受试者中的外周动脉疾病的生物标志物。

7. 发明授权

US07244569B2 Plasmid autonomously replicable in coryneform bacteria 失效
标题翻译：质粒在棒状细菌中自主复制
公开(公告)号：US07244569B2
公开(公告)日：2007-07-17
申请号：US10832299
申请日：2004-04-27
申请人： Yumi Matsuzaki , Eiichiro Kimura , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yoshio Kawahara , Shinichi Sugimoto
发明人： Yumi Matsuzaki , Eiichiro Kimura , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yoshio Kawahara , Shinichi Sugimoto
IPC分类号： C12N15/74 , C12N15/77 , C12N15/10 , C12N15/31 , C07H21/04 , C07K14/195 , C07K14/34
CPC分类号： C12N15/77
摘要： A plasmid isolatable from Corynebacterium thermoaminogenes, which comprises a gene coding for a Rep protein having the amino acid sequence shown in SEQ ID NO: 8 or an amino acid sequence having homology of 90% or more to the amino acid sequence shown in SEQ ID NO: 8, and has a size of about 4.4 kb or about 6 kb, or a derivative thereof.
摘要翻译：可从热棒状杆菌分离的质粒，其包含编码具有SEQ ID NO：8所示氨基酸序列的Rep蛋白的基因或与SEQ ID NO所示的氨基酸序列具有90％以上同源性的氨基酸序列：8，并且具有约4.4kb或约6kb的大小，或其衍生物。

8. 发明申请

US20070031913A1 Amino-acid biosensor, fischer-ratio biosensor and health information management system 失效
标题翻译：氨基酸生物传感器，费 - 比生物传感器和健康信息管理系统
公开(公告)号：US20070031913A1
公开(公告)日：2007-02-08
申请号：US11498982
申请日：2006-08-04
申请人： Eiichiro Kimura
发明人： Eiichiro Kimura
IPC分类号： C12Q1/37
CPC分类号： C12Q1/32
摘要： Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor (200) for measuring a total concentration of a plurality of specific amino acids, comprises a measuring electrode (202) which includes as components a mediator and an enzyme which selectively act on the plurality of specific amino acids each serving as a substrate, and a counter electrode (203). The enzyme has a substrate affinity to each of the plurality of specific amino acids. The enzyme is operable to catalyze a reaction in each of the plurality of specific amino acids as a substrate so as to form a reaction product, and the mediator is operable, during amino-acid concentration measurement, to carry electrons between the reaction product and the measuring electrode. The amino-acid biosensor is designed to apply a voltage between the measuring electrode and the counter electrode during the measurement in such a manner that, in an analytical curve representing a relationship between an applied voltage and a current value for each of the plurality of specific amino acids, the applied voltage includes a voltage allowing the variety of the current values for the amino acids at the same applied voltage to fall within a given range.
摘要翻译：公开了能够测定多种氨基酸的总浓度的生物传感器。用于测量多种特定氨基酸的总浓度的氨基酸生物传感器（200）包括测量电极（202），其包含作为成分的介质和选择性地作用于多个特定氨基酸的酶，每个氨基酸用作基板和对电极（203）。该酶对多种特定氨基酸中的每一种具有底物亲和力。该酶可操作地催化多种特定氨基酸中的每一种作为底物的反应以形成反应产物，并且在氨基酸浓度测量期间，介体可操作地在反应产物和测量电极。氨基酸生物传感器被设计成在测量期间在测量电极和对电极之间施加电压，使得在分析曲线中，表示施加的电压与多个特定的电极中的每一个的电流值之间的关系氨基酸，所施加的电压包括允许在相同施加电压下的氨基酸的各种电流值落在给定范围内的电压。

9. 发明授权

US06905819B1 Plasmid autonomously replicable in coryneform bacteria 失效
标题翻译：质粒在棒状细菌中自主复制
公开(公告)号：US06905819B1
公开(公告)日：2005-06-14
申请号：US09636458
申请日：2000-08-11
申请人： Yumi Matsuzaki , Eiichiro Kimura , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yoshio Kawahara , Shinichi Sugimoto
发明人： Yumi Matsuzaki , Eiichiro Kimura , Tsuyoshi Nakamatsu , Osamu Kurahashi , Yoshio Kawahara , Shinichi Sugimoto
IPC分类号： C12N15/00 , C12N1/21 , C12N15/77 , C12R1/15 , C12N15/10 , C12N1/20 , C12Q1/68
CPC分类号： C12N15/77
摘要： A plasmid which is able to be isolated from Corynebacterium thermoaminogenes, and which comprises a gene coding for a Rep protein having the amino acid sequence shown in SEQ ID NO: 4 or an amino acid sequence having homology of 90% or more to the amino acid sequence shown in SEQ ID NO: 4. and has a size of about 4.4 kb or about 6 kb, or a derivative thereof.
摘要翻译：能够从嗜热棒杆菌分离的质粒，其包含编码具有SEQ ID NO：4所示的氨基酸序列的Rep蛋白的基因或与氨基酸同源性为90％以上的氨基酸序列 SEQ ID NO：4所示的序列，其大小为约4.4kb或约6kb，或其衍生物。

10. 发明授权

US08440068B2 Amino-acid biosensor, fischer-ratio biosensor and health information management system 有权
标题翻译：氨基酸生物传感器，费 - 比生物传感器和健康信息管理系统
公开(公告)号：US08440068B2
公开(公告)日：2013-05-14
申请号：US12585638
申请日：2009-09-21
申请人： Eiichiro Kimura
发明人： Eiichiro Kimura
IPC分类号： G01N27/26 , C12Q1/32
CPC分类号： C12Q1/32
摘要： Disclosed is a biosensor capable of measuring a total concentration of plural types of amino acids. An amino-acid biosensor (200) for measuring a total concentration of a plurality of specific amino acids, comprises a measuring electrode (202) which includes as components a mediator and an enzyme which selectively act on the plurality of specific amino acids each serving as a substrate, and a counter electrode (203). The enzyme has a substrate affinity to each of the plurality of specific amino acids. The enzyme is operable to catalyze a reaction in each of the plurality of specific amino acids as a substrate so as to form a reaction product, and the mediator is operable, during amino-acid concentration measurement, to carry electrons between the reaction product and the measuring electrode. The amino-acid biosensor is designed to apply a voltage between the measuring electrode and the counter electrode during the measurement in such a manner that, in an analytical curve representing a relationship between an applied voltage and a current value for each of the plurality of specific amino acids, the applied voltage includes a voltage allowing the variety of the current values for the amino acids at the same applied voltage to fall within a given range.
摘要翻译：公开了能够测定多种氨基酸的总浓度的生物传感器。用于测量多种特定氨基酸的总浓度的氨基酸生物传感器（200）包括测量电极（202），其包含作为成分的介质和选择性地作用于多个特定氨基酸的酶，每个氨基酸用作基板和对电极（203）。该酶对多种特定氨基酸中的每一种具有底物亲和力。该酶可操作地催化多种特定氨基酸中的每一种作为底物的反应以形成反应产物，并且在氨基酸浓度测量期间，介体可操作地在反应产物和测量电极。氨基酸生物传感器被设计成在测量期间在测量电极和对电极之间施加电压，使得在分析曲线中，表示施加的电压与多个特定的电极中的每一个的电流值之间的关系氨基酸，所施加的电压包括允许在相同施加电压下的氨基酸的各种电流值落在给定范围内的电压。

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