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1. 发明授权

US07259014B2 Fusion protein delivery system and uses thereof 有权
标题翻译：融合蛋白递送系统及其用途
公开(公告)号：US07259014B2
公开(公告)日：2007-08-21
申请号：US10245475
申请日：2002-09-17
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12N15/867 , C12N15/86 , C12N15/63 , C12N15/64 , A61K48/00
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N15/86 , C12N2710/16122 , C12N2740/10022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
摘要翻译：本发明提供一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpx蛋白质的DNA。在本发明的另一个实施方案中，提供了一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpr蛋白的DNA。本发明还提供了与慢病毒gag-pol无关的用于以反式表达慢病毒pol基因的DNA，载体和方法。任选将基因转导元件递送至根据本发明的慢病毒载体。还提供了将病毒抑制分子递送到动物中的靶的各种方法。进一步提供药物组合物。

2. 发明申请

US20110229964A1 Fusion Protein Delivery System and Uses Thereof 审中-公开
标题翻译：融合蛋白递送系统及其用途
公开(公告)号：US20110229964A1
公开(公告)日：2011-09-22
申请号：US13035891
申请日：2011-02-25
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12N5/10 , C12N15/63 , C07H21/00 , C12N1/21
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N15/86 , C12N2710/16122 , C12N2740/10022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
摘要翻译：本发明提供一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpx蛋白质的DNA。在本发明的另一个实施方案中，提供了一种物质组合物，其包含编码与编码蛋白质的DNA融合的病毒Vpr蛋白的DNA。本发明还提供了与慢病毒gag-pol无关的用于以反式表达慢病毒pol基因的DNA，载体和方法。任选将基因转导元件递送至根据本发明的慢病毒载体。还提供了将病毒抑制分子递送到动物中的靶的各种方法。进一步提供药物组合物。

3. 发明申请

US20110004951A1 METHODS AND COMPOSITIONS FOR IDENTIFYING COMPOUNDS THAT INHIBIT HIV-1 SUBUNIT-SPECIFIC REVERSE TRANSCRIPTASE 审中-公开
标题翻译：用于鉴定抑制HIV-1亚型特异性逆转录酶的化合物的方法和组合物
公开(公告)号：US20110004951A1
公开(公告)日：2011-01-06
申请号：US10599851
申请日：2005-05-24
申请人： John C. Kappes , Alok Mulky , Xiaoyun Wu
发明人： John C. Kappes , Alok Mulky , Xiaoyun Wu
IPC分类号： A01K67/00 , C12Q1/70 , C07D265/36 , C07D487/14 , C12N15/63 , C12N5/10 , G01N33/567 , A61K31/538 , A61K31/551 , A61P31/18 , A61P31/14
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/00 , C12N2740/16043 , C12N2740/16222 , C12N2740/16322
摘要： This invention relates to methods and compositions for identifying compounds that inhibit HIV-1 subunit-specific reverse transcriptase.
摘要翻译：本发明涉及用于鉴定抑制HIV-1亚基特异性逆转录酶的化合物的方法和组合物。

4. 发明申请

US20080233639A1 Fusion protein delivery system and uses thereof 审中-公开
标题翻译：融合蛋白递送系统及其用途
公开(公告)号：US20080233639A1
公开(公告)日：2008-09-25
申请号：US11894224
申请日：2007-08-20
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12N5/06 , C07H21/02 , C12N5/00 , C12N1/20
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N15/86 , C12N2710/16122 , C12N2740/10022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
摘要翻译：本发明提供一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpx蛋白质的DNA。在本发明的另一个实施方案中，提供了一种物质组合物，其包含编码与编码蛋白质的DNA融合的病毒Vpr蛋白的DNA。本发明还提供了与慢病毒gag-pol无关的用于以反式表达慢病毒pol基因的DNA，载体和方法。任选将基因转导元件递送至根据本发明的慢病毒载体。还提供了将病毒抑制分子递送到动物中的靶的各种方法。进一步提供药物组合物。

5. 发明授权

US07622300B2 Trans-lentiviral vector particles and transduction of eukaryotic cells therewith 有权
标题翻译：反式慢病毒载体颗粒和真核细胞的转导
公开(公告)号：US07622300B2
公开(公告)日：2009-11-24
申请号：US10202457
申请日：2002-07-24
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12N15/867 , C12N15/56
CPC分类号： C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N7/00 , C12N15/62 , C12N15/86 , C12N2740/10022 , C12N2740/16043 , C12N2740/16052 , Y10T428/273
摘要： Trans-lentiviral gene transfer vectors, vector systems, vector particles, and methods for transduction of primary nondividing cells using the same, are described. Further described are modifications to the gene transfer vectors that improve transduction efficiency and/or gene expression, e.g., by incorporating the cis-acting sequences, PPT-CTS and/or WPRE, and derivatives or analogs thereof.
摘要翻译：描述了跨慢病毒基因转移载体，载体系统，载体颗粒以及使用其转导初级非分裂细胞的方法。进一步描述的是通过掺入顺式作用序列PPT-CTS和/或WPRE及其衍生物或类似物来改善转导效率和/或基因表达的基因转移载体。

6. 发明授权

US07534603B2 Fusion protein delivery system and uses thereof 有权
公开(公告)号：US07534603B2
公开(公告)日：2009-05-19
申请号：US10272147
申请日：2002-10-15
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12N5/00 , C07H21/04
CPC分类号： C07K14/005 , A61K38/00 , A61K47/645 , C07K2319/00 , C12N2740/16322
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.

7. 发明授权

US06797462B1 Cell-based assay for immunodeficiency virus infectivity and sensitivity 有权
标题翻译：基于细胞的方法和测定免疫缺陷病毒的感染性和药物敏感性
公开(公告)号：US06797462B1
公开(公告)日：2004-09-28
申请号：US09719340
申请日：2001-04-13
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12Q170
CPC分类号： G01N33/56988 , C12Q1/703 , G01N33/5091 , G01N2333/70514 , G01N2333/715
摘要： Methods and reagents for the capture of primary HIV are provided. A cell line expressing CCR5, CXCR4 and CD4 receptors binds and is infected by primary HIV. The cell line contains a marker gene sequence, the marker gene sequence expressed in near linear quantities over at least two orders of magnitude in response to HIV infection. Primary HIV is amplified to create a primary virus stock through insertion of an amplicon gene into the receptor expressing cell line. HIV amplification occurs rapidly and is operative with noninfectious HIV through amplification in the presence of an infectivity complement. The present invention is useful in determining host HIV titer, drug sensitivity, HIV amplification, gene sequencing and co-receptor utilization.
摘要翻译：提供了捕获初级艾滋病毒的方法和试剂。表达CCR5，CXCR4和CD4受体的细胞系结合并被原发性HIV感染。细胞系含有标记基因序列，标记基因序列以接近线性的数量表达，响应于HIV感染至少两个数量级。通过将扩增子基因插入受体表达细胞系中，将主要的HIV扩增以产生初级病毒库。 HIV扩增快速发生，并通过在感染性补体存在下扩增而与非感染性HIV进行手术。本发明可用于确定宿主HIV滴度，药物敏感性，HIV扩增，基因测序和辅助受体利用。

8. 发明授权

US06555342B1 Fusion protein delivery system and uses thereof 有权
公开(公告)号：US06555342B1
公开(公告)日：2003-04-29
申请号：US09460548
申请日：1999-12-14
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12P2100
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N15/86 , C12N2710/16122 , C12N2740/10022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.

9. 发明申请

US20120005773A1 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强农业条件的转基因植物
公开(公告)号：US20120005773A1
公开(公告)日：2012-01-05
申请号：US12998243
申请日：2009-09-30
申请人： Eric D. Aasen , Mark Scott Abad , Edwards Allen , Thandoni Rao Ambika , Veena S. Anil , Alice Clara Augustine , Stephanie L. Back , Pranesh Badami , Amarjit Basra , Kraig L. Brustad , Molian Deng , Todd Dezwaan , Charles Dietrich , Stephen M. Duff , Karen K. Gabbert , Steve He , Bill L. Hendrix , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Balasulojini Karunanandaa , Kevin R. Kosola , Kempagangaiah Krishnamurthy , Ganesh Kumar , Saritha V. Kuriakose , Shantala Lakkanna , Mark E. Leibman , Linda Lutfiyya , Savitha Madappa , Sivalinganna Manjunath , Robert J. Meister , Bellur Narasimba Prasad , Sasha Preuss , Qungang Qi , Dhanalakshmi Ramachandra , S. Sangeetha , Scott Saracco , Chitresh Sharma , Vijay K. Sharma , Rajani Monnanda Somaiah , Padmini Sudarshana , Rebecca L. Thompson-Mize , Srikanth Venkatachalayya , Tyamagondlu V. Venkatesh , Huai Wang , Jingrui Wu , Xiaoyun Wu , Xiaofeng Sean Yang , Qin Zeng , Jianmin Zhao
发明人： Eric D. Aasen , Mark Scott Abad , Edwards Allen , Thandoni Rao Ambika , Veena S. Anil , Alice Clara Augustine , Stephanie L. Back , Pranesh Badami , Amarjit Basra , Kraig L. Brustad , Molian Deng , Todd Dezwaan , Charles Dietrich , Stephen M. Duff , Karen K. Gabbert , Steve He , Bill L. Hendrix , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Balasulojini Karunanandaa , Kevin R. Kosola , Kempagangaiah Krishnamurthy , Ganesh Kumar , Saritha V. Kuriakose , Shantala Lakkanna , Mark E. Leibman , Linda Lutfiyya , Savitha Madappa , Sivalinganna Manjunath , Robert J. Meister , Bellur Narasimba Prasad , Sasha Preuss , Qungang Qi , Dhanalakshmi Ramachandra , S. Sangeetha , Scott Saracco , Chitresh Sharma , Vijay K. Sharma , Rajani Monnanda Somaiah , Padmini Sudarshana , Rebecca L. Thompson-Mize , Srikanth Venkatachalayya , Tyamagondlu V. Venkatesh , Huai Wang , Jingrui Wu , Xiaoyun Wu , Xiaofeng Sean Yang , Qin Zeng , Jianmin Zhao
IPC分类号： A01H1/02 , C12N15/63 , A01G7/00 , A01H5/00 , A01H5/10 , A23L1/20 , C12N15/29 , C12N5/10
CPC分类号： C12N15/8251 , C12N15/8247 , C12N15/8261 , C12N15/8273 , C12N15/8274 , C12N15/8275 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐冷性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白和增强种子油。还公开了用于制备具有增强特征的转基因种子和植物的方法。

10. 发明授权

US07339626B2 Deinterlacing video images with slope detection 有权
标题翻译：用斜率检测去隔行视频图像
公开(公告)号：US07339626B2
公开(公告)日：2008-03-04
申请号：US10862215
申请日：2004-06-07
申请人： Hong Jiang , Kim N. Matthews , Lesley Jen-Yuan Wu , Xiaoyun Wu
发明人： Hong Jiang , Kim N. Matthews , Lesley Jen-Yuan Wu , Xiaoyun Wu
IPC分类号： H04N7/01
CPC分类号： H04N5/142 , H04N7/012
摘要： An apparatus and method for deinterlacing video images with improved slope detection is described. In one exemplary implementation, the apparatus includes an input buffer, a processor, and an output buffer. The input buffer is configured to receive a video stream in an interlaced format. The processor is configured to convert the video stream from the interlaced format to a progressive format. This conversion process includes calculating the slope for a diagonal line of an image at a pixel to-be-interpolated (i.e., at a missing pixel) using a slope protection operation to increase the accuracy of the slope calculation. The output buffer is then configured to transmit the video stream in the progressive format.
摘要翻译：描述了一种用于具有改进的斜率检测的用于去隔行视频图像的装置和方法。在一个示例性实现中，该装置包括输入缓冲器，处理器和输出缓冲器。输入缓冲器被配置为以隔行格式接收视频流。处理器被配置为将视频流从隔行格式转换成渐进格式。该转换处理包括使用斜率保护操作来计算要被内插的像素（即，在缺失像素处）的图像的对角线的斜率，以增加斜率计算的精度。然后，输出缓冲器被配置为以逐行格式发送视频流。

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