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1. 发明申请

US20120005773A1 TRANSGENIC PLANTS WITH ENHANCED AGRONOMIC TRAITS 审中-公开
标题翻译：具有增强农业条件的转基因植物
公开(公告)号：US20120005773A1
公开(公告)日：2012-01-05
申请号：US12998243
申请日：2009-09-30
申请人： Eric D. Aasen , Mark Scott Abad , Edwards Allen , Thandoni Rao Ambika , Veena S. Anil , Alice Clara Augustine , Stephanie L. Back , Pranesh Badami , Amarjit Basra , Kraig L. Brustad , Molian Deng , Todd Dezwaan , Charles Dietrich , Stephen M. Duff , Karen K. Gabbert , Steve He , Bill L. Hendrix , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Balasulojini Karunanandaa , Kevin R. Kosola , Kempagangaiah Krishnamurthy , Ganesh Kumar , Saritha V. Kuriakose , Shantala Lakkanna , Mark E. Leibman , Linda Lutfiyya , Savitha Madappa , Sivalinganna Manjunath , Robert J. Meister , Bellur Narasimba Prasad , Sasha Preuss , Qungang Qi , Dhanalakshmi Ramachandra , S. Sangeetha , Scott Saracco , Chitresh Sharma , Vijay K. Sharma , Rajani Monnanda Somaiah , Padmini Sudarshana , Rebecca L. Thompson-Mize , Srikanth Venkatachalayya , Tyamagondlu V. Venkatesh , Huai Wang , Jingrui Wu , Xiaoyun Wu , Xiaofeng Sean Yang , Qin Zeng , Jianmin Zhao
发明人： Eric D. Aasen , Mark Scott Abad , Edwards Allen , Thandoni Rao Ambika , Veena S. Anil , Alice Clara Augustine , Stephanie L. Back , Pranesh Badami , Amarjit Basra , Kraig L. Brustad , Molian Deng , Todd Dezwaan , Charles Dietrich , Stephen M. Duff , Karen K. Gabbert , Steve He , Bill L. Hendrix , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Hongwu Jia , Vidya Kammaradi Ramanath Bhat , Balasulojini Karunanandaa , Kevin R. Kosola , Kempagangaiah Krishnamurthy , Ganesh Kumar , Saritha V. Kuriakose , Shantala Lakkanna , Mark E. Leibman , Linda Lutfiyya , Savitha Madappa , Sivalinganna Manjunath , Robert J. Meister , Bellur Narasimba Prasad , Sasha Preuss , Qungang Qi , Dhanalakshmi Ramachandra , S. Sangeetha , Scott Saracco , Chitresh Sharma , Vijay K. Sharma , Rajani Monnanda Somaiah , Padmini Sudarshana , Rebecca L. Thompson-Mize , Srikanth Venkatachalayya , Tyamagondlu V. Venkatesh , Huai Wang , Jingrui Wu , Xiaoyun Wu , Xiaofeng Sean Yang , Qin Zeng , Jianmin Zhao
IPC分类号： A01H1/02 , C12N15/63 , A01G7/00 , A01H5/00 , A01H5/10 , A23L1/20 , C12N15/29 , C12N5/10
CPC分类号： C12N15/8251 , C12N15/8247 , C12N15/8261 , C12N15/8273 , C12N15/8274 , C12N15/8275 , Y02A40/146
摘要： This invention provides transgenic plant cells with recombinant DNA for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil. Also disclosed are methods for manufacturing transgenic seed and plants with enhanced trait.
摘要翻译：本发明提供具有用于表达蛋白质的重组DNA的转基因植物细胞，其可用于赋予转基因作物植物增强的农艺性状。本发明还提供包含转基因植物细胞的转基因植物和后代种子，其中植物被选择用于具有增强的性状，所述性状选自由增强的水利用效率，增强的耐冷性，增加的产量，增强的氮利用效率，增强的氮利用效率，种子蛋白和增强种子油。还公开了用于制备具有增强特征的转基因种子和植物的方法。

2. 发明授权

US07339626B2 Deinterlacing video images with slope detection 有权
标题翻译：用斜率检测去隔行视频图像
公开(公告)号：US07339626B2
公开(公告)日：2008-03-04
申请号：US10862215
申请日：2004-06-07
申请人： Hong Jiang , Kim N. Matthews , Lesley Jen-Yuan Wu , Xiaoyun Wu
发明人： Hong Jiang , Kim N. Matthews , Lesley Jen-Yuan Wu , Xiaoyun Wu
IPC分类号： H04N7/01
CPC分类号： H04N5/142 , H04N7/012
摘要： An apparatus and method for deinterlacing video images with improved slope detection is described. In one exemplary implementation, the apparatus includes an input buffer, a processor, and an output buffer. The input buffer is configured to receive a video stream in an interlaced format. The processor is configured to convert the video stream from the interlaced format to a progressive format. This conversion process includes calculating the slope for a diagonal line of an image at a pixel to-be-interpolated (i.e., at a missing pixel) using a slope protection operation to increase the accuracy of the slope calculation. The output buffer is then configured to transmit the video stream in the progressive format.
摘要翻译：描述了一种用于具有改进的斜率检测的用于去隔行视频图像的装置和方法。在一个示例性实现中，该装置包括输入缓冲器，处理器和输出缓冲器。输入缓冲器被配置为以隔行格式接收视频流。处理器被配置为将视频流从隔行格式转换成渐进格式。该转换处理包括使用斜率保护操作来计算要被内插的像素（即，在缺失像素处）的图像的对角线的斜率，以增加斜率计算的精度。然后，输出缓冲器被配置为以逐行格式发送视频流。

3. 发明申请

US20050014260A1 Fusion protein delivery system and uses thereof 有权
标题翻译：融合蛋白递送系统及其用途
公开(公告)号：US20050014260A1
公开(公告)日：2005-01-20
申请号：US10245475
申请日：2002-09-17
申请人： John Kappes , Xiaoyun Wu
发明人： John Kappes , Xiaoyun Wu
IPC分类号： C12N15/09 , C07H21/04 , C07K14/15 , C12N5/10 , C12N15/62 , C12N15/63 , C12N15/867 , C12P21/00 , C12N15/86 , C12N7/00
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N15/86 , C12N2710/16122 , C12N2740/10022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
摘要翻译：本发明提供一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpx蛋白质的DNA。在本发明的另一个实施方案中，提供了一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpr蛋白的DNA。本发明还提供了与慢病毒gag-pol无关的用于以反式表达慢病毒pol基因的DNA，载体和方法。任选将基因转导元件递送至根据本发明的慢病毒载体。还提供了将病毒抑制分子递送到动物中的靶的各种方法。进一步提供药物组合物。

4. 发明授权

US09015083B1 Distribution of parameter calculation for iterative optimization methods 有权
标题翻译：迭代优化方法的参数计算分布
公开(公告)号：US09015083B1
公开(公告)日：2015-04-21
申请号：US13428985
申请日：2012-03-23
申请人： Rajat Monga , Xiaoyun Wu , Andrew Yan-Tak Ng
发明人： Rajat Monga , Xiaoyun Wu , Andrew Yan-Tak Ng
IPC分类号： G06N7/00 , G06F17/17
CPC分类号： G06F17/10 , G06F17/17 , G06F17/18 , G06F17/5009 , G06N7/005 , G06N99/005
摘要： Systems and methods are disclosed for distributed first- or higher-order model fitting algorithms. Determination of the parameter set for the objective function is divided into a plurality of sub-processes, each performed by one of a plurality of worker computers. A master computer coordinates the operation of the plurality of worker computers, each operating on a portion of the parameter set such that no two worker computers contain exactly the same parameter subset nor the complete parameter set. Each worker computer performs its sub-processes on its parameter subset, together with training data. For maximum efficiency, the sub-processes are performed using a compact set of instruction primitives. The results are evaluated by the master computer, which may coordinate additional sub-process operations to perform higher-order optimization or terminate the optimization method and proceed to formulation of a model function.
摘要翻译：公开了分布式一阶或更高阶模型拟合算法的系统和方法。确定目标函数的参数集被划分为多个子进程，每个子进程由多个工作计算机之一执行。主计算机协调多个工作计算机的操作，每个操作计算机在参数集的一部分上操作，使得没有两个工作计算机包含完全相同的参数子集和完整的参数集。每个工作计算机在其参数子集上与训练数据一起执行其子进程。为了最大限度地提高效率，使用一组紧凑的指令原语执行子进程。结果由主计算机评估，主计算机可以协调附加的子过程操作以执行更高阶优化或终止优化方法并且继续制定模型函数。

5. 发明授权

US08754107B2 Aminopyrrolidines as chemokine receptor antagonists 失效
标题翻译：氨基吡咯烷作为趋化因子受体拮抗剂
公开(公告)号：US08754107B2
公开(公告)日：2014-06-17
申请号：US11985724
申请日：2007-11-16
申请人： Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
发明人： Dawn M. George , Richard W. Dixon , Michael Friedman , Adrian D. Hobson , Biqin Li , Lu Wang , Xiaoyun Wu , Neil Wishart
IPC分类号： A61K31/553 , A61K31/55 , A61K31/5377 , A61K31/506 , A61K31/517 , A61K31/4709 , A61K31/4545 , A61K31/454 , A61K31/4747 , A61K31/438 , A61K31/437 , C07D487/04 , C07D487/10 , C07D487/14 , C07D471/10 , C07D471/04 , C07D417/14 , C07D413/14 , C07D401/14 , C07D401/04
CPC分类号： A61K31/454 , A61K31/437 , A61K31/438 , A61K31/4545 , A61K31/4709 , A61K31/4747 , A61K31/506 , A61K31/517 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D207/14 , C07D401/04 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D471/10 , C07D487/04 , C07D487/10 , C07D487/14
摘要： The present invention is directed to novel aminopyrrolidines of formula I pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, stereoisomers thereof or pro-drugs thereof, wherein the variables are as defined herein. The compounds of formula (I) are useful as chemokine receptor antagonists and as such would be useful in treating certain conditions and diseases, especially inflammatory conditions and diseases and proliferative disorders and conditions, for example, cancers.
摘要翻译：本发明涉及式I的药学上可接受的盐的新型氨基吡咯烷，其代谢物，其异构体，其立体异构体或其前体药物，其中变量如本文所定义。式（I）化合物可用作趋化因子受体拮抗剂，因此可用于治疗某些病症和疾病，特别是炎性病症和疾病以及增殖性疾病和病症，例如癌症。

6. 发明申请

US20090183286A1 PROMOTER MOLECULES FOR USE IN PLANTS 审中-公开
标题翻译：在植物中使用促进分子
公开(公告)号：US20090183286A1
公开(公告)日：2009-07-16
申请号：US12368132
申请日：2009-02-09
申请人： Nordine Cheikh , Molian Deng , Steve He , Wei Wu , Xiaoyun Wu , Zhidong Xie
发明人： Nordine Cheikh , Molian Deng , Steve He , Wei Wu , Xiaoyun Wu , Zhidong Xie
IPC分类号： A01H5/00 , C07H21/00 , A01H5/10
CPC分类号： C12N15/8234 , C07K14/415
摘要： The present invention provides nucleic acid molecules isolated from Zea mays and Oryza sativa and useful for expressing transgenes in plants. The present invention also provides expression constructs containing the nucleic acid molecules useful for expressing transgenes in plants. The present invention also provides transgenic plants and seeds containing the nucleic acid molecules useful for expressing transgenes in plants.
摘要翻译：本发明提供从玉米和水稻中分离并用于在植物中表达转基因的核酸分子。本发明还提供含有用于在植物中表达转基因的核酸分子的表达构建体。本发明还提供含有可用于在植物中表达转基因的核酸分子的转基因植物和种子。

7. 发明授权

US07518035B2 Promoter molecules for use in plants 有权
标题翻译：用于植物的启动子分子
公开(公告)号：US07518035B2
公开(公告)日：2009-04-14
申请号：US11086904
申请日：2005-03-22
申请人： Nordine Cheikh , Molian Deng , Steve He , Wei Wu , Xiaoyun Wu , Zhidong Xie
发明人： Nordine Cheikh , Molian Deng , Steve He , Wei Wu , Xiaoyun Wu , Zhidong Xie
IPC分类号： C12N15/63 , C12N15/82 , C12N5/10 , C12N15/00 , A01H5/00
CPC分类号： C12N15/8234 , C07K14/415
摘要： The present invention provides nucleic acid molecules isolated from Zea mays and Oryza sativa and useful for expressing transgenes in plants. The present invention also provides expression constructs containing the nucleic acid molecules useful for expressing transgenes in plants. The present invention also provides transgenic plants and seeds containing the nucleic acid molecules useful for expressing transgenes in plants.
摘要翻译：本发明提供从玉米和水稻中分离并用于在植物中表达转基因的核酸分子。本发明还提供含有用于在植物中表达转基因的核酸分子的表达构建体。本发明还提供含有可用于在植物中表达转基因的核酸分子的转基因植物和种子。

8. 发明授权

US07259014B2 Fusion protein delivery system and uses thereof 有权
标题翻译：融合蛋白递送系统及其用途
公开(公告)号：US07259014B2
公开(公告)日：2007-08-21
申请号：US10245475
申请日：2002-09-17
申请人： John C. Kappes , Xiaoyun Wu
发明人： John C. Kappes , Xiaoyun Wu
IPC分类号： C12N15/867 , C12N15/86 , C12N15/63 , C12N15/64 , A61K48/00
CPC分类号： C12N7/00 , C07K14/005 , C07K2319/00 , C07K2319/23 , C07K2319/40 , C07K2319/735 , C12N15/62 , C12N15/86 , C12N2710/16122 , C12N2740/10022 , C12N2740/16023 , C12N2740/16043 , C12N2740/16052
摘要： The present invention provides a composition of matter, comprising: DNA encoding a viral Vpx protein fused to DNA encoding a protein. In another embodiment of the present invention, there is provided a composition of matter, comprising: DNA encoding a viral Vpr protein fused to DNA encoding a protein. The present invention further provides DNA, vectors and methods for expressing a lentiviral pol gene in trans, independent of the lentiviral gag-pol. A gene transduction element is optionally delivered to a lentiviral vector according to the present invention. Also provided are various methods of delivering a virus inhibitory molecule to a target in an animal. Further provided is a pharmaceutical composition.
摘要翻译：本发明提供一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpx蛋白质的DNA。在本发明的另一个实施方案中，提供了一种物质组合物，其包含：编码与编码蛋白质的DNA融合的病毒Vpr蛋白的DNA。本发明还提供了与慢病毒gag-pol无关的用于以反式表达慢病毒pol基因的DNA，载体和方法。任选将基因转导元件递送至根据本发明的慢病毒载体。还提供了将病毒抑制分子递送到动物中的靶的各种方法。进一步提供药物组合物。

9. 发明申请

US20070074312A1 Plants containing a heterologous flavohemoglobin gene and methods of use thereof 审中-公开
标题翻译：含有异源黄体血红蛋白基因的植物及其使用方法
公开(公告)号：US20070074312A1
公开(公告)日：2007-03-29
申请号：US11429629
申请日：2006-05-05
申请人： Amarjit Basra , Mike Edgerton , Garrett Lee , Maolong Lu , Linda Lutfiyya , Wei Wu , Xiaoyun Wu
发明人： Amarjit Basra , Mike Edgerton , Garrett Lee , Maolong Lu , Linda Lutfiyya , Wei Wu , Xiaoyun Wu
IPC分类号： A01H1/00 , A01H5/00 , C12N15/82 , C12N5/04
CPC分类号： C12N15/8251 , C07K14/805 , C12N15/8261 , C12N15/8271 , Y02A40/146
摘要： Plant nitrogen use efficiency in corn has been improved by transformation with a flavohemoglobin gene. Plants comprising a flavohemoglobin gene have decreased nitric oxide (NO) levels, increased biomass accumulation under a sufficient nitrogen growth condition, and increased chlorophyll content under a limiting nitrogen growth condition. Additionally, these transformed plants evidence higher levels of yield.
摘要翻译：通过黄素血红蛋白基因转化，提高了玉米的氮素利用效率。包含黄高血红蛋白基因的植物具有降低的一氧化氮（NO）水平，在足够的氮生长条件下增加的生物量积累，并且在极限氮生长条件下增加叶绿素含量。此外，这些转化的植物表现出较高的产量水平。

10. 发明申请

US20050032046A1 Cell-based method and assay for measuring the infectivity and drug sensitivity of immunodeficiency virus 审中-公开
标题翻译：基于细胞的方法和测定免疫缺陷病毒的感染性和药物敏感性
公开(公告)号：US20050032046A1
公开(公告)日：2005-02-10
申请号：US10936037
申请日：2004-09-08
申请人： John Kappes , Xiaoyun Wu
发明人： John Kappes , Xiaoyun Wu
IPC分类号： C12N5/00 , C12N5/08 , C12N7/02 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/569
CPC分类号： G01N33/56988 , C12Q1/703 , G01N33/5091 , G01N2333/70514 , G01N2333/715
摘要： Methods and reagents for the capture of primary HIV are provided. A cell line expressing CCR5, CXCR4 and CD4 receptors binds and is infected by primary HIV. The cell line contains a marker gene sequence, the marker gene sequence expressed in near linear quantities over at least two orders of magnitude in response to HIV infection. Primary HIV is amplified to create a primary virus stock through insertion of an amplicon gene into the receptor expressing cell line. HIV amplification occurs rapidly and is operative with noninfectious HIV through amplification in the presence of an infectivity complement. The present invention is useful in determining host HIV titer, drug sensitivity, HIV amplification, gene sequencing and co-receptor utilization.
摘要翻译：提供了捕获初级艾滋病毒的方法和试剂。表达CCR5，CXCR4和CD4受体的细胞系结合并被原发性HIV感染。细胞系含有标记基因序列，标记基因序列以接近线性的数量表达，响应于HIV感染至少两个数量级。通过将扩增子基因插入受体表达细胞系中，将主要的HIV扩增以产生初级病毒库。 HIV扩增快速发生，并通过在感染性补体存在下扩增而与非感染性HIV进行手术。本发明可用于确定宿主HIV滴度，药物敏感性，HIV扩增，基因测序和辅助受体利用。

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