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1. 发明授权

US4229527A Process and reagent for the kinetic determination of enzyme substrates 失效
标题翻译：用于酶底物动力学测定的方法和试剂
公开(公告)号：US4229527A
公开(公告)日：1980-10-21
申请号：US954139
申请日：1978-10-23
申请人： Joachim Ziegenhorn , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruaber , Hans U. Bergmeyer
发明人： Joachim Ziegenhorn , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruaber , Hans U. Bergmeyer
IPC分类号： G01N33/50 , C12Q1/00 , C12Q1/54 , C12Q1/60 , C12Q1/61 , G01N21/75 , G01N33/48 , G01N33/66 , G01N33/92 , C12Q1/50 , C12Q1/44 , C12Q1/48
CPC分类号： C12Q1/61 , C12Q1/00 , C12Q1/54 , C12Q1/60 , Y10S435/81
摘要： Kinetic determination of enzyme substrates by means of coupled reactions comprising selecting the reaction parameters so that the most specific part reaction of a reaction sequence becomes rate-determining for the whole reaction sequence wherein the rate-determining part reaction follows first or pseudo-first order kinetics.
摘要翻译：通过偶联反应动力学测定酶底物，包括选择反应参数，使得反应序列的最具体的部分反应成为整个反应顺序的速率确定，其中速率确定部分反应遵循第一或伪一级动力学。

2. 发明授权

US5108913A Process for preparing a maltoheptaose derivative 失效
标题翻译：制备MALTOHEPTAOSE衍生物的方法
公开(公告)号：US5108913A
公开(公告)日：1992-04-28
申请号：US545092
申请日：1990-06-27
申请人： Elli Rauscher , Ulrich Neumann , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruber , Joachim Ziegenhorn , Eugen Schaich , Ulfert Deneke , Michal Gerhard , Gunter Weimann
发明人： Elli Rauscher , Ulrich Neumann , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruber , Joachim Ziegenhorn , Eugen Schaich , Ulfert Deneke , Michal Gerhard , Gunter Weimann
IPC分类号： G01N33/50 , C07H15/04 , C07H15/203 , C12Q1/40
CPC分类号： C12Q1/40 , C12Q2334/10 , Y10S435/805 , Y10S435/81
摘要： .alpha.-Amylase is determined by the enzymatic splitting of an .alpha.-amylase substrate and measurement of a fission product, wherein there is used as a substrate a maltoheptaose compound of the formula ##STR1## wherein R is a glucoside, phenylglucoside, mononitrophenylglucoside, dinitrophenylglucoside, sorbitol or gluconic acid group. Reagents comprising such a substrate and a system for the determination of a fission product formed from the amylase substrate by .alpha.-amylase, are also provided. A process for the preparation of a maltoheptaose will Bacillus macerans amylase, free of p-nitrophenyl-alpha-glucoside splitting activity is disclosed.

3. 发明授权

US4544631A Process and reagent for the determination of .alpha.-amylase 失效
标题翻译：用于测定α-淀粉酶的方法和试剂
公开(公告)号：US4544631A
公开(公告)日：1985-10-01
申请号：US311856
申请日：1981-10-16
申请人： Elli Rauscher , Ulrich Neumann , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruber , Joachim Ziegenhorn , Eugen Schaich , Ulfert Deneke , Gerhard Michal , Gunter Weimann
发明人： Elli Rauscher , Ulrich Neumann , August W. Wahlefeld , Alexander Hagen , Wolfgang Gruber , Joachim Ziegenhorn , Eugen Schaich , Ulfert Deneke , Gerhard Michal , Gunter Weimann
IPC分类号： G01N33/50 , C07H15/04 , C07H15/203 , C12Q1/40 , C12Q1/54 , C12Q1/32 , C12Q1/34 , C12Q1/48
CPC分类号： C12Q1/40 , C12Q2334/10 , Y10S435/805 , Y10S435/81
摘要： .alpha.-Amylase is determined by the enzymatic splitting of an .alpha.-amylase substrate and measurement of a fission product, wherein there is used as a substrate a maltoheptaose compound of the formula ##STR1## wherein R is a glucoside, phenylglucoside, mononitrophenylglucoside, dinitrophenylglucoside, sorbitol or gluconic acid group. Reagents comprising such a substrate and a system for the determination of a fission product formed from the amylase substrate by .alpha.-amylase, are also provided.
摘要翻译： α-淀粉酶通过α-淀粉酶底物的酶裂解和裂变产物的测定来确定，其中用作底物的麦芽麦角糖化合物，其中R是葡萄糖苷，苯基葡糖苷，单硝基苯基葡糖苷，二硝基苯基葡糖苷，山梨糖醇或葡萄糖酸基团。还提供了包含这种底物的试剂和用于通过α-淀粉酶测定由淀粉酶底物形成的裂变产物的系统。

4. 发明授权

US4212938A Reagent and method for the determination of cholesterol 失效
标题翻译：用于测定胆固醇的试剂和方法
公开(公告)号：US4212938A
公开(公告)日：1980-07-15
申请号：US360515
申请日：1973-05-15
申请人： Wolfgang Gruber , Hans U. Bergmeyer , Erich Bernt , Alexander Hagen , Peter Roeschlau , Gunter Lang , Klaus Beaucamp
发明人： Wolfgang Gruber , Hans U. Bergmeyer , Erich Bernt , Alexander Hagen , Peter Roeschlau , Gunter Lang , Klaus Beaucamp
IPC分类号： G01N33/92 , A61B10/00 , C07J9/00 , C12Q1/26 , C12Q1/60 , G01N33/15 , G01N33/48 , C12Q1/50
CPC分类号： C12Q1/60
摘要： Cholesterol is determined by incubating a sample suspected of containing cholesterol in an aqueous medium with cholesterol oxidase and determining either the oxygen consumption, the hydrogen peroxide formed, or cholestenone, as a measure of the initial cholesterol content; reagent compositions comprising cholesterol oxidase and a system for the determination of H.sub.2 O.sub.2 or for the determination of cholestenone are provided.
摘要翻译：胆固醇通过将怀疑含有胆固醇的样品置于水性介质中与胆固醇氧化酶并测定氧消耗，形成的过氧化氢或胆碱酯酶作为初始胆固醇含量的量度来确定; 提供了包含胆固醇氧化酶的试剂组合物和用于测定H 2 O 2或测定胆碱酯的系统。

5. 发明授权

US4247630A Method and reagent for the determination of uric acid 失效
标题翻译：测定尿酸的方法和试剂
公开(公告)号：US4247630A
公开(公告)日：1981-01-27
申请号：US892360
申请日：1978-03-31
申请人： Joachim Ziegenhorn , Eberhard Munz , Brigitte Draeger , Alexander Hagen , Wolfgang Gruber
发明人： Joachim Ziegenhorn , Eberhard Munz , Brigitte Draeger , Alexander Hagen , Wolfgang Gruber
IPC分类号： G01N33/50 , C12Q1/62 , C12Q1/30
CPC分类号： C12Q1/62
摘要： The invention relates to an improvement in a conventional method for the determination of uric acid involving uricase/catalase/aldehyde dehydrogenase, resulting in the formation of produced NAD(P)H as a measure of the initial uric acid present, which improvement comprises adding at least one compound selected from oxalates, malonic acid mono-lower alkyl esters, trihaloethanols, pyrazole, pyridine, substituted pyrazole and pyridine wherein the substituents are selected from lower alkyl and halogen, pyridine carboxylic acids, pyridine carboxylic acids substituted with a lower radical, pyridine carboxylic acid amides and pyridine carboxylic acid lower alkyl esters, thiourea, isobutyramide and chelate-forming complexing agents, in order to suppress disturbance-causing creep reactions in said method. Reagents containing such additive compounds are also provided.
摘要翻译：本发明涉及用于测定尿酸/过氧化氢酶/醛脱氢酶的尿酸的常规方法的改进，导致产生的NAD（P）H的形成作为存在的初始尿酸的量度，其改进包括在选自草酸盐，丙二酸单低级烷基酯，三卤代乙醇，吡唑，吡啶，取代的吡唑和吡啶中的至少一种化合物，其中取代基选自低级烷基和卤素，吡啶羧酸，被低级基团取代的吡啶羧酸，吡啶羧酸酰胺和吡啶羧酸低级烷基酯，硫脲，异丁酰胺和螯合形成络合剂，以抑制所述方法中的扰动引起的蠕变反应。还提供了含有这些添加剂化合物的试剂。

6. 发明授权

US4268628A Method for the determination of .alpha.-amylase 失效
标题翻译：测定α-淀粉酶的方法
公开(公告)号：US4268628A
公开(公告)日：1981-05-19
申请号：US22011
申请日：1979-03-19
申请人： Sigmar Klose , Hans-Georg Batz , Michael Stoltz , Alexander Hagen , Gunter Weimann
发明人： Sigmar Klose , Hans-Georg Batz , Michael Stoltz , Alexander Hagen , Gunter Weimann
IPC分类号： G01N33/50 , C08B31/00 , C12Q1/40 , G01N33/02
CPC分类号： C08B31/00 , C12Q1/40 , C12Q2334/00 , Y10S435/805
摘要： Novel method for the determination of .alpha.-amylase which method comprises contacting a sample suspected of containing .alpha.-amylase with a starch derivative carrying a substituent capable of dyestuff-forming coupling; separating from the resulting starch-containing phase the low molecular weight soluble fission products formed by splitting of said starch derivative by .alpha.-amylase; coupling the said couplable substituent with another dyestuff forming component; and measuring the dyestuff so formed as a measure of the initial .alpha.-amylase content.
摘要翻译：用于测定α-淀粉酶的新方法，该方法包括使怀疑含有α-淀粉酶的样品与携带能够进行染料形成偶联的取代基的淀粉衍生物接触; 从所得含淀粉相中分离出由α-淀粉酶分解所述淀粉衍生物形成的低分子量可溶裂解产物; 将所述可连接取代基与另一种形成染料的成分偶联; 并测量如此形成的染料作为初始α-淀粉酶含量的量度。

7. 发明授权

US4102742A Process for enzymatic analysis 失效
标题翻译：酶分析方法
公开(公告)号：US4102742A
公开(公告)日：1978-07-25
申请号：US692701
申请日：1976-06-03
申请人： Sigmar Klose , Alexander Hagen
发明人： Sigmar Klose , Alexander Hagen
IPC分类号： C12Q1/00 , C12Q1/30 , C12Q1/32 , C12Q1/54 , C12Q1/60 , G01N31/14
CPC分类号： C12Q1/32 , C12Q1/00 , C12Q1/30 , C12Q1/54 , C12Q1/60 , Y10S435/813
摘要： Process for enzymatic analysis by the enzymatic reaction of a substance to be determined and measurement of the increase or decrease of a reaction component of the main reaction or subsequent reaction, comprising adding to a solution which contains dissolved therein the enzyme necessary for the reaction, a sample solution containing a substance to be determined, measuring a particular reaction component, and then circulating the enzyme solution through a reactor which completely removes the measured reaction component from the solution (or converts it to a non-disturbing product) and again mixing the enzyme solution, if necessary after replenishing the used up components, with a new sample solution.
摘要翻译：通过待测定物质的酶促反应进行酶分析的方法，以及测定主反应或随后反应的反应成分的增加或减少的方法，包括向溶解有反应所需的酶的溶液中加入含有待测物质的样品溶液，测量特定的反应组分，然后使酶溶液循环通过将溶液中完全除去测量的反应组分的反应器（或将其转化为不干扰产物）并再次混合该酶解决方案，如果需要，补充用完的组件后，用新的样品溶液。

8. 发明授权

US07792527B2 Wireless network handoff key 失效
标题翻译：无线网络切换密钥
公开(公告)号：US07792527B2
公开(公告)日：2010-09-07
申请号：US10290650
申请日：2002-11-08
申请人： Gang Wu , Fujio Watanabe , Alexander Hagen
发明人： Gang Wu , Fujio Watanabe , Alexander Hagen
IPC分类号： H04W4/00 , H04M11/00 , H04J3/16
CPC分类号： H04L63/062 , H04W12/04 , H04W36/0038 , H04W36/08 , H04W80/02 , H04W88/08 , H04W92/20
摘要： A handoff key is provided for facilitating a hand off of a wireless terminal from a first access point to a second access point. The handoff key may be generated by a server and communicated to the first and second access points. Alternatively, the handoff key may be generated one of the access points and transmitted to the other access point. The first access point may transmit the handoff key to the wireless terminal before the handoff. Shortly after the handoff, the wireless terminal and the second access point may communicate data encrypted with the handoff key. Later, an authentication server may authenticate the wireless terminal, causing the second access point to provide the wireless terminal with a session key. Thereafter, the wireless terminal and the second access point may communicate data encrypted with the session key.
摘要翻译：提供切换密钥以便于将无线终端从第一接入点切换到第二接入点。切换密钥可以由服务器生成并传送到第一和第二接入点。或者，切换密钥可以生成接入点中的一个并被发送到另一个接入点。第一接入点可以在切换之前将切换密钥发送到无线终端。切换后不久，无线终端和第二接入点可以传送用切换密钥加密的数据。之后，认证服务器可认证无线终端，使得第二接入点向无线终端提供会话密钥。此后，无线终端和第二接入点可以传送用会话密钥加密的数据。

9. 发明授权

US4279991A Process and apparatus for preparing multi-component reagent solutions 失效
标题翻译：制备多组分试剂溶液的方法和装置
公开(公告)号：US4279991A
公开(公告)日：1981-07-21
申请号：US100168
申请日：1979-12-04
申请人： Alexander Hagen , Hermann Edelmann , Sigmar Klose
发明人： Alexander Hagen , Hermann Edelmann , Sigmar Klose
IPC分类号： G01N31/00 , C12Q1/00 , G01N31/22 , G01N33/52 , G01N35/00 , C12M1/00
CPC分类号： G01N35/00009 , C12Q1/00 , G01N31/22 , G01N33/521 , Y10S435/805 , Y10T83/169 , Y10T83/2066 , Y10T83/902
摘要： The invention provides a process for the production of reagent solutions containing a plurality of components for analytical purposes, wherein the individual components of several differently composed reagents are each introduced into a solid, proportionable carrier material in easily redissolvable form in such an amount that each part by volume or weight of the carrier material carries a definite amount of one reagent component, the carriers of the components are brought together in a magazine-like manner and, for the production of a particular reagent, from all carriers which carry a component of the reagent, there are simultaneously taken off the amounts corresponding to the required amounts of the components, which are then dissolved to form the reagent solution. Apparatus for carrying out the process is also provided.
摘要翻译：本发明提供一种用于生产含有用于分析目的的多种组分的试剂溶液的方法，其中几种不同组成的试剂的各组分各自以容易再溶解的形式引入固体，可配比的载体材料中，载体材料的体积或重量承载一定量的一种试剂组分，将组分的载体以杂志状的方式汇集在一起，并且为了生产特定试剂，从携带一种试剂组分的所有载体试剂，同时取出与所需量的组分相对应的量，然后将其溶解以形成试剂溶液。还提供了用于执行该过程的装置。

10. 发明授权

US4153513A Method and apparatus for the continuous determination of the concentration of an enzyme substrate 失效
标题翻译：用于连续测定酶底物浓度的方法和装置
公开(公告)号：US4153513A
公开(公告)日：1979-05-08
申请号：US826008
申请日：1977-08-19
申请人： Hermann Edelmann , Peter Kraft , Karlheinz Mann , Peter Schuler , Alexander Hagen
发明人： Hermann Edelmann , Peter Kraft , Karlheinz Mann , Peter Schuler , Alexander Hagen
IPC分类号： G01N27/02 , C12Q1/00 , G01N27/416 , G01N33/487
CPC分类号： G01N27/3271
摘要： Enzyme substrates in aqueous liquids are continuously measured by introducing a sample containing the substrate to be determined into a current of buffer solution, reacting the substrate on an immobilized enzyme and measuring, in a measurement chamber, a physical change in the solution brought about by the reaction, wherein a current of buffer solution containing the sample to be determined is passed alternatingly (i) directly through the measurement chamber with the production of a reference signal and (ii) first over the immobilized enzyme and thereafter through the measurement chamber with the production of a measurement signal, and relating the reference signal to the measurement signal to indicate the enzyme substrate initially present.
摘要翻译：在含水液体中的酶底物通过将含有要测定的底物的样品引入缓冲溶液的电流来连续测量，使底物反应在固定化酶上，并在测量室中测量溶液产生的溶液的物理变化反应，其中包含要测定的样品的缓冲溶液的电流交替（i）通过测量室直接通过参考信号的产生，和（ii）首先在固定化酶上，然后通过测量室进行生产的测量信号，并将参考信号与测量信号相关联，以指示最初存在的酶底物。

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