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    • 1. 发明申请
    • FUSED HETEROARYL MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kappaB ACTIVITY AND USE THEREOF
    • GLUCOCORTICOID受体,AP-1和/或NF-κB活性的融合血管调节剂及其用途
    • US20110002952A1
    • 2011-01-06
    • US12866270
    • 2009-02-05
    • Jingwu DuanDavid S. WeinsteinBin Jiang
    • Jingwu DuanDavid S. WeinsteinBin Jiang
    • A61K31/5377C07D491/147A61K31/4375A61K38/26A61K38/28A61K39/00A61P37/00A61P29/00A61P3/00A61P37/06A61P19/02A61P25/00A61P11/06A61P1/00A61P17/06
    • C07D491/147
    • Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; -A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B1 and B2 rings are pyridyl rings, wherein the B1 and B2 rings are each fused to the A ring and the B1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R1, R2, and R4, and the B2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R3, R7, and R3 71, J2, and J3 are at each occurrence the same or different and are independently -AIQA2-; Q is a bond, O, S, S(0), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3 alkylene, substituted C1-3 alkylene, C24 alkenylene, and substituted C24 alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein.
    • 提供新的非甾体化合物,其可用于治疗与调节糖皮质激素受体,AP-1和/或NF-κB活性相关的疾病或病症,包括具有结构的代谢和炎症和免疫疾病或病症 式(I)的化合物:其对映异构体,非对映异构体或其互变异构体或其前药酯或其药学上可接受的盐,其中:Z是杂环基或杂芳基; -A是5-至8-元碳环或5-至8-元杂环; B1和B2环是吡啶环,其中B1和B2环各自与A环稠合,B1环任选被一至三个相同或不同并且独立地选自R 1,R 2和R 4的基团取代 并且B2环任选地被一至三个相同或不同并且独立地选自R3,R7和R371的基团取代,J2和J3在每次出现时相同或不同,并且独立地为-AIQA2- ; Q是键,O,S,S(0)或S(O)2; A1和A2相同或不同,并且在每次出现时独立地选自键,C1-3亚烷基,取代的C1-3亚烷基,C24亚烯基和取代的C24亚烯基,条件是选择A1和A2,使得环A为 5-至8-元碳环或杂环; R1至R11如本文所定义。
    • 2. 发明申请
    • MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kB ACTIVITY AND USE THEREOF
    • GLUCOCORTICOID受体的调节剂,AP-1和/或NF-kB活性及其用途
    • US20090075995A1
    • 2009-03-19
    • US11835438
    • 2007-08-08
    • David S. WeinsteinPing ChenT.G. Murali DharJingwu DuanHua GongBin JiangBingwei Vera YangArthur M. Doweyko
    • David S. WeinsteinPing ChenT.G. Murali DharJingwu DuanHua GongBin JiangBingwei Vera YangArthur M. Doweyko
    • A61K31/5377A61K31/436C07D491/052A61P31/12A61K31/427C07D417/12
    • C07D417/12C07D277/46C07D405/12C07D417/14C07D491/04
    • Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R5, R6, R7, and R8; J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3alkylene, substituted C1-3alkylene, C2-4alkenylene, and substituted C2-4alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
    • 提供了新的非甾体化合物,其可用于治疗与式(I)结构的糖皮质激素受体,AP-1和/或NF-κB活性(包括炎症和免疫疾病)调节相关的疾病:对映异构体 ,非对映异构体或其互变异构体,或其前药酯或其药学上可接受的盐,其中:Z是杂环或杂芳基; A是5至8元碳环或5至8元杂环; B是环烷基,环烯基,芳基,杂环基或杂芳基环,其中每个环与相邻原子上的A环稠合并任选地被一至四个相同或不同的基团取代,并且独立地选自R5,R6, R7和R8; J1,J2和J3各自出现相同或不同,独立地为-A1QA2-; Q是键,O,S,S(O)或S(O)2; A1和A2相同或不同,并且在每次出现时独立地选自键,C1-3亚烷基,取代的C1-3亚烷基,C2-4亚烯基和取代的C2-4亚烯基,条件是选择A1和A2使得环A为 5-至8-元碳环或杂环; R1至R11如本文所定义。 还提供了使用所述化合物治疗炎性或免疫相关疾病和肥胖症和糖尿病的药物组合物和方法。
    • 3. 发明授权
    • Modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
    • 糖皮质激素受体,AP-1和/或NF-κB活性的调节剂及其用途
    • US08034940B2
    • 2011-10-11
    • US11835438
    • 2007-08-08
    • David S. WeinsteinPing ChenT. G. Murali DharJingwu DuanHua GongBin JiangBingwei Vera YangArthur M. Doweyko
    • David S. WeinsteinPing ChenT. G. Murali DharJingwu DuanHua GongBin JiangBingwei Vera YangArthur M. Doweyko
    • C07D491/052A61K31/436
    • C07D417/12C07D277/46C07D405/12C07D417/14C07D491/04
    • Novel non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including inflammatory and immune diseases, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B is a cycloalkyl, cycloalkenyl, aryl, heterocyclo, or heteroaryl ring, wherein each ring is fused to the A ring on adjacent atoms and optionally substituted by one to four groups which are the same or different and are independently selected from R5, R6, R7, and R8; J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3alkylene, substituted C1-3alkylene, C2-4alkenylene, and substituted C2-4alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein. Also provided are pharmaceutical compositions and methods of treating inflammatory- or immune-associated diseases and obesity and diabetes employing said compounds.
    • 提供新的非甾体化合物,其可用于治疗与式(I)结构的糖皮质激素受体,AP-1和/或NF-κB活性(包括炎症和免疫疾病)的调节相关的疾病: 其对映异构体,非对映体或其互变异构体或其前药酯或其药学上可接受的盐,其中:Z是杂环或杂芳基; A是5至8元碳环或5至8元杂环; B是环烷基,环烯基,芳基,杂环基或杂芳基环,其中每个环与相邻原子上的A环稠合并任选地被一至四个相同或不同的基团取代,并且独立地选自R5,R6, R7和R8; J1,J2和J3各自出现相同或不同,独立地为-A1QA2-; Q是键,O,S,S(O)或S(O)2; A1和A2相同或不同,并且在每次出现时独立地选自键,C1-3亚烷基,取代的C1-3亚烷基,C2-4亚烯基和取代的C2-4亚烯基,条件是选择A1和A2使得环A为 5-至8-元碳环或杂环; R1至R11如本文所定义。 还提供了使用所述化合物治疗炎性或免疫相关疾病和肥胖症和糖尿病的药物组合物和方法。
    • 5. 发明授权
    • Fused heteroaryl modulators of glucocorticoid receptor, AP-1, and/or NF-κB activity and use thereof
    • 糖皮质激素受体,AP-1和/或NF-κB活性的融合杂芳基调节剂及其用途
    • US08304539B2
    • 2012-11-06
    • US12866270
    • 2009-02-05
    • Jingwu DuanDavid S. WeinsteinBin Jiang
    • Jingwu DuanDavid S. WeinsteinBin Jiang
    • C07D491/147C07D413/00
    • C07D491/147
    • Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or taυtomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; •A is a S- to 8-membered carbocyclic ring or a S- to 8-membered heterocyclic ring; B1 and B2 rings are pyridyl rings, wherein the B1 and B2 rings are each fused to the A ring and the B1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R1, R2, and R4, and the B2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R5, R7, and R3 J1, J2, and J3 are at each occurrence the same or different and are independently -A1QA2-; Q is a bond, O, S, S(O), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3 alkylene, substituted C1-3 alkylene, C2-4 alkenylene, and substituted C2-4 alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein.
    • 提供新的非甾体化合物,其可用于治疗与调节糖皮质激素受体,AP-1和/或NF-κB活性相关的疾病或病症,包括具有结构的代谢和炎症和免疫疾病或病症 式(I)的化合物:其对映异构体,非对映异构体或其互变异构体或其前药酯或其药学上可接受的盐,其中:Z是杂环基或杂芳基; A是5至8元碳环或5至8元杂环; B1和B2环是吡啶环,其中B1和B2环各自与A环稠合,B1环任选被一至三个相同或不同并且独立地选自R 1,R 2和R 4的基团取代 并且B2环任选被一至三个相同或不同并且独立地选自R5,R7和R8的基团取代,J1,J2和J3在每次出现时相同或不同,并且独立地为-A 1 QA 2 - ; Q是键,O,S,S(O)或S(O)2; A1和A2相同或不同,并且在每次出现时独立地选自键,C1-3亚烷基,取代的C1-3亚烷基,C2-4亚烯基和取代的C2-4亚烯基,条件是A1和A2被选择为 该环A为5-至8-元碳环或杂环; R1至R11如本文所定义。