专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20110002952A1 FUSED HETEROARYL MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-kappaB ACTIVITY AND USE THEREOF 有权
标题翻译： GLUCOCORTICOID受体，AP-1和/或NF-κB活性的融合血管调节剂及其用途
公开(公告)号：US20110002952A1
公开(公告)日：2011-01-06
申请号：US12866270
申请日：2009-02-05
申请人： Jingwu Duan , David S. Weinstein , Bin Jiang
发明人： Jingwu Duan , David S. Weinstein , Bin Jiang
IPC分类号： A61K31/5377 , C07D491/147 , A61K31/4375 , A61K38/26 , A61K38/28 , A61K39/00 , A61P37/00 , A61P29/00 , A61P3/00 , A61P37/06 , A61P19/02 , A61P25/00 , A61P11/06 , A61P1/00 , A61P17/06
CPC分类号： C07D491/147
摘要： Novel non-steroidal compounds are provided which are useful in treating diseases or disorders associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity, including metabolic and inflammatory and immune diseases or disorders, having the structure of formula (I): an enantiomer, diastereomer, or tautomer thereof, or a prodrug ester thereof, or a pharmaceutically-acceptable salt thereof, in which: Z is heterocyclo or heteroaryl; -A is a 5- to 8-membered carbocyclic ring or a 5- to 8-membered heterocyclic ring; B1 and B2 rings are pyridyl rings, wherein the B1 and B2 rings are each fused to the A ring and the B1 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R1, R2, and R4, and the B2 ring is optionally substituted by one to three groups which are the same or different and are independently selected from R3, R7, and R3 71, J2, and J3 are at each occurrence the same or different and are independently -AIQA2-; Q is a bond, O, S, S(0), or S(O)2; A1 and A2 are the same or different and are at each occurrence independently selected from a bond, C1-3 alkylene, substituted C1-3 alkylene, C24 alkenylene, and substituted C24 alkenylene, provided that A1 and A2 are chosen so that ring A is a 5- to 8-membered carbocyclic or heterocyclic ring; R1 to R11 are as defined herein.
摘要翻译：提供新的非甾体化合物，其可用于治疗与调节糖皮质激素受体，AP-1和/或NF-κB活性相关的疾病或病症，包括具有结构的代谢和炎症和免疫疾病或病症式（I）的化合物：其对映异构体，非对映异构体或其互变异构体或其前药酯或其药学上可接受的盐，其中：Z是杂环基或杂芳基; -A是5-至8-元碳环或5-至8-元杂环; B1和B2环是吡啶环，其中B1和B2环各自与A环稠合，B1环任选被一至三个相同或不同并且独立地选自R 1，R 2和R 4的基团取代并且B2环任选地被一至三个相同或不同并且独立地选自R3，R7和R371的基团取代，J2和J3在每次出现时相同或不同，并且独立地为-AIQA2- ; Q是键，O，S，S（0）或S（O）2; A1和A2相同或不同，并且在每次出现时独立地选自键，C1-3亚烷基，取代的C1-3亚烷基，C24亚烯基和取代的C24亚烯基，条件是选择A1和A2，使得环A为 5-至8-元碳环或杂环; R1至R11如本文所定义。

2. 发明授权

US07294624B2 Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases 有权
标题翻译：巴比妥酸衍生物作为TNF-α转化酶（TACE）和/或基质金属蛋白酶的抑制剂
公开(公告)号：US07294624B2
公开(公告)日：2007-11-13
申请号：US10321144
申请日：2002-12-17
申请人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William J. Pitts
发明人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William J. Pitts
IPC分类号： A01N43/58 , A61K31/50 , C07D237/00 , C07D239/02
CPC分类号： C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10
摘要： The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译：本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式，其中A，B，L，R 1，R 2， R 4，R 4，R 5，n，W，U，X，Y，Z，U a，在本说明书中定义，其可用作TNF-α转化酶（TACE）和/或基质金属蛋白酶（MMP）抑制剂。

3. 发明授权

US06495565B2 &bgr;-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-&agr; 有权
标题翻译： β-氨基酸衍生物作为基质金属蛋白酶和TNF-α的抑制剂
公开(公告)号：US06495565B2
公开(公告)日：2002-12-17
申请号：US09811116
申请日：2001-03-16
申请人： Jingwu Duan , Bryan W. King , Carl Decicco , Thomas P. Maduskuie, Jr. , Matthew E. Voss
发明人： Jingwu Duan , Bryan W. King , Carl Decicco , Thomas P. Maduskuie, Jr. , Matthew E. Voss
IPC分类号： A61K314709
CPC分类号： C07D401/06 , C07D211/34 , C07D211/58 , C07D215/14 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/12
摘要： The present application describes novel &bgr;-amino acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, X, Z, Ua, Xa, Ya, Za, R1, R2, R3, R4, and R4a are defined in the present specification, which are useful as metalloprotease and/or as TNF-&agr; inhibitors.
摘要翻译：本申请描述了式I的新型β-氨基酸衍生物或其药学上可接受的盐或前药形式，其中A，X，Z，Ua，Xa，Ya，Za，R 1，R 2，R 3，R 4和R 4定义在本说明书中，其可用作金属蛋白酶和/或作为TNF-α抑制剂。

4. 发明授权

US08586751B2 Nicotinamide compounds useful as kinase modulators 有权
标题翻译：可用作激酶调节剂的烟酰胺化合物
公开(公告)号：US08586751B2
公开(公告)日：2013-11-19
申请号：US13377157
申请日：2010-06-10
申请人： George V. De Lucca , Qing Shi , Chunjian Liu , Jingwu Duan , Andrew J. Tebben
发明人： George V. De Lucca , Qing Shi , Chunjian Liu , Jingwu Duan , Andrew J. Tebben
IPC分类号： A61K31/4433 , C07D401/14
CPC分类号： C07D401/04 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D498/10
摘要： Disclosed are nicotinamide compounds of Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. Also disclosed are methods of using such compounds in the treatment of at least one Btk associated condition, such as, for example, inflammatory disease, and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的烟酰胺化合物或其立体异构体或其药学上可接受的盐。还公开了使用这些化合物治疗至少一种Btk相关病症例如炎性疾病的方法和包含这些化合物的药物组合物。

5. 发明申请

US20120295899A1 BENZYLPYRROLIDINONE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权
标题翻译：作为化合物受体活性调节剂的苄基吡咯烷酮衍生物
公开(公告)号：US20120295899A1
公开(公告)日：2012-11-22
申请号：US13576706
申请日：2011-02-08
申请人： Ian K. Mangion , Percy H. Carter , Jingwu Duan , Andrew J. Tebben
发明人： Ian K. Mangion , Percy H. Carter , Jingwu Duan , Andrew J. Tebben
IPC分类号： A61K31/5365 , C07D401/06 , A61P37/06 , A61K31/438 , A61P29/00 , A61P37/08 , C07D498/04 , A61K31/454
CPC分类号： C07D498/04 , C07D207/27
摘要： The present application describes modulators of MCP-1 or CCR-2 of formula or stereoisomers or prodrugs or pharmaceutically acceptable salts thereof, wherein m, n, W, X, R1 and R6, are defined herein. In addition, methods of treating and preventing inflammatory diseases such as asthma and allergic diseases, as well as autoimmune pathologies such as rheumatoid arthritis and transplant rejection using modulators of formula (I) are disclosed.
摘要翻译：本申请描述了式或其立体异构体或其前药或其药学上可接受的盐的MCP-1或CCR-2的调节剂，其中m，n，W，X，R 1和R 6在本文中定义。此外，公开了使用式（I）的调节剂治疗和预防炎性疾病如哮喘和过敏性疾病以及类风湿性关节炎和移植排斥反应的自身免疫病态的方法。

6. 发明申请

US20120082702A1 NICOTINAMIDE COMPOUNDS USEFUL AS KINASE MODULATORS 有权
标题翻译： NICOTINAMIDE化合物作为激酶调节剂有用
公开(公告)号：US20120082702A1
公开(公告)日：2012-04-05
申请号：US13377157
申请日：2010-06-10
申请人： George V. DeLucca , Qing Shi , Chunjian Liu , Jingwu Duan , Andrew J. Tebben
发明人： George V. DeLucca , Qing Shi , Chunjian Liu , Jingwu Duan , Andrew J. Tebben
IPC分类号： A61K47/22 , A61K31/5377 , C07D401/14 , A61K31/497 , A61P37/08 , C07D401/04 , A61K31/4545 , A61K31/438 , A61P35/00 , A61P37/06 , C07D413/14 , C07D401/12
CPC分类号： C07D401/04 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14 , C07D498/10
摘要： Disclosed are nicotinamide compounds of Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof. Also disclosed are methods of using such compounds in the treatment of at least one Btk associated condition, such as, for example, inflammatory disease, and pharmaceutical compositions comprising such compounds.
摘要翻译：公开了式（I）的烟酰胺化合物或其立体异构体或其药学上可接受的盐。还公开了使用这些化合物治疗至少一种Btk相关病症例如炎性疾病的方法和包含这些化合物的药物组合物。

7. 发明授权

US07595317B2 Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases 有权
标题翻译：巴比妥酸衍生物作为TNF-α转化酶（TACE）和/或基质金属蛋白酶的抑制剂
公开(公告)号：US07595317B2
公开(公告)日：2009-09-29
申请号：US11696847
申请日：2007-04-05
申请人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William J. Pitts
发明人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William J. Pitts
IPC分类号： A01N43/58 , A61K31/50 , C07D237/00 , C07D239/02
CPC分类号： C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10
摘要： The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译：本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式，其中A，B，L，R 1，R 2，R 3，R 4，R 5，n，W，U，X，Y， Ua，Xa，Ya和Za在本说明书中定义，其可用作TNF-α转化酶（TACE）和基质金属蛋白酶（MMP）抑制剂。

8. 发明申请

US20070167451A1 BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES 有权
标题翻译：作为TNF-α转化酶（TACE）和/或基质金属蛋白酶抑制剂的巴比妥酸衍生物
公开(公告)号：US20070167451A1
公开(公告)日：2007-07-19
申请号：US11696847
申请日：2007-04-05
申请人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William Pitts
发明人： Jingwu Duan , Bin Jiang , Lihua Chen , Zhonghui Lu , Joseph Barbosa , William Pitts
IPC分类号： A61K31/53 , A61K31/517 , A61K31/515 , C07D413/02 , C07D403/02
CPC分类号： C07D239/54 , C07D239/62 , C07D239/70 , C07D401/12 , C07D403/12 , C07D417/12 , C07D471/10 , C07D487/10 , C07D491/10
摘要： The present application describes novel barbituric acid derivatives of formula I: or pharmaceutically acceptable salt or prodrug forms thereof, wherein A, B, L, R1, R2, R3, R4, R5, n, W, U, X, Y, Z, Ua, Xa, Ya, and Za are defined in the present specification, which are useful as TNF-α converting enzyme (TACE) and matrix metalloproteinases (MMP) inhibitors.
摘要翻译：本申请描述了式I的新型巴比妥酸衍生物或其药学上可接受的盐或前药形式，其中A，B，L，R 1，R 2， R 4，R 4，R 5，n，W，U，X，Y，Z，U a，在本说明书中定义，其可用作TNF-α转化酶（TACE）和/或基质金属蛋白酶（MMP）抑制剂。

9. 发明申请

US20070129400A1 Modulators of glucocorticoid receptor, AP-1, and/or NF-kB activity, and use thereof 有权
标题翻译：糖皮质激素受体，AP-1和/或NF-kB活性的调节剂及其用途
公开(公告)号：US20070129400A1
公开(公告)日：2007-06-07
申请号：US11451660
申请日：2006-06-13
申请人： Jingwu Duan , Zhonghui Lu , David Weinstein , Bin Jiang
发明人： Jingwu Duan , Zhonghui Lu , David Weinstein , Bin Jiang
IPC分类号： A61K31/4709 , A61K31/4439 , A61K31/428 , A61K31/427 , A61K31/416 , C07D417/02 , C07D403/02 , C07D405/02 , C07D409/02
CPC分类号： C07D401/04 , C07D231/56 , C07D401/06 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/06 , C07D417/06 , C07D417/12
摘要： Non-steroidal compounds are provided which are useful in treating diseases associated with modulation of the glucocorticoid receptor, AP-1, and/or NF-κB activity including obesity, diabetes, inflammatory and immune diseases, and have the structure of formula (I) or an enantiomer, a diastereomer, a pharmaceutically acceptable salt, or hydrate thereof, where J is selected from NR1 or C(R4)(R4a); K is selected from NR2 or C(R5)(R5a); L is selected from NR3 or C(R6)(R6a); and A, X, Y, R1, R2, R3, R4, R4a, R5, R5a, R6, R6a, R8, R10, R11, and n are defined herein. Also provided are pharmaceutical compositions and methods of treating obesity, diabetes and inflammatory or immune associated diseases comprising said compounds.
摘要翻译：提供非甾体化合物，其可用于治疗与糖皮质激素受体，AP-1和/或NF-κB活性（包括肥胖症，糖尿病，炎症和免疫疾病）的调节相关的疾病，并且具有式（I）的结构，或其对映异构体，非对映异构体，药学上可接受的盐或水合物，其中J选自NR 1或C（R 4 S 4）（R 4a） / SUB>）; K选自NR 2或C（R 5）（R 5a）; L选自NR 3或C（R 6 S）（R 6a）; 和A，X，Y，R 1，R 2，R 3，R 4，R SUB R 4a，R 5，R 5a，R 6，R 6a，R SUB， R 8，R 11，R 11和n如本文所定义。还提供了治疗肥胖症，糖尿病和包含所述化合物的炎性或免疫相关疾病的药物组合物和方法。

10. 发明授权

US06984648B2 Cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α 有权
标题翻译：环状β-氨基酸衍生物作为基质金属蛋白酶和TNF-α的抑制剂
公开(公告)号：US06984648B2
公开(公告)日：2006-01-10
申请号：US10779539
申请日：2004-02-13
申请人： Zhonghui Lu , Thomas P. Maduskuie, Jr. , Matthew E. Voss , Chu-Biao Xue , Jingwu Duan , Gregory Ott , Lihua Chen , Carl Decicco
发明人： Zhonghui Lu , Thomas P. Maduskuie, Jr. , Matthew E. Voss , Chu-Biao Xue , Jingwu Duan , Gregory Ott , Lihua Chen , Carl Decicco
IPC分类号： A61K31/47 , A61K31/445 , C07D215/02 , C07D413/00 , C07D211/68
CPC分类号： C07D417/14 , C07C259/08 , C07C2601/08 , C07D213/56 , C07D213/82 , C07D215/12 , C07D215/14 , C07D261/02 , C07D307/24 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/04 , C07D417/12
摘要： The present application describes novel cyclic β-amino acid derivatives of formula I: or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and/or as TNF-α inhibitors.
摘要翻译：本申请描述了式I的新型环状β-氨基酸衍生物或其药学上可接受的盐形式，其中环B是含有0-2个选自O，N，NR a的杂原子的5-7元环系和/或S（O）p，和0-1个羰基，其它变量在本说明书中定义，其可用作金属蛋白酶和/或作为TNF-α抑制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式