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1. 发明授权

US06350524B1 Hydrophilic polyurethane-coated chloride-selective electrodes 有权
标题翻译：亲水性聚氨酯涂层氯化物选择性电极
公开(公告)号：US06350524B1
公开(公告)日：2002-02-26
申请号：US09477173
申请日：2000-01-04
申请人： Jin Seo Lee , Hyo Jung Yoon , Gang Cui , Jae Ho Shin , Hakhyun Nam , Geun Sig Cha
发明人： Jin Seo Lee , Hyo Jung Yoon , Gang Cui , Jae Ho Shin , Hakhyun Nam , Geun Sig Cha
IPC分类号： B32B2740
CPC分类号： G01N27/333 , G01N27/40 , Y10T428/3158 , Y10T428/31598 , Y10T428/31609
摘要： The present invention relates to chloride-selective electrodes which comprise insoluble metal salt layer and a protecting membrane formed of hydrophilic polyurethane thereon, wherein the hydrophilic polyurethane coated chloride-selective electrodes show fast activation and response time and are usefully employed to accurately measure the chloride by reducing the interference from bromide and iodide or preventing the surface of the electrode from protein adsorption.
摘要翻译：本发明涉及包含不溶性金属盐层和由其上的亲水性聚氨酯形成的保护膜的氯化物选择性电极，其中亲水性聚氨酯涂覆的氯化物选择性电极显示快速的活化和响应时间，并且有用地用于通过减少溴化物和碘化物的干扰，或阻止电极表面的蛋白质吸附。

2. 发明申请

US20140014512A1 AMPEROMETRIC SENSORS AND DEVICES FOR MEASURING CONCENTRATION OF S-NITROSOTHIOLS BASED ON PHOTO-INDUCED DECOMPOSITION OF S-NITROSOTHIOLS 有权
标题翻译：用于测量S-NITROSOTOLOLS的光诱导分解的S-硝基酚的浓度的电位传感器和装置
公开(公告)号：US20140014512A1
公开(公告)日：2014-01-16
申请号：US13264382
申请日：2011-04-14
申请人： Sung A Hong , Da Yeon Sung , Jun Hee Han , Jea Hun Song , Hakhyun Nam , Geun Sig Cha , Jae Ho Shin
发明人： Sung A Hong , Da Yeon Sung , Jun Hee Han , Jea Hun Song , Hakhyun Nam , Geun Sig Cha , Jae Ho Shin
IPC分类号： G01N27/30
CPC分类号： G01N27/30 , G01N27/3271
摘要： Provided are an amperometric sensor and device for electrochemically quantifying nitrosothiol (RSNO), which is associated with storage and delivery of nitric oxide (NO) in the human body. The amperometric sensor for measuring a concentration of RSNO includes an electrode configured to measure an electric current generated by an oxidation reaction of NO, and a means configured to start and stop photo-induced decomposition of RSNO. Here, the electric current is measured by the oxidation reaction of NO before and after the photo-induced decomposition of RSNO. The amperometric sensor may measure separate signals of RSNO and NO, which are present in the sample at the same time, using one electrode, thereby preventing an inhibition action caused by NO during the measurement of RSNO. Also, the amperometric sensor is simple in structure and easy to manufacture and may be applied to manufacture of a small electrode, and thus may be developed as a sensor for in vivo measurements.
摘要翻译：提供了用于电化学量化亚硝基硫醇（RSNO）的电流传感器和装置，其与人体中一氧化氮（NO）的储存和递送相关。用于测量RSNO浓度的电流传感器包括配置为测量由NO的氧化反应产生的电流的电极和被配置为启动和停止光诱导的RSNO分解的装置。这里，通过在RSNO的光诱导分解之前和之后的NO的氧化反应来测量电流。电流传感器可以使用一个电极同时测量样品中存在的RSNO和NO的单独信号，从而防止在RSNO测量期间由NO引起的抑制作用。此外，电流传感器的结构简单，易于制造，并且可以应用于小电极的制造，因此可以被开发为用于体内测量的传感器。

3. 发明授权

US06554982B1 Miniaturized solid-state reference electrode with self-diagnostic function 失效
标题翻译：具有自诊断功能的小型化固态参比电极
公开(公告)号：US06554982B1
公开(公告)日：2003-04-29
申请号：US09889032
申请日：2001-07-12
申请人： Jae Ho Shin , Sung Dong Lee , Hakhyun Nam , Geun Sig Cha , Byeong Woo Bae
发明人： Jae Ho Shin , Sung Dong Lee , Hakhyun Nam , Geun Sig Cha , Byeong Woo Bae
IPC分类号： G01N27401
CPC分类号： G01N27/301
摘要： The present invention relates to a reference electrode for a potentiometric electrode system, characterized in that the junction in contact with a sample solution is enlarged and an ion-sensitive membrane containing an ion selective material as a protective membrane for the inner reference solution is employed, which comprises a substrate; a metal layer; an insoluble metal salt layer; an insulating film for insulating the metal layer from an aqueous solution; a hydrogel serving as an inner reference solution; the junction on the hydrogel contacting with a sample solution; the ion-sensitive, protective membrane formed over all surface areas of the hydrogel, except for the junction, to separate the sample solution from the inner reference solution or act as an ion-sensing membrane upon the contamination of the junction, whereby the operational abnormality caused by junction contamination may be easily checked and fast activation may be achieved.
摘要翻译：本发明涉及一种用于电位电极系统的参考电极，其特征在于，与样品溶液接触的接合点被扩大，并且使用含有作为内部参比溶液的保护膜的离子选择性材料的离子敏感膜，其包括基底; 金属层; 不溶性金属盐层; 用于将金属层与水溶液绝缘的绝缘膜; 作为内参照溶液的水凝胶; 水凝胶上的接头与样品溶液接触; 在水凝胶的所有表面区域之外形成的离子敏感的保护膜除了接合部分之外，以将样品溶液与内部参考溶液分离，或者当接合部被污染时用作离子感测膜，由此操作异常可以容易地检查结点污染引起的并且可以实现快速激活。

4. 发明授权

US09702842B2 Amperometric sensors and devices for measuring concentration of S-nitrosothiols based on photo-induced decomposition of S-nitrosothiols 有权
公开(公告)号：US09702842B2
公开(公告)日：2017-07-11
申请号：US13264382
申请日：2011-04-14
申请人： Sung A Hong , Da Yeon Sung , Jun Hee Han , Jea Hun Song , Hakhyun Nam , Geun Sig Cha , Jae Ho Shin
发明人： Sung A Hong , Da Yeon Sung , Jun Hee Han , Jea Hun Song , Hakhyun Nam , Geun Sig Cha , Jae Ho Shin
IPC分类号： G01N27/30 , G01N27/327
CPC分类号： G01N27/30 , G01N27/3271
摘要： Provided are an amperometric sensor and device for electrochemically quantifying nitrosothiol (RSNO), which is associated with storage and delivery of nitric oxide (NO) in the human body. The amperometric sensor for measuring a concentration of RSNO includes an electrode configured to measure an electric current generated by an oxidation reaction of NO, and a means configured to start and stop photo-induced decomposition of RSNO. Here, the electric current is measured by the oxidation reaction of NO before and after the photo-induced decomposition of RSNO. The amperometric sensor may measure separate signals of RSNO and NO, which are present in the sample at the same time, using one electrode, thereby preventing an inhibition action caused by NO during the measurement of RSNO. Also, the amperometric sensor is simple in structure and easy to manufacture and may be applied to manufacture of a small electrode, and thus may be developed as a sensor for in vivo measurements.

5. 发明授权

US06177417B1 Cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives, process for preparation and use thereof 有权
标题翻译：基于苯基乙酸的4-（三氟乙酰基）苯基衍生物，其制备方法和用途
公开(公告)号：US06177417B1
公开(公告)日：2001-01-23
申请号：US09338028
申请日：1999-06-22
申请人： Junho Chu , Hyung Jung Pyun , In Jun Yoon , Jae Ho Shin , Hakhyun Nam , Geun Sig Cha
发明人： Junho Chu , Hyung Jung Pyun , In Jun Yoon , Jae Ho Shin , Hakhyun Nam , Geun Sig Cha
IPC分类号： A61K3156
CPC分类号： A61K31/56 , C07J9/00
摘要： The present invention relates to a cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the following formula 1, process for preparation and use thereof. The cholanic acid ring based 4-(trifluoroacetyl)phenyl derivatives of the present invention may be used as a host material in the host-guest chemistry, in detail as a material for ion sensors, optical sensors, gas sensors, biosensors, chromatographies, photostimulated ion-binding resins, ion exchange resins and organic reactions. (In the above formula 1, R, R1, R2, R3 and n are defined in the specifications).
摘要翻译：本发明涉及下述通式1的4-（三氟乙酰基）苯基衍生物，其制备方法和使用方法。作为离子传感器，光学传感器，气体传感器，生物传感器，色谱，光刺激的材料，可以将本发明的基于胆酸的环状4-（三氟乙酰基）苯基衍生物用作主客体化学中的主体材料离子结合树脂，离子交换树脂和有机反应（在上述式1中，R，R 1，R 2，R 3和n在规格中定义）。

6. 发明授权

US06793789B2 Reference electrode with a polymeric reference electrode membrane 失效
标题翻译：具有聚合物参比电极膜的参比电极
公开(公告)号：US06793789B2
公开(公告)日：2004-09-21
申请号：US09960432
申请日：2001-09-22
申请人： Yong Suk Choi , Sung Dong Lee , Seong Hee Oh , Hyo Lin Lee , Jae Ho Shin , Jeonghan Ha , Hakhyun Nam , Geun Sig Cha
发明人： Yong Suk Choi , Sung Dong Lee , Seong Hee Oh , Hyo Lin Lee , Jae Ho Shin , Jeonghan Ha , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N2731
CPC分类号： G01N27/301
摘要： Disclosed is a polymeric reference electrode membrane comprising (a) one selected from a porous polymer or a hydrophilic plasticizer; (b) a lipophilic polymer; and optionally an adhesion-enhancing material. A reference electrode equipped with the polymeric reference electrode membrane can be shortened the preconditioning time, and extended lifetime for storage and use owing to excellent adhesion, and showed reproducibility and good yield. So, a miniaturized multi-potentiometric sensor can be fabricated comprising a solid-state reference electrode of the present invention and a set of ion-selective electrodes, thus being useful in the potentiometric fields, including clinical, environmental, food and industrial analysis.
摘要翻译：公开了一种聚合物参比电极膜，其包含（a）选自多孔聚合物或亲水性增塑剂中的一种; （b）亲脂性聚合物; 和任选的粘附增强材料。配备有聚合物参比电极膜的参比电极可以缩短预处理时间，并且由于优异的粘附性而延长存储和使用寿命，并且显示出重现性和良好的产率。因此，可以制造包括本发明的固态参考电极和一组离子选择性电极的小型化多电位传感器，因此可用于电位计领域，包括临床，环境，食品和工业分析。

7. 发明授权

US09512458B2 Electrochemical biosensor with sample introduction channel capable of uniform introduction of small amount of sample 有权
标题翻译：电化学生物传感器，样品引入通道能均匀引入少量样品
公开(公告)号：US09512458B2
公开(公告)日：2016-12-06
申请号：US12740016
申请日：2008-10-24
申请人： Gang Cui , Jae Hyun Yoo , Ju Yong Kim , Keun Ki Kim , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Gang Cui , Jae Hyun Yoo , Ju Yong Kim , Keun Ki Kim , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： C12Q1/00 , G01N27/327 , B01L3/00
CPC分类号： C12Q1/006 , B01L3/5027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N27/3272
摘要： Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.
摘要翻译：公开了一种具有样品导入通道的电化学生物传感器，其中采用绝缘体均匀且准确地引入少量样品并调节工作电极的面积，从而保证了样品的准确定量分析。在样品入口处提供样品收集屏障，生物传感器允许以更高的精度引入样品并以更高的再现性和可靠性进行分析。

8. 发明授权

US06746583B2 Microchip-based carbon dioxide gas sensor 失效
标题翻译：基于Microchip的二氧化碳气体传感器
公开(公告)号：US06746583B2
公开(公告)日：2004-06-08
申请号：US09877857
申请日：2001-06-08
申请人： Jae Seon Lee , Jae Ho Shin , Min Hyung Lee , Hakhyun Nam , Geun Sig Cha
发明人： Jae Seon Lee , Jae Ho Shin , Min Hyung Lee , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27327
CPC分类号： G01N27/333 , G01N27/4162 , G01N33/004
摘要： There is provided a microchip-based differential-type carbon dioxide gas sensor for detecting dissolved carbon dioxide levels. It functions with at least one working electrode composed of an unbuffered hydrogel membrane containing a certain amount of sodium bicarbonate and a pH-sensitive gas-permeable membrane; and a reference electrode composed of a buffered hydrogel membrane and a pH-sensitive gas-permeable membrane. The unbuffered hydrogel membrane contains carbonic anhydrase, which reduces the time period for the hydration of carbon dioxide, thereby allowing the quick measurement of the level of carbon dioxide. In addition to being significantly improved in stabilization, sensing, and recovering time periods, the differential-type carbon dioxide gas sensor can be fabricated in small sizes and quickly measure levels of carbon dioxide dissolved in sample solution.
摘要翻译：提供了一种用于检测溶解二氧化碳水平的基于微芯片的差分式二氧化碳气体传感器。它与至少一个由含有一定量碳酸氢钠和pH敏感性透气膜的无缓冲水凝胶膜组成的工作电极起作用; 以及由缓冲水凝胶膜和pH敏感性透气膜构成的参比电极。无缓冲水凝胶膜含有碳酸酐酶，减少了二氧化碳水化的时间，从而可以快速测定二氧化碳的含量。除了稳定化，感测和恢复时间段的显着改进之外，差分型二氧化碳气体传感器可以制造成小尺寸并且快速测量溶解在样品溶液中的二氧化碳的水平。

9. 发明授权

US06509148B2 Method for fabricating biosensors using hydrophilic polyurethane 有权
标题翻译：使用亲水性聚氨酯制造生物传感器的方法
公开(公告)号：US06509148B2
公开(公告)日：2003-01-21
申请号：US09485513
申请日：2000-02-10
申请人： Geun Sig Cha , Hakhyun Nam , Jae Ho Shin
发明人： Geun Sig Cha , Hakhyun Nam , Jae Ho Shin
IPC分类号： C12Q100
CPC分类号： C12Q1/002
摘要： Disclosed is a method for fabricating biosensors, using hydrophilic polyurethane. Bio-active reagents, including enzymes, antibodies, antigens, cells and receptors, are mixed with hydrophilic polyurethane and the mixture is directly coated over a signal transducer to form a sensing film which serves as a signal detector. The method using hydrophilic polyurethane allows the simplification of the fabrication of biosensors without conducting complicated chemical reactions and washing steps, such as crosslinking. The bio-active reagent entrapped within the hydrophilic polyurethane film can retains its high activity for an extended period of time and the intrinsic potentiometric response of the underlying ion-selective polymeric membrane is not affected by the bio-active reagent immobilized polyurethane film coated on its sensing surface. Therefore, the biosensors are superior in specificity, selectivity, and stability. Also, the adoption of solid-state type electrodes by virtue of the direct immobilization of the bio-active reagents allows the biosensors to be miniaturized, offering the advantages of the detection of small quantities of samples and mass production for low cost.
摘要翻译：公开了使用亲水性聚氨酯制造生物传感器的方法。将生物活性试剂（包括酶，抗体，抗原，细胞和受体）与亲水性聚氨酯混合，并将混合物直接涂覆在信号传感器上以形成用作信号检测器的感测膜。使用亲水性聚氨酯的方法允许简化生物传感器的制造，而不进行复杂的化学反应和洗涤步骤，例如交联。包埋在亲水性聚氨酯膜内的生物活性试剂可以在长时间内保持其高活性，并且潜在的离子选择性聚合物膜的固有电位响应不受其上涂覆的生物活性试剂固定化聚氨酯膜的影响传感表面。因此，生物传感器的特异性，选择性和稳定性优异。此外，通过生物活性试剂的直接固定，采用固态电极使得生物传感器小型化，提供少量样品的检测和低成本的批量生产的优点。

10. 发明授权

US08377272B2 Electrochemical biosensor measuring system 有权
标题翻译：电化学生物传感器测量系统
公开(公告)号：US08377272B2
公开(公告)日：2013-02-19
申请号：US12529008
申请日：2008-02-26
申请人： Keun Ki Kim , Moon Hwan Kim , Jae Hyun Yoo , Gang Cui , Hakhyun Nam , Geun Sig Cha
发明人： Keun Ki Kim , Moon Hwan Kim , Jae Hyun Yoo , Gang Cui , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/327
CPC分类号： A61B5/1486 , A61B5/14532 , G01N33/48771 , G01N2035/00851
摘要： Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：公开了一种可与电化学生物传感器一起使用的电化学生物传感器测量装置。生物传感器测量装置包括电连接部分，其在将生物传感器插入其中时与生物传感器的电极电连接;以及连接器，具有其中至少一个光吸收或反射路径顺序地包括发光 - 提供生产批次信息识别部分检测器单元以识别记录在生物传感器中的生产批次信息。当将电化学生物传感器插入到测量装置中时，电化学生物传感器测量装置可以自动识别以色调或孔痕形式编码的生物传感器的生产批量信息，从而避免需要手动输入生产批次信息的生物传感器。因此，可以减少当用户亲自输入生产批量信息时发生的不便和错误频率，结果可以方便和准确地获取测量值。

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