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1. 发明授权

US06350524B1 Hydrophilic polyurethane-coated chloride-selective electrodes 有权
标题翻译：亲水性聚氨酯涂层氯化物选择性电极
公开(公告)号：US06350524B1
公开(公告)日：2002-02-26
申请号：US09477173
申请日：2000-01-04
申请人： Jin Seo Lee , Hyo Jung Yoon , Gang Cui , Jae Ho Shin , Hakhyun Nam , Geun Sig Cha
发明人： Jin Seo Lee , Hyo Jung Yoon , Gang Cui , Jae Ho Shin , Hakhyun Nam , Geun Sig Cha
IPC分类号： B32B2740
CPC分类号： G01N27/333 , G01N27/40 , Y10T428/3158 , Y10T428/31598 , Y10T428/31609
摘要： The present invention relates to chloride-selective electrodes which comprise insoluble metal salt layer and a protecting membrane formed of hydrophilic polyurethane thereon, wherein the hydrophilic polyurethane coated chloride-selective electrodes show fast activation and response time and are usefully employed to accurately measure the chloride by reducing the interference from bromide and iodide or preventing the surface of the electrode from protein adsorption.
摘要翻译：本发明涉及包含不溶性金属盐层和由其上的亲水性聚氨酯形成的保护膜的氯化物选择性电极，其中亲水性聚氨酯涂覆的氯化物选择性电极显示快速的活化和响应时间，并且有用地用于通过减少溴化物和碘化物的干扰，或阻止电极表面的蛋白质吸附。

2. 发明授权

US09512458B2 Electrochemical biosensor with sample introduction channel capable of uniform introduction of small amount of sample 有权
标题翻译：电化学生物传感器，样品引入通道能均匀引入少量样品
公开(公告)号：US09512458B2
公开(公告)日：2016-12-06
申请号：US12740016
申请日：2008-10-24
申请人： Gang Cui , Jae Hyun Yoo , Ju Yong Kim , Keun Ki Kim , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Gang Cui , Jae Hyun Yoo , Ju Yong Kim , Keun Ki Kim , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： C12Q1/00 , G01N27/327 , B01L3/00
CPC分类号： C12Q1/006 , B01L3/5027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N27/3272
摘要： Disclosed is an electrochemical biosensor having a sample introduction channel in which an insulator is employed to introduce a small amount of a sample uniformly and accurately and to adjust an area of a working electrode, thereby guaranteeing the accurate quantitative analysis of a sample. Provided with a sample collection barrier at a sample entrance, the biosensor allows a sample to be introduced at higher accuracy and to be analyzed with higher reproducibility and reliability.
摘要翻译：公开了一种具有样品导入通道的电化学生物传感器，其中采用绝缘体均匀且准确地引入少量样品并调节工作电极的面积，从而保证了样品的准确定量分析。在样品入口处提供样品收集屏障，生物传感器允许以更高的精度引入样品并以更高的再现性和可靠性进行分析。

3. 发明授权

US08377272B2 Electrochemical biosensor measuring system 有权
标题翻译：电化学生物传感器测量系统
公开(公告)号：US08377272B2
公开(公告)日：2013-02-19
申请号：US12529008
申请日：2008-02-26
申请人： Keun Ki Kim , Moon Hwan Kim , Jae Hyun Yoo , Gang Cui , Hakhyun Nam , Geun Sig Cha
发明人： Keun Ki Kim , Moon Hwan Kim , Jae Hyun Yoo , Gang Cui , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/327
CPC分类号： A61B5/1486 , A61B5/14532 , G01N33/48771 , G01N2035/00851
摘要： Disclosed is an electrochemical biosensor measuring device which can be used together with an electrochemical biosensor. The biosensor measuring device comprises an electrical connection portion which is electrically connected with the electrodes of the biosensor upon the insertion of the biosensor there into, and a connector having a structure in which at least one light absorption or reflection path sequentially comprising a light emitter-production lot information identification portion-detector unit is provided to identify the production lot information recorded in the biosensor. The electrochemical biosensor measuring device can automatically identify the production lot information of the biosensor, encoded in the form of a hue or hole marks, upon the insertion of the electrochemical biosensor into the measuring device, thereby obviating the need to manually input the production lot information of the biosensor. Thus, inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：公开了一种可与电化学生物传感器一起使用的电化学生物传感器测量装置。生物传感器测量装置包括电连接部分，其在将生物传感器插入其中时与生物传感器的电极电连接;以及连接器，具有其中至少一个光吸收或反射路径顺序地包括发光 - 提供生产批次信息识别部分检测器单元以识别记录在生物传感器中的生产批次信息。当将电化学生物传感器插入到测量装置中时，电化学生物传感器测量装置可以自动识别以色调或孔痕形式编码的生物传感器的生产批量信息，从而避免需要手动输入生产批次信息的生物传感器。因此，可以减少当用户亲自输入生产批量信息时发生的不便和错误频率，结果可以方便和准确地获取测量值。

4. 发明授权

US08314613B2 Electrochemical biosensor measuring system 有权
标题翻译：电化学生物传感器测量系统
公开(公告)号：US08314613B2
公开(公告)日：2012-11-20
申请号：US12672596
申请日：2008-02-26
申请人： Gang Cui , Keun Ki Kim , Dong Hoon Han , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Gang Cui , Keun Ki Kim , Dong Hoon Han , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01V3/00
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , C12Q1/004
摘要： Disclosed are an electrochemical biosensor which comprises a production lot information identification portion, on which information is recorded in a magnetization mark, and a measuring device which can automatically identify the production lot information of the biosensor with the insertion of the electrochemical biosensor into the measuring device. The electrochemical biosensor and the measuring device thereof can record production lot information in the form of magnetization marks on an electrochemical biosensor strip and read the information as digital signals through a magnetoresistance sensor device, which can be mounted on the surface of a circuit board using Surface Mounted Technology (SMT). Without the need for a high-priced filter or a complicated calculation system, the magnetic detector system has a simple construction and realizes economic efficiency in the construction of the measuring device. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that inconvenience and the frequency of errors, which occur when a user personally inputs the production lot information, can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：公开了一种电化学生物传感器，其包括将信息记录在磁化标记中的生产批次信息识别部分和能够通过将电化学生物传感器插入到测量装置中来自动识别生物传感器的生产批次信息的测量装置。电化学生物传感器及其测量装置可以在电化学生物传感器条上以磁化标记的形式记录生产批量信息，并通过磁阻传感器装置读取作为数字信号的信息，该磁阻传感器装置可以使用表面安装在电路板的表面上安装技术（SMT）。不需要高价格的过滤器或复杂的计算系统，磁检测系统结构简单，实现了测量装置结构的经济效益。此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生产批次信息时出现的不便和错误频率，结果是测量值可以是方便准确地获取。

5. 发明申请

US20100126882A1 ELECTROCHEMICAL BIOSENSOR MEASURING SYSTEM 有权
标题翻译：电化学传感器测量系统
公开(公告)号：US20100126882A1
公开(公告)日：2010-05-27
申请号：US12530128
申请日：2008-02-26
申请人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun Sig Cha
发明人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/26
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , A61B2562/08 , B01L3/545 , B01L2200/148 , B01L2300/0645 , B01L2300/0825 , G01N2035/00752 , G01N2035/00811
摘要： Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that the frequency of inconvenience and error that occur when a user personally inputs the production lot information of the biosensor can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：本文公开了一种电化学生物传感器测量装置，其包括至少两个光电二极管，用于以顺序方式以规则的时间间隔发射光束，同时插入电化学生物传感器，以及用于感测发射的光束的检测器，从而识别生产记录在电化学生物传感器上的生产批次信息识别部分上的批次信息。因此，该设备具有经济上的优点，即不需要高价格的光学滤波器来检测由生物传感器中记录的生产识别信息吸收或反射的光，以及复杂的软件算法来恢复生产批次信息。此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生物传感器的生产批次信息时发生的不便和错误的频率，结果是测量值可以方便，准确地获得。

6. 发明授权

US08277635B2 Electrochemical biosensor measuring system 有权
标题翻译：电化学生物传感器测量系统
公开(公告)号：US08277635B2
公开(公告)日：2012-10-02
申请号：US12530128
申请日：2008-02-26
申请人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun Sig Cha
发明人： Moon Hwan Kim , Keun Ki Kim , Gang Cui , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/327 , G01N27/403 , G01N27/26 , G01N33/53
CPC分类号： G01N33/48771 , A61B5/14532 , A61B5/1486 , A61B2562/08 , B01L3/545 , B01L2200/148 , B01L2300/0645 , B01L2300/0825 , G01N2035/00752 , G01N2035/00811
摘要： Disclosed herein is an electrochemical biosensor measuring device which comprises at least two photodiodes for emitting light beams at regular time intervals in a sequential manner, with the insertion of an electrochemical biosensor thereto, and a detector for sensing the emitted light beams, thereby identifying the production lot information recorded on a production lot information identification portion on the electrochemical biosensor. Thus, the device enjoys economic advantages of not requiring a high-priced optical filter in detecting the light absorbed through or reflected from the production identification information recorded in biosensor and a complicated software algorithm to recover the production lot information. Also, the measuring device automatically identifies the production lot information recorded on the biosensor, so that the frequency of inconvenience and error that occur when a user personally inputs the production lot information of the biosensor can be reduced, with the result that the measured values can be conveniently and accurately acquired.
摘要翻译：本文公开了一种电化学生物传感器测量装置，其包括至少两个光电二极管，用于以顺序方式以规则的时间间隔发射光束，同时插入电化学生物传感器，以及用于感测发射的光束的检测器，从而识别生产记录在电化学生物传感器上的生产批次信息识别部分上的批次信息。因此，该设备具有经济上的优点，即不需要高价格的光学滤波器来检测由生物传感器中记录的生产识别信息吸收或反射的光，以及复杂的软件算法来恢复生产批次信息。此外，测量装置自动识别记录在生物传感器上的生产批次信息，从而可以减少当用户亲自输入生物传感器的生产批次信息时发生的不便和错误的频率，结果是测量值可以方便，准确地获得。

7. 发明授权

US08226004B2 Biosensor measuring apparatus and a method thereof 有权
标题翻译：生物传感器测量装置及其方法
公开(公告)号：US08226004B2
公开(公告)日：2012-07-24
申请号：US13060049
申请日：2008-11-11
申请人： Geun Sig Cha , Hakhyun Nam , Gang Cui , Keun-Ki Kim , Shim-Ho Lee
发明人： Geun Sig Cha , Hakhyun Nam , Gang Cui , Keun-Ki Kim , Shim-Ho Lee
IPC分类号： G06K7/10
CPC分类号： G01N33/48771 , A61B5/14532 , A61B2560/0276 , G01N2035/00772
摘要： A biosensor can be measured by a method that includes: determining malfunction of a production lot information sensing unit; alerting malfunction when the production lot information sensing unit malfunctions; encoding the production lot information through the production lot information sensing unit when the production lot information sensing unit does not malfunction; and detecting a component of a sample through a biosensor strip by using the encoded production lot information.
摘要翻译：可以通过以下方法测量生物传感器：包括：确定生产批次信息感测单元的故障; 当生产批量信息传感单元发生故障时发出警报故障; 当生产批次信息感测单元不发生故障时，通过生产批次信息感测单元对生产批次信息进行编码; 以及通过使用编码的生产批次信息通过生物传感器条检测样品的成分。

8. 发明授权

US07695608B2 Electrochemical biosensor and biosensor measuring device 有权
标题翻译：电化学生物传感器和生物传感器测量装置
公开(公告)号：US07695608B2
公开(公告)日：2010-04-13
申请号：US11747945
申请日：2007-05-14
申请人： Keun Ki Kim , Jae Hyun Yoo , Gang Cui , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
发明人： Keun Ki Kim , Jae Hyun Yoo , Gang Cui , Moon Hwan Kim , Hakhyun Nam , Geun Sig Cha
IPC分类号： G01N27/403 , G01N27/327 , G01N21/00 , G06K9/36 , G03B7/08
CPC分类号： B01L3/545 , B01L3/5027 , B01L2300/0645 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N27/3272 , G01N35/00732 , G01N2035/00772 , G01N2035/00851
摘要： An electrochemical biosensor and a biosensor measuring device. The electrochemical biosensor includes a plurality of electrodes, capillary sample cell portions, reaction reagent layers, electrode connection portions, and a production lot information identification portion. The production lot information identification portion is configured such that the production lot information is recorded thereon has one or more infrared absorption/reflection marks, which indicate information about differences between production lots through the printing and/or attachment of colored or colorless materials, having differences in absorbency or reflectivity of infrared rays, in conformity of a predetermined pattern or through the attachment of transparent films. The electrochemical biosensor measuring device includes a plurality of integrated photo-reflector sensing devices that emit and receive infrared rays to identify the production lot information recorded on the production lot information identification portion of the biosensor.
摘要翻译：电化学生物传感器和生物传感器测量装置。电化学生物传感器包括多个电极，毛细管样品池部分，反应试剂层，电极连接部分和生产批次信息识别部分。生产批次信息识别部被配置为使得生产批次信息被记录在其上，具有一个或多个红外吸收/反射标记，其表示通过有色或无色材料的印刷和/或附着的生产批次之间的差异的信息，其具有差异红外线的吸收性或反射率，符合预定图案或通过透明膜的附着。电化学生物传感器测量装置包括发射和接收红外线的多个集成光反射器感测装置，以识别记录在生物传感器的生产批次信息识别部分上的生产批次信息。

9. 发明授权

US07288174B2 Electrochemical biosensor 有权
标题翻译：电化学生物传感器
公开(公告)号：US07288174B2
公开(公告)日：2007-10-30
申请号：US10778685
申请日：2004-02-12
申请人： Gang Cui , Jae-Hyun Yoo , Moon-Hwan Kim , Ju-Yong Kim , Jung-Hee Uhm , Hakhyun Nam , Geun-Sig Cha
发明人： Gang Cui , Jae-Hyun Yoo , Moon-Hwan Kim , Ju-Yong Kim , Jung-Hee Uhm , Hakhyun Nam , Geun-Sig Cha
IPC分类号： G01N27/327
CPC分类号： C12Q1/004 , C12Q1/001
摘要： There is provided the reagent layer composition that can substantially reduce the measurement bias arising from hematocrits. The addition of fatty acid (4-20 carbons) and quaternary ammonium salt to a commonly used reagent layer composition composed of an enzyme, an electron transfer mediator, and several water soluble polymers not only reduce the hematocrit level-dependent bias but also provide very stable performance for an extended period of time. Disclosed are also various types of sub microliter sample volume electrochemical biosensors that are suitable to use with the reagent layer composition of present invention.
摘要翻译：提供了可以显着降低由血细胞比容引起的测量偏差的试剂层组合物。向酶，电子传递介质和几种水溶性聚合物组成的常用试剂层组合物中加入脂肪酸（4-20碳）和季铵盐不仅可降低血细胞比容水平依赖性偏倚，稳定的性能在较长的一段时间。还公开了适用于本发明的试剂层组合物的各种类型的微微升样品体积电化学生物传感器。

10. 发明授权

US07133712B2 Method and apparatus for non-invasive monitoring of blood substances using self-sampled tears 有权
公开(公告)号：US07133712B2
公开(公告)日：2006-11-07
申请号：US10404702
申请日：2003-04-01
申请人： Bruce E. Cohan , Geun Sig Cha , Mark E. Meyerhoff , Hakhyun Nam , Donald E. Gillespie , Gang Cui , Jong Sik Kim , Zvi Flanders
发明人： Bruce E. Cohan , Geun Sig Cha , Mark E. Meyerhoff , Hakhyun Nam , Donald E. Gillespie , Gang Cui , Jong Sik Kim , Zvi Flanders
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： C12Q1/006 , A61B5/1486 , A61B2562/0295 , C12Q1/32 , C12Q1/54 , G01N27/3272 , G01N33/528 , G01N2001/1056 , G01N2001/149 , G01N2035/0465 , Y10T436/144444
摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor in communication with the sample portion for generating a signal related to the tear substance concentration, and a processor in communication with the sensor for determining a blood substance concentration corresponding to the tear substance concentration.

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