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1. 发明授权

US09050025B2 System and method for determining volume-related parameters of ocular and other biological tissues 有权
标题翻译：用于确定眼部和其他生物组织的体积相关参数的系统和方法
公开(公告)号：US09050025B2
公开(公告)日：2015-06-09
申请号：US12487143
申请日：2009-06-18
申请人： David S. Dilworth , Bruce E. Cohan , Zvi Flanders , Hannah R. Peshkin
发明人： David S. Dilworth , Bruce E. Cohan , Zvi Flanders , Hannah R. Peshkin
IPC分类号： A61B6/00 , A61B3/10 , A61B3/00 , A61B3/12 , A61B5/00 , A61B5/107
CPC分类号： A61B3/1005 , A61B3/0025 , A61B3/12 , A61B5/0075 , A61B5/1072 , A61B5/1079 , A61B5/7235
摘要： A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.
摘要翻译：用于确定诸如眼组织的生物组织的体积相关参数的系统和方法包括用于将光投射到生物组织的光源，用于接收以两个光谱波长从生物组织反射的光的接收器，以及图像与接收器通信的采集系统，用于从每个波长处的反射光形成图像。处理器将数学模型应用于图像，其比较在两个光谱波长中的每一个处的选定图像点处的生物组织对光的吸收，以确定体积相关参数，例如相对厚度和材料性质生物组织在那个位置。

2. 发明授权

US07556380B2 Apparatus and method for self-measurement of intraocular pressure 失效
标题翻译：眼压自我测量的装置和方法
公开(公告)号：US07556380B2
公开(公告)日：2009-07-07
申请号：US10598002
申请日：2003-10-20
申请人： Bruce E. Cohan , Andrew C. Pearch , Zvi Flanders , Donald E. Gillespie
发明人： Bruce E. Cohan , Andrew C. Pearch , Zvi Flanders , Donald E. Gillespie
IPC分类号： A61B3/02 , A61B3/10
CPC分类号： A61B3/16
摘要： An apparatus and method for the self-measurement of intraocular pressure utilize a tonometer disposed within a housing and having a tonometer tip. The apparatus further includes an adjustment mechanism in communication with the tonometer for positioning the tonometer tip in contact with a test eye of the user, and an illuminator mounted within the housing adjacent the tonometer tip. A receiver is aligned with the tonometer tip for receiving an applanation pattern created by contact of the tonometer tip with the test eye, and a display is provided in communication with the receiver for displaying the applanation pattern to an observing eye of the user. The intraocular pressure of the test eye is determined from a force applied by the tonometer tip upon observation of a selected applanation pattern by the observing eye.
摘要翻译：用于眼内自我测量的装置和方法利用设置在壳体内并具有眼压计尖端的眼压计。该装置还包括与眼压计连通的调节机构，用于将眼压计尖端定位成与用户的测试眼接触，以及安装在邻近眼压计尖端的壳体内的照明器。接收器与眼压计尖端对齐，用于接收通过眼压计尖端与测试眼睛的接触而产生的压平图案，并且提供与接收器通信的显示器，用于向用户的观察眼睛显示压平图案。通过观察眼观察选定的压平图案，由眼压计尖端施加的力确定测试眼睛的眼内压。

3. 发明申请

US20140305796A1 METHODS AND SYSTEMS FOR MEASUREMENT OF TEAR GLUCOSE LEVELS 审中-公开
标题翻译：测量葡萄糖水平的方法和系统
公开(公告)号：US20140305796A1
公开(公告)日：2014-10-16
申请号：US14253747
申请日：2014-04-15
申请人： MARK E. MEYERHOFF , BRUCE E. COHAN , QINYI YAN , BO PENG , ZVI FLANDERS
发明人： MARK E. MEYERHOFF , BRUCE E. COHAN , QINYI YAN , BO PENG , ZVI FLANDERS
IPC分类号： G01N27/327
CPC分类号： G01N27/3271 , A61B5/1486
摘要： A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
摘要翻译：用于测定泪液样品中的葡萄糖浓度的传感器系统包括工作电极，其包括用于与泪液样品中的葡萄糖反应的固定的葡萄糖氧化酶部分和用于提高对泪液中的电活性干扰物种的葡萄糖选择性的选择性部分流体样品。或者，用于接收泪液样品的容器可以包括在其内壁上的酶部分。参考电极设置在工作电极附近，其中酶部分与泪液样品中的葡萄糖的电化学反应产生与泪液样品中的葡萄糖浓度相关的电流。

4. 发明申请

US20100160789A1 System and Method for Determining Volume-Related Parameters of Ocular and Other Biological Tissues 有权
标题翻译：用于确定眼部和其他生物组织的体积相关参数的系统和方法
公开(公告)号：US20100160789A1
公开(公告)日：2010-06-24
申请号：US12487143
申请日：2009-06-18
申请人： David S. Dilworth , Bruce E. Cohan , Zvi Flanders , Hannah R. Peshkin
发明人： David S. Dilworth , Bruce E. Cohan , Zvi Flanders , Hannah R. Peshkin
IPC分类号： A61B6/00
CPC分类号： A61B3/1005 , A61B3/0025 , A61B3/12 , A61B5/0075 , A61B5/1072 , A61B5/1079 , A61B5/7235
摘要： A system and method for determining volume-related parameters of a biological tissue, such as ocular tissue, include a light source for projecting light towards the biological tissue, a receiver for receiving light reflected from the biological tissue at two spectral wavelengths, and an image acquisition system in communication with the receiver for forming an image from the reflected light at each wavelength. A processor applies a mathematical model to the image which compares the absorption of light by the biological tissue at a selected image point at each of the two spectral wavelengths to determine the volume-related parameters, such as the relative thickness and material properties, of the biological tissue at that location.
摘要翻译：用于确定诸如眼组织的生物组织的体积相关参数的系统和方法包括用于将光投射到生物组织的光源，用于接收以两个光谱波长从生物组织反射的光的接收器，以及图像与接收器通信的采集系统，用于从每个波长处的反射光形成图像。处理器将数学模型应用于图像，其比较在两个光谱波长中的每一个处的选定图像点处的生物组织对光的吸收，以确定体积相关参数，例如相对厚度和材料性质生物组织在那个位置。

5. 发明申请

US20130008803A1 Methods and Systems for Measurement of Tear Glucose Levels 审中-公开
标题翻译：用于测量泪液葡萄糖水平的方法和系统
公开(公告)号：US20130008803A1
公开(公告)日：2013-01-10
申请号：US13342634
申请日：2012-01-03
申请人： Mark E. Meyerhoff , Bruce E. Cohan , Qinyi Yan , Bo Peng , Zvi Flanders
发明人： Mark E. Meyerhoff , Bruce E. Cohan , Qinyi Yan , Bo Peng , Zvi Flanders
IPC分类号： G01N27/327
CPC分类号： G01N27/3271 , A61B5/1486
摘要： A sensor system for determining glucose concentration in a tear fluid sample includes a working electrode including an immobilized glucose oxidase enzyme portion for reacting with glucose in the tear fluid sample, and a selectivity portion for enhancing the selectivity for glucose over electroactive interferent species in the tear fluid sample. Alternatively, a vessel for receiving the tear fluid sample may include the enzyme portion on an inner wall thereof. A reference electrode is disposed adjacent the working electrode, wherein the electrochemical reaction of the enzyme portion with glucose in the tear fluid sample generates a current related to the glucose concentration in the tear fluid sample.
摘要翻译：用于测定泪液样品中的葡萄糖浓度的传感器系统包括工作电极，其包括用于与泪液样品中的葡萄糖反应的固定的葡萄糖氧化酶部分和用于提高对泪液中的电活性干扰物种的葡萄糖选择性的选择性部分流体样品。或者，用于接收泪液样品的容器可以包括在其内壁上的酶部分。参考电极设置在工作电极附近，其中酶部分与泪液样品中的葡萄糖的电化学反应产生与泪液样品中的葡萄糖浓度相关的电流。

6. 发明授权

US07133712B2 Method and apparatus for non-invasive monitoring of blood substances using self-sampled tears 有权
公开(公告)号：US07133712B2
公开(公告)日：2006-11-07
申请号：US10404702
申请日：2003-04-01
申请人： Bruce E. Cohan , Geun Sig Cha , Mark E. Meyerhoff , Hakhyun Nam , Donald E. Gillespie , Gang Cui , Jong Sik Kim , Zvi Flanders
发明人： Bruce E. Cohan , Geun Sig Cha , Mark E. Meyerhoff , Hakhyun Nam , Donald E. Gillespie , Gang Cui , Jong Sik Kim , Zvi Flanders
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： C12Q1/006 , A61B5/1486 , A61B2562/0295 , C12Q1/32 , C12Q1/54 , G01N27/3272 , G01N33/528 , G01N2001/1056 , G01N2001/149 , G01N2035/0465 , Y10T436/144444
摘要： A method and apparatus for non-invasively determining the concentration of a substance in blood, such as glucose, include a sample portion arranged for contacting an eye region of a user to obtain a tear fluid sample, a sensor in communication with the sample portion for generating a signal related to the tear substance concentration, and a processor in communication with the sensor for determining a blood substance concentration corresponding to the tear substance concentration.

7. 发明授权

US06196993B1 Ophthalmic insert and method for sustained release of medication to the eye 有权
标题翻译：眼用插入物和药物持续释放到眼睛的方法
公开(公告)号：US06196993B1
公开(公告)日：2001-03-06
申请号：US09294720
申请日：1999-04-19
申请人： Bruce E. Cohan , Howard Diamond
发明人： Bruce E. Cohan , Howard Diamond
IPC分类号： A61K922
CPC分类号： A61F9/0017 , A61F9/00772 , A61K9/0051 , Y10S977/904
摘要： An ophthalmic insert and method for sustained release of medication to the eye are provided. The insert includes a body portion sized to pass through a lacrimal punctum and be positioned within a lacrimal canaliculus of the eyelid. The insert further includes a collarette connected to the body portion and sized to rest on the exterior of the lacrimal punctum, the collarette having a pore provided therein. A reservoir is contained at least partially within the body portion and in fluid communication with the pore, wherein the reservoir is designed to store and release medication through the pore and onto the eye over time in a controlled manner while the insert is positioned in the eyelid. Preferably, the pore is constructed with a specific geometry appropriate to control the rate of release of the medication onto the eye.
摘要翻译：提供了一种用于将药物持续释放至眼睛的眼科插入物和方法。插入物包括尺寸适于穿过泪点并被定位在眼睑的泪小管内的体部。插入件还包括连接到主体部分并且尺寸适于搁置在泪点的外部上的小针coll，所述coll tte具有设置在其中的孔。储存器至少部分地容纳在主体部分内并且与孔流体连通，其中储存器被设计成在受控的方式下随着时间的流逝通过孔存储和释放药物，同时将插入物定位在眼睑中。优选地，孔被构造成具有适合于控制药物释放到眼睛上的速率的特定几何形状。

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