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1. 发明授权

US09199965B2 Benzoimidazole derivatives and pharmaceutical composition comprising the same 有权
标题翻译：苯并咪唑衍生物和包含其的药物组合物
公开(公告)号：US09199965B2
公开(公告)日：2015-12-01
申请号：US11815009
申请日：2006-01-27
申请人： Ji Duck Kim , Hong Chul Yoon , In Woo Kim , Hyae Jung Hyun
发明人： Ji Duck Kim , Hong Chul Yoon , In Woo Kim , Hyae Jung Hyun
IPC分类号： C07D401/10 , C07D417/14 , C07D471/04 , C07D403/04 , C07D403/14
CPC分类号： C07D401/10 , C07D417/14 , C07D471/04
摘要： Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.
摘要翻译：本文公开了用作香草素受体-1的拮抗剂的新型苯并咪唑衍生物和包含其的药物组合物。它们可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸系统疾病作为哮喘，慢性阻塞性肺病等，烧伤，牛皮癣，瘙痒，呕吐，对皮肤，眼睛和粘膜的刺激，胃十二指肠溃疡，炎症性肠病和炎性疾病。

2. 发明授权

US08436022B2 Biaryl benzolmidazole derivatives and pharmaceutical composition comprising the same 有权
标题翻译：双芳基苯并咪唑衍生物及其组合物
公开(公告)号：US08436022B2
公开(公告)日：2013-05-07
申请号：US12373193
申请日：2007-07-11
申请人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Hyae Jung Hyun
发明人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Hyae Jung Hyun
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07D401/10 , C07D401/04 , C07D401/14 , C07D413/14 , C07D471/04
摘要： Disclosed are biaryl benzoimidazo derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.
摘要翻译：公开了联芳基苯并咪唑衍生物。它们对HEK细胞中的钙流入具有抑制作用，从而对香草素受体具有强大的拮抗作用，并具有镇痛作用，因此可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经系统疾病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸障碍如咳嗽，哮喘和慢性阻塞性肺病，灼烧，牛皮癣，瘙痒，呕吐，刺激皮肤，眼睛和粘膜，胃十二指肠溃疡，炎性肠道疾病和炎性疾病。

3. 发明申请

US20090209540A1 Novel Biaryl Benzolmidazole Derivatives and Pharmaceutical Composition Comprising The Same 有权
标题翻译：新型双芳基苯并咪唑衍生物和药物组合物
公开(公告)号：US20090209540A1
公开(公告)日：2009-08-20
申请号：US12373193
申请日：2007-07-11
申请人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Hyae Jung Hyun
发明人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Hyae Jung Hyun
IPC分类号： A61K31/5377 , C07D413/14 , C07D401/14 , A61K31/496 , C07D401/02 , A61K31/4439 , A61K31/444 , A61K31/437 , C07D471/04 , A61P29/00 , A61P25/06 , A61P11/06 , A61P17/06 , A61P11/00
CPC分类号： C07D401/10 , C07D401/04 , C07D401/14 , C07D413/14 , C07D471/04
摘要： Disclosed are biaryl benzoimidazole derivatives. They have an inhibitory effect on calcium influx in HEK cells, thereby showing a powerful antagonistic effect on a vanilloid receptor, and further have an analgesic effect, thereby being useful for preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraine, arthralgia, neuropathies, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, stroke, bladder hypersensitivity, irritable bowel syndrome, a respiratory disorder such as cough, asthma, and chronic obstructive pulmonary disease, burning, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.
摘要翻译：公开了联芳基苯并咪唑衍生物。它们对HEK细胞中的钙流入具有抑制作用，从而对香草素受体具有强大的拮抗作用，并具有镇痛作用，因此可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经系统疾病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸障碍如咳嗽，哮喘和慢性阻塞性肺病，灼烧，牛皮癣，瘙痒，呕吐，刺激皮肤，眼睛和粘膜，胃十二指肠溃疡，炎性肠道疾病和炎性疾病。

4. 发明申请

US20090018124A1 Novel Benzoimidazole Derivatives and Pharmaceutical Composition Comprising the Same 有权
标题翻译：新型苯并咪唑衍生物和药物组合物
公开(公告)号：US20090018124A1
公开(公告)日：2009-01-15
申请号：US11815009
申请日：2006-01-26
申请人： Ji Duck Kim , Hong Chul Yoon , In Woo Kim , Hyae Jung Hyun
发明人： Ji Duck Kim , Hong Chul Yoon , In Woo Kim , Hyae Jung Hyun
IPC分类号： A61K31/541 , C07D401/10 , A61K31/4439 , A61K31/437 , A61P25/00 , C07D471/04 , C07D417/14
CPC分类号： C07D401/10 , C07D417/14 , C07D471/04
摘要： Disclosed herein are novel benzoimidazole derivatives functioning as antagonists to vanilloid receptor-1, and a pharmaceutical composition comprising the same. They are useful in preventing or treating pain, acute pain, chronic pain, neuropathic pain, postoperative pain, migraines, arthralgia, neuropathy, nerve injury, diabetic neuropathy, neurological illness, neurodermatitis, strokes, bladder hypersensitivity, irritable bowel syndrome, respiratory disorders such as asthma, chronic obstructive pulmonary disease, etc., burns, psoriasis, itching, vomiting, irritation of the skin, eyes, and mucous membranes, gastric-duodenal ulcers, inflammatory intestinal diseases, and inflammatory diseases.
摘要翻译：本文公开了用作香草素受体-1的拮抗剂的新型苯并咪唑衍生物和包含其的药物组合物。它们可用于预防或治疗疼痛，急性疼痛，慢性疼痛，神经性疼痛，术后疼痛，偏头痛，关节痛，神经病，神经损伤，糖尿病性神经病，神经病，神经性皮炎，中风，膀胱过敏，肠易激综合征，呼吸系统疾病作为哮喘，慢性阻塞性肺病等，烧伤，牛皮癣，瘙痒，呕吐，对皮肤，眼睛和粘膜的刺激，胃十二指肠溃疡，炎症性肠病和炎性疾病。

5. 发明授权

US08026235B1 Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof 有权
标题翻译：吡啶基苯并恶嗪衍生物，包含它们的药物组合物及其用途
公开(公告)号：US08026235B1
公开(公告)日：2011-09-27
申请号：US12909513
申请日：2010-10-21
申请人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Min Jae Cho , In Young Lee , Sang Ho Lee , Eun Kyung Park , Kwon Jo Lim , Sang Hyun Nam
发明人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Min Jae Cho , In Young Lee , Sang Ho Lee , Eun Kyung Park , Kwon Jo Lim , Sang Hyun Nam
IPC分类号： C07D413/14 , A61K31/538
CPC分类号： C07D413/14
摘要： Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1, without hyperthermia: wherein, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译：公开了用作对香草素受体-1的拮抗剂的化学式1表示的苯并恶嗪苯并咪唑衍生物，包含它们的药物组合物及其用途。苯并恶嗪苯并咪唑衍生物可用于预防或治疗与没有高热的香草素受体-1的拮抗活性相关的疾病：其中，R1，R2，R3，R4和R5如说明书中所定义。

6. 发明授权

US09040572B2 Method of preparing benzoimidazole derivatives 有权
标题翻译：苯并咪唑衍生物的制备方法
公开(公告)号：US09040572B2
公开(公告)日：2015-05-26
申请号：US13821067
申请日：2011-09-27
申请人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
发明人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
IPC分类号： C07D401/14 , C07D235/18 , C07D471/04 , C07D401/10 , C07D413/14 , C07B37/04
CPC分类号： C07D401/10 , C07B37/04 , C07D235/18 , C07D401/14 , C07D413/14 , C07D471/04
摘要： This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.
摘要翻译：本发明涉及以高纯度和高收率制备苯并咪唑衍生物的方法，以便能够制备苯并咪唑衍生物化合物作为抗香草酸反应器-1的拮抗剂，特别涉及一种制备高浓度苯并咪唑衍生物的方法纯度和高产率，其中苯并咪唑衍生物是使用新型中间体即苯甲醛合成的，因此制备方法简单，从而可以应用于生产。

7. 发明申请

US20130231477A1 NOVEL METHOD OF PREPARING BENZOIMIDAZOLE DERIVATIVES 有权
标题翻译：制备苯甲酰胺衍生物的新方法
公开(公告)号：US20130231477A1
公开(公告)日：2013-09-05
申请号：US13821067
申请日：2011-09-27
申请人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
发明人： In Woo Kim , Ji Duck Kim , Hong Chul Yoon , Hee Kyoon Yoon , Byung Goo Lee , Joon Hwan Lee , Young Mook Lim , Soo Jin Choi
IPC分类号： C07D401/10 , C07D413/14 , C07D401/14 , C07D235/18 , C07D471/04
CPC分类号： C07D401/10 , C07B37/04 , C07D235/18 , C07D401/14 , C07D413/14 , C07D471/04
摘要： This invention relates to a method of preparing a benzoimidazole derivative at high purity and high yield so as to enable the production of the benzoimidazole derivative compound as an antagonist against a vanilloid reactor-1, and particularly to a method of preparing a benzoimidazole derivative at high purity and high yield, wherein the benzoimidazole derivative is synthesized using a novel intermediate, namely, benzaldehyde, and thereby the preparation process is simple so that it can be applied to production.
摘要翻译：本发明涉及以高纯度和高收率制备苯并咪唑衍生物的方法，以便能够制备苯并咪唑衍生物化合物作为抗香草酸反应器-1的拮抗剂，特别涉及一种制备高浓度苯并咪唑衍生物的方法纯度和高产率，其中苯并咪唑衍生物是使用新型中间体即苯甲醛合成的，因此制备方法简单，从而可以应用于生产。

8. 发明授权

US08887615B2 Firearm having dual barrels 有权
标题翻译：枪炮有双重桶
公开(公告)号：US08887615B2
公开(公告)日：2014-11-18
申请号：US13229495
申请日：2011-09-09
申请人： In Woo Kim , Suk Kyun Hong , Sung Bae Lee , Eui Jung Choe , Je Wook Chae
发明人： In Woo Kim , Suk Kyun Hong , Sung Bae Lee , Eui Jung Choe , Je Wook Chae
IPC分类号： F42C17/00 , F41A19/21 , F41A21/06
CPC分类号： F41A21/06 , F41A19/21
摘要： Disclosed is a firearm having dual barrels comprising a firearm body which is equipped with a small caliber barrel and a large caliber barrel; a selector installed on one side of the firearm body to select the type of bullet and the mode of firing; a fire control system installed on the firearm body to enable aiming the target through detecting the target both at day and night time; a firearm switch unit installed on the firearm body to transmit the information on the firing of the bullet; a fuse setter installed on the firearm body to transmit the control signal of the fire control system to the fuse of the explosive bullet which is introduced into the large caliber barrel; and a sensor device unit installed on the firearm body to transmit the position of the selector and sensed firing signal to the fire control system.
摘要翻译：公开了一种具有双筒的枪械，其包括装备有小口径筒和大口径筒的枪支主体; 安装在枪支身体一侧的选择器选择子弹的类型和射击方式; 安装在火器身上的消防系统，以便能够通过昼夜探测目标瞄准目标; 安装在枪支身上的枪支开关单元，用于传送关于子弹射击的信息; 保险丝安装器，安装在枪支身上，将消防系统的控制信号传送到引入大口径枪管的爆炸子弹的保险丝; 以及安装在枪支体上的传感器装置单元，用于将选择器的位置和感测到的点火信号传送到消防控制系统。

9. 发明授权

US08145392B2 System and method for controlling automatic leveling of heavy equipment 有权
标题翻译：控制重型设备自动调平的系统和方法
公开(公告)号：US08145392B2
公开(公告)日：2012-03-27
申请号：US12239167
申请日：2008-09-26
申请人： Jin Seop Kim , Chang Soo Lee , In Woo Kim
发明人： Jin Seop Kim , Chang Soo Lee , In Woo Kim
IPC分类号： B62D33/06
CPC分类号： B62D33/07 , B62D33/0617 , B62D33/063 , B62D55/116 , Y10S37/907 , Y10S280/01
摘要： A system and method for controlling an automatic leveling of heavy equipment. The system, in which a lower frame having a traveling unit and an upper frame are combined together by a tilting unit, includes a sensor unit, provided in the equipment, for sensing twist angles of the lower frame and the upper frame against a reference horizontal surface and a traveling speed of the equipment. A control unit receives the twist angles and the traveling speed, sets a limit of an operation time for the automatic leveling in a standstill state of the equipment while calculating a corrected angle to which a twist angle of the upper frame is to be corrected, without setting the limit of the operation time for the automatic leveling, in a traveling state of the equipment, and generates a control signal for instructing an operation of a tilting unit in accordance with the corrected angle. A driving unit performs a tilting control through the tilting unit in accordance with the received control signal.
摘要翻译：一种用于控制重型设备自动调平的系统和方法。其中具有行进单元和上框架的下框架通过倾斜单元组合在一起的系统包括设置在设备中的用于感测下框架和上框架相对于参考水平线的扭转角度的传感器单元表面和设备的行驶速度。控制单元接收扭转角度和行进速度，在计算修正了上部框架的扭转角度的校正角度的同时，在设备的停止状态下设定用于自动调平的操作时间的限制，而没有在设备的行驶状态下设定用于自动调平的操作时间的限制，并且根据校正角度产生用于指示倾斜单元的操作的控制信号。驱动单元根据接收到的控制信号通过倾斜单元执行倾斜控制。

10. 发明申请

US20090151483A1 LEVELING CONTROL SYSTEM AND METHOD FOR HEAVY EQUIPMENT 失效
标题翻译：用于重型设备的调整控制系统和方法
公开(公告)号：US20090151483A1
公开(公告)日：2009-06-18
申请号：US12326375
申请日：2008-12-02
申请人： Jin Seop KIM , Chang Soo Lee , In Woo Kim
发明人： Jin Seop KIM , Chang Soo Lee , In Woo Kim
IPC分类号： F16H59/36 , B23Q1/72
CPC分类号： B62D55/116 , B60G2300/09 , B62D33/063 , G05D1/0891 , Y10S37/907 , Y10T74/11 , Y10T74/111
摘要： A leveling control system and method for heavy equipment is provided. The leveling control system for heavy equipment, in which a lower frame having a traveling means and an upper frame are combined together by a tilting means, includes a sensor unit, provided in the equipment, for measuring twist angles of the lower frame and the upper frame against a reference horizontal surface and a traveling speed of the equipment, and detecting working state information of working devices; a control unit for receiving the twist angles, the traveling speed, and the working state information, calculating a correction angle for the leveling control of the upper frame, and generating a control signal for instructing an operation of an actuator in accordance with the correction angle; and a driving unit for performing the leveling through the actuator in accordance with the control signal received therein. The control unit is provided with an auto leveling mode module for performing the leveling against a reference horizontal surface, a re-leveling mode module for performing the leveling against the reference horizontal surface in a standstill state of the equipment for a limited time, and a track leveling mode module for performing the leveling against the lower frame.
摘要翻译：提供了重型设备的调平控制系统和方法。重型设备的调平控制系统，其中具有行进装置的下框架和上框架通过倾斜装置组合在一起，包括设置在设备中的传感器单元，用于测量下框架和上框架的扭转角度相对于参考水平面和设备的行进速度，并检测工作装置的工作状态信息; 控制单元，用于接收扭转角度，行进速度和工作状态信息，计算用于上部框架的调平控制的校正角度，并且根据校正角度产生用于指示致动器的操作的控制信号 ; 以及驱动单元，用于根据在其中接收的控制信号通过致动器执行调平。所述控制单元设置有用于对参考水平面执行调平的自动调平模式模块，用于在限定时间内在所述设备的静止状态下对所述参考水平面执行调平的再平整模块模块，以及轨道平整模块模块，用于对下框架执行调平。

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