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1. 发明申请

US20100035809A1 STABLE LIQUID COMPOSITIONS FOR TREATING STOMATITIS COMPRISING EPIDERMAL GROWTH FACTOR 有权
标题翻译：稳定液体组合物，用于处理包含生物生长因子的STOMATITI
公开(公告)号：US20100035809A1
公开(公告)日：2010-02-11
申请号：US12444961
申请日：2007-10-09
申请人： Sun-Hee Kim , Sang-Kil Lee , Chae-Ha Yoon , Sun-Mee Yang , Sang-Hyun Nam , Kyeong-Sun Shin , Seung-Kook Park , Sang-Wook Lee
发明人： Sun-Hee Kim , Sang-Kil Lee , Chae-Ha Yoon , Sun-Mee Yang , Sang-Hyun Nam , Kyeong-Sun Shin , Seung-Kook Park , Sang-Wook Lee
IPC分类号： A61K38/18
CPC分类号： A61K9/006 , A61K38/1808 , A61K47/10 , C07K14/485
摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.
摘要翻译：本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。因此，液体组合物可以长期储存和分配。稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。

2. 发明授权

US09155697B2 Stable liquid compositions for treating stomatitis comprising epidermal growth factor 有权
标题翻译：用于治疗包含表皮生长因子的口腔炎的稳定液体组合物
公开(公告)号：US09155697B2
公开(公告)日：2015-10-13
申请号：US12444961
申请日：2007-10-09
申请人： Sun-Hee Kim , Sang-Kil Lee , Chae-Ha Yoon , Sun-Mee Yang , Sang-Hyun Nam , Kyeong-Sun Shin , Seung-Kook Park , Sang-Wook Lee
发明人： Sun-Hee Kim , Sang-Kil Lee , Chae-Ha Yoon , Sun-Mee Yang , Sang-Hyun Nam , Kyeong-Sun Shin , Seung-Kook Park , Sang-Wook Lee
IPC分类号： A61K38/18 , C07K14/485 , A61K9/00 , A61K47/10
CPC分类号： A61K9/006 , A61K38/1808 , A61K47/10 , C07K14/485
摘要： Provided is a liquid composition for treating stomatitis, the liquid composition including: an epidermal growth factor; an adhesive polymer; and at least one stabilizer selected from the group consisting of ethylenediaminetetraacetic acid (EDTA) and salts thereof, histidine, lysine and inorganic acid salts thereof, arginin and inorganic acid salts thereof, and dextran. The liquid composition includes a stabilizer selected from EDTA (or salts thereof) and a certain amino acid (or inorganic acid salts thereof) and thus, physicochemical and biological stability of the epidermal growth factor can be substantially increased. Thus, the liquid composition can be stored and distributed for a long period of time. The stabilized composition includes an adhesive polymer, and thus, when ejected in a spray form in the mouth of a user, the liquid composition can be quickly attached to an inflammation site and exhibits effectiveness for a long period of time.
摘要翻译：本发明提供一种用于治疗口腔炎的液体组合物，该液体组合物包括：表皮生长因子; 粘合剂聚合物; 和选自乙二胺四乙酸（EDTA）及其盐，组氨酸，赖氨酸及其无机酸盐，精氨酸及其无机酸盐和右旋糖酐的至少一种稳定剂。液体组合物包括选自EDTA（或其盐）和某些氨基酸（或其无机酸盐）的稳定剂，因此可以显着增加表皮生长因子的物理化学和生物学稳定性。因此，液体组合物可以长期储存和分配。稳定化的组合物包括粘合剂聚合物，因此当以使用者口中喷雾形式喷射时，液体组合物可以快速地附着于炎症部位并且长时间显示出有效性。

3. 发明申请

US20220318867A1 LOTTERY TICKET SHARE SALES SYSTEM USING INTERNET 有权
公开(公告)号：US20220318867A1
公开(公告)日：2022-10-06
申请号：US17607925
申请日：2020-03-05
申请人： Sang Hyun NAM
发明人： Sang Hyun NAM
IPC分类号： G06Q30/06 , G06Q50/34 , G07F17/32
摘要： A lotto ticket shares selling system using Internet is disclosed. The server of the lotto ticket shares selling system includes a selling information management unit configured to transmit selling information including lotto selection information consisting of numbered lotto designated by a seller or a purchaser and unnumbered lotto and shares selection information divided for each selected lotto to the purchaser terminal, a purchase information management unit configured to receive purchase information including lotto purchase information and shares purchase information selected by a purchaser with respect to the selling information from the plurality of purchaser terminals, a lotto management unit configured to selectively combine a plurality of lottos included in the purchase information, and match the actual lotto according to a result of summing the combined plurality of lotto shares, and a winning management unit configured to transmit lotto lottery result information and winning money information according to the corresponding shares of the won lotto to the plurality of purchaser terminals.

4. 发明授权

US08026235B1 Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof 有权
标题翻译：吡啶基苯并恶嗪衍生物，包含它们的药物组合物及其用途
公开(公告)号：US08026235B1
公开(公告)日：2011-09-27
申请号：US12909513
申请日：2010-10-21
申请人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Min Jae Cho , In Young Lee , Sang Ho Lee , Eun Kyung Park , Kwon Jo Lim , Sang Hyun Nam
发明人： Ji Duck Kim , Hong-Chul Yoon , In Woo Kim , Min Jae Cho , In Young Lee , Sang Ho Lee , Eun Kyung Park , Kwon Jo Lim , Sang Hyun Nam
IPC分类号： C07D413/14 , A61K31/538
CPC分类号： C07D413/14
摘要： Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1, without hyperthermia: wherein, R1, R2, R3, R4 and R5 are as defined in the specification.
摘要翻译：公开了用作对香草素受体-1的拮抗剂的化学式1表示的苯并恶嗪苯并咪唑衍生物，包含它们的药物组合物及其用途。苯并恶嗪苯并咪唑衍生物可用于预防或治疗与没有高热的香草素受体-1的拮抗活性相关的疾病：其中，R1，R2，R3，R4和R5如说明书中所定义。

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