专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080138393A1 Water soluble extract of spinach for prevention and repair of DNA damage 审中-公开
标题翻译：菠菜水溶性提取物，用于预防和修复DNA损伤
公开(公告)号：US20080138393A1
公开(公告)日：2008-06-12
申请号：US11698016
申请日：2007-01-25
申请人： Jesse C. Leverett , Rodney M. Johnson , Stephen R. Missler , David J. Fast , Tom La , John V. Scimeca
发明人： Jesse C. Leverett , Rodney M. Johnson , Stephen R. Missler , David J. Fast , Tom La , John V. Scimeca
IPC分类号： A61K36/00 , A61K9/127 , A61K36/31 , A61K38/47 , A61P43/00
CPC分类号： A61K38/05 , A61K9/127 , A61K31/683
摘要： Compositions comprising a water soluble spinach extract, compositions comprising a water soluble spinach extract, a liposome, a cardiolipin, and at least one antioxidant, compositions comprising a water soluble spinach extract, an extract of Arabidopsis thaliana or of the mustard (Brassica) plant, a liposome, a cardiolipin, and at least one antioxidant, processes for obtaining such compositions, and methods of using such compositions to repair damage to nuclear DNA, mitochondrial DNA, or both, prevent or decrease damage to such DNA from, for example, reactive oxygen species or 8-hydroxydeoxyguanosine and/or to repair or prevent mitochondrial damage and loss of membrane fluidity are disclosed. Compositions of the present invention may be topically administered, orally administered or parenterally, such as administration by injection. When topically administered, additives such as penetration enhancers, fragrances, preservatives, moisturizers and cosmetic adjuvants may be included in compositions of the present invention.
摘要翻译：包含水溶性菠菜提取物的组合物，包含水溶性菠菜提取物，脂质体，心磷脂和至少一种抗氧化剂的组合物，包含水溶性菠菜提取物，拟南芥提取物或芥菜（芸苔属）植物的组合物，脂质体，心磷脂和至少一种抗氧化剂，获得这样的组合物的方法，以及使用这些组合物来修复对核DNA，线粒体DNA或两者的损伤的方法，从例如反应性的公开了氧类或8-羟基脱氧鸟苷和/或修复或预防线粒体损伤和膜流动性的丧失。本发明的组合物可以局部施用，口服给药或肠胃外给药，例如通过注射给药。当局部施用时，可以在本发明的组合物中包括添加剂，例如渗透促进剂，香料，防腐剂，保湿剂和化妆品佐剂。

2. 发明申请

US20080138392A1 Liposome containing cardiolipin for improvement of mitochondrial function 有权
标题翻译：含有心磷脂的脂质体用于改善线粒体功能
公开(公告)号：US20080138392A1
公开(公告)日：2008-06-12
申请号：US11636889
申请日：2006-12-11
申请人： Jesse C. Leverett , Stephen R. Missler , David J. Fast
发明人： Jesse C. Leverett , Stephen R. Missler , David J. Fast
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K45/06
摘要： Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and/or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.
摘要翻译：本文公开了包含脂质体，心磷脂和至少一种抗氧化剂的组合物，其中所述组合物可用于改善，维持或恢复线粒体膜和/或线粒体功能。在一个实例中，脂质体主要由磷脂酰胆碱组成，心磷脂是四油酰 - 心磷脂，至少一种抗氧化剂是甲基化，1-肌肽或二者。组合物可以局部给药，口服给药或胃肠外给药，例如通过注射给药。如果局部施用，组合物可以例如作为乳膏，洗剂，凝胶，糊剂，喷雾剂，补品或其它合适的形式施用，并且可以含有各种添加剂，例如润肤剂，保湿剂，渗透促进剂，维生素，香料，颜料和保湿剂。

3. 发明授权

US07824708B2 Liposome containing cardiolipin for improvement of mitochondrial function 有权
标题翻译：含有心磷脂的脂质体用于改善线粒体功能
公开(公告)号：US07824708B2
公开(公告)日：2010-11-02
申请号：US11636889
申请日：2006-12-11
申请人： Jesse C. Leverett , Stephen R. Missler , David J. Fast
发明人： Jesse C. Leverett , Stephen R. Missler , David J. Fast
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K45/06
摘要： Disclosed herein is a composition comprising a liposome, a cardiolipin, and at least one antioxidant, wherein the composition is useful for improving, maintaining, or restoring a mitochondrial membrane and/or mitochondrial function. In one example, the liposome is primarily composed of phosphatidylcholine, the cardiolipin is tetraoleoyl-cardiolipin, and the at least one antioxidant is methylgentisate, l-carnosine, or both. The composition may be topically administered, orally administered, or parenterally administered, for example administered by injection. If topically administered, the composition may be administered for example, as a cream, lotion, gel, paste, spray, tonic, or other suitable form and may contain various additives, for example, one or more of an emollient, a humectant, a penetration enhancer, a vitamin, a fragrance, a pigment, and a moisturizer.
摘要翻译：本文公开了包含脂质体，心磷脂和至少一种抗氧化剂的组合物，其中所述组合物可用于改善，维持或恢复线粒体膜和/或线粒体功能。在一个实例中，脂质体主要由磷脂酰胆碱组成，心磷脂是四油酰 - 心磷脂，至少一种抗氧化剂是甲基化，1-肌肽或二者。组合物可以局部给药，口服给药或胃肠外给药，例如通过注射给药。如果局部施用，组合物可以例如作为乳膏，洗剂，凝胶，糊剂，喷雾剂，补品或其它合适的形式施用，并且可以含有各种添加剂，例如润肤剂，保湿剂，渗透促进剂，维生素，香料，颜料和保湿剂。

4. 发明授权

US07875302B2 Methods of using grape seed extract to stimulate tyrosinase gene expression 有权
标题翻译：使用葡萄籽提取物刺激酪氨酸酶基因表达的方法
公开(公告)号：US07875302B2
公开(公告)日：2011-01-25
申请号：US11300095
申请日：2005-12-14
申请人： Lane A. Duvel , Diego Rua , Stephen R. Missler , David J. Fast , Amitabh Chandra
发明人： Lane A. Duvel , Diego Rua , Stephen R. Missler , David J. Fast , Amitabh Chandra
IPC分类号： A61K36/87
CPC分类号： A61Q17/04 , A61K8/97 , A61K36/87 , A61Q5/12 , A61K2300/00
摘要： The present invention relates to methods of increasing tyrosinase synthesis, expression, or activity in a cell comprising administering at least one grape seed extract to the cell. The grape seed extract may be obtained by any extraction process including solvent sequential fractionation and supercritical fluid extraction.
摘要翻译：本发明涉及增加细胞中酪氨酸酶合成，表达或活性的方法，包括向细胞施用至少一种葡萄籽提取物。葡萄籽提取物可以通过任何提取方法获得，包括溶剂顺序分级和超临界流体萃取。

5. 发明授权

US11207368B2 Anti-resorptive and bone building dietary supplements and methods of use 有权
公开(公告)号：US11207368B2
公开(公告)日：2021-12-28
申请号：US15235752
申请日：2016-08-12
申请人： Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/804 , A61K36/489 , A23L33/105 , A61K36/254
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

6. 发明申请

US20160346344A1 Anti-Resorptive and Bone Building Dietary Supplements and Methods of Use 审中-公开
标题翻译：抗再吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US20160346344A1
公开(公告)日：2016-12-01
申请号：US15235752
申请日：2016-08-12
申请人： Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K36/484 , A23L33/105 , A61K36/489 , A61K36/185 , A61K31/352 , A61K36/254
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

7. 发明授权

US09446087B2 Anti-resorptive and bone building dietary supplements and methods of use 有权
标题翻译：抗吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US09446087B2
公开(公告)日：2016-09-20
申请号：US11977696
申请日：2007-10-24
申请人： David W. Krempin , Laurie Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K36/489 , A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/804
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

8. 发明申请

US20080199545A1 Anti-resorptive and bone building dietary supplements and methods of use 审中-公开
标题翻译：抗吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US20080199545A1
公开(公告)日：2008-08-21
申请号：US11977696
申请日：2007-10-24
申请人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
IPC分类号： A61K36/254 , A61K36/48 , A61K36/87 , A61P19/00
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

9. 发明授权

US07348034B2 Plant based formulations for improving skin moisture, texture, and appearance 有权
标题翻译：用于改善皮肤水分，质地和外观的基于植物的制剂
公开(公告)号：US07348034B2
公开(公告)日：2008-03-25
申请号：US11075006
申请日：2005-03-07
申请人： Mary A. Murray , Aaron W. Crawford , David J. Fast , Dora Dong , Michael Huang , Lynne Marie Connor
发明人： Mary A. Murray , Aaron W. Crawford , David J. Fast , Dora Dong , Michael Huang , Lynne Marie Connor
IPC分类号： A61K36/73 , A61K36/87 , A61K36/815
CPC分类号： A61K36/815 , A61K8/97 , A61K31/355 , A61K36/232 , A61K36/738 , A61K36/87 , A61Q19/08 , A61K2300/00
摘要： The present invention relates to formulations of ingredients that are useful for improving the appearance, texture and/or moisture of skin. In particular, the formulations of the present invention stimulate collagen, elastin, and lipid synthesis and/or inhibit or minimize the loss of collagen, elastin, and lipids in the skin. Additionally, the formulations of the present invention inhibit matrix metalloproteases, such as MMP-1, MMP-9, collagenase, or elastase.
摘要翻译：本发明涉及可用于改善皮肤的外观，质地和/或水分的成分配方。特别地，本发明的制剂刺激胶原蛋白，弹性蛋白和脂质合成和/或抑制或最小化皮肤中胶原，弹性蛋白和脂质的损失。此外，本发明的制剂抑制基质金属蛋白酶，例如MMP-1，MMP-9，胶原酶或弹性蛋白酶。

10. 发明申请

US20080199546A1 Anti-resorptive and bone building dietary supplements and methods of use 审中-公开
标题翻译：抗吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US20080199546A1
公开(公告)日：2008-08-21
申请号：US11977395
申请日：2007-10-24
申请人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
IPC分类号： A61K36/82 , C12N5/02 , A61K36/87 , A61K36/00 , A61K31/352
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长和减少或预防骨吸收的膳食补充剂组合物和方法，其包含第一组合物，所述第一组合物包含以下组合中的至少两种：槲皮素，地黄，地黄，根，西伯利亚人参，苦参，甘草和异丙酚，其中第一组合物的组合增加BMP-2基因表达，启动子活性或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式