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1. 发明授权

US11207368B2 Anti-resorptive and bone building dietary supplements and methods of use 有权
公开(公告)号：US11207368B2
公开(公告)日：2021-12-28
申请号：US15235752
申请日：2016-08-12
申请人： Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/804 , A61K36/489 , A23L33/105 , A61K36/254
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.

2. 发明申请

US20080199546A1 Anti-resorptive and bone building dietary supplements and methods of use 审中-公开
标题翻译：抗吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US20080199546A1
公开(公告)日：2008-08-21
申请号：US11977395
申请日：2007-10-24
申请人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
IPC分类号： A61K36/82 , C12N5/02 , A61K36/87 , A61K36/00 , A61K31/352
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长和减少或预防骨吸收的膳食补充剂组合物和方法，其包含第一组合物，所述第一组合物包含以下组合中的至少两种：槲皮素，地黄，地黄，根，西伯利亚人参，苦参，甘草和异丙酚，其中第一组合物的组合增加BMP-2基因表达，启动子活性或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

3. 发明申请

US20160346344A1 Anti-Resorptive and Bone Building Dietary Supplements and Methods of Use 审中-公开
标题翻译：抗再吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US20160346344A1
公开(公告)日：2016-12-01
申请号：US15235752
申请日：2016-08-12
申请人： Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K36/484 , A23L33/105 , A61K36/489 , A61K36/185 , A61K31/352 , A61K36/254
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

4. 发明授权

US09446087B2 Anti-resorptive and bone building dietary supplements and methods of use 有权
标题翻译：抗吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US09446087B2
公开(公告)日：2016-09-20
申请号：US11977696
申请日：2007-10-24
申请人： David W. Krempin , Laurie Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast
IPC分类号： A61K36/87 , A61K36/489 , A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/804
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

5. 发明申请

US20080199545A1 Anti-resorptive and bone building dietary supplements and methods of use 审中-公开
标题翻译：抗吸收和骨骼建筑膳食补充剂和使用方法
公开(公告)号：US20080199545A1
公开(公告)日：2008-08-21
申请号：US11977696
申请日：2007-10-24
申请人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
发明人： David W. Krempin , Mary A. Murray , Yumei Lin , Kevin W. Gellenbeck , Silvia R. da Costa , Leon M. Wilkins , Haeri Roh-Schmidt , Jatinder Rana , John F. Rebhun , David J. Fast , Laurie Krempin
IPC分类号： A61K36/254 , A61K36/48 , A61K36/87 , A61P19/00
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

6. 发明授权

US07384656B2 Anti-allergy composition and related method 有权
标题翻译：抗过敏成分及相关方法
公开(公告)号：US07384656B2
公开(公告)日：2008-06-10
申请号：US11351963
申请日：2006-02-10
申请人： Gopi R. Menon , David J. Fast , Lisa A. Rozga , Yumei Lin , David W. Krempin , John N. Goolsby
发明人： Gopi R. Menon , David J. Fast , Lisa A. Rozga , Yumei Lin , David W. Krempin , John N. Goolsby
IPC分类号： A61K36/00 , A61K36/54
CPC分类号： A61K31/015 , A61K31/192 , A61K31/704 , A61K36/28 , A61K36/53 , A61K36/535 , A61K36/59 , A61K36/736 , A61K36/906 , A61K2300/00
摘要： An composition and related method that prevents, inhibits and/or mitigates an allergic response by down regulating the production of IgE, down regulating the binding of IgE antibodies to receptors on cells, and/or inhibiting allergy mediators, for example, histamine, prostoglandin D2, or luekotriene C4 release. The composition comprises at least one of the following ingredients: luteolin from Perilla leaf or seed, Cinnamon, Kiwi, Picao preto, Hesperidin, Acerola cherry, Guaco, Holy Basil, Kakadu, Solamum, Rosmarinic acid, Tinospora and Aframomum. In one embodiment, the composition at least three different ingredients selected from Cinnamon, Acerola, Luteolin and Picao preto. Optionally, these ingredients can be combined with at least one of Aframomum, Rosmarinic acid, and Tinospora. The composition is administered with effective amounts to prevent, inhibit and/or mitigate allergic responses.
摘要翻译：通过调节IgE的产生来抑制，抑制和/或减轻过敏反应的组合物和相关方法，可以减少IgE抗体与细胞上的受体的结合，和/或抑制过敏介质，例如组胺，前列腺素D 或二烯三醇C 4 N 3脱离物。组合物包含以下成分中的至少一种：来自紫苏叶或种子的木犀草素，肉桂，猕猴桃，Picao preto，Hesperidin，Acerola cherry，Guaco，Holy Basil，Kakadu，Solamum，Rosmarinic acid，Tinospora和Aframomum。在一个实施方案中，组合物至少三种不同的成分选自肉桂，Acerola，木犀草素和Picao preto。任选地，这些成分可以与Aframomum，迷迭香酸和Tinospora中的至少一种组合。施用有效量的组合物以预防，抑制和/或减轻过敏反应。

7. 发明申请

US20090216559A1 SYSTEM FOR PROVIDING ANONYMOUS ACCESS TO HEALTH INFORMATION 审中-公开
标题翻译：提供健康信息获取的系统
公开(公告)号：US20090216559A1
公开(公告)日：2009-08-27
申请号：US12367272
申请日：2009-02-06
申请人： David W. Krempin , Kenneth S. Kornman , Russell K. Randolph , Haeri Roh-Schmidt
发明人： David W. Krempin , Kenneth S. Kornman , Russell K. Randolph , Haeri Roh-Schmidt
IPC分类号： G06Q50/00 , G06F17/30 , G06F17/40
CPC分类号： G06Q50/24 , G16H10/20 , G16H50/70 , Y02A90/22 , Y02A90/26
摘要： A system for providing anonymous access to health information may include an interface, a memory and a web portal. The interface may be operative to receive a test result of a biological sample of an individual and a unique identifier associated with the test result. The individual may not be identifiable by the unique identifier. The memory may be operative to store a record in a database. The record may include the test result and the unique identifier associated with the test result. The web portal may be coupled with the database and may be operative to receive the unique identifier from a user. The web portal may retrieve the record comprising of the unique identifier, and display the test result stored in the record to the user.
摘要翻译：用于提供对健康信息的匿名访问的系统可以包括接口，存储器和web门户。接口可以操作以接收个体的生物样品的测试结果和与测试结果相关联的唯一标识符。个人可能无法通过唯一标识符来识别。存储器可以用于将数据库中的记录存储起来。记录可以包括测试结果和与测试结果相关联的唯一标识符。网络门户可以与数据库耦合，并且可以用于从用户接收唯一的标识符。门户网站可以检索包含唯一标识符的记录，并将存储在记录中的测试结果显示给用户。

8. 发明授权

US06818234B1 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 有权
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US06818234B1
公开(公告)日：2004-11-16
申请号：US10084575
申请日：2002-02-27
申请人： Muraleedharan G. Nair , Haibo Wang , David L. Dewitt , David W. Krempin , Dipak K. Mody , Yong Qian , David G. Groh , Audra J. Davies , Mary A. Murray , Robin Dykhouse , Marc Lemay
发明人： Muraleedharan G. Nair , Haibo Wang , David L. Dewitt , David W. Krempin , Dipak K. Mody , Yong Qian , David G. Groh , Audra J. Davies , Mary A. Murray , Robin Dykhouse , Marc Lemay
IPC分类号： A61K3578
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/29 , A61K36/35 , Y10S514/816 , A61K2300/00 , A23V2250/2104
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

9. 发明授权

US08337914B2 Dietary food supplement containing natural cyclooxygenase inhibitors and methods for inhibiting pain and inflammation 失效
标题翻译：含有天然环氧合酶抑制剂的膳食补充剂和抑制疼痛和炎症的方法
公开(公告)号：US08337914B2
公开(公告)日：2012-12-25
申请号：US10945609
申请日：2004-09-21
申请人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
发明人： Muraleedharan G. Nair , David L. Dewitt , Haibo Wang , David W. Krempin , Dipak K. Mody , David G. Groh , Mary A. Murray , Marc Lemay , Yong Qian , Audra J. Davies , Robin Dykhouse
IPC分类号： A61K36/04 , A61K36/736 , A61K36/00
CPC分类号： A61K36/736 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/29 , A61K36/35 , A61K36/45 , A23V2250/2104 , A61K2300/00
摘要： The present invention describes food supplements that contain one or more fruit extracts useful for pain relief and anti-inflammation. The food supplements may be used to inhibit inflammation mediated by cyclooxygenase and more particularly by cyclooxygenase-2.
摘要翻译：本发明描述了含有一种或多种可用于缓解疼痛和抗炎的水果提取物的食品添加剂。食物补充剂可用于抑制由环加氧酶介导的炎症，更特别地通过环氧合酶-2。

10. 发明授权

US07384654B2 Anti-Allergy composition and related method 有权
标题翻译：抗过敏成分及相关方法
公开(公告)号：US07384654B2
公开(公告)日：2008-06-10
申请号：US11051905
申请日：2005-02-04
申请人： Gopl R. Menon , David J. Fast , David W. Krempin , John N. Goolsby
发明人： Gopl R. Menon , David J. Fast , David W. Krempin , John N. Goolsby
IPC分类号： A61K36/00 , A61K31/19
CPC分类号： A61K31/015 , A61K31/192 , A61K31/704 , A61K36/28 , A61K36/53 , A61K36/535 , A61K36/59 , A61K36/736 , A61K36/906 , A61K2300/00
摘要： An composition and related method that prevents, inhibits and/or mitigates an allergic response by down regulating the production of IgE, down regulating the binding of IgE antibodies to receptors on cells, and/or inhibiting allergy mediators, for example, histamine, prostoglandin D2, or luekotriene C4 release. The composition comprises at least one of the following ingredients: luteolin from Perilla leaf or seed, Cinnamon, Kiwi, Picao preto, Hesperidin, Acerola cherry, Guaco, Holy Basil, Kakadu, Solamum, Rosmarinic acid, Tinospora and Aframomum. In one embodiment, the composition at least three different ingredients selected from Cinnamon, Acerola, Luteolin and Picao preto. Optionally, these ingredients can be combined with at least one of Aframomum, Rosmarinic acid, and Tinospora. The composition is administered with effective amounts to prevent, inhibit and/or mitigate allergic responses.
摘要翻译：通过调节IgE的产生来抑制，抑制和/或减轻过敏反应的组合物和相关方法，可以减少IgE抗体与细胞上的受体的结合，和/或抑制过敏介质，例如组胺，前列腺素D 或二烯三醇C 4 N 3脱离物。组合物包含以下成分中的至少一种：来自紫苏叶或种子的木犀草素，肉桂，猕猴桃，Picao preto，Hesperidin，Acerola cherry，Guaco，Holy Basil，Kakadu，Solamum，Rosmarinic acid，Tinospora和Aframomum。在一个实施方案中，组合物至少三种不同的成分选自肉桂，Acerola，木犀草素和Picao preto。任选地，这些成分可以与Aframomum，迷迭香酸和Tinospora中的至少一种组合。施用有效量的组合物以预防，抑制和/或减轻过敏反应。

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