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1. 发明授权

US4288449A N-Arylsulfonylpyrroles, their preparation, and therapeutic agents containing these compounds 失效
标题翻译： N-芳基磺酰吡咯，它们的制备和含有这些化合物的治疗剂
公开(公告)号：US4288449A
公开(公告)日：1981-09-08
申请号：US154036
申请日：1980-05-28
申请人： Jens-Uwe Bliesener , Karl-Heinz Geiss , Dieter Lenke , Claus D. Mueller
发明人： Jens-Uwe Bliesener , Karl-Heinz Geiss , Dieter Lenke , Claus D. Mueller
IPC分类号： C07D207/48 , C07D307/68 , C07D333/28 , C07D333/38 , A61K31/40
CPC分类号： C07D333/28 , C07D207/48 , C07D307/68 , C07D333/38
摘要： Compounds of the formula 1 ##STR1## where R.sup.1 is a saturated, unsubstituted or substituted aliphatic radical of 1 to 8 carbon atoms, an unsaturated alkyl radical of 2 to 8 carbon atoms, a cycloalkyl radical of 3 to 7 carbon atoms in the ring or an alkyl radical of 1 to 4 carbon atoms which is substituted by phenyl or by a 5- or 6-membered aromatic heterocyclic ring containing an N, O or S atom, the phenyl ring or the heterocyclic ring itself being unsubstituted, monosubstituted or polysubstituted, andR.sup.2 is hydrogen orR.sup.1 and R.sup.2 together with the nitrogen are a 4-membered to 6-membered cycloaliphatic saturated heterocyclic ring,R.sup.3 is hydrogen or alkyl of 1 to 5 carbon atoms,R.sup.4 and R.sup.5 are identical or different and each is hydrogen or alkyl of 1 to 5 carbon atoms,X is oxygen, sulfur or >SO- or >NH- andAr is unsubstituted, monosubstituted, disubstituted or trisubstituted phenyl,and their therapeutically useful ammonium salts, alkali metal salts or acid addition salts, which compounds and salts thereof exhibit valuable pharmacological properties, their preparation, therapeutic agents containing these products, and their use as drugs.
摘要翻译：式1的化合物其中R1是1至8个碳原子的饱和，未取代或取代的脂族基团，2至8个碳原子的不饱和烷基，环中3至7个碳原子的环烷基，或由苯基或含有N，O或S原子的5-或6-元芳族杂环取代的具有1至4个碳原子的烷基，苯环或杂环本身未被取代，单取代或多取代，并且R 2是氢或R 1和R 2与氮一起是4元至6元环脂族饱和杂环，R 3是氢或1至5个碳原子的烷基，R 4和R 5是相同或不同的，各自是氢或 1至5个碳原子的烷基，X是氧，硫或> SO-或> NH-，Ar是未取代的，单取代的，二取代的或三取代的苯基及其治疗上有用的铵盐，碱金属盐或酸加成盐，其盐显示出有价值的药理学性质，其制备方法，含有这些产品的治疗剂及其作为药物的用途。

2. 发明授权

US4335138A Novel carbamates, their preparation, and pharmaceutical formulations containing these compounds 失效
标题翻译：新型氨基甲酸酯，其制备方法和含有这些化合物的药物制剂
公开(公告)号：US4335138A
公开(公告)日：1982-06-15
申请号：US186841
申请日：1980-09-15
申请人： Walter-Wielant Wiersdorff , Karl-Heinz Geiss , Harald Weifenbach , Wolfgang Worstmann , Dieter Lenke , Rolf Kretzschmar
发明人： Walter-Wielant Wiersdorff , Karl-Heinz Geiss , Harald Weifenbach , Wolfgang Worstmann , Dieter Lenke , Rolf Kretzschmar
IPC分类号： A61K31/27 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61P25/20 , C07C45/62 , C07C45/69 , C07C45/75 , C07C45/79 , C07C45/81 , C07C49/21 , C07C49/337 , C07C49/345 , C07C49/543 , C07C49/573 , C07C67/00 , C07C239/00 , C07C271/06 , C07C271/08 , C07C313/00 , C07C319/20 , C07C323/43 , C07D307/14 , C07D307/22 , C07D307/52 , C07D309/04 , C07D309/14 , C07D317/28 , C07D319/06 , C07D333/20 , C07C125/065 , A01N47/12 , A01N47/20 , C07C125/04 , C07D307/66 , C07D333/36 , C07D339/06 , C07D339/08
CPC分类号： C07D333/20 , C07C45/62 , C07C45/69 , C07C45/75 , C07C45/79 , C07C45/81 , C07C49/21 , C07C49/337 , C07C49/345 , C07C49/543 , C07C49/573 , C07D307/14 , C07D307/52 , C07D309/04 , C07D309/14 , C07D317/28 , C07D319/06 , Y10S514/923
摘要： Novel carbamates derived from substituted cyclic .beta.-keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.
摘要翻译：衍生自取代的环状β-酮醇的新型氨基甲酸酯，其制备物和含有这些化合物的药物制剂，其可用作治疗睡眠障碍的催眠药和镇静剂。

3. 发明授权

US4966894A Polysulfated heparins for treating diseases caused by retroviruses 失效
标题翻译：用于治疗由逆转录病毒引起的疾病的多硫酸肝素
公开(公告)号：US4966894A
公开(公告)日：1990-10-30
申请号：US288444
申请日：1988-12-22
申请人： Dieter Herr , Thomas Doerper , Lothar Daum , Karl-Heinz Geiss , Achim Moeller
发明人： Dieter Herr , Thomas Doerper , Lothar Daum , Karl-Heinz Geiss , Achim Moeller
IPC分类号： C08B37/10 , A61K20060101 , A61K31/715 , A61P31/12
CPC分类号： A61K31/715
摘要： Polysulfated heparins are used for the preparation of drugs for the prophylaxis and therapy of diseases caused by retroviruses.
摘要翻译：多硫酸肝素用于制备用于预防和治疗由逆转录病毒引起的疾病的药物。

4. 发明授权

US5102892A 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom 失效
标题翻译： 2-ALKYL-4-ARYLMETHYLAMINOQUINOLINES，其使用及其制备的药物
公开(公告)号：US5102892A
公开(公告)日：1992-04-07
申请号：US486824
申请日：1990-03-01
申请人： Karl-Heinz Geiss , Klaus Ruebsamen , Martin Traut
发明人： Karl-Heinz Geiss , Klaus Ruebsamen , Martin Traut
IPC分类号： A61K31/47 , A61K31/475 , A61P1/00 , A61P1/04 , A61P29/00 , C07D215/42
CPC分类号： C07D215/42
摘要： 2-alkyl-4-arylmethylaminoquinolines of the general formula I ##STR1## where R.sup.1, R.sup.2, R.sup.5 and R.sup.6 have the meanings specified in the claims, and the physiologically tolerated salts thereof, the use thereof for the preparation of drugs and the drugs thus obtained as described for the inhibition of gastric acid secretion.
摘要翻译：通式Ⅰ的2-烷基-4-芳基甲基氨基喹啉其中R 1，R 2，R 5和R 6具有权利要求书中规定的含义，及其生理上可耐受的盐，其用于制备药物和因此获得的药物如抑制胃酸分泌所述。

5. 发明授权

US4772598A 2-aryl-3,4-diazabicyclo(4.n.O)alk-2-en-5-ones for the preparation of an agent for treating cardiac insufficiency 失效
标题翻译： 2-芳基-3,4-二氮杂双环（4.n.O）烷-2-烯-5-酮用于制备治疗心功能不全的药物
公开(公告)号：US4772598A
公开(公告)日：1988-09-20
申请号：US914729
申请日：1986-10-01
申请人： Karl-Heinz Geiss , Phillip A. Rossy , Marco Thyes , Horst Koenig , Hans D. Lehmann , Martin Traut , Josef Gries
发明人： Karl-Heinz Geiss , Phillip A. Rossy , Marco Thyes , Horst Koenig , Hans D. Lehmann , Martin Traut , Josef Gries
IPC分类号： C07D401/04 , A61K31/50 , A61K31/55 , A61P3/02 , A61P9/04 , A61P9/08 , A61P9/10 , C07D209/34 , C07D215/22 , C07D223/16 , C07D237/00 , C07D403/04 , C12N9/99 , A61K31/495
CPC分类号： A61K31/55 , A61K31/50
摘要： 2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.
摘要翻译：其中m，n，R，R 1，R 2和R 3具有所述含义，其中m，n，R 1，R 2，R 3，R 3，R 3，用于治疗心功能不全。

6. 发明授权

US4710496A Pyrrol-1-ylphenyldihydropyridazinones, their preparation and their use 失效
标题翻译：吡咯-1-基苯基二氢哒嗪酮，其制备及其应用
公开(公告)号：US4710496A
公开(公告)日：1987-12-01
申请号：US753278
申请日：1985-07-09
申请人： Karl-Heinz Geiss , Bernhard Schmied , Manfred Raschack , Hans-Dieter Lehmann , Josef Gries , Klaus Ruebsamen
发明人： Karl-Heinz Geiss , Bernhard Schmied , Manfred Raschack , Hans-Dieter Lehmann , Josef Gries , Klaus Ruebsamen
IPC分类号： A61K31/50 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/04 , A61P9/12 , C07D237/00 , C07D403/04 , C07D403/10 , C07D401/14 , C07D403/14
CPC分类号： C07D403/04 , C07D403/10
摘要： Novel pyrrol-1-ylphenyldihydropyridazinones of the formula ##STR1## their preparation and their use in the treatment of disorders.
摘要翻译：具有下式的新型吡咯-1-基苯基二氢哒嗪酮其制备方法及其在治疗疾病中的应用。

7. 发明授权

US4350636A Preparation of phenylacetonitriles carrying basic substituents 失效
标题翻译：制备具有碱性取代基的苯基丙腈
公开(公告)号：US4350636A
公开(公告)日：1982-09-21
申请号：US296893
申请日：1981-08-27
申请人： Gerhard Kastner , Hardo Siegel , Karl-Heinz Geiss
发明人： Gerhard Kastner , Hardo Siegel , Karl-Heinz Geiss
IPC分类号： C07D317/58 , A61K31/275 , A61K38/095 , C07C20060101 , C07C67/00 , C07C253/00 , C07C255/00 , C07C255/42 , C07C255/43 , C07C255/58 , C07D317/48 , C07D317/60 , C07D317/62 , C07C121/78
CPC分类号： C07C255/00
摘要： A process for the preparation of phenylacetonitriles, carrying basic substituents, of the formula I ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7 and R.sup.8 have the meanings given in the description, by reacting an aldehyde of the formula II ##STR2## with an amine of the formula III ##STR3##
摘要翻译：制备式I的基本取代基的苯基丙腈的制备方法，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 8具有本说明书中给出的含义，通过使式II的化合物II与式III的胺反应

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