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1. 发明授权

US4335138A Novel carbamates, their preparation, and pharmaceutical formulations containing these compounds 失效
标题翻译：新型氨基甲酸酯，其制备方法和含有这些化合物的药物制剂
公开(公告)号：US4335138A
公开(公告)日：1982-06-15
申请号：US186841
申请日：1980-09-15
申请人： Walter-Wielant Wiersdorff , Karl-Heinz Geiss , Harald Weifenbach , Wolfgang Worstmann , Dieter Lenke , Rolf Kretzschmar
发明人： Walter-Wielant Wiersdorff , Karl-Heinz Geiss , Harald Weifenbach , Wolfgang Worstmann , Dieter Lenke , Rolf Kretzschmar
IPC分类号： A61K31/27 , A61K31/34 , A61K31/341 , A61K31/357 , A61K31/38 , A61K31/381 , A61P25/20 , C07C45/62 , C07C45/69 , C07C45/75 , C07C45/79 , C07C45/81 , C07C49/21 , C07C49/337 , C07C49/345 , C07C49/543 , C07C49/573 , C07C67/00 , C07C239/00 , C07C271/06 , C07C271/08 , C07C313/00 , C07C319/20 , C07C323/43 , C07D307/14 , C07D307/22 , C07D307/52 , C07D309/04 , C07D309/14 , C07D317/28 , C07D319/06 , C07D333/20 , C07C125/065 , A01N47/12 , A01N47/20 , C07C125/04 , C07D307/66 , C07D333/36 , C07D339/06 , C07D339/08
CPC分类号： C07D333/20 , C07C45/62 , C07C45/69 , C07C45/75 , C07C45/79 , C07C45/81 , C07C49/21 , C07C49/337 , C07C49/345 , C07C49/543 , C07C49/573 , C07D307/14 , C07D307/52 , C07D309/04 , C07D309/14 , C07D317/28 , C07D319/06 , Y10S514/923
摘要： Novel carbamates derived from substituted cyclic .beta.-keto-alcohols, their preparation, and pharmaceutical formulations which contain these compounds and which may be used as hypnotics in the treatment of sleep disturbance and as sedatives.
摘要翻译：衍生自取代的环状β-酮醇的新型氨基甲酸酯，其制备物和含有这些化合物的药物制剂，其可用作治疗睡眠障碍的催眠药和镇静剂。

2. 发明授权

US4619929A Phenylpiperazine derivatives of hetarylphenols and hetarylanilines, their preparation, and therapeutic agents containing these compounds 失效
标题翻译：苯二甲基苯酚和杂芳基苯胺的苯基哌嗪衍生物，它们的制备和含有这些化合物的治疗剂
公开(公告)号：US4619929A
公开(公告)日：1986-10-28
申请号：US590746
申请日：1984-03-19
申请人： Peter C. Thieme , Gerd Steiner , Wolfgang Rohr , Dieter Lenke , Josef Gries , Harald Weifenbach , Hans-Juergen Teschendorf , Hans P. Hofmann , Horst Kreiskott
发明人： Peter C. Thieme , Gerd Steiner , Wolfgang Rohr , Dieter Lenke , Josef Gries , Harald Weifenbach , Hans-Juergen Teschendorf , Hans P. Hofmann , Horst Kreiskott
IPC分类号： C07D249/08 , A61K31/495 , A61K31/496 , A61P9/02 , A61P11/00 , A61P25/20 , C07D231/12 , C07D233/60 , C07D233/61 , C07D271/10 , C07D295/06 , C07D295/067 , C07D295/096 , C07D521/00 , C07D413/12 , C07D403/12 , C07D417/12
CPC分类号： C07D271/10 , C07D231/12 , C07D233/56 , C07D249/08 , C07D295/067 , C07D295/096
摘要： Novel phenylpiperazinylpropane and -butane derivatives of hetarylphenols and hetarylanilines of the formula ##STR1## where R.sup.1 is hydrogen or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, X is oxygen or an NH group, and the heterocyclic structure Het. is 1,3,4-oxadiazolyl, triazolyl, imidazolyl or pyrazolyl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly sedative, neuroleptic and hypotensive properties.
摘要翻译：式（I）的芳基苯酚和杂芳基苯胺的新型苯基哌嗪基丙烷和丁烷衍生物，其中R 1为氢或1至4个碳原子的烷基，R 2为氢，卤素，1至4个碳原子的烷基或烷氧基，其中烷基为1〜 3个碳原子，苯环可以被R2单取代或二取代，X是氧或NH基，杂环结构Het。是1,3,4-恶二唑基，三唑基，咪唑基或吡唑基，以及它们与酸的生理学上可耐受的加成盐，其制备方法和含有这些化合物并且主要表现出镇静，抗精神病药和降血压性质的药物制剂。

3. 发明授权

US4824862A 3-phenyl-2-styrylpyrrolidines, preparation and use thereof 失效
标题翻译： 3-苯基-2-苯乙烯基吡咯烷酮，其制备和用途
公开(公告)号：US4824862A
公开(公告)日：1989-04-25
申请号：US197275
申请日：1988-05-23
申请人： Walter Himmele , Gerd Steiner , Hans-Juergen Teschendorf , Harald Weifenbach
发明人： Walter Himmele , Gerd Steiner , Hans-Juergen Teschendorf , Harald Weifenbach
IPC分类号： A61K31/40 , A61P25/20 , C07D207/06 , C07D207/08
CPC分类号： C07D207/08 , C07D207/06
摘要： Novel 3-phenyl-2-styrylpyrrolidines of the formula I ##STR1## where R.sup.1 -R.sup.7 have defined meanings, are suitable for treating disorders.
摘要翻译：式I的新型3-苯基-2-苯乙烯基吡咯烷酮其中R 1 -R 7具有定义的含义，适用于治疗疾病。

4. 发明授权

US5414006A Arylalkoxythiocoumarins, the preparation thereof and therapeutic compositions containing these 失效
标题翻译：芳基烷氧基硫香环素，其制备方法和含有它们的治疗组合物
公开(公告)号：US5414006A
公开(公告)日：1995-05-09
申请号：US136033
申请日：1993-10-14
申请人： Beatrice Rendenbach-Mueller , Ulrich Karl , Harald Weifenbach
发明人： Beatrice Rendenbach-Mueller , Ulrich Karl , Harald Weifenbach
IPC分类号： C07D311/16 , C07D405/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/37
CPC分类号： C07D405/12 , C07D311/16 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Arylalkoxythiocoumarins of the formula ##STR1## where R.sup.1 and R.sup.2 are each, independently of one another, hydrogen, C.sub.1 -C.sub.5 -alkyl, trifluoromethyl, phenyl or halogen, or together are a C.sub.3 -C.sub.5 -alkylene chain, andX is oxygen or sulfur,R.sup.3 is C.sub.1 -C.sub.5 -alkyl or halogen,n is an integer from 0 to 3,R.sup.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl andAr is phenyl, which can be mono- or disubstituted by halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1 -C.sub.6 -alkoxy, nitro, cyano, trifluoromethyl or a combination of these substituents or is a heteraromatic ring which has from one to three heteroatoms which can, independently of one another, be N, O or S, and which can be substituted by C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.7 -cycloalkyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.4 -alkoxy-substituted C.sub.1 -C.sub.6 -alkyl, 5-6-membered oxacycloalkyl, benzyl, C.sub.1 -C.sub.5 -alkoxycarbonyl, perfluoro-C.sub.1 -C.sub.2 -alkyl, phenyl or halogen, are prepared as described and used in therapeutic compositions, especially for treating disorders of the central nervous system.
摘要翻译：其中R 1和R 2各自独立地为氢，C 1 -C 5 - 烷基，三氟甲基，苯基或卤素，或一起为C 3 -C 5 - 亚烷基链，并且X为氧或芳基烷氧基，硫，R3是C1-C5-烷基或卤素，n是0-3的整数，R4是氢或C1-C4-烷基，Ar是可以被卤素单 - 或二取代的苯基，C1-C6-烷基 C 3 -C 7 - 环烷基，C 1 -C 6 - 烷氧基，硝基，氰基，三氟甲基或这些取代基的组合，或者是具有1至3个杂原子的杂芳环，它们可以彼此独立地为N，O或S 可以被C 1 -C 6 - 烷基，C 3 -C 7 - 环烷基，C 1 -C 6 - 烷氧基，C 1 -C 4 - 烷氧基取代的C 1 -C 6 - 烷基，5-6元氧杂环烷基，苄基，C 1 -C 5 - 烷氧基羰基，全氟-C 1 - C 2 - 烷基，苯基或卤素，如治疗组合物中所述和使用，特别是用于治疗中枢神经系统疾病。

5. 发明授权

US5227392A Alkoxycoumarins substituted by a heterocyclic radical, their preparation and therapeutic agents containing these compounds 失效
标题翻译：被杂环基团取代的烷氧基香豆素，其制备物和含有这些化合物的治疗剂
公开(公告)号：US5227392A
公开(公告)日：1993-07-13
申请号：US888445
申请日：1992-05-28
申请人： Fritz-Frieder Frickel , Thomas Kuekenhoehner , Beatrice Rendenbach-Mueller , Harald Weifenbach , Hans-Juergen Teschendorf
发明人： Fritz-Frieder Frickel , Thomas Kuekenhoehner , Beatrice Rendenbach-Mueller , Harald Weifenbach , Hans-Juergen Teschendorf
IPC分类号： C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D405/12 , C07D407/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： An alkoxycoumarin substituted by a heterocyclic radical, or the formula ##STR1## R.sup.1 and R.sup.2 independently of one another are each hydrogen, C.sub.1 -C.sub.5 -alkyl, trifluoromethyl, phenyl or halogen, or together form a C.sub.3 -C.sub.5 -alkylene chain, R.sup.3 is C.sub.1 -C.sub.5 -alkyl or halogen, n is an integer of from 0 to 3, R.sup.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl and Het is one of the following heterocyclic radicals: ##STR2##
摘要翻译：被杂环基取代的烷氧基香豆素或式Ⅰ和R1分别独立地为氢，C1-C5-烷基，三氟甲基，苯基或卤素，或一起形成C 3 -C 5 - 亚烷基链，R 3 是C 1 -C 5烷基或卤素，n是0至3的整数，R 4是氢或C 1 -C 4烷基，Het是以下杂环之一：

6. 发明授权

US5073563A Alkoxycoumarins substituted by a heterocyclic radical, their preparation and therapeutic agents containing these compounds 失效
标题翻译：由其他化合物取代的烷氧基化物，其制备和含有这些化合物的治疗剂
公开(公告)号：US5073563A
公开(公告)日：1991-12-17
申请号：US417451
申请日：1989-10-05
申请人： Fritz-Frieder Frickel , Thomas Kuekenhoehner , Beatrice Rendenbach-Mueller , Harald Weifenbach , Hans-Juergen Teschendorf
发明人： Fritz-Frieder Frickel , Thomas Kuekenhoehner , Beatrice Rendenbach-Mueller , Harald Weifenbach , Hans-Juergen Teschendorf
IPC分类号： A61K31/335 , A61K31/41 , A61K31/44 , A61K31/443 , A61K31/4433 , A61P25/00 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D419/12
CPC分类号： C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： An alkoxycoumarin substituted by a heterocyclic radical, of the formula ##STR1## Het is one of the following heterocyclic radicals: where X is oxygen or sulfur.
摘要翻译：由下式杂环基取代的烷氧基香豆素：下列杂环基：其中X是氧，或者其中X是氧或硫。

7. 发明授权

US4877807A 5-phenyl-1,2,3a,4,5,9b-hexahydro-3H-benz(e)indotes preparation and use thereof as drugs 失效
标题翻译： 5-苯基-1,2,3a，4,5,9b-六氢-3H-苯并（e）将其制备和用途作为药物
公开(公告)号：US4877807A
公开(公告)日：1989-10-31
申请号：US197274
申请日：1988-05-23
申请人： Gerd Steiner , Walter Himmele , Ernst Buschmann , Hans-Juergen Teschendorf , Harald Weifenbach
发明人： Gerd Steiner , Walter Himmele , Ernst Buschmann , Hans-Juergen Teschendorf , Harald Weifenbach
IPC分类号： A61K31/40 , A61K31/403 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , C07D209/60
CPC分类号： C07D209/60
摘要： A 5-phenyl-1,3,3a,4,5,9b-hexahydro-3H-benz(e)indole compound of the formula I: ##STR1## wherein R.sup.1 is hydrogen or C.sub.1-6 alkyl, R.sup.2 is hydrogen or C.sub.1-3 alkyl in the 3a- or 4-position, R.sup.3 and R.sup.4 are each hydrogen, hydroxyl, halogen, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or trifluoromethyl, acetylamino or amino and R.sup.5 is hydrogen or C.sub.1-3 alkyl, or a salt thereof with a physiologically tolerated acid. The compounds and compositions are useful for treating depression or trating convulsions and which exhibit a sedative and tranquilizing effect when administered to a patient.
摘要翻译：式I的5-苯基-1,3,3a，4,5,9b-六氢-3H-苯并（e）吲哚化合物：其中R 1是氢或C 1-6烷基，R 2是氢或 R 3和R 4各自为氢，羟基，卤素，C 1-3烷基，C 1-3烷氧基，C 1-3烷硫基或三氟甲基，乙酰氨基或氨基，R 5为氢或C 1 -C 3烷基 -3烷基或其盐与生理上耐受的酸反应。所述化合物和组合物可用于治疗抑郁症或治疗惊厥，并且当施用于患者时其具有镇静和镇静作用。

8. 发明授权

US5100914A Arylalkoxycoumarins 失效
标题翻译： ARYLALKOXYCOUMARINS
公开(公告)号：US5100914A
公开(公告)日：1992-03-31
申请号：US414307
申请日：1989-09-29
申请人： Beatrice Rendenbach-Mueller , Harald Weifenbach , Jans-Juergen Teschendorf
发明人： Beatrice Rendenbach-Mueller , Harald Weifenbach , Jans-Juergen Teschendorf
IPC分类号： A61K31/00 , A61K31/37 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/24 , A61P25/26 , A61P25/28 , C07D311/16
CPC分类号： C07D311/16
摘要： Arylalkoxycoumarins of the general formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, lower alkyl, phenyl or halogen, or the two radicals together form an alkylene bridge of 3 to 5 carbon atoms, R.sup.3 is lower alkyl or halogen, n is an integer of from 0 to 3, m is an integer of from 0 to 4, R.sup.4 is hydrogen or lower alkyl and Ar is a phenyl ring which is monosubstituted to trisubstituted by halogen, C.sub.1 -C.sub.6 -alkyl or C.sub.1 -C.sub.6 -alkoxy or monosubstituted by nitro, cyano or trifluoromethyl or is a naphthyl ring, with the proviso that m is not 0 when Ar is unsubstituted phenyl, processes for their preparation, and drugs prepared therefrom.
摘要翻译：其中R 1和R 2彼此独立地为氢，低级烷基，苯基或卤素，或两个基团一起形成3至5个碳原子的亚烷基桥，R 3为低级烷基或卤素，n为0〜3的整数，m为0〜4的整数，R4为氢或低级烷基，Ar为被卤素，C1-C6烷基或C1-C6烷基单取代为三取代的苯基环， C6烷氧基或被硝基，氰基或三氟甲基单取代或是萘环，条件是当Ar是未取代的苯基时m不为0，制备方法及由其制备的药物。

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