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1. 发明授权

US5102892A 2-alkyl-4-arylmethylaminoquinolines, the use thereof and drugs prepared therefrom 失效
标题翻译： 2-ALKYL-4-ARYLMETHYLAMINOQUINOLINES，其使用及其制备的药物
公开(公告)号：US5102892A
公开(公告)日：1992-04-07
申请号：US486824
申请日：1990-03-01
申请人： Karl-Heinz Geiss , Klaus Ruebsamen , Martin Traut
发明人： Karl-Heinz Geiss , Klaus Ruebsamen , Martin Traut
IPC分类号： A61K31/47 , A61K31/475 , A61P1/00 , A61P1/04 , A61P29/00 , C07D215/42
CPC分类号： C07D215/42
摘要： 2-alkyl-4-arylmethylaminoquinolines of the general formula I ##STR1## where R.sup.1, R.sup.2, R.sup.5 and R.sup.6 have the meanings specified in the claims, and the physiologically tolerated salts thereof, the use thereof for the preparation of drugs and the drugs thus obtained as described for the inhibition of gastric acid secretion.
摘要翻译：通式Ⅰ的2-烷基-4-芳基甲基氨基喹啉其中R 1，R 2，R 5和R 6具有权利要求书中规定的含义，及其生理上可耐受的盐，其用于制备药物和因此获得的药物如抑制胃酸分泌所述。

2. 发明授权

US4772598A 2-aryl-3,4-diazabicyclo(4.n.O)alk-2-en-5-ones for the preparation of an agent for treating cardiac insufficiency 失效
标题翻译： 2-芳基-3,4-二氮杂双环（4.n.O）烷-2-烯-5-酮用于制备治疗心功能不全的药物
公开(公告)号：US4772598A
公开(公告)日：1988-09-20
申请号：US914729
申请日：1986-10-01
申请人： Karl-Heinz Geiss , Phillip A. Rossy , Marco Thyes , Horst Koenig , Hans D. Lehmann , Martin Traut , Josef Gries
发明人： Karl-Heinz Geiss , Phillip A. Rossy , Marco Thyes , Horst Koenig , Hans D. Lehmann , Martin Traut , Josef Gries
IPC分类号： C07D401/04 , A61K31/50 , A61K31/55 , A61P3/02 , A61P9/04 , A61P9/08 , A61P9/10 , C07D209/34 , C07D215/22 , C07D223/16 , C07D237/00 , C07D403/04 , C12N9/99 , A61K31/495
CPC分类号： A61K31/55 , A61K31/50
摘要： 2-aryl-3,4-diazabicyclo[4.n.0]-alk-2-en-5-ones of the formula ##STR1## where m, n, R, R.sup.1, R.sup.2 and R.sup.3 have the stated meanings, are used for the treatment of cardiac insufficiency.
摘要翻译：其中m，n，R，R 1，R 2和R 3具有所述含义，其中m，n，R 1，R 2，R 3，R 3，R 3，用于治疗心功能不全。

3. 发明授权

US4500467A Benzoylthio compounds, their preparation and their use as drugs 失效
标题翻译：苯甲酰硫基化合物，其制备及其作为药物的用途
公开(公告)号：US4500467A
公开(公告)日：1985-02-19
申请号：US554098
申请日：1983-11-21
申请人： Hugo Kubinyi , Martin Traut , Josef Gries
发明人： Hugo Kubinyi , Martin Traut , Josef Gries
IPC分类号： A61K31/16 , A61K31/21 , A61K38/00 , A61K38/55 , A61P9/12 , A61P43/00 , C07C327/20 , C07D205/04 , C07D207/10 , C07D207/16 , C07D209/20 , C07D211/60 , C07D217/26 , C07D277/06 , C07K5/04 , C07K5/06 , C07K5/062 , C07K5/065 , C07K5/078 , C07K5/083 , C07K14/81 , C07C153/00 , C01B25/10 , C07C103/52
CPC分类号： C07K5/0806 , C07C327/00 , C07D205/04 , C07D209/20 , C07D211/60 , C07D217/26 , C07D277/06 , C07K5/06026 , C07K5/06052 , C07K5/0606 , C07K5/06078 , C07K5/06156 , C07K5/06165
摘要： Benzoylthio compounds of the formula I ##STR1## where R.sup.1 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.4 -alkyl, R.sup.2 and R.sup.4 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl which is unsubstituted or substituted by hydroxyl, mercapto, C.sub.1 -C.sub.4 -alkylthio, a carboxylic ester group, carboxamido or acylamino or are each an aryl, hetaryl, arylalkylene or hetarylalkylene radical which is unsubstituted or substituted in the aryl moiety by hydroxyl, C.sub.1 -C.sub.4 -alkoxy, arylalkoxy or halogen, R.sup.1 and R.sup.2 and/or R.sup.3 and R.sup.4 together may furthermore be a radical --(CH.sub.2).sub.p -- (p=2, 3, 4), --CH.sub.2 --S--CH.sub.2 -- or --CH.sub.2 --C.sub.6 H.sub.4 --CH.sub.2 --(ortho), X is NH or sulfur, m and n are identical or different and are each 0 or 1, and q is 0 or 1 where X is S, and is 0 where X is NH, and their salts with physiologically tolerated bases, their preparation, drugs containing these compounds and the use of these drugs in treating disorders.
摘要翻译：其中R 1和R 3相同或不同并且各自为氢或C 1 -C 4 - 烷基，R 2和R 4相同或不同并且分别为氢或C 1 -C 6 - 烷基的苯甲酰硫基化合物，未被取代或被羟基，巯基，C 1 -C 4 - 烷硫基，羧酸酯基，甲酰氨基或酰基氨基取代的烷基，或者是芳基，杂芳基，芳基亚烷基或杂芳基亚烷基，其未被取代或在芳基部分被羟基取代，C1 -C 1-4 - 烷氧基，芳基烷氧基或卤素，R 1和R 2和/或R 3和R 4一起还可以是 - （CH 2）p - （p = 2,3,4），-CH 2 -S-CH 2 - 或-CH 2 -C 6 H 4 -CH 2 - （邻位），X是NH或硫，m和n相同或不同，各自为0或1，q为0或1，其中X为S，X为NH时为0，与生理上耐受的碱的盐，它们的制备，含有这些化合物的药物以及这些药物在治疗疾病中的用途。

4. 发明授权

US4618622A Sulfonates of hydroxycoumarins 失效
标题翻译：羟基香豆素磺酸盐
公开(公告)号：US4618622A
公开(公告)日：1986-10-21
申请号：US552787
申请日：1983-11-17
申请人： Rainer Schlecker , Peter Schmidt , Peter C. Thieme , Dieter Lenke , Hans-Jurgen Teschendorf , Martin Traut , Claus D. Mueller , Hans P. Hofmann , Horst Kreiskott
发明人： Rainer Schlecker , Peter Schmidt , Peter C. Thieme , Dieter Lenke , Hans-Jurgen Teschendorf , Martin Traut , Claus D. Mueller , Hans P. Hofmann , Horst Kreiskott
IPC分类号： A61K31/35 , A61K31/352 , A61K31/365 , A61P25/18 , A61P25/24 , A61P25/26 , A61P37/08 , A61P43/00 , C07D311/08 , C07D311/16 , C07D311/80 , A61K31/37
CPC分类号： C07D311/80 , C07D311/16
摘要： Sulfonates of hydroxycoumarins of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen or alkyl of 1 to 5 carbon atoms which can be substituted by --NR.sup.4 R.sup.5, --OR.sup.4 or --OC(O)R.sup.4, where R.sup.4 and R.sup.5 are identical or different and are each hydrogen or alkyl of 1 to 4 carbon atoms, or R.sup.1 and R.sup.2 are each a carboxylic acid group --OC(O)R.sup.4 or a carboxamido radical, with the proviso that R.sup.1 is not methyl when R.sup.2 is hydrogen, or R.sup.1 and R.sup.2 together form a --(CH.sub.2).sub.n -- chain where n is 3-5, and R.sup.3 is a straight-chain or branched alkyl radical of 1 to 8 carbon atoms or cycloalkyl of 3 to 8 carbon atoms, each of which can be substituted by halogen, --OR.sup.4, --NR.sup.4 R.sup.5, --CN or phenyl, or R.sup.3 is a straight-chain or branched alkenyl radical of 3 to 8 carbon atoms, an amino group -- NR.sup.4 R.sup.5, or phenyl or naphthyl, each of which is unsubstituted or monosubstituted or polysubstituted by --OR.sup.4, --NR.sup.4 R.sup.5, --NO.sub.2, halogen, --SR.sup.4, --S(O)R.sup.4, --OS(O)R.sup.4, --SCF.sub.3, --OS(O)CF.sub.3, --CN, --C(O)R.sup.4, --OC(O)R.sup.4, --NHC(O)R.sup.4, --CF.sub.3, C.sub.1 -C.sub.4 -alkyl or a combination of these substituents, a process for their preparation, drugs containing these compounds, and compounds of the formula I, in which R.sup.1 is methyl and R.sup.2 is hydrogen, for use as drugs.
摘要翻译：式I的羟基香豆素的磺酸盐其中R 1和R 2相同或不同，各自为氢，卤素或可被-NR 4 R 5，-OR 4或-OC（O）取代的1至5个碳原子的烷基）R 4，其中R 4和R 5相同或不同并且各自为氢或1至4个碳原子的烷基，或者R 1和R 2各自为羧酸基-OC（O）R 4或甲酰胺基，条件是R 1 当R 2为氢时，R 1和R 2一起形成 - （CH 2）n - 链，其中n为3-5，R 3为1至8个碳原子的直链或支链烷基或3个环烷基至8个碳原子，每个可以被卤素，-OR4，-NR4R5，-CN或苯基取代，或R3是3-8个碳原子的直链或支链烯基，氨基-NR4R5或苯基或萘基，它们各自被-OR4，-NR4R5，-NO2，卤素，-SR4，-S（O）R4，-OS（O）R4，-SCF3，-OS（O）未取代或单取代或多取代， CF 3，-CN，-C（O）R 4，-OC（O）R 4， -NHC（O）R 4，-CF 3，C 1 -C 4烷基或这些取代基的组合，其制备方法，含有这些化合物的药物和式I化合物，其中R 1是甲基，R 2是氢，用作药物。

5. 发明授权

US4499087A 7-Phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepines and their use 失效
标题翻译： 7-苯基-7-苯氧基甲基 - 六氢-1,4-氧氮杂及其用途
公开(公告)号：US4499087A
公开(公告)日：1985-02-12
申请号：US554097
申请日：1983-11-21
申请人： Hans J. Treiber , Hans P. Hofmann , Horst Kreiskott , Hans-Juergen Teschendorf , Martin Traut
发明人： Hans J. Treiber , Hans P. Hofmann , Horst Kreiskott , Hans-Juergen Teschendorf , Martin Traut
IPC分类号： A61K31/55 , A61P25/24 , A61P25/26 , C07D267/08 , C07D267/10
CPC分类号： C07C255/00 , C07D267/10
摘要： 7-phenyl-7-phenoxymethyl-hexahydro-1,4-oxazepines of the formula I ##STR1## wherein R.sup.1 is hydrogen, chlorine or methoxy and R.sup.2 is hydrogen or methyl, and their salts with physiologically tolerated acids, and their preparation, are described. The substances are useful for treating disorders.
摘要翻译：其中R 1是氢，氯或甲氧基，R 2是氢或甲基，以及它们与生理上耐受的酸的盐及其制备方法，其中R1是氢，被描述。该物质可用于治疗疾病。

6. 发明授权

US4820821A Novel pyridazinone-imines and their physiologically tolerated addition salts with acids, their preparation and therapeutic agents containing these compounds 失效
标题翻译：新的哒嗪酮亚胺及其与酸的生理学耐受加成盐，它们的制备和含有这些化合物的治疗剂
公开(公告)号：US4820821A
公开(公告)日：1989-04-11
申请号：US39765
申请日：1987-04-17
申请人： Rudolf Kropp , Marco Thyes , Rainer Schlecker , Albrecht Franke , Franz Reicheneder , Dora I. Reicheneder , August Amann , Hans-Juergen Teschendorf , Rolf Kretzschmar , Martin Traut , Josef Gries
发明人： Rudolf Kropp , Marco Thyes , Rainer Schlecker , Albrecht Franke , Franz Reicheneder , Dora I. Reicheneder , August Amann , Hans-Juergen Teschendorf , Rolf Kretzschmar , Martin Traut , Josef Gries
IPC分类号： A61K31/50 , A61P9/02 , A61P25/00 , A61P25/24 , A61P25/26 , C07D237/20 , C07D237/22 , C07D239/06
CPC分类号： C07D237/22 , C07D237/20
摘要： Novel 1-phenyl-4(1H)-pyridazinone-imines of the formula (I) ##STR1## which are substituted at the imine nitrogen, and their addition salts with a physiologically tolerated acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs, in particular as antidepressants, antiparkinson drugs and antihypotonic agents.
摘要翻译：在亚胺氮取代的式（I）的新型1-苯基-4（1H） - 哒嗪酮 - 亚胺及其与生理耐受酸的加成盐，其制备方法，药物制剂含有这些化合物及其作为药物的用途，特别是作为抗抑郁药，抗帕金森药物和抗低血糖剂。

7. 发明授权

US4564641A Substituted 1-oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes, their preparation and their use 失效
标题翻译：取代的1-氧代-2-苯基-2-（2-烷基氨基乙基）-1,2,3,4-四氢萘，其制备及其用途
公开(公告)号：US4564641A
公开(公告)日：1986-01-14
申请号：US554298
申请日：1983-11-22
申请人： Werner Seitz , Hans-Jurgen Teschendorf , Alfred Michel , Martin Traut , Hans P. Hofmann , Horst Kreiskott
发明人： Werner Seitz , Hans-Jurgen Teschendorf , Alfred Michel , Martin Traut , Hans P. Hofmann , Horst Kreiskott
IPC分类号： C07C225/18 , A61K31/135 , A61K31/205 , A61K31/395 , A61P25/24 , A61P25/26 , C07D207/08 , C07D211/32 , C07D295/10 , C07D295/116 , C07D295/12 , C07D295/145 , C07C91/16
CPC分类号： C07D295/116 , C07C255/00 , C07D295/145
摘要： 1-Oxo-2-phenyl-2-(2-alkylaminoethyl)-1,2,3,4-tetrahydronaphthalenes of the formula I ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, halogen, trifluoromethyl, C.sub.1 -C.sub.4 -alkyl or C.sub.1 -C.sub.4 -alkoxy, R.sup.3 is C.sub.1 -C.sub.6 -alkyl and R.sup.4 is hydrogen, C.sub.1 -C.sub.6 -alkyl or benzyl, or R.sup.3 and R.sup.4 together may furthermore be a C.sub.2 -C.sub.5 -alkylene chain, and their salts with physiologically tolerated acids, and their preparation, are described.The novel compounds are useful active compounds for treating disorders.
摘要翻译：式I的1-氧代-2-苯基-2-（2-烷基氨基乙基）-1,2,3,4-四氢萘其中R 1和R 2相同或不同，各自为氢，卤素，三氟甲基， C 1 -C 4 - 烷基或C 1 -C 4 - 烷氧基，R 3是C 1 -C 6 - 烷基，R 4是氢，C 1 -C 6烷基或苄基，或者R 3和R 4可以一起可以是C 2 -C 5亚烷基链，描述了与生理上耐受的酸的盐及其制备方法。新型化合物是用于治疗疾病的有用的活性化合物。

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