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1. 发明授权

US08748390B2 Immunogenic epitopes of NGEP antigen 有权
标题翻译： NGEP抗原的免疫原性表位
公开(公告)号：US08748390B2
公开(公告)日：2014-06-10
申请号：US13265490
申请日：2010-04-19
申请人： Jeffrey Schlom , Kwong-Yok Tsang , Ira Pastan
发明人： Jeffrey Schlom , Kwong-Yok Tsang , Ira Pastan
IPC分类号： A61K38/08 , A61K39/00 , C07K7/06
CPC分类号： A61K39/0011 , A61K38/00 , A61K38/191 , A61K38/193 , A61K38/20 , A61K38/217 , A61K39/00 , C07K7/06 , C07K14/4748 , C07K14/705 , Y02A50/466
摘要： The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in vaccine prevention or therapy of prostate cancer, as well as a nucleic acid encoding the peptide, a vector comprising the nucleic acid, a cell comprising the peptide, nucleic acid, or vector, and compositions thereof.
摘要翻译：本发明提供了一种肽，其包含来自人肿瘤相关抗原（TAA）在前列腺中表达的新基因（NGEP）的人溶细胞T淋巴细胞（CTL）表位，其可用于预防或治疗前列腺癌，以及编码所述肽的核酸，包含所述核酸的载体，包含所述肽，核酸或载体的细胞及其组合物。

2. 发明申请

US20120052116A1 IMMUNOGENIC EPITOPES OF NGEP ANTIGEN 有权
标题翻译： NGEP抗原的免疫原性抗体
公开(公告)号：US20120052116A1
公开(公告)日：2012-03-01
申请号：US13265490
申请日：2010-04-19
申请人： Jeffrey Schlom , Kwong-Yok Tsang , Ira Pastan
发明人： Jeffrey Schlom , Kwong-Yok Tsang , Ira Pastan
IPC分类号： A61K9/127 , A61K38/20 , A61K38/21 , A61K39/00 , A61K45/08 , A61K35/26 , C12N5/10 , C12N15/63 , A61P35/00 , A61K38/10 , A61K38/08 , C07K7/08 , C07K7/06 , A61P37/00 , A61P31/12 , A61P31/04 , A61P31/10 , A61K38/19
CPC分类号： A61K39/0011 , A61K38/00 , A61K38/191 , A61K38/193 , A61K38/20 , A61K38/217 , A61K39/00 , C07K7/06 , C07K14/4748 , C07K14/705 , Y02A50/466
摘要： The invention provides a peptide comprising a human cytolytic T lymphocyte (CTL) epitope from the human tumor-associated antigen (TAA) New Gene Expressed in Prostate (NGEP), which can be used in vaccine prevention or therapy of prostate cancer, as well as a nucleic acid encoding the peptide, a vector comprising the nucleic acid, a cell comprising the peptide, nucleic acid, or vector, and compositions thereof.
摘要翻译：本发明提供了一种肽，其包含来自人肿瘤相关抗原（TAA）在前列腺中表达的新基因（NGEP）的人溶细胞T淋巴细胞（CTL）表位，其可用于预防或治疗前列腺癌，以及编码所述肽的核酸，包含所述核酸的载体，包含所述肽，核酸或载体的细胞及其组合物。

3. 发明授权

US09592304B2 Recombinant antibodies and immunoconjugates targeted to CD-22 bearing cells and tumors 有权
标题翻译：靶向CD-22携带细胞和肿瘤的重组抗体和免疫缀合物
公开(公告)号：US09592304B2
公开(公告)日：2017-03-14
申请号：US12433737
申请日：2009-04-30
申请人： David J. FitzGerald , Ira Pastan , Elizabeth Mansfield , Robert Kreitman
发明人： David J. FitzGerald , Ira Pastan , Elizabeth Mansfield , Robert Kreitman
IPC分类号： A61K39/395 , A61K47/48 , C07K16/28 , A61K38/00
CPC分类号： A61K47/48561 , A61K38/00 , A61K47/6849 , C07K16/2803 , C07K2319/00
摘要： Methods and compositions relating to anti-CD22 antibodies with high binding affinity, and immunoconjugates comprising the anti-CD22 antibody linked to a therapeutic agent such as a Pseudomonas exotoxin or a detectable label. The invention provides diagnostic methods, and means to inhibit the growth of malignant B cells.
摘要翻译：与具有高结合亲和力的抗CD22抗体相关的方法和组合物，以及包含与治疗剂如假单胞菌外毒素或可检测标记物连接的抗-CD22抗体的免疫偶联物。本发明提供诊断方法和抑制恶性B细胞生长的手段。

4. 发明授权

US07572887B2 Gene expressed in prostate cancer, methods and use thereof 失效
标题翻译：在前列腺癌中表达的基因，其方法和用途
公开(公告)号：US07572887B2
公开(公告)日：2009-08-11
申请号：US10552515
申请日：2004-04-05
申请人： Ira Pastan , Tapan K. Bera , Byungkook Lee
发明人： Ira Pastan , Tapan K. Bera , Byungkook Lee
IPC分类号： C07K14/00 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： A61K38/168 , A61K38/164 , A61K47/64 , C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , G01N33/57434 , G01N2500/00
摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
摘要翻译：公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合SV-NGEP的抗体和免疫结合物。公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。公开了检测前列腺癌的测定。还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。这些药物组合物可用于治疗前列腺癌。

5. 发明申请

US20070248972A1 Page-4, an X-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor 审中-公开
标题翻译：第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的X连接的量规样基因，并用于其
公开(公告)号：US20070248972A1
公开(公告)日：2007-10-25
申请号：US11704714
申请日：2007-02-09
申请人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
发明人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
IPC分类号： C12Q1/68 , C07H21/00 , C12N1/00 , C12N1/21 , C12N15/00 , C12N5/00
CPC分类号： C07K14/4748 , A61K39/00
摘要： PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
摘要翻译： PAGE-4是在正常男性和女性生殖组织，前列腺，睾丸，输卵管，子宫和胎盘以及前列腺癌，睾丸癌和子宫癌中优先表达的基因。这种表达模式使其成为诊断和基于疫苗的前列腺，睾丸和子宫肿瘤的治疗的目标。本发明提供包含PAGE-4蛋白或其免疫原性肽的免疫原性组合物，抑制表达PAGE-4的恶性细胞生长的方法，以及诱导对表达PAGE-4的癌症增强的免疫应答的方法。

6. 发明申请

US20060058336A1 Pharmaceutical composition for treatment of drug dependence 审中-公开
标题翻译：用于治疗药物依赖的药物组合物
公开(公告)号：US20060058336A1
公开(公告)日：2006-03-16
申请号：US10493488
申请日：2004-02-26
申请人： Shigetada Nakanishi , Takatoshi Hikida , Ira Pastan
发明人： Shigetada Nakanishi , Takatoshi Hikida , Ira Pastan
IPC分类号： A61K31/4745 , A61K31/473 , A61K31/47 , A61K31/4178 , A61K31/407
CPC分类号： A61K31/407 , A61K31/00 , A61K31/4178 , A61K31/445 , A61K31/47 , A61K31/473 , A61K31/4745 , A61K31/55
摘要： The present invention relates to the use of a medicinal substance capable of enhancing or disinhibiting the actions of acetylcholine, and provides a pharmaceutical composition for treating drug dependence comprising said substance as an active ingredient, and a method of treating drug dependence using the same.
摘要翻译：本发明涉及能够增强或抑制乙酰胆碱作用的药物的用途，提供一种治疗药物依赖性的药物组合物，其含有所述物质作为活性成分，以及使用该组合物治疗药物依赖性的方法。

7. 发明授权

US06232086B1 Method for detecting cancer cells 失效
标题翻译：癌细胞检测方法
公开(公告)号：US06232086B1
公开(公告)日：2001-05-15
申请号：US09234232
申请日：1999-01-20
申请人： Ira Pastan , Ulrich Brinkmann
发明人： Ira Pastan , Ulrich Brinkmann
IPC分类号： A61K39395
CPC分类号： C07K16/18 , A61K38/00 , C07K14/4747 , Y10S435/81
摘要： The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents or inhibits apoptosis in the cells.
摘要翻译：用于细胞凋亡敏感性（CAS）蛋白的cDNA和氨基酸序列用于检测正常和癌细胞中CAS基因的表达和扩增。引入活细胞的反义CAS基因序列抑制CAS蛋白活性，从而阻止或抑制细胞凋亡。

8. 发明授权

US5990296A Single chain B3 antibody fusion proteins and their uses 失效
标题翻译：单链B3抗体融合蛋白及其用途
公开(公告)号：US5990296A
公开(公告)日：1999-11-23
申请号：US759804
申请日：1996-12-03
申请人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
发明人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C07H21/04
CPC分类号： A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57419 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00 , Y10S530/866 , Y10S530/867
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供单克隆抗体B3的单链Fv区。本发明还提供了一种方法，其将VH区域的95位缺失丝氨酸的抗体与包含突变位置95的丝氨酸相结合。

9. 发明授权

US5846535A Methods for reducing tumor cell growth by using antibodies with broad tumor reactivity and limited normal tissue reactivity 失效
标题翻译：通过使用具有广泛肿瘤反应性和有限正常组织反应性的抗体来减少肿瘤细胞生长的方法
公开(公告)号：US5846535A
公开(公告)日：1998-12-08
申请号：US467959
申请日：1995-06-06
申请人： Ira Pastan , Mark C. Willingham
发明人： Ira Pastan , Mark C. Willingham
IPC分类号： A61K38/00 , C07K16/30 , A61K39/395
CPC分类号： C07K16/3046 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622
摘要： The subject invention relates to methods for reducing tumor cell growth in a mammal by administering compositions which include an antibody having the binding specificity of a monoclonal antibody selected from the group comprising one of those referred to as B1, B3 or B5 conjugated to a toxin, radionuclide or drug.
摘要翻译：本发明涉及通过施用组合物来减少哺乳动物肿瘤细胞生长的方法，所述组合物包括具有与毒素缀合的被称为B1，B3或B5的那些之一的单克隆抗体的结合特异性的抗体，放射性核素或药物。

10. 发明授权

US5759782A Cellular apoptosis susceptibility protein (CSP) and antisense CSP 失效
标题翻译：细胞凋亡敏感性蛋白（CSP）和反义CSP
公开(公告)号：US5759782A
公开(公告)日：1998-06-02
申请号：US480662
申请日：1995-06-07
申请人： Ira Pastan , Ulrich Brinkmann
发明人： Ira Pastan , Ulrich Brinkmann
IPC分类号： A61K38/00 , C07K14/47 , C07K16/18 , C07H21/00 , C07H21/04 , C12N15/09 , C12N15/63
CPC分类号： C07K16/18 , C07K14/4747 , A61K38/00 , Y10S435/81
摘要： The cDNA and amino acid sequences for a cellular apoptosis susceptibility (CAS) protein are used to detect expression and amplification of the CAS gene in normal and cancer cells. An antisense CAS gene sequence introduced into living cells inhibits CAS protein activity and thus prevents or inhibits apoptosis in the cells.
摘要翻译：用于细胞凋亡敏感性（CAS）蛋白的cDNA和氨基酸序列用于检测正常和癌细胞中CAS基因的表达和扩增。引入活细胞的反义CAS基因序列抑制CAS蛋白活性，从而阻止或抑制细胞凋亡。

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